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The map label for this gene is pdhA [H]

Identifier: 160875312

GI number: 160875312

Start: 2611784

End: 2612962

Strand: Direct

Name: pdhA [H]

Synonym: Sbal195_2199

Alternate gene names: 160875312

Gene position: 2611784-2612962 (Clockwise)

Preceding gene: 160875311

Following gene: 160875313

Centisome position: 48.84

GC content: 48.69

Gene sequence:

>1179_bases
ATGAGCAAAGCAACACTCAACACTGATACAGTGCACCGTGTCGGCTTCTTGGATAAGGCATCGCTACACATTCCTATCCT
TCGAATTCTACAAGCCGACGGCACCACTTATGAAACCGCGGTTTTGCCTGTGATAGATGAAACCTTAGCCACTAAAATTT
ACGATACCTGTGTATTCACTCGGGTACTCGATGAACGTATGTTAGGTGCCCAGCGTCAAGGGCGCATCAGCTTCTATATG
ACCTGTACAGGTGAAGAAGCGGCGATTGTCGGCAGTGTGGCCGCTCTCGATCAAGAAGACGTTATCCTCGCGCAATACCG
TGAGCATGCGGCGCTGCGTTATCGCGGCTTTACCACTGAACAGTTTATGAATCAGATGTTTAGTAACGAGAAAGATCTTG
GTAAAGGTCGCCAAATGCCCATTCACTACGGCAGTGCGGCATTGCATTATCAAACGATTTCTTCACCCCTTGCGACACAA
ATCCCGCAGGCGGCGGGTGTGGGCTACAGCTTAAAAATGCAAGGTAAGCGCAAAGTCGCGGTTTGCTATTTTGGCGAAGG
CGCTGCATCGGAAGGAGACTTCCATGCTGGTCTAAACATGGCCGCAGTATTGAAGTGTCCAGTGATTTTCTTCTGTCGTA
ACAATGGCTACGCCATTTCAACCCCAACTGAAGAGCAGTTTGCCGGTAACGGTATTGCGAGCCGCGGCGTGGGTTATGGC
ATGCACACCATTCGTGTTGACGGCAATGACATGTTGGCCGTGTTAGCGGCAACGCAGCAAGCCCGTGCCTATGCGATTGA
GCATAATGCGCCTGTGCTGATTGAAGCCATGACTTACCGTCTCGGCGCGCATTCATCATCAGACGATCCATCTGGTTATC
GCTCGAAAGATGAAGAAGCCAAGTGGCAGCAACACGATCCGGTTAAACGCTTCAAATTATGGCTTATAAACAAAGGTTGG
TTAGCTGAAGCGGATGATGTGAAACTGCATGAGAAATATCGTGAAGAAGTATTGGCTGCGGTAAAAGTGGCTGAAAAAAT
TCCTGTGCCTATGCTGGATGAAATTATTGAAGATGTGTACGACAAGCCGACGCCAGTGCTGAGAAAGCAACTCGCCGATC
TTAAAGAACATATCAAGAAATATCCGCAAGCCTATCCAAAAAGTGCAGGGAGACTATAA

Upstream 100 bases:

>100_bases
TTGATAGGTAGTTTACGTTAACGTAATGTTCGTCGGGCATATTCGTATAAACAGACGCATCAAAACGCTTTGGTGCGTAA
TGAGATAACAAGAGCACAAT

Downstream 100 bases:

>100_bases
GCCGTGGCTGAAATGAATATGTTACAGGCCGTCAATGAGGCCTTGTCGATCGCCATGCAAGCCGATGAGCGCATGGTGGT
TTTTGGTGAAGATGTGGGTC

Product: 3-methyl-2-oxobutanoate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDETLATKIYDTCVFTRVLDERMLGAQRQGRISFYM
TCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGSAALHYQTISSPLATQ
IPQAAGVGYSLKMQGKRKVAVCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKDEEAKWQQHDPVKRFKLWLINKGW
LAEADDVKLHEKYREEVLAAVKVAEKIPVPMLDEIIEDVYDKPTPVLRKQLADLKEHIKKYPQAYPKSAGRL

