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The map label for this gene is parE [H]

Identifier: 160873940

GI number: 160873940

Start: 955998

End: 957884

Strand: Direct

Name: parE [H]

Synonym: Sbal195_0818

Alternate gene names: 160873940

Gene position: 955998-957884 (Clockwise)

Preceding gene: 160873939

Following gene: 160873941

Centisome position: 17.88

GC content: 47.64

Gene sequence:

>1887_bases
ATGACGAATCAATACACCTCTGACGCCATTGAAGTTCTCAACGGACTCGATCCTGTTAAACGCCGTCCAGGTATGTATAC
CGACACCTCCAGGCCGAACCATTTGGGCCAAGAGGTCATAGACAACAGTGTCGATGAAGCATTAGCGGGCCACGCGACCA
AAATTGAAGTTGTTCTACATACAGATAACTCCCTCGAAGTCACCGATGATGGCCGTGGTATGCCGGTGGATATCCACCCT
GAAGAAGGCATTCCTGGGGTCGAGTTAATCCTGACCAAATTACATGCCGGCGGTAAATTTTCGAATAAAAACTACCAGTT
CTCTGGCGGTTTGCATGGTGTGGGGATTTCAGTCGTTAACGCGCTGTCGCGCCGTGTTGAAGTGACAGTTCGCCGTGATG
GCCAAGTGTATGATATCGCATTTGAAAATGGCTTTAAGGTTGAAGAGTTACGCCCAACGGGAACTTGTGGTCGTCGTAAT
ACCGGAACACGAGTGCATTTTTGGCCCGACGCCAGCTATTTTGATTCGGCTAACTTCTCAAATTCAAAATTGATTTATCT
GCTGCGGGCTAAAGCGGTACTGTGCCCAGGCTTACGGATTAAATTCACCAACAAACAGACAAATGAAGTCCATGAATGGT
TCTATGAAAGCGGCCTAACTGATTATTTGAAGGCGGCGATTGGCGACAATTTAAGGTTGCCAGATGAGCCGTTTGTCGGC
TGTTTTAAGGGCCAGCTAGAAGCCGCTGATTGGGCGATTACTTGGCTGCCAGAAGGCGGTGAATCCATTGGCGAGAGTTA
TGTTAACTTAATTCCGACTCCGCTCGGTGGTACTCATGTGAATGGTTTCCGCCAAGGCTTATTGGAGTCAATGCGCGAAT
TTTGTGAGTTCAGAAACTTAATTCCTCGCGGCATTAAACTTTCACCCGAAGACATTTGGGATCGCGCCGCATTTATTTTG
TCGGTGAAGATGCAAGAACCGCAGTTTGCTGGCCAAACCAAAGAAAAGCTTTCTAGCCGTCAATGCGCCGCATTTGTGTC
TGGCGTTGTGCGTGATGCCTTTTCACTCTGGTTGAACTCAAATACTGAGCTCGCTGAATCGTTAGCCGAAATGTGCATTA
ATAATGCCCAGAGTCGGTTAAAGGCCGCTAAAAAAGTTGCTCGAAAAAAGGTGACTTCAGGGCCTGCTCTGCCGGGTAAG
CTAACGGACTGTAGTGGTCAAGATCCAATGCGCGGAGAGTTATTCCTCGTGGAAGGGGATTCTGCGGGTGGCAGTGCTAA
ACAAGCTCGCGATCGTGAGTTTCAAGCCATCATGCCGCTGCGTGGGAAAATCTTAAACACCTGGGAAGTTGATGCTTCAC
AAGTATTAGCCTCGCAGGAAGTCCATGATATTTCGGTCGCAATTGGTTGCGATCCCGATAGTAGTGATATTTCAGAACTA
CGTTATGGCAAGATTTGTATCCTTGCGGATGCCGACTCGGACGGACTGCACATTGCTACATTGTTATGCGCGCTATTTTT
GAAGCATTACCGTATCTTGGTTGAACAGGGTCATGTGTATATTGCCATGCCGCCGTTGTTCCGTATCGATATCGGCAAAG
AGGTGTATTACGCCTTAGATGAGGCCGAAAGAGCGGGGATTTTAGATCGCATTGCCGCTGAGAATAAAAAGGGTAAGGTA
CAAGTCACCCGCTTTAAAGGCTTGGGTGAGATGAATCCTTTACAACTTCGTGAAACAACGATGGATCCGAACACCCGTCG
TTTAGTACAGTTGACCATAGATGATATCGAAGAGACTGATGCTTTGATGGATATGTTGCTCGCTAAGAAGCGTTCGCCGG
ACCGTAAAAACTGGCTTGAAGATAAGGGTGACATGGCTTTACTTTAA

Upstream 100 bases:

>100_bases
AATCGCATCTGCAAACTGTAAGCCAATTTTTACACTTACCTTGACAAACAGACATGCCGAGCCGCAACATGGCCGGATAT
AACAACCTATAGCGTGCCCT

Downstream 100 bases:

>100_bases
TGTTGTGCACTATATTGCCGATAACAATAAAACATAGGCATAAAGAAAATTACAATGTTGTGTATTAAAACTAATAATTA
TAATTGCTTAAAGGTGTTTT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHATKIEVVLHTDNSLEVTDDGRGMPVDIHP
EEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSRRVEVTVRRDGQVYDIAFENGFKVEELRPTGTCGRRN
TGTRVHFWPDASYFDSANFSNSKLIYLLRAKAVLCPGLRIKFTNKQTNEVHEWFYESGLTDYLKAAIGDNLRLPDEPFVG
CFKGQLEAADWAITWLPEGGESIGESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLIPRGIKLSPEDIWDRAAFIL
SVKMQEPQFAGQTKEKLSSRQCAAFVSGVVRDAFSLWLNSNTELAESLAEMCINNAQSRLKAAKKVARKKVTSGPALPGK
LTDCSGQDPMRGELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSSDISEL
RYGKICILADADSDGLHIATLLCALFLKHYRILVEQGHVYIAMPPLFRIDIGKEVYYALDEAERAGILDRIAAENKKGKV
QVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDIEETDALMDMLLAKKRSