Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 160876290

GI number: 160876290

Start: 3756047

End: 3756865

Strand: Direct

Name: proC [H]

Synonym: Sbal195_3184

Alternate gene names: 160876290

Gene position: 3756047-3756865 (Clockwise)

Preceding gene: 160876289

Following gene: 160876291

Centisome position: 70.24

GC content: 46.64

Gene sequence:

>819_bases
ATGGATCAACAGAAAATCTGCTTTATCGGTGCCGGCAACATGACGCGCAGCATCATCAGTGGCCTAGTTCATAGCGGCTA
TCCTGCTCAACTCATCCAAGCGACCAATCCTAGCCAAGGTAAACTCGACGCACTAAAAGCCGATTTAGGGATTTTGGTTT
CTCAAGACAATTTAGCCGCAGCGCAAGCTGCCGATGTCATAGTGCTGTCGGTAAAACCGCAATTGATGCAGCAAGTGTGT
GAAGCATTACAAACTGTCGACATGTCGCAAAAGTTAGTCATCACTATTGCTGCAGGCATTAAAGCAAAGCGTTATACCGA
TTATCTGGCGCAGGATATTAAGCTTATCCGCGCTATGCCCAATACACCGATGCAGATTAGTGTGGGCATGACTGGCCTCT
ATGCGCCTCAGGCTATTTCTACCGAGCAAAAAGCCATTTGCGATCGTTTGATGTCAAGCGGCGGCGAAATTGTGTGGGTT
AATGAAGAGTCAGAATTAGATCAAGTGATTGCACTATCGGGCAGTTCACCGGCTTATTTCTTTTTGCTAATGGAGTCTAT
GATAGATGCAGGCAAAGAAATGGGAATGGATGAAGACAAAGCCAGAACTTTAGTGCAGCAAGCCGCGCTCGGCGCTGCTA
TGATGGCAAAGCAAAATCCACAACTGACCTTAGGTAATCTAAGGGAGAATGTCACCTCAAAGGGCGGTACCACCGCACAG
GCGCTGGCGACATTTGAAGCTGCGGATATGCGTGGTTTAGTAAAAAAAGCCATGGAAAACTGCATTAAACGTGCAGAAGA
AATGGCTAAGACATTTTAA

Upstream 100 bases:

>100_bases
GACTAATCTGGCTCTGACATTCAAATGACTAACCGTTTTATCATCTTGATTTAAGGTGAGTCTGTTACAAATTAACGGTT
AACACACTGAAGAGAATCAA

Downstream 100 bases:

>100_bases
TTTCCACTAACGCGTTTTTATATCGGACTTTAATAGGTAGAAATCTCGATGAATGCATTTACCTTTTTAATCACCACACT
ATTCGACTTATATTTGATGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDQQKICFIGAGNMTRSIISGLVHSGYPAQLIQATNPSQGKLDALKADLGILVSQDNLAAAQAADVIVLSVKPQLMQQVC
EALQTVDMSQKLVITIAAGIKAKRYTDYLAQDIKLIRAMPNTPMQISVGMTGLYAPQAISTEQKAICDRLMSSGGEIVWV
NEESELDQVIALSGSSPAYFFLLMESMIDAGKEMGMDEDKARTLVQQAALGAAMMAKQNPQLTLGNLRENVTSKGGTTAQ
ALATFEAADMRGLVKKAMENCIKRAEEMAKTF

Sequences:

>Translated_272_residues
MDQQKICFIGAGNMTRSIISGLVHSGYPAQLIQATNPSQGKLDALKADLGILVSQDNLAAAQAADVIVLSVKPQLMQQVC
EALQTVDMSQKLVITIAAGIKAKRYTDYLAQDIKLIRAMPNTPMQISVGMTGLYAPQAISTEQKAICDRLMSSGGEIVWV
NEESELDQVIALSGSSPAYFFLLMESMIDAGKEMGMDEDKARTLVQQAALGAAMMAKQNPQLTLGNLRENVTSKGGTTAQ
ALATFEAADMRGLVKKAMENCIKRAEEMAKTF
>Mature_272_residues
MDQQKICFIGAGNMTRSIISGLVHSGYPAQLIQATNPSQGKLDALKADLGILVSQDNLAAAQAADVIVLSVKPQLMQQVC
EALQTVDMSQKLVITIAAGIKAKRYTDYLAQDIKLIRAMPNTPMQISVGMTGLYAPQAISTEQKAICDRLMSSGGEIVWV
NEESELDQVIALSGSSPAYFFLLMESMIDAGKEMGMDEDKARTLVQQAALGAAMMAKQNPQLTLGNLRENVTSKGGTTAQ
ALATFEAADMRGLVKKAMENCIKRAEEMAKTF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=31.7343173431734, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=31.7343173431734, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=31.7343173431734, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=25.830258302583, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=35.7933579335793, Blast_Score=154, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=31.3207547169811, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=27.0462633451957, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=24.3055555555556, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=33.8289962825279, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=34.8837209302326, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29225; Mature: 29225

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQQKICFIGAGNMTRSIISGLVHSGYPAQLIQATNPSQGKLDALKADLGILVSQDNLAA
CCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHCCCEEEECCCHHH
AQAADVIVLSVKPQLMQQVCEALQTVDMSQKLVITIAAGIKAKRYTDYLAQDIKLIRAMP
HHHCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
NTPMQISVGMTGLYAPQAISTEQKAICDRLMSSGGEIVWVNEESELDQVIALSGSSPAYF
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHEEEECCCCCHHH
FLLMESMIDAGKEMGMDEDKARTLVQQAALGAAMMAKQNPQLTLGNLRENVTSKGGTTAQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCHHH
ALATFEAADMRGLVKKAMENCIKRAEEMAKTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQQKICFIGAGNMTRSIISGLVHSGYPAQLIQATNPSQGKLDALKADLGILVSQDNLAA
CCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHCCCEEEECCCHHH
AQAADVIVLSVKPQLMQQVCEALQTVDMSQKLVITIAAGIKAKRYTDYLAQDIKLIRAMP
HHHCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
NTPMQISVGMTGLYAPQAISTEQKAICDRLMSSGGEIVWVNEESELDQVIALSGSSPAYF
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHEEEECCCCCHHH
FLLMESMIDAGKEMGMDEDKARTLVQQAALGAAMMAKQNPQLTLGNLRENVTSKGGTTAQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCHHH
ALATFEAADMRGLVKKAMENCIKRAEEMAKTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]