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The map label for this gene is bioF [H]

Identifier: 160874911

GI number: 160874911

Start: 2157352

End: 2158590

Strand: Direct

Name: bioF [H]

Synonym: Sbal195_1796

Alternate gene names: 160874911

Gene position: 2157352-2158590 (Clockwise)

Preceding gene: 160874910

Following gene: 160874912

Centisome position: 40.34

GC content: 50.93

Gene sequence:

>1239_bases
ATGCTTGAGACTAGATCGATGAGTTCTCTGCTTGAGACTAAAATTGCCGCCAGTCAGCATGCTTTGCGTGAGCAAGGATT
ACTGCGACAACGTAAAGTGCTGAGTGTCGATCGCCCCCTTAATACCAACGCATCGACTTCGAGCCCGCGTTTTGTTTTCG
AAGGTCGCGCCTATGTCAATTTCAGCAGTAATGATTATTTAGGTTTATCCCGCGTACCAGAACTCGCTGAGGCCTTGCAC
CTTGGCGCGCAAACCTACGGTGTGGGCAGCGGCGCATCGCCCTTAGTGACTGGTTACAGTGACGCACATTTGGCGCTGGA
GCGTGAGCTTTGCGCCTTAACTGGGCATGAAGCGGCATTGTTATTTTGCTCGGGCTTTAGTGCTAATACGGCACTGATGA
AAACCCTGTTTGATCAGCACGATATTGTGGTTGCCGACAAACTCGTACATGCCTCCATTATTGATGGTTTGCAAGATAGT
GGCGCGCAGCTGAAACGTTTTTTACACAATTCATTAGAAAGCGCTGAGCGGTTACTCGCTCGACATCACACATCGGCGTT
AATCACTGAAAGCGTGTTTAGCATGGACGGAGATTGCGCGCCGATTTCTGAGTTATCGGCGCTTTGTCAGCAAAATAACA
CTTGGTTGATTGTAGATGATGCCCATGGTTTTGCGGTGCTCGATGGCTATAACAATGCTGATGCCGCCAAGCTTATCGAT
GTGCAAGTGGTCACTTTTGGTAAAGCATTAGGTTGCCAAGGTGCGGCCGTGTTGGGGAGTCAGGCGCTGATCGATTATTT
AGTCAGTAACGCCCGTGAATACATTTACTCAACCGCTTTATCGCCCGCCAATGCCGCATTAGCGTTAGCCGCTGCTCAGT
ACTGCACAGCACATCCCGAGTTACAGCAAAAACTGCGTGAGAATATCACGCTGTTCAAACGATTATGCCTTCAGGCGAAT
GTGCCCCTTTTAGGTTCAGATACCGCGATTCAGCCGCTGATCATTGGGGATGCGCGGCAAACATTGCAAGTAGCCGAGGA
GCTAAGGGCTGCAGGAATTTGGGTTGGCGCGATTCGCCCGCCGACCGTGCCTGTGGGCTCAGCACGTTTACGTATTACCT
TAACGGCAGCCCATGCCGCGGAAGATATCGCAGCCTGTGCTGCGCAATTAGCTCAAGTACTCAGTCATGTCGGCGTGCCA
CTTATGACTGAGCGACAAGCGGCAGATGATCACAGATAA

Upstream 100 bases:

>100_bases
ATTCAATGTGCTCCATTTCTAAGGCAATCGTCTTGAACCGAACACTCATAGGGTAACCATTGTTGAAACCATTGTTGAAA
CAGTCATATTTGAGACAGTC

Downstream 100 bases:

>100_bases
ATGTACGCTATAGAACGAGTTATTCTATTGAAATTTAAGTTTTTATGGTCGAGTGTTAACTGCAATGCCAAGCCCGGTTA
AATCCAGCAAGCCCAACGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MLETRSMSSLLETKIAASQHALREQGLLRQRKVLSVDRPLNTNASTSSPRFVFEGRAYVNFSSNDYLGLSRVPELAEALH
LGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDS
GAQLKRFLHNSLESAERLLARHHTSALITESVFSMDGDCAPISELSALCQQNNTWLIVDDAHGFAVLDGYNNADAAKLID
VQVVTFGKALGCQGAAVLGSQALIDYLVSNAREYIYSTALSPANAALALAAAQYCTAHPELQQKLRENITLFKRLCLQAN
VPLLGSDTAIQPLIIGDARQTLQVAEELRAAGIWVGAIRPPTVPVGSARLRITLTAAHAAEDIAACAAQLAQVLSHVGVP
LMTERQAADDHR

Sequences:

>Translated_412_residues
MLETRSMSSLLETKIAASQHALREQGLLRQRKVLSVDRPLNTNASTSSPRFVFEGRAYVNFSSNDYLGLSRVPELAEALH
LGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDS
GAQLKRFLHNSLESAERLLARHHTSALITESVFSMDGDCAPISELSALCQQNNTWLIVDDAHGFAVLDGYNNADAAKLID
VQVVTFGKALGCQGAAVLGSQALIDYLVSNAREYIYSTALSPANAALALAAAQYCTAHPELQQKLRENITLFKRLCLQAN
VPLLGSDTAIQPLIIGDARQTLQVAEELRAAGIWVGAIRPPTVPVGSARLRITLTAAHAAEDIAACAAQLAQVLSHVGVP
LMTERQAADDHR
>Mature_412_residues
MLETRSMSSLLETKIAASQHALREQGLLRQRKVLSVDRPLNTNASTSSPRFVFEGRAYVNFSSNDYLGLSRVPELAEALH
LGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAALLFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDS
GAQLKRFLHNSLESAERLLARHHTSALITESVFSMDGDCAPISELSALCQQNNTWLIVDDAHGFAVLDGYNNADAAKLID
VQVVTFGKALGCQGAAVLGSQALIDYLVSNAREYIYSTALSPANAALALAAAQYCTAHPELQQKLRENITLFKRLCLQAN
VPLLGSDTAIQPLIIGDARQTLQVAEELRAAGIWVGAIRPPTVPVGSARLRITLTAAHAAEDIAACAAQLAQVLSHVGVP
LMTERQAADDHR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=31.1046511627907, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI7657118, Length=344, Percent_Identity=31.1046511627907, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4502025, Length=354, Percent_Identity=31.0734463276836, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40316939, Length=354, Percent_Identity=31.0734463276836, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI83977442, Length=359, Percent_Identity=31.1977715877437, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI83977444, Length=359, Percent_Identity=31.1977715877437, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI83977440, Length=359, Percent_Identity=31.1977715877437, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=27.1232876712329, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI119220554, Length=360, Percent_Identity=26.1111111111111, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI5454084, Length=294, Percent_Identity=26.530612244898, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786993, Length=342, Percent_Identity=47.6608187134503, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1790046, Length=390, Percent_Identity=31.7948717948718, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=32.3943661971831, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=25.1351351351351, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=26.3586956521739, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=26.3586956521739, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71982617, Length=273, Percent_Identity=24.5421245421245, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=273, Percent_Identity=24.5421245421245, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=354, Percent_Identity=31.0734463276836, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320267, Length=392, Percent_Identity=24.234693877551, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=279, Percent_Identity=25.4480286738351, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=31.1053984575836, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137420, Length=361, Percent_Identity=29.6398891966759, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=26.4864864864865, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653280, Length=306, Percent_Identity=23.8562091503268, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24653276, Length=306, Percent_Identity=23.8562091503268, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24653278, Length=306, Percent_Identity=23.8562091503268, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 44056; Mature: 44056

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETRSMSSLLETKIAASQHALREQGLLRQRKVLSVDRPLNTNASTSSPRFVFEGRAYVN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECEEEEE
FSSNDYLGLSRVPELAEALHLGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAAL
ECCCCCCCHHHHHHHHHHHHHCCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCEEE
LFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKRFLHNSLESAERLLA
EEEECCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
RHHTSALITESVFSMDGDCAPISELSALCQQNNTWLIVDDAHGFAVLDGYNNADAAKLID
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCHHEEE
VQVVTFGKALGCQGAAVLGSQALIDYLVSNAREYIYSTALSPANAALALAAAQYCTAHPE
EEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
LQQKLRENITLFKRLCLQANVPLLGSDTAIQPLIIGDARQTLQVAEELRAAGIWVGAIRP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCEEEECCCC
PTVPVGSARLRITLTAAHAAEDIAACAAQLAQVLSHVGVPLMTERQAADDHR
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC
>Mature Secondary Structure
MLETRSMSSLLETKIAASQHALREQGLLRQRKVLSVDRPLNTNASTSSPRFVFEGRAYVN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECEEEEE
FSSNDYLGLSRVPELAEALHLGAQTYGVGSGASPLVTGYSDAHLALERELCALTGHEAAL
ECCCCCCCHHHHHHHHHHHHHCCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCEEE
LFCSGFSANTALMKTLFDQHDIVVADKLVHASIIDGLQDSGAQLKRFLHNSLESAERLLA
EEEECCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
RHHTSALITESVFSMDGDCAPISELSALCQQNNTWLIVDDAHGFAVLDGYNNADAAKLID
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCHHEEE
VQVVTFGKALGCQGAAVLGSQALIDYLVSNAREYIYSTALSPANAALALAAAQYCTAHPE
EEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
LQQKLRENITLFKRLCLQANVPLLGSDTAIQPLIIGDARQTLQVAEELRAAGIWVGAIRP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCEEEECCCC
PTVPVGSARLRITLTAAHAAEDIAACAAQLAQVLSHVGVPLMTERQAADDHR
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA