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The map label for this gene is pepB [H]

Identifier: 160874007

GI number: 160874007

Start: 1047174

End: 1048466

Strand: Direct

Name: pepB [H]

Synonym: Sbal195_0886

Alternate gene names: 160874007

Gene position: 1047174-1048466 (Clockwise)

Preceding gene: 160873996

Following gene: 160874008

Centisome position: 19.58

GC content: 51.74

Gene sequence:

>1293_bases
ATGAGTGAACTAAAAGTAACTGAATTAATGAAAGTGAAATTAACCAAAGAAGCGCCGGCCGCCCACTGGGGCAAAGCCGA
TGTGACTTATACCGCCGACGGTGCGCAAATTCATTTAGCGGGTGGTGATGAGCTGCGTCAAATTCAAATGGCGGCCCGTA
AACTGCGCAGTCAAGGCATTAGCTGTGTGGTATTAGCCGGGCAGCTTTGGGATCTGAATAGCCAGTGGGTGTTTGCCCAA
GGTTTCGCGACGGCAAAACCAGGTTATCAAATCCATTGGTGTGGTGATGAAGCTGTACAAGCTGAATTGCAACGTCGACT
CGATGTGGCAACCTTTGCCCGTCAACTGATCAACGATACGCCTGAAAACCTGTCGCCAGTGAAGCTCGCCCAACAAGCGG
CGAAATGGTTAGCTGAAATTGGTGGCGACAAGGTGAGTTATCGGATTATCGAAGGTGAAGCGTTGCTGGAAGAACAGTGG
ATTGGTATCCATGCTGTCGGTCGCGGCAGTGAGCGTCCACCGGCAATGTTAGCGTTAGACTTCAACCCATTAGCTGCTGA
TGCACCCGTGTCTGTGGCGCTTGTGGGTAAAGGAATTACTTTTGATTCTGGCGGTTACAGCATCAAAGCTTCTGAAGGCA
TGTTAGGCATGAAATGCGACATGGGCGGCGCGGCGACTGTGACTGCAGCGCTCGGTTTAGCGATCAAATCTGGCCTAAAC
AAACGGGTTAAACTCTTCTTATGTTGTGCTGAAAACTTGATCAGCGGCCGCGCCTATAAGTTAGGCGATATCCTGACCTA
CAAAAATGGCGTGACAGTTGAAGTGGTGAACACAGATGCGGAAGGGCGCTTAGTGTTGGCCGATGGTCTGCAAGCCGCCT
CTGCGACAGGCGCTCCTTTTATTATCGATGCAGCGACCCTTACAGGCGCCGCTGTGATGGCAGTGGGTTCTAACTACAAC
GCGATTTTCTCGCCACAGACTGATGTGTTGCAACTGGCTCAGCAAAAAGCCACGAGTGTTGCCGAGCGTGTATGGCCGCT
GCCGCTGGATCCTTGGCACAAAGAAATGTGTCCATCAGCCTATGCTGACACAGCCAACAGCCGCGCAATGAAAGGTGGCG
GTGCTGGTGGTGCTTCCAATGCAGCTGGTTTCCTATGGCGCTTTGTTTCACCAGAAGCTAAATGGTTGCACGTTGATTTA
GCGGGCGCCTTTGAAGATTCAGCTTCTGTCATGTGGGGCGCGGGTGCAACGACCCACGGCGTATTGACCATTAGTGAATT
GATCAAAGGCTAA

Upstream 100 bases:

>100_bases
CGCTTTGCGTCATCGCCTGCTAGCAGTAAACTGCCGCCATAAAGTTTGTTCTGATTGCTGATTGATTGTTCTAAAACGAA
TCGAAAAATAAGGATCCCTA

Downstream 100 bases:

>100_bases
GCCTAGATTTAAGTCTAGCGCTAAGACTCAGTTAGATAAGTCTGCGCAGATCCATTAAGGTTCTGCTGACTGGATTAAAA
CCGCCTACGGGCGGTTTTTT

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSELKVTELMKVKLTKEAPAAHWGKADVTYTADGAQIHLAGGDELRQIQMAARKLRSQGISCVVLAGQLWDLNSQWVFAQ
GFATAKPGYQIHWCGDEAVQAELQRRLDVATFARQLINDTPENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQW
IGIHAVGRGSERPPAMLALDFNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYN
AIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSAYADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDL
AGAFEDSASVMWGAGATTHGVLTISELIKG

Sequences:

>Translated_430_residues
MSELKVTELMKVKLTKEAPAAHWGKADVTYTADGAQIHLAGGDELRQIQMAARKLRSQGISCVVLAGQLWDLNSQWVFAQ
GFATAKPGYQIHWCGDEAVQAELQRRLDVATFARQLINDTPENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQW
IGIHAVGRGSERPPAMLALDFNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYN
AIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSAYADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDL
AGAFEDSASVMWGAGATTHGVLTISELIKG
>Mature_429_residues
SELKVTELMKVKLTKEAPAAHWGKADVTYTADGAQIHLAGGDELRQIQMAARKLRSQGISCVVLAGQLWDLNSQWVFAQG
FATAKPGYQIHWCGDEAVQAELQRRLDVATFARQLINDTPENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQWI
GIHAVGRGSERPPAMLALDFNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLNK
RVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYNA
IFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSAYADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDLA
GAFEDSASVMWGAGATTHGVLTISELIKG

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=323, Percent_Identity=35.9133126934984, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI47155554, Length=313, Percent_Identity=36.4217252396166, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI87082123, Length=427, Percent_Identity=49.8829039812646, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1790710, Length=289, Percent_Identity=39.1003460207612, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=296, Percent_Identity=35.8108108108108, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=311, Percent_Identity=26.6881028938907, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221379063, Length=292, Percent_Identity=37.6712328767123, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379062, Length=292, Percent_Identity=37.6712328767123, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21357381, Length=292, Percent_Identity=37.6712328767123, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355725, Length=295, Percent_Identity=31.864406779661, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=31.864406779661, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24662227, Length=297, Percent_Identity=28.2828282828283, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI161077148, Length=296, Percent_Identity=30.4054054054054, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20130057, Length=296, Percent_Identity=30.4054054054054, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20129969, Length=369, Percent_Identity=26.5582655826558, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21355645, Length=328, Percent_Identity=25.609756097561, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24662223, Length=328, Percent_Identity=25.609756097561, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=29.2517006802721, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922386, Length=295, Percent_Identity=26.7796610169492, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646701, Length=207, Percent_Identity=29.951690821256, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646703, Length=207, Percent_Identity=29.951690821256, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358201, Length=207, Percent_Identity=29.951690821256, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 45440; Mature: 45309

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKVTELMKVKLTKEAPAAHWGKADVTYTADGAQIHLAGGDELRQIQMAARKLRSQGI
CCCCCHHHEEEEEECCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCC
SCVVLAGQLWDLNSQWVFAQGFATAKPGYQIHWCGDEAVQAELQRRLDVATFARQLINDT
EEEEEECEEECCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
PENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQWIGIHAVGRGSERPPAMLALD
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCEEEEECCCCCCCCEEEEEE
FNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
CCCCCCCCCEEEEEEECCEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCC
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPF
CEEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
IIDAATLTGAAVMAVGSNYNAIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSA
EEEEHHHCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCH
YADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDLAGAFEDSASVMWGAGATTHG
HHCCCCCCEECCCCCCCCCCCHHEEEEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCH
VLTISELIKG
HEEHHHHHCC
>Mature Secondary Structure 
SELKVTELMKVKLTKEAPAAHWGKADVTYTADGAQIHLAGGDELRQIQMAARKLRSQGI
CCCCHHHEEEEEECCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCC
SCVVLAGQLWDLNSQWVFAQGFATAKPGYQIHWCGDEAVQAELQRRLDVATFARQLINDT
EEEEEECEEECCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
PENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQWIGIHAVGRGSERPPAMLALD
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCEEEEECCCCCCCCEEEEEE
FNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
CCCCCCCCCEEEEEEECCEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCC
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPF
CEEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
IIDAATLTGAAVMAVGSNYNAIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSA
EEEEHHHCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCH
YADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDLAGAFEDSASVMWGAGATTHG
HHCCCCCCEECCCCCCCCCCCHHEEEEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCH
VLTISELIKG
HEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA