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The map label for this gene is serA [H]

Identifier: 160873994

GI number: 160873994

Start: 1034158

End: 1035387

Strand: Reverse

Name: serA [H]

Synonym: Sbal195_0873

Alternate gene names: 160873994

Gene position: 1035387-1034158 (Counterclockwise)

Preceding gene: 160873997

Following gene: 160873993

Centisome position: 19.36

GC content: 50.24

Gene sequence:

>1230_bases
ATGGCGAAACATTCGCTGGACAAGGATAAGATCAAGATCCTGCTGTTGGAAGGCGTCCACCAATCTGCGGTCGATGTACT
TGAGCGTGCGGGATACACCAACATCGAATACCACAAAGCCTCATTAGGCGATGAAGCATTAATTGAATCCATCAAAGATG
CACATTTCGTGGGACTTCGTTCGCGTACCCAATTAACTGCCGAAGTGCTAAAACGCGCCGAGAAGTTGATCGCGGTCGGT
TGCTTCTGTATCGGAACCAATCAAGTTGATCTTGCCACCGCCGAATCCCTTGGTATCCCAGTATTTAACGCGCCATTCTC
CAACACTCGCAGTGTTGCCGAACTCGTGATTGGCGAAATCATTATGCTGATGCGCGGTATCCCTGAGCGTAACGCCATCG
CCCACCGTGGTGGCTGGATGAAAACCGCCGCAGGCAGCTACGAAGTGCGCGGTAAAACCTTAGGCGTAATCGGTTACGGT
CATATCGGTACTCAGCTTGGCATTCTGGCTGAGACGCTGGGCATGCGCGTGGTGTTCTTCGATATCGAAGACAAATTGCC
ACTGGGTAATGCACAGCAAATTCATTCAATGGAACAGTTACTGGCGCAAGCTGACGTAGTGAGCTTACACGTACCAGAAA
CCCCACAAACCAAAGACATGATAGGCGCAGCTGAATTTGCGGCGATGAAAAAGGGCAGCATCTTTATCAACGCCTCACGC
GGTACTGTGGTTGATATCGAGGCCTTAACGGTCGCCTTGAAAGAACGTCACCTCGCTGGCGCGGCGATTGATGTGTTCCC
AGTTGAGCCGCAATCTAATGACGATGAATTTATCAGCCCACTTCGAGGTCTTGATAACGTATTACTGACACCGCATGTGG
GTGGGAGTACTGCAGAAGCCCAAGAAAACATTGGTATCGAAGTCGCGGGCAAGCTCGCTAAATACTCAGATAACGGCTCG
ACCGTATCTGCAGTTAACTTCCCTGAAGTATCGCTACCTATGCATAAAGGCACCTCACGCTTACTGCATATTCACCAAAA
CCGTCCTGGCGTGCTGATCAAGATCAACCAAGCCTTCTCGGAAAAAGGCATCAACATTGCCGCGCAATATCTGCAAACTA
CCGCTGAGATTGGTTATGTGGTCATGGAAGTCGACACTCACCAAGCCGAAGAAGCCTTAGTGGAGTTAAAGGCAATTGAA
GGCACACTGCGTACCCGCGTGCTGTTTTAA

Upstream 100 bases:

>100_bases
TCTAGCCCTCCACACTGAGTAAAAAAAGTGCTATTTTGGTGGGTGAAGGTTGTCAGCATATCATAAGAAACATTTCTATT
AATTAGAGGGTACCCATATC

Downstream 100 bases:

>100_bases
CTGCATACCCGCGTGCTGTTTAATAGTTAAGTCCAATCGCATTAAGCGTTTCGGCTAAAGTACAAAAACTAAGGCGCACA
TATCATTCACAGATATGTGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKHSLDKDKIKILLLEGVHQSAVDVLERAGYTNIEYHKASLGDEALIESIKDAHFVGLRSRTQLTAEVLKRAEKLIAVG
CFCIGTNQVDLATAESLGIPVFNAPFSNTRSVAELVIGEIIMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYG
HIGTQLGILAETLGMRVVFFDIEDKLPLGNAQQIHSMEQLLAQADVVSLHVPETPQTKDMIGAAEFAAMKKGSIFINASR
GTVVDIEALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TVSAVNFPEVSLPMHKGTSRLLHIHQNRPGVLIKINQAFSEKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIE
GTLRTRVLF

Sequences:

>Translated_409_residues
MAKHSLDKDKIKILLLEGVHQSAVDVLERAGYTNIEYHKASLGDEALIESIKDAHFVGLRSRTQLTAEVLKRAEKLIAVG
CFCIGTNQVDLATAESLGIPVFNAPFSNTRSVAELVIGEIIMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYG
HIGTQLGILAETLGMRVVFFDIEDKLPLGNAQQIHSMEQLLAQADVVSLHVPETPQTKDMIGAAEFAAMKKGSIFINASR
GTVVDIEALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TVSAVNFPEVSLPMHKGTSRLLHIHQNRPGVLIKINQAFSEKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIE
GTLRTRVLF
>Mature_408_residues
AKHSLDKDKIKILLLEGVHQSAVDVLERAGYTNIEYHKASLGDEALIESIKDAHFVGLRSRTQLTAEVLKRAEKLIAVGC
FCIGTNQVDLATAESLGIPVFNAPFSNTRSVAELVIGEIIMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYGH
IGTQLGILAETLGMRVVFFDIEDKLPLGNAQQIHSMEQLLAQADVVSLHVPETPQTKDMIGAAEFAAMKKGSIFINASRG
TVVDIEALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGST
VSAVNFPEVSLPMHKGTSRLLHIHQNRPGVLIKINQAFSEKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIEG
TLRTRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=320, Percent_Identity=34.0625, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=30.8880308880309, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=30.8880308880309, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=30.8880308880309, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=28.8973384030418, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI61743967, Length=263, Percent_Identity=28.8973384030418, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI6912396, Length=243, Percent_Identity=27.1604938271605, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=69.8296836982968, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=32.5396825396825, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=31.2252964426877, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788660, Length=347, Percent_Identity=27.0893371757925, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=34.1614906832298, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=28.3582089552239, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=50, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=49.2753623188406, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=28.2157676348548, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=26.953125, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=199, Percent_Identity=25.1256281407035, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=33.2225913621262, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=30.4182509505703, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=29.6153846153846, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=29.6153846153846, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=29.6153846153846, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=29.6153846153846, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=29.6153846153846, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571528, Length=297, Percent_Identity=27.6094276094276, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=302, Percent_Identity=25.4966887417219, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574282, Length=302, Percent_Identity=25.4966887417219, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551003, Length=302, Percent_Identity=25.4966887417219, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=302, Percent_Identity=25.4966887417219, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574284, Length=302, Percent_Identity=25.4966887417219, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585516, Length=272, Percent_Identity=26.1029411764706, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44196; Mature: 44065

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHSLDKDKIKILLLEGVHQSAVDVLERAGYTNIEYHKASLGDEALIESIKDAHFVGLR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHEEECC
SRTQLTAEVLKRAEKLIAVGCFCIGTNQVDLATAESLGIPVFNAPFSNTRSVAELVIGEI
CHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEHHHCCCCEEECCCCCHHHHHHHHHHHH
IMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYGHIGTQLGILAETLGMRVVFF
HHHHCCCCCCCCHHHCCCCEEECCCCEEECCEEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQIHSMEQLLAQADVVSLHVPETPQTKDMIGAAEFAAMKKGSIFINASR
ECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCC
GTVVDIEALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTVSAVNFPEVSLPMHKGTSRLLHIHQNRPGVLIKINQAFS
HHCCCEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHC
EKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIEGTLRTRVLF
CCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
AKHSLDKDKIKILLLEGVHQSAVDVLERAGYTNIEYHKASLGDEALIESIKDAHFVGLR
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHEEECC
SRTQLTAEVLKRAEKLIAVGCFCIGTNQVDLATAESLGIPVFNAPFSNTRSVAELVIGEI
CHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEHHHCCCCEEECCCCCHHHHHHHHHHHH
IMLMRGIPERNAIAHRGGWMKTAAGSYEVRGKTLGVIGYGHIGTQLGILAETLGMRVVFF
HHHHCCCCCCCCHHHCCCCEEECCCCEEECCEEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQIHSMEQLLAQADVVSLHVPETPQTKDMIGAAEFAAMKKGSIFINASR
ECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCC
GTVVDIEALTVALKERHLAGAAIDVFPVEPQSNDDEFISPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTVSAVNFPEVSLPMHKGTSRLLHIHQNRPGVLIKINQAFS
HHCCCEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHC
EKGINIAAQYLQTTAEIGYVVMEVDTHQAEEALVELKAIEGTLRTRVLF
CCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]