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The map label for this gene is edd [H]

Identifier: 160875290

GI number: 160875290

Start: 2587778

End: 2589604

Strand: Direct

Name: edd [H]

Synonym: Sbal195_2177

Alternate gene names: 160875290

Gene position: 2587778-2589604 (Clockwise)

Preceding gene: 160875289

Following gene: 160875291

Centisome position: 48.39

GC content: 49.37

Gene sequence:

>1827_bases
ATGCACTCAGTAGTTCAAGCTGTTACCGACAGAATTATTGCCCGTAGCAAAGCGTCACGTGAAGGTTATCTCGCCGCATT
GAATGATGCCCGTAACCATGGTGTACACCGTAGCTCATTGAGCTGTGGCAACTTAGCCCATGGTTTTGCCGCCTGTAATC
CAGACGACAAAAATGCATTGCGTCAATTGAATAAAGCGAACATTGGCATAGTGACGGCATTTAACGACATGTTATCTGCG
CACCAACCCTATGAAAGCTATCCTGAATTGCTTAAAAAAGCCTGTCAGGAAGTCGGCAGTGTTGCACAAGTGGCGGGCGG
TGTTCCGGCCATGTGTGACGGTGTGACTCAAGGTCAACCCGGTATGGAATTGAGCTTACTGAGTCGTGAAGTTATTGCTA
TGGCAACGGCAGTGGGCTTGTCTCACAACATGTTTGATGGCGCTTTACTGCTCGGCATTTGCGATAAAATCGTTCCTGGT
TTGCTTATCGGCGCCTTAAGCTTTGGTCACTTACCTATGTTATTCGTGCCTGCTGGGCCGATGAAATCAGGTATCCCGAA
CAAAGAAAAAGCCCGTATTCGTCAGCAATTTGCCCAAGGTAAAGTGGATCGCGCGCAGCTGTTAGAAGCTGAAGCCCAGT
CTTACCACAGTGCAGGAACCTGTACTTTCTACGGCACTGCAAACTCGAATCAGCTGATGCTTGAAGTGATGGGGCTGCAG
TTACCAGGCTCGTCATTTGTGAATCCTGATGATCCACTGCGCGAAGCCTTAAACAAGATGGCCGCTAAGCAAGTGTGTCG
TTTAACCGAAATGGGTACTCAATATACCCCAATTGGTGAAGTGGTCAGTGAAAAGTCTGTGGTTAACGGCATTGTGGCGC
TCTTGGCTACCGGCGGTTCTACTAACTTGACTATGCACATCGTCGCCGCGGCTAGAGCTGCCGGTATTATCGTGAATTGG
GATGATTTTTCTGAATTATCCGATGCCGTGCCATTAGTGGCGCGCGTGTATCCAAACGGTCACGCCGATATCAACCATTT
CCACGCAGCAGGCGGCATGGCGTACTTAATCAAAGAATTACTTGATGCGGGTCTATTGCATGAAGATGTGAATACCGTTG
CGGGCTTTGGTTTACGCCGTTATACCCAAGAGCCAAAACTGCTCGACGGTGAACTTCGCTGGGTCGATGGCCCTACAACA
AGTTTAGATACTGAAGTGTTGACTTCAGTCGCATCGCCTTTCCAAGGCAATGGTGGTTTGAAATTACTGAAAGGTAACTT
GGGCCGCGCTGTAATCAAAGTATCAGCGGTACAAGAACAACATCGTGTCGTTGAAGCGCCAGCGGTAGTCATTGACGATC
AAAACAAACTCGATGCCTTGTTCCAAGCAGGGGCTCTGGATAGAGATTGTGTTGTGGTGGTTAAAGGTCAAGGGCCGAAA
GCCAACGGTATGCCAGAACTGCACAAGTTAACCCCATTATTGGGTACGCTTCAGGACAAAGGCTTTAAAGTCGCGCTGCT
GACCGACGGTCGTATGTCTGGCGCGTCGGGTAAAGTCCCCGCGGCCATTCACTTGACGCCAGAAGCCTTAGATGGCGGCT
TAATTGCCAAAGTCAAAGATGGCGACTTGATCCGTGTCGATGCGTTAACAGGCGAACTGAGTCTGCTCGTCTCTGAAGCT
GAACTTGCCACCAGAACCGCCGGAATAGTCGATTTACATCGGTCACGTTATGGCATGGGCCGCGAGTTATTTAGTGCGCT
ACGTTCCAATCTAAGCAGTCCAGAAACTGGTGCGCGTTGTACTAATGCCATCGATGAACTTTATTAA

Upstream 100 bases:

>100_bases
AGCGTTAGAAAGTGATGATGTCCATGCTATGCCTATCAGAGCCGTATTAGCGCAGCGTAAAACGCCCGTTGATGTGTTCT
GGAGCGCTTAAGGAGTCAAG

Downstream 100 bases:

>100_bases
TACAAAGGAAGAATAACGCAATGCTTGAGAATAACTGGTCACTACAGCCACAAGATATTTTTAAACGCAGCCCTATTGTT
CCTGTTATGGTGATTAACAA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHSVVQAVTDRIIARSKASREGYLAALNDARNHGVHRSSLSCGNLAHGFAACNPDDKNALRQLNKANIGIVTAFNDMLSA
HQPYESYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREALNKMAAKQVCRLTEMGTQYTPIGEVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLVARVYPNGHADINHFHAAGGMAYLIKELLDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTT
SLDTEVLTSVASPFQGNGGLKLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLDALFQAGALDRDCVVVVKGQGPK
ANGMPELHKLTPLLGTLQDKGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKVKDGDLIRVDALTGELSLLVSEA
ELATRTAGIVDLHRSRYGMGRELFSALRSNLSSPETGARCTNAIDELY

Sequences:

>Translated_608_residues
MHSVVQAVTDRIIARSKASREGYLAALNDARNHGVHRSSLSCGNLAHGFAACNPDDKNALRQLNKANIGIVTAFNDMLSA
HQPYESYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREALNKMAAKQVCRLTEMGTQYTPIGEVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLVARVYPNGHADINHFHAAGGMAYLIKELLDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTT
SLDTEVLTSVASPFQGNGGLKLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLDALFQAGALDRDCVVVVKGQGPK
ANGMPELHKLTPLLGTLQDKGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKVKDGDLIRVDALTGELSLLVSEA
ELATRTAGIVDLHRSRYGMGRELFSALRSNLSSPETGARCTNAIDELY
>Mature_608_residues
MHSVVQAVTDRIIARSKASREGYLAALNDARNHGVHRSSLSCGNLAHGFAACNPDDKNALRQLNKANIGIVTAFNDMLSA
HQPYESYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREALNKMAAKQVCRLTEMGTQYTPIGEVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLVARVYPNGHADINHFHAAGGMAYLIKELLDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTT
SLDTEVLTSVASPFQGNGGLKLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLDALFQAGALDRDCVVVVKGQGPK
ANGMPELHKLTPLLGTLQDKGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKVKDGDLIRVDALTGELSLLVSEA
ELATRTAGIVDLHRSRYGMGRELFSALRSNLSSPETGARCTNAIDELY

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=593, Percent_Identity=68.4654300168634, Blast_Score=848, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=546, Percent_Identity=28.9377289377289, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI2367371, Length=486, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1786464, Length=508, Percent_Identity=28.9370078740157, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=501, Percent_Identity=30.5389221556886, Blast_Score=181, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64454; Mature: 64454

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSVVQAVTDRIIARSKASREGYLAALNDARNHGVHRSSLSCGNLAHGFAACNPDDKNAL
CCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCCCCCHHCCCCCCCCCHHHHH
RQLNKANIGIVTAFNDMLSAHQPYESYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQP
HHHHCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREALNKMAAKQVCRLTEMGTQYTPIGEVVSEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLVARVYPNGHADINHFHAAGGMAYLIKEL
CCEEEEEEEHHHHCEEEEECCCHHHHHHHHCCHHEECCCCCCCCCHHHHCCCHHHHHHHH
LDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTTSLDTEVLTSVASPFQGNGGL
HHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCE
KLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLDALFQAGALDRDCVVVVKGQGPK
EEEECCCCCEEEEHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
ANGMPELHKLTPLLGTLQDKGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKVKD
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEECC
GDLIRVDALTGELSLLVSEAELATRTAGIVDLHRSRYGMGRELFSALRSNLSSPETGARC
CCEEEEEECCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
TNAIDELY
HHHHHHCC
>Mature Secondary Structure
MHSVVQAVTDRIIARSKASREGYLAALNDARNHGVHRSSLSCGNLAHGFAACNPDDKNAL
CCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCCCCCHHCCCCCCCCCHHHHH
RQLNKANIGIVTAFNDMLSAHQPYESYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQP
HHHHCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREALNKMAAKQVCRLTEMGTQYTPIGEVVSEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLVARVYPNGHADINHFHAAGGMAYLIKEL
CCEEEEEEEHHHHCEEEEECCCHHHHHHHHCCHHEECCCCCCCCCHHHHCCCHHHHHHHH
LDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTTSLDTEVLTSVASPFQGNGGL
HHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCE
KLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLDALFQAGALDRDCVVVVKGQGPK
EEEECCCCCEEEEHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
ANGMPELHKLTPLLGTLQDKGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKVKD
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEECC
GDLIRVDALTGELSLLVSEAELATRTAGIVDLHRSRYGMGRELFSALRSNLSSPETGARC
CCEEEEEECCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHH
TNAIDELY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]