Click here to switch to the map view.

The map label for this gene is glmU [H]

Identifier: 160874204

GI number: 160874204

Start: 1283472

End: 1284149

Strand: Direct

Name: glmU [H]

Synonym: Sbal195_1084

Alternate gene names: 160874204

Gene position: 1283472-1284149 (Clockwise)

Preceding gene: 160874203

Following gene: 160874205

Centisome position: 24.0

GC content: 52.21

Gene sequence:

>678_bases
ATGAAAGCCATGATCTTGGCCGCCGGACGAGGTGAGAGGTTACGGCCGTTAACGGATAATATGCCTAAACCTATGGTGCC
AGTATTAGGTAAACCGTTGATTGTTTACCATATTGAAAAACTCGCCGCGTTAGGCATAGTCGATATCGTCATCAACCATG
CTTGGCTAGGGCATAAATTAGTCGAGGCGCTGGGCGATGGCAGCGCTTTTGGGGTGCGAATTCGCTATAGCGCCGAAGAG
AGTGCGCTTGAAACCGGCGGCGGCATTAAACGGGCTTTGCCTTTATTGTGTGAGGGGGAAAGCGATGAACCCTTTTTGGT
CATTAATGGTGATGTGTTTATCGATGCCTTACCGCCAATAACGCAGCTTGCTGCCGATACGCTCGCCCATCTCTGGCTAG
TGCCTAATCCTGAGCAGCATCCGCAGGGGGATTTCGCCTTGAGTGGCAATAGAGTGCAGGAGCTTGGTGAGACTAAGTAC
ACTTTCTCTGGCATGGGCATTTATCGGCCGTCGCTGTTTAATCACACGCCGCAGGGCGCGTTTGCACTCGGTCCGTTGTT
GAGAGCACAAATGGCTCAAGGCCGAGTCAGTGGCGCGCTGTTTCACGGGCTTTGGTGCGATGTTGGCACGATAGCACGCT
TGCAAGGGCTCGAACTCAGATTACAAAGCAATACCTAA

Upstream 100 bases:

>100_bases
TTGCCATGCAGTATCCCGAACTCGTGTCATTTGCACACTGGTTGACTCGTCGCGTGTTGCCTGCGTTTGCAGCTAGCCAG
TCTTTATCTGAGGTTAAGCA

Downstream 100 bases:

>100_bases
ATATCCGTGTTGGCTTATCCATAGGATTTCGCTTACACATCAAATACATAATAGAAATCAGGAAATAAGATGCGGCTTTG
GGGTAAGTTTTTTGGATTTG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKAMILAAGRGERLRPLTDNMPKPMVPVLGKPLIVYHIEKLAALGIVDIVINHAWLGHKLVEALGDGSAFGVRIRYSAEE
SALETGGGIKRALPLLCEGESDEPFLVINGDVFIDALPPITQLAADTLAHLWLVPNPEQHPQGDFALSGNRVQELGETKY
TFSGMGIYRPSLFNHTPQGAFALGPLLRAQMAQGRVSGALFHGLWCDVGTIARLQGLELRLQSNT

Sequences:

>Translated_225_residues
MKAMILAAGRGERLRPLTDNMPKPMVPVLGKPLIVYHIEKLAALGIVDIVINHAWLGHKLVEALGDGSAFGVRIRYSAEE
SALETGGGIKRALPLLCEGESDEPFLVINGDVFIDALPPITQLAADTLAHLWLVPNPEQHPQGDFALSGNRVQELGETKY
TFSGMGIYRPSLFNHTPQGAFALGPLLRAQMAQGRVSGALFHGLWCDVGTIARLQGLELRLQSNT
>Mature_225_residues
MKAMILAAGRGERLRPLTDNMPKPMVPVLGKPLIVYHIEKLAALGIVDIVINHAWLGHKLVEALGDGSAFGVRIRYSAEE
SALETGGGIKRALPLLCEGESDEPFLVINGDVFIDALPPITQLAADTLAHLWLVPNPEQHPQGDFALSGNRVQELGETKY
TFSGMGIYRPSLFNHTPQGAFALGPLLRAQMAQGRVSGALFHGLWCDVGTIARLQGLELRLQSNT

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=239, Percent_Identity=29.2887029288703, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI11761619, Length=239, Percent_Identity=29.2887029288703, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1788351, Length=233, Percent_Identity=27.0386266094421, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=27.7310924369748, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=131, Percent_Identity=39.6946564885496, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355443, Length=238, Percent_Identity=27.3109243697479, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644084, Length=238, Percent_Identity=27.3109243697479, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24653912, Length=122, Percent_Identity=37.7049180327869, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 24320; Mature: 24320

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERLRPLTDNMPKPMVPVLGKPLIVYHIEKLAALGIVDIVINHAWLGHKL
CCEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VEALGDGSAFGVRIRYSAEESALETGGGIKRALPLLCEGESDEPFLVINGDVFIDALPPI
HHHHCCCCEEEEEEEECCCHHHHHCCCCHHHHCCEEECCCCCCCEEEEECCEEEECCCCH
TQLAADTLAHLWLVPNPEQHPQGDFALSGNRVQELGETKYTFSGMGIYRPSLFNHTPQGA
HHHHHHHHHHEEECCCCCCCCCCCEEECCHHHHHHCCCEEEECCCCEECCHHCCCCCCCC
FALGPLLRAQMAQGRVSGALFHGLWCDVGTIARLQGLELRLQSNT
HHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHCCEEEEEECCC
>Mature Secondary Structure
MKAMILAAGRGERLRPLTDNMPKPMVPVLGKPLIVYHIEKLAALGIVDIVINHAWLGHKL
CCEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VEALGDGSAFGVRIRYSAEESALETGGGIKRALPLLCEGESDEPFLVINGDVFIDALPPI
HHHHCCCCEEEEEEEECCCHHHHHCCCCHHHHCCEEECCCCCCCEEEEECCEEEECCCCH
TQLAADTLAHLWLVPNPEQHPQGDFALSGNRVQELGETKYTFSGMGIYRPSLFNHTPQGA
HHHHHHHHHHEEECCCCCCCCCCCEEECCHHHHHHCCCEEEECCCCEECCHHCCCCCCCC
FALGPLLRAQMAQGRVSGALFHGLWCDVGTIARLQGLELRLQSNT
HHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]