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The map label for this gene is ttcA1 [H]

Identifier: 160875323

GI number: 160875323

Start: 2626214

End: 2627182

Strand: Reverse

Name: ttcA1 [H]

Synonym: Sbal195_2210

Alternate gene names: 160875323

Gene position: 2627182-2626214 (Counterclockwise)

Preceding gene: 160875324

Following gene: 160875320

Centisome position: 49.13

GC content: 47.57

Gene sequence:

>969_bases
ATGCTTGAAGCTATATCTGAAGTTACGGCAAATCCTATGTCTGAAGAATTATCAAAAAAACACACTACCCGTCTGAATAA
ATTACAGAAACGTCTGCGTCGTGAAGTGGGTAGCGCAATCGCCGATTACAATATGATTGAAGATGGCGATAAGATCATGT
GCTGCCTAAGTGGCGGTAAAGACAGCTATGCGATGCTCGATATTTTGATGAATCTGCAGCAACGCGCGCCCATTCAGTTT
GAAATCATTGCGGTTAATTTAGATCAGAAGCAACCCGGCTTTCCTGAGCACGTGCTGCCCGCCTATTTAGAAAAGCTCAA
TGTGCCTTATCACATCCTCGAGAAAGACACTTACTCGATAGTGAAAGATAAAATCCCTGAAGGTAAAACTACCTGCTCCC
TGTGCTCTCGCCTACGCCGCGGTACGCTCTATGGCTTTGCCCAGCGCATCGGCGCCACTAAAATCGCCCTAGGCCACCAC
AGGGATGACATTATCGAGACCTTGTTCTTGAACATGTTCTTTGGCGGCAAGATGAAAGCTATGCCGCCAAAGCTACTGTC
GGATGATGGCGCTAATGTGGTCATTCGCCCTCTGGCCTATTGCCGTGAAAAAGATCTCGAAGAATATGCCAACTTAAGAG
AATTCCCGATCATCCCTTGTAACTTGTGTGGCTCGCAGGAAAACTTAAAGCGCGCCGCAGTCAAAGACATGCTTAATCAG
TGGGATAGACAGTACCCTGGTCGTATTGAAACGATCTTCACCGCCATGCAAAACACCGCACCATCACAGGGTGTTGACCG
TGAGCAGTTCGACTTTGTGTCTCTAACGCGTGACCCTAACGCGCCTATGCGTGGTGATGTTGCCGAAGCCAATCTACCCG
CATTCGATTTCCTTGATATCGCCAACAGCGGCCGTATTGATTTGGATGCGGCAAAACGCATTGATATCGTTAACACTTAT
GAAGTCTAA

Upstream 100 bases:

>100_bases
ATCACCGTTAGAAGAAGCCTAAGCGATACGCGGCACTTTACCCCGCCAAAGATAGCTGGAATAATACGCGCCCTGAAACT
GAGTTACTGGGCGCTTTTTT

Downstream 100 bases:

>100_bases
CTAAGTCTGAATTTAGCGCTCTAGTTAGTAAAAGAAGTTAACCCAACGAAAGTATGCAAGATAAATTAGCTAAACAAAAA
TGCCCACATTAAGTGGGCAT

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MLEAISEVTANPMSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNLQQRAPIQF
EIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHH
RDDIIETLFLNMFFGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYANLREFPIIPCNLCGSQENLKRAAVKDMLNQ
WDRQYPGRIETIFTAMQNTAPSQGVDREQFDFVSLTRDPNAPMRGDVAEANLPAFDFLDIANSGRIDLDAAKRIDIVNTY
EV

Sequences:

>Translated_322_residues
MLEAISEVTANPMSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNLQQRAPIQF
EIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHH
RDDIIETLFLNMFFGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYANLREFPIIPCNLCGSQENLKRAAVKDMLNQ
WDRQYPGRIETIFTAMQNTAPSQGVDREQFDFVSLTRDPNAPMRGDVAEANLPAFDFLDIANSGRIDLDAAKRIDIVNTY
EV
>Mature_322_residues
MLEAISEVTANPMSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNLQQRAPIQF
EIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHH
RDDIIETLFLNMFFGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYANLREFPIIPCNLCGSQENLKRAAVKDMLNQ
WDRQYPGRIETIFTAMQNTAPSQGVDREQFDFVSLTRDPNAPMRGDVAEANLPAFDFLDIANSGRIDLDAAKRIDIVNTY
EV

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=275, Percent_Identity=68.7272727272727, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI193211090, Length=249, Percent_Identity=33.7349397590361, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17540090, Length=198, Percent_Identity=29.7979797979798, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=25.6410256410256, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 36392; Mature: 36392

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAISEVTANPMSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGK
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
DSYAMLDILMNLQQRAPIQFEIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSI
CHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHH
VKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCC
MPPKLLSDDGANVVIRPLAYCREKDLEEYANLREFPIIPCNLCGSQENLKRAAVKDMLNQ
CCCHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCHHHHHHHHHHHHHHH
WDRQYPGRIETIFTAMQNTAPSQGVDREQFDFVSLTRDPNAPMRGDVAEANLPAFDFLDI
HHHCCCCHHHHHHHHHHHCCCCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHC
ANSGRIDLDAAKRIDIVNTYEV
CCCCCEEECHHHHCCCEECCCC
>Mature Secondary Structure
MLEAISEVTANPMSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGK
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
DSYAMLDILMNLQQRAPIQFEIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSI
CHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHH
VKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCC
MPPKLLSDDGANVVIRPLAYCREKDLEEYANLREFPIIPCNLCGSQENLKRAAVKDMLNQ
CCCHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCHHHHHHHHHHHHHHH
WDRQYPGRIETIFTAMQNTAPSQGVDREQFDFVSLTRDPNAPMRGDVAEANLPAFDFLDI
HHHCCCCHHHHHHHHHHHCCCCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHC
ANSGRIDLDAAKRIDIVNTYEV
CCCCCEEECHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA