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The map label for this gene is folK [H]

Identifier: 160874347

GI number: 160874347

Start: 1463272

End: 1463775

Strand: Direct

Name: folK [H]

Synonym: Sbal195_1228

Alternate gene names: 160874347

Gene position: 1463272-1463775 (Clockwise)

Preceding gene: 160874346

Following gene: 160874348

Centisome position: 27.36

GC content: 47.42

Gene sequence:

>504_bases
ATGGCACGTATTTATATCAGTCTGGGTAGCAATATCGAGCCTGAACAGCATCTGCAAGCAGGATTAACATCGCTGCGAGC
GTGTTTCGGGCCGCTGCGCCTCTCTTCTATGTATGAAAGTGAAGCGGTAGGTTTCAGTGGCACTAACTTTTTGAATATGG
TTGCTAGCGCTGAAACTGATCTTAATATAGCGGCGGTAGTTGCACAGTTTAAGCAAATCGAGCAGAATCACGGCCGGCTT
GCCGGGGCGAAGAAATTTAGCCCAAGAACCTTAGATTTAGACCTGCTGCTTTATGACCATGTGGTATGCCAAACGCCTGT
TGTGCTGCCCCGTGCTGAGATAGTCAATAATGCCTTTGTGTTATGGCCTTTAGCTGAGTTAGCGCCGGAATTGATTCATC
CCGTGGTAGATAAAAGCTATGCAAGTTTGTGGCAAGAGTATGACAAAAATTCACAGCGACTTTGGCCTGTGACGTTTGAA
TGGCCCCCAGGGCTGACGTTTTAA

Upstream 100 bases:

>100_bases
GGTTGGCGTCGAGATTGAACGTTCACGTTAGATGAGTACTTGATCAACTGCGCTGTTGATTGAGAAATAGTGTTTATCTT
CAGATAAATCGGACATTAGC

Downstream 100 bases:

>100_bases
TTTATTGATAGGATTGTCATGGATACGTTTCAGGTCATTATTTTAGCGCTTATTCAAGGGCTAACCGAGTTTTTACCTAT
TTCTAGTTCTGCCCACTTAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MARIYISLGSNIEPEQHLQAGLTSLRACFGPLRLSSMYESEAVGFSGTNFLNMVASAETDLNIAAVVAQFKQIEQNHGRL
AGAKKFSPRTLDLDLLLYDHVVCQTPVVLPRAEIVNNAFVLWPLAELAPELIHPVVDKSYASLWQEYDKNSQRLWPVTFE
WPPGLTF

Sequences:

>Translated_167_residues
MARIYISLGSNIEPEQHLQAGLTSLRACFGPLRLSSMYESEAVGFSGTNFLNMVASAETDLNIAAVVAQFKQIEQNHGRL
AGAKKFSPRTLDLDLLLYDHVVCQTPVVLPRAEIVNNAFVLWPLAELAPELIHPVVDKSYASLWQEYDKNSQRLWPVTFE
WPPGLTF
>Mature_166_residues
ARIYISLGSNIEPEQHLQAGLTSLRACFGPLRLSSMYESEAVGFSGTNFLNMVASAETDLNIAAVVAQFKQIEQNHGRLA
GAKKFSPRTLDLDLLLYDHVVCQTPVVLPRAEIVNNAFVLWPLAELAPELIHPVVDKSYASLWQEYDKNSQRLWPVTFEW
PPGLTF

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=34.5323741007194, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18673; Mature: 18541

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIYISLGSNIEPEQHLQAGLTSLRACFGPLRLSSMYESEAVGFSGTNFLNMVASAETD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
LNIAAVVAQFKQIEQNHGRLAGAKKFSPRTLDLDLLLYDHVVCQTPVVLPRAEIVNNAFV
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCHHHHHCCCEE
LWPLAELAPELIHPVVDKSYASLWQEYDKNSQRLWPVTFEWPPGLTF
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure 
ARIYISLGSNIEPEQHLQAGLTSLRACFGPLRLSSMYESEAVGFSGTNFLNMVASAETD
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
LNIAAVVAQFKQIEQNHGRLAGAKKFSPRTLDLDLLLYDHVVCQTPVVLPRAEIVNNAFV
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCHHHHHCCCEE
LWPLAELAPELIHPVVDKSYASLWQEYDKNSQRLWPVTFEWPPGLTF
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]