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The map label for this gene is umuC [H]

Identifier: 160875154

GI number: 160875154

Start: 2420751

End: 2422007

Strand: Direct

Name: umuC [H]

Synonym: Sbal195_2040

Alternate gene names: 160875154

Gene position: 2420751-2422007 (Clockwise)

Preceding gene: 160875153

Following gene: 160875155

Centisome position: 45.27

GC content: 45.27

Gene sequence:

>1257_bases
ATGTTTGCCTTGGTTGACGCCAACAGTTTTTATTGCAGTGCCGAGCAGGTATTTAGACCTGATTGGCGTGGTAAGCCAAT
GATTGTGTTGAGCAACAATGATGGCTGCATCGTGGCGGCAAACAAGCAAGCGAAAGAACGGGGTGTTCCTAAGTTTGCAC
CATACTTTCAGGTCAAAGACCTGTGCACGAAATTAGGTGTCATTGTTTGTTCAAGTAACTATGAGCTCTATGCCGATTTA
TCCGCAAAGATGATGAATATCATTGGCCGATTTGCACCAGAGCAGCATGTCTATTCGATTGATGAAAGCTTTCTCTCCTT
TAAAAATTGTTACCCCGCCATTAAGTGCTTACAAGCCCAAGGCCAGTTGATTCGAAAAGCGGTTTGGAAAGAGACACGTT
TGCCGGTTTGTGTCGGTATCGGCTCAACACTCACACTGGCTAAAGCTGCAAATCATGCGGCAAAGAAGTTACCTGGCTAT
CAGGGTGTGTGTGTTATCGATAATGAACAAGATAGGATTTCAATTTTACAATCAATGAGTGTGAATGATGTCTGGGGCAT
TGGGCGCAGGATAAGCAAAAAACTTGAATTGATGAACGTCAAGACCGCCTATGACTTAGCCAAAATCCCTGCAGGTTTAG
CGCGGAAGCAATTTAGTATTGAAATAGAACGCACTGTGCGTGAACTTAATGGGCAAGCGTGCAAAGTGTGGGACGAGGCG
AGGGCGGATAAGAAACAAATATTCTCAACTCGTAGTGTGGGCGAGCGTATTACCGAGTATGAAGATTTACTGCAAGCCTT
AAGTAAACATGTGGCGATTGCTGCAGCGAAAGCGCGCAAGCAAGGTTCAAGCTGTAAAACCATGTTGTTGTTTGCTAGCA
ATTCTCCCTACGATGAACGCCCAACAGGCTTTAAGACCTTAGTGCACTTTGCTTGTGCCACCGATTGCAGCATTGAACTC
ACTCAAGGTATGACACAAGCAGCATCTCAACTTTTCCGTGCCGGTGTACGTTATTATAAAGTCGGTGTAGGTCTGATTGA
TTTGGTCAGCACTCAGCATGACCAGTTAGATTTATTCAATGTCTCAAAAGCCAAGCCAGCGTTAATGAAGACCCTCGATG
GCATCAATCAACGTTATGGCACAGACACCTTATTCATTGCAGCCCAAGGTATCGAGCAAAAATGGGCCATGCGTCGAGAC
CTGCTCTCACCACAATACACAACCAAGTGGCATTGTCTGCCTGAGATAAAGTGTTGA

Upstream 100 bases:

>100_bases
AACCTCAGCCTATTCATGATTACGATAACTTTACCATTGAAGGTGTTGTTATTCGTTCTGTTCGTTGTCATCGCCAAAGT
CCATTATTAGCGGATATCTG

Downstream 100 bases:

>100_bases
TATCTGACAGTAGATGGATTTACACGTTTATGCCCCAAAAGTGTGCCATGACTCGAAAATCTGCTCTTTGTGGCCTGGTA
ATTTGAGATACAAATGGTAA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKDLCTKLGVIVCSSNYELYADL
SAKMMNIIGRFAPEQHVYSIDESFLSFKNCYPAIKCLQAQGQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGY
QGVCVIDNEQDRISILQSMSVNDVWGIGRRISKKLELMNVKTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDERPTGFKTLVHFACATDCSIEL
TQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHDQLDLFNVSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRD
LLSPQYTTKWHCLPEIKC

Sequences:

>Translated_418_residues
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKDLCTKLGVIVCSSNYELYADL
SAKMMNIIGRFAPEQHVYSIDESFLSFKNCYPAIKCLQAQGQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGY
QGVCVIDNEQDRISILQSMSVNDVWGIGRRISKKLELMNVKTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDERPTGFKTLVHFACATDCSIEL
TQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHDQLDLFNVSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRD
LLSPQYTTKWHCLPEIKC
>Mature_418_residues
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKDLCTKLGVIVCSSNYELYADL
SAKMMNIIGRFAPEQHVYSIDESFLSFKNCYPAIKCLQAQGQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGY
QGVCVIDNEQDRISILQSMSVNDVWGIGRRISKKLELMNVKTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDERPTGFKTLVHFACATDCSIEL
TQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHDQLDLFNVSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRD
LLSPQYTTKWHCLPEIKC

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=426, Percent_Identity=42.9577464788732, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1786425, Length=266, Percent_Identity=24.0601503759398, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 46698; Mature: 46698

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKD
CEEEEECCCCEECHHHHCCCCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCHHHHHH
LCTKLGVIVCSSNYELYADLSAKMMNIIGRFAPEQHVYSIDESFLSFKNCYPAIKCLQAQ
HHHHCCEEEECCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGYQGVCVIDNEQDRISILQSMS
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCC
VNDVWGIGRRISKKLELMNVKTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHEEHHHHHHHHHCCCEEEHHHHH
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PTGFKTLVHFACATDCSIELTQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHDQLDLFN
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHEECCCHHHHHHCCCCCCEEEEE
VSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRDLLSPQYTTKWHCLPEIKC
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKD
CEEEEECCCCEECHHHHCCCCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCHHHHHH
LCTKLGVIVCSSNYELYADLSAKMMNIIGRFAPEQHVYSIDESFLSFKNCYPAIKCLQAQ
HHHHCCEEEECCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGYQGVCVIDNEQDRISILQSMS
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCC
VNDVWGIGRRISKKLELMNVKTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHEEHHHHHHHHHCCCEEEHHHHH
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PTGFKTLVHFACATDCSIELTQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHDQLDLFN
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHEECCCHHHHHHCCCCCCEEEEE
VSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRDLLSPQYTTKWHCLPEIKC
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]