Sequences:

>Translated_392_residues
MSKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDETLATKIYDTCVFTRVLDERMLGAQRQGRISFYM
TCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGSAALHYQTISSPLATQ
IPQAAGVGYSLKMQGKRKVAVCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKDEEAKWQQHDPVKRFKLWLINKGW
LAEADDVKLHEKYREEVLAAVKVAEKIPVPMLDEIIEDVYDKPTPVLRKQLADLKEHIKKYPQAYPKSAGRL
>Mature_391_residues
SKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDETLATKIYDTCVFTRVLDERMLGAQRQGRISFYMT
CTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGSAALHYQTISSPLATQI
PQAAGVGYSLKMQGKRKVAVCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYGM
HTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKDEEAKWQQHDPVKRFKLWLINKGWL
AEADDVKLHEKYREEVLAAVKVAEKIPVPMLDEIIEDVYDKPTPVLRKQLADLKEHIKKYPQAYPKSAGRL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=364, Percent_Identity=50.2747252747253, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI258645172, Length=364, Percent_Identity=50.2747252747253, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI291084742, Length=290, Percent_Identity=31.0344827586207, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4505685, Length=290, Percent_Identity=31.0344827586207, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4885543, Length=285, Percent_Identity=29.1228070175439, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI291084744, Length=283, Percent_Identity=30.7420494699647, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI291084757, Length=291, Percent_Identity=27.4914089347079, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=365, Percent_Identity=50.958904109589, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI86563357, Length=365, Percent_Identity=50.958904109589, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17536047, Length=303, Percent_Identity=30.3630363036304, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=303, Percent_Identity=30.3630363036304, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=315, Percent_Identity=29.8412698412698, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI21355903, Length=366, Percent_Identity=45.9016393442623, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24639746, Length=301, Percent_Identity=31.8936877076412, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24639740, Length=301, Percent_Identity=31.8936877076412, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24639744, Length=301, Percent_Identity=31.8936877076412, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI28571106, Length=301, Percent_Identity=31.8936877076412, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24639748, Length=300, Percent_Identity=30.6666666666667, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 43537; Mature: 43406

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDETLATKIYDTCVFT
CCCCCCCCCHHHHHCCCCCCCCCHHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHH
RVLDERMLGAQRQGRISFYMTCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTE
HHHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHCCCCCHHHHHHHHHHHHEECCCCHH
QFMNQMFSNEKDLGKGRQMPIHYGSAALHYQTISSPLATQIPQAAGVGYSLKMQGKRKVA
HHHHHHHCCCCCCCCCCCCCEEECCEEEEHHHHCCHHHHHCCHHHCCCEEEEECCCCEEE
VCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
EEEECCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKDEEA
EEEEEECCCCEEEEEEHHHHHHEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCCCCC
KWQQHDPVKRFKLWLINKGWLAEADDVKLHEKYREEVLAAVKVAEKIPVPMLDEIIEDVY
CCCCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DKPTPVLRKQLADLKEHIKKYPQAYPKSAGRL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDETLATKIYDTCVFT
CCCCCCCCHHHHHCCCCCCCCCHHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHH
RVLDERMLGAQRQGRISFYMTCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTE
HHHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHCCCCCHHHHHHHHHHHHEECCCCHH
QFMNQMFSNEKDLGKGRQMPIHYGSAALHYQTISSPLATQIPQAAGVGYSLKMQGKRKVA
HHHHHHHCCCCCCCCCCCCCEEECCEEEEHHHHCCHHHHHCCHHHCCCEEEEECCCCEEE
VCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
EEEECCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKDEEA
EEEEEECCCCEEEEEEHHHHHHEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCCCCC
KWQQHDPVKRFKLWLINKGWLAEADDVKLHEKYREEVLAAVKVAEKIPVPMLDEIIEDVY
CCCCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DKPTPVLRKQLADLKEHIKKYPQAYPKSAGRL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA