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The map label for this gene is hipA [C]

Identifier: 160876585

GI number: 160876585

Start: 4100950

End: 4102212

Strand: Direct

Name: hipA [C]

Synonym: Sbal195_3479

Alternate gene names: 160876585

Gene position: 4100950-4102212 (Clockwise)

Preceding gene: 160876584

Following gene: 160876590

Centisome position: 76.69

GC content: 44.81

Gene sequence:

>1263_bases
ATGAAACCTGCTGAATCAGTAGAGGCTCTCGCGCTTTATTTAAATCATCAACGGATTGCGATACTCACCCATTATTCAGG
TGGTAAAAACATTCTGAAATTTGACCCTGAATATATCGCGATGCCAAAAGCACTTCGACCAACATTAACGCTCACCCAAC
TGCTAGACCCCCACTACATCGATAAAATACAAGTCAGAACACAAAGATTATCACCGGTGCTGTCTAACTTGCTCCCCGAG
GGCGCATTGCGGCATTGGATGTCAGCCGCGCTAAAAGTACATGAGAACAACGAATTTCCCATATTGGCGTGGGCAGGGAA
CAATCTTCCCGGCGGCTTAATCGCATCAGCCATAGCAAAAGAAGATATTCCAGCTTGGGCACTATCGCCACGGGAAAGAA
CAGAAGCCATCGTAATCGACATCACCCACACCAGTAATAAATTCTCACTTGCCGGTGTTCAAATGAAATTCTCGACAAGC
AGAAACGATGGACGATTCAACATAAATGCCGATCAAGATGGCCAAGATAGTTGGATTATCAAGACGCCTTCAACAGTACA
CCGCAACGTCCCACAAAATGAATACACTGCAATGAAGTTGGCACAAATAATCGGAGTGAACATCCCTGAAATTGAGCTCA
TCTCGCTTAATGCATTGGATAATTTACCCAACATCAAACTCCCAGATGAACCAACGGCTTATGCAATTAAACGCTTTGAC
CGCAGTGATACGGGCCGCATTCATGCAGAGGACTTTGCCCAAATATTCGAAGTTTACGCCCATGATAAATACGGTAAATA
CAACTACGAAGCCATAGCGAAAGCTCTATACATGAGCAGCTACAATGGACTAAAAGACGTGCAGCAAATGGCAAGGCGAT
TGCTGGCCAATATCTTGCTCGCCAACGGTGATGCCCACTTAAAAAATTGGAGTGTTATCTACCCAGATAACCAAAATGCG
ATACTCTCACCCGCTTACGATATTGTGAGCACCTTACCCTACATAGAAGGCGAAACCGCCATTGCTCTCAACATAAATAA
ACAAAAACTATGGTACGCCATTGATATCACTACCTTCCAAGCATGGGCAACGAGAACAGGCATACCATGGCCCGCGATAA
AGGTTCATTTACTGGATGCCATGCAAAAAGCCCGTACTCTTTGGCCAGAGGCACTTGCTGAACTCCCCATGCATGAAGTG
CATAAAACGATATTAAAAGCTCACTGGGCCAAACTACATAACGACTTTAAAATCCTCTGCTAG

Upstream 100 bases:

>100_bases
AACCAGAAATTGACCGTCATTCGCCTAACCACTTAACGGCAGAGACGGGCACATCTTGGGAAAAGGTCTTACATTCAGTT
GATGATAAAGAAGAAAATCT

Downstream 100 bases:

>100_bases
CTATGATATCAGCCCCAATAACAATATTGATTTCGGTGGCAACATTGGGGTATAGGTGTGAATCAGTTATCTAGAGATTT
GATTTATCTTAAGGGAAAAA

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MKPAESVEALALYLNHQRIAILTHYSGGKNILKFDPEYIAMPKALRPTLTLTQLLDPHYIDKIQVRTQRLSPVLSNLLPE
GALRHWMSAALKVHENNEFPILAWAGNNLPGGLIASAIAKEDIPAWALSPRERTEAIVIDITHTSNKFSLAGVQMKFSTS
RNDGRFNINADQDGQDSWIIKTPSTVHRNVPQNEYTAMKLAQIIGVNIPEIELISLNALDNLPNIKLPDEPTAYAIKRFD
RSDTGRIHAEDFAQIFEVYAHDKYGKYNYEAIAKALYMSSYNGLKDVQQMARRLLANILLANGDAHLKNWSVIYPDNQNA
ILSPAYDIVSTLPYIEGETAIALNINKQKLWYAIDITTFQAWATRTGIPWPAIKVHLLDAMQKARTLWPEALAELPMHEV
HKTILKAHWAKLHNDFKILC

Sequences:

>Translated_420_residues
MKPAESVEALALYLNHQRIAILTHYSGGKNILKFDPEYIAMPKALRPTLTLTQLLDPHYIDKIQVRTQRLSPVLSNLLPE
GALRHWMSAALKVHENNEFPILAWAGNNLPGGLIASAIAKEDIPAWALSPRERTEAIVIDITHTSNKFSLAGVQMKFSTS
RNDGRFNINADQDGQDSWIIKTPSTVHRNVPQNEYTAMKLAQIIGVNIPEIELISLNALDNLPNIKLPDEPTAYAIKRFD
RSDTGRIHAEDFAQIFEVYAHDKYGKYNYEAIAKALYMSSYNGLKDVQQMARRLLANILLANGDAHLKNWSVIYPDNQNA
ILSPAYDIVSTLPYIEGETAIALNINKQKLWYAIDITTFQAWATRTGIPWPAIKVHLLDAMQKARTLWPEALAELPMHEV
HKTILKAHWAKLHNDFKILC
>Mature_420_residues
MKPAESVEALALYLNHQRIAILTHYSGGKNILKFDPEYIAMPKALRPTLTLTQLLDPHYIDKIQVRTQRLSPVLSNLLPE
GALRHWMSAALKVHENNEFPILAWAGNNLPGGLIASAIAKEDIPAWALSPRERTEAIVIDITHTSNKFSLAGVQMKFSTS
RNDGRFNINADQDGQDSWIIKTPSTVHRNVPQNEYTAMKLAQIIGVNIPEIELISLNALDNLPNIKLPDEPTAYAIKRFD
RSDTGRIHAEDFAQIFEVYAHDKYGKYNYEAIAKALYMSSYNGLKDVQQMARRLLANILLANGDAHLKNWSVIYPDNQNA
ILSPAYDIVSTLPYIEGETAIALNINKQKLWYAIDITTFQAWATRTGIPWPAIKVHLLDAMQKARTLWPEALAELPMHEV
HKTILKAHWAKLHNDFKILC

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4mE [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=457, Percent_Identity=24.507658643326, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 47393; Mature: 47393

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS50222 EF_HAND_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAESVEALALYLNHQRIAILTHYSGGKNILKFDPEYIAMPKALRPTLTLTQLLDPHYI
CCCHHHHHHHHHEECCCEEEEEEEECCCCCEEEECCHHHCCCCHHCCHHHHHHHCCCHHH
DKIQVRTQRLSPVLSNLLPEGALRHWMSAALKVHENNEFPILAWAGNNLPGGLIASAIAK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEECCCCEEEEEEECCCCCHHHHHHHHHH
EDIPAWALSPRERTEAIVIDITHTSNKFSLAGVQMKFSTSRNDGRFNINADQDGQDSWII
CCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEEEECCCCCCEEEECCCCCCCCCEEE
KTPSTVHRNVPQNEYTAMKLAQIIGVNIPEIELISLNALDNLPNIKLPDEPTAYAIKRFD
ECCHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCC
RSDTGRIHAEDFAQIFEVYAHDKYGKYNYEAIAKALYMSSYNGLKDVQQMARRLLANILL
CCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ANGDAHLKNWSVIYPDNQNAILSPAYDIVSTLPYIEGETAIALNINKQKLWYAIDITTFQ
CCCCCCCCCCEEEECCCCCCEECHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEEEEE
AWATRTGIPWPAIKVHLLDAMQKARTLWPEALAELPMHEVHKTILKAHWAKLHNDFKILC
HHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure
MKPAESVEALALYLNHQRIAILTHYSGGKNILKFDPEYIAMPKALRPTLTLTQLLDPHYI
CCCHHHHHHHHHEECCCEEEEEEEECCCCCEEEECCHHHCCCCHHCCHHHHHHHCCCHHH
DKIQVRTQRLSPVLSNLLPEGALRHWMSAALKVHENNEFPILAWAGNNLPGGLIASAIAK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEECCCCEEEEEEECCCCCHHHHHHHHHH
EDIPAWALSPRERTEAIVIDITHTSNKFSLAGVQMKFSTSRNDGRFNINADQDGQDSWII
CCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEEEECCCCCCEEEECCCCCCCCCEEE
KTPSTVHRNVPQNEYTAMKLAQIIGVNIPEIELISLNALDNLPNIKLPDEPTAYAIKRFD
ECCHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCC
RSDTGRIHAEDFAQIFEVYAHDKYGKYNYEAIAKALYMSSYNGLKDVQQMARRLLANILL
CCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ANGDAHLKNWSVIYPDNQNAILSPAYDIVSTLPYIEGETAIALNINKQKLWYAIDITTFQ
CCCCCCCCCCEEEECCCCCCEECHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEEEEE
AWATRTGIPWPAIKVHLLDAMQKARTLWPEALAELPMHEVHKTILKAHWAKLHNDFKILC
HHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]