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The map label for this gene is fadE [H]

Identifier: 160875285

GI number: 160875285

Start: 2580247

End: 2582526

Strand: Direct

Name: fadE [H]

Synonym: Sbal195_2172

Alternate gene names: 160875285

Gene position: 2580247-2582526 (Clockwise)

Preceding gene: 160875284

Following gene: 160875288

Centisome position: 48.25

GC content: 48.07

Gene sequence:

>2280_bases
ATGTTGACGATTATAATTCTTGCCCTGATAGCCATTGTCGTGTTGTTTGCGGTGAAAAATATCCGGATGCAGTTTATTAC
CCGCCCAGTTTTTAGTTTTTTCAAGAAGGTCTTACCGCCACTTTCAGATACCGAGCGCGAAGCGATGGAAGCCGGTGATG
TCTGGTGGGAAGGGGAGTTATTCCGCGGAAATCCTAACTGGAATACCTTGCACAGCTACGGCAAACCGACGCTGAGCGCT
GAAGAAAAAGACTTTATCGATAATCAAGTGATGACAGCACTGACGATGATTGATGATTTCGACATAGTGCATAACCGTAA
AGATTTACCGCCAGAGTTGTGGGAATACTTCAAGAAAGAAGGCTTCTTCGCCCTAATCATTCCGAAGAAATTCGGTGGTA
AAGCTTTCTCTGCCTATGCTAACTCTACCATTGTCAGCAAATTAGCCAGCCGTAGCGTAAGCGCCGCCGTGACCGTAATG
GTGCCTAACTCTTTAGGCCCTGGTGAGTTGTTGACCCATTATGGTACGAGTGAGCAGAAAGAACGTTGGTTACCTGCTTT
AGCTAAAGGCGATGAAATTCCTTGTTTTGCGTTAACCGGTCCAGAAGCGGGCAGTGATGCCGGCGCTATCCCGGATGTGG
GTATTGTGTGCCGTGATACCTTCAATGGCGAAGAAATGCTCGGGCTAAAACTCACTTGGGATAAGCGTTATATCACGCTG
GCGCCTGTGGCGACGGTTCTGGGTTTAGCCTTCCAAATGCGCGATCCTGAAGGCCTGCTTGGTGATAAGAAAAATTTAGG
CATTACCTGTGCGCTGATCCCAACGGATCATCCTGGTGTGGTTATCGGTCGTCGTCATAATCCACTAGGTATGGCGTTTA
TGAACGGTACCACCCAAGGTAAAGAAGTGTTTATCCCGCTGGATTGGATTATCGGTGGCCCTGAATTTGCCGGTAAAGGC
TGGCGTATGCTGGTTGAGTGTTTGTCGGCGGGCCGCGGTATTTCATTGCCTGCATTGGCAACGGCTTCTGGTCACATGGC
GACAAAGACGACAACGGCTTACAGCTATGTGCGTCACCAGTTTGGTATGGCAATTGGCCAATTTGAAGGGGTGCAAGAAG
CGCTGGCGCGTATTATTGCCAACACTTATCAGTTAGAAGCTGCACGTCGTTTAACAACCACGGGTATCGATCTTAAAGTT
AAACCTTCGGTTGTGACTGCGATTGCTAAGTACCACATGACTGAGCTAGGCCGTTCTGTGATGAACGATGCCATGGATAT
TCAATCGGGTAAGGGCATTCAATTAGGACCTAAAAACTATTTAGGCCACCCTTATATGTCGAATCCGATTTCGATCACTG
TGGAAGGCGCGAACATTCTAACCCGCTCCTTGATGATTTTTGGTCAAGGTGCGACTCGCTGCCATCCTTATGTGCTTGCC
GAAATGGAAGCCGCTGCGATGGAAAACCAACATGAAGCCTTAGAGCGTTTTGATGCGCTATTAATGGGCCACATGGGTTA
TGCCACGCGTAATGCTTTCAGTGCGTTGTTTAGCGCCTTAAGTGGTAGCCGTTTTGGCAGTGCGCCAGTGAGCGGTGAAA
CTAAGCAGTACTATAAAGATATGTCGCGTATTTCATCTGCATTAGCCTTAATGACGGATTTATCCATGCTGATCATGGGC
GGCGATTTAAAACGCAAAGAAATGCTGTCGGCACGTATGGGTGATGTGCTCAGCCAGTTGTATTTAGGCTCAGCAACCTT
GAAGTTGTTTGAAGACAATGGCCGTCAACAGGACGATTTACCCGCGGTACGTTACGTAATGGCCAATCGTTTGCACTTAG
CGGCGAAAGCACTGGAAGACACGATTCGTAACTTCCCGAGCCGTCCTGTGGCATGGTTACTGCGCGGCTTAATTTTCCCG
CTGGGTAATCACTTCAATGCGCCGAGCGACAAAATGGCGACCGATTTAGTCGGCGGCATGTTGAAGCCTGGCCCTGCTCG
TGACCGTATTACCTTCCTATGTCCTGAATTTGAAGGAGATAAAGGCGGTATTGCAGAAGTTGAGCAAGCATTTATTGCGC
AATATGCCTGTAAAGATATTTATAAAAAGCTGAAGAAAGCGCAGCGTGCCGGTGAACTGCCAGCCAAAGTGCCTAATCTC
GTCTTGTTTGCAAAAGCACTCGAGACTGGCGTTATCACTGCTGATGAAGAGCAGAAATTGCAGCATGCTGATAAGTTACG
CTTAGCGGCAATTAATGTGAATGATTTCGAAGCGTTATAG

Upstream 100 bases:

>100_bases
GGTGAGCATAACGACATCGAAGCCGTTATCCGTAAAGTGATCCCATACATGGCGGCTGGCGTATCAGTCCCCGTTTCTTC
TTAATTAAAAGGTCTTGATA

Downstream 100 bases:

>100_bases
TGATTGCTAGTGTTTGATATTAGCGTTTAATGTTAGTGCGGTCTGGTCTAAGCGGTATTAGGTTCAATGATTACTCCGCT
TGGGCGATAGGGCCGCTGAG

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MLTIIILALIAIVVLFAVKNIRMQFITRPVFSFFKKVLPPLSDTEREAMEAGDVWWEGELFRGNPNWNTLHSYGKPTLSA
EEKDFIDNQVMTALTMIDDFDIVHNRKDLPPELWEYFKKEGFFALIIPKKFGGKAFSAYANSTIVSKLASRSVSAAVTVM
VPNSLGPGELLTHYGTSEQKERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRDTFNGEEMLGLKLTWDKRYITL
APVATVLGLAFQMRDPEGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLGMAFMNGTTQGKEVFIPLDWIIGGPEFAGKG
WRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRHQFGMAIGQFEGVQEALARIIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKYHMTELGRSVMNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAAMENQHEALERFDALLMGHMGYATRNAFSALFSALSGSRFGSAPVSGETKQYYKDMSRISSALALMTDLSMLIMG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDLPAVRYVMANRLHLAAKALEDTIRNFPSRPVAWLLRGLIFP
LGNHFNAPSDKMATDLVGGMLKPGPARDRITFLCPEFEGDKGGIAEVEQAFIAQYACKDIYKKLKKAQRAGELPAKVPNL
VLFAKALETGVITADEEQKLQHADKLRLAAINVNDFEAL

Sequences:

>Translated_759_residues
MLTIIILALIAIVVLFAVKNIRMQFITRPVFSFFKKVLPPLSDTEREAMEAGDVWWEGELFRGNPNWNTLHSYGKPTLSA
EEKDFIDNQVMTALTMIDDFDIVHNRKDLPPELWEYFKKEGFFALIIPKKFGGKAFSAYANSTIVSKLASRSVSAAVTVM
VPNSLGPGELLTHYGTSEQKERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRDTFNGEEMLGLKLTWDKRYITL
APVATVLGLAFQMRDPEGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLGMAFMNGTTQGKEVFIPLDWIIGGPEFAGKG
WRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRHQFGMAIGQFEGVQEALARIIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKYHMTELGRSVMNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAAMENQHEALERFDALLMGHMGYATRNAFSALFSALSGSRFGSAPVSGETKQYYKDMSRISSALALMTDLSMLIMG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDLPAVRYVMANRLHLAAKALEDTIRNFPSRPVAWLLRGLIFP
LGNHFNAPSDKMATDLVGGMLKPGPARDRITFLCPEFEGDKGGIAEVEQAFIAQYACKDIYKKLKKAQRAGELPAKVPNL
VLFAKALETGVITADEEQKLQHADKLRLAAINVNDFEAL
>Mature_759_residues
MLTIIILALIAIVVLFAVKNIRMQFITRPVFSFFKKVLPPLSDTEREAMEAGDVWWEGELFRGNPNWNTLHSYGKPTLSA
EEKDFIDNQVMTALTMIDDFDIVHNRKDLPPELWEYFKKEGFFALIIPKKFGGKAFSAYANSTIVSKLASRSVSAAVTVM
VPNSLGPGELLTHYGTSEQKERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRDTFNGEEMLGLKLTWDKRYITL
APVATVLGLAFQMRDPEGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLGMAFMNGTTQGKEVFIPLDWIIGGPEFAGKG
WRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRHQFGMAIGQFEGVQEALARIIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKYHMTELGRSVMNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAAMENQHEALERFDALLMGHMGYATRNAFSALFSALSGSRFGSAPVSGETKQYYKDMSRISSALALMTDLSMLIMG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDLPAVRYVMANRLHLAAKALEDTIRNFPSRPVAWLLRGLIFP
LGNHFNAPSDKMATDLVGGMLKPGPARDRITFLCPEFEGDKGGIAEVEQAFIAQYACKDIYKKLKKAQRAGELPAKVPNL
VLFAKALETGVITADEEQKLQHADKLRLAAINVNDFEAL

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=425, Percent_Identity=27.7647058823529, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4557233, Length=320, Percent_Identity=30, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI4501859, Length=408, Percent_Identity=27.6960784313726, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI4557235, Length=337, Percent_Identity=26.1127596439169, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI76496475, Length=337, Percent_Identity=26.1127596439169, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI7669494, Length=390, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI87081702, Length=759, Percent_Identity=51.1198945981555, Blast_Score=775, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=24.6719160104987, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=283, Percent_Identity=30.7420494699647, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506239, Length=282, Percent_Identity=29.7872340425532, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71985192, Length=349, Percent_Identity=24.3553008595989, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32563615, Length=248, Percent_Identity=29.4354838709677, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=245, Percent_Identity=31.0204081632653, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=333, Percent_Identity=25.8258258258258, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=331, Percent_Identity=25.9818731117825, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=344, Percent_Identity=24.7093023255814, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356377, Length=358, Percent_Identity=26.2569832402235, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646207, Length=337, Percent_Identity=27.893175074184, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281363737, Length=327, Percent_Identity=27.217125382263, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666513, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 83199; Mature: 83199

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIIILALIAIVVLFAVKNIRMQFITRPVFSFFKKVLPPLSDTEREAMEAGDVWWEGEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEECCEE
FRGNPNWNTLHSYGKPTLSAEEKDFIDNQVMTALTMIDDFDIVHNRKDLPPELWEYFKKE
EECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHC
GFFALIIPKKFGGKAFSAYANSTIVSKLASRSVSAAVTVMVPNSLGPGELLTHYGTSEQK
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCHHH
ERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRDTFNGEEMLGLKLTWDKRYITL
HHHCHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEH
APVATVLGLAFQMRDPEGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLGMAFMNGTTQG
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEECCCCCC
KEVFIPLDWIIGGPEFAGKGWRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRHQ
CEEEEEEHEEECCHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCEEHHHHHHHHHHHH
FGMAIGQFEGVQEALARIIANTYQLEAARRLTTTGIDLKVKPSVVTAIAKYHMTELGRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHHH
MNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
HHHHHHCCCCCCCEECCHHCCCCCCCCCCEEEEEECHHHHHHHHHEECCCCCCCCCHHHH
EMEAAAMENQHEALERFDALLMGHMGYATRNAFSALFSALSGSRFGSAPVSGETKQYYKD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
MSRISSALALMTDLSMLIMGGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCCCCCCH
PAVRYVMANRLHLAAKALEDTIRNFPSRPVAWLLRGLIFPLGNHFNAPSDKMATDLVGGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
LKPGPARDRITFLCPEFEGDKGGIAEVEQAFIAQYACKDIYKKLKKAQRAGELPAKVPNL
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VLFAKALETGVITADEEQKLQHADKLRLAAINVNDFEAL
HHHHHHHHCCCCCCCHHHHHHHHCCEEEEEECCCCCCCC
>Mature Secondary Structure
MLTIIILALIAIVVLFAVKNIRMQFITRPVFSFFKKVLPPLSDTEREAMEAGDVWWEGEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEECCEE
FRGNPNWNTLHSYGKPTLSAEEKDFIDNQVMTALTMIDDFDIVHNRKDLPPELWEYFKKE
EECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHC
GFFALIIPKKFGGKAFSAYANSTIVSKLASRSVSAAVTVMVPNSLGPGELLTHYGTSEQK
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCHHH
ERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRDTFNGEEMLGLKLTWDKRYITL
HHHCHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEH
APVATVLGLAFQMRDPEGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLGMAFMNGTTQG
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEECCCCCC
KEVFIPLDWIIGGPEFAGKGWRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRHQ
CEEEEEEHEEECCHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCEEHHHHHHHHHHHH
FGMAIGQFEGVQEALARIIANTYQLEAARRLTTTGIDLKVKPSVVTAIAKYHMTELGRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHHH
MNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
HHHHHHCCCCCCCEECCHHCCCCCCCCCCEEEEEECHHHHHHHHHEECCCCCCCCCHHHH
EMEAAAMENQHEALERFDALLMGHMGYATRNAFSALFSALSGSRFGSAPVSGETKQYYKD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
MSRISSALALMTDLSMLIMGGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCCCCCCH
PAVRYVMANRLHLAAKALEDTIRNFPSRPVAWLLRGLIFPLGNHFNAPSDKMATDLVGGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
LKPGPARDRITFLCPEFEGDKGGIAEVEQAFIAQYACKDIYKKLKKAQRAGELPAKVPNL
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VLFAKALETGVITADEEQKLQHADKLRLAAINVNDFEAL
HHHHHHHHCCCCCCCHHHHHHHHCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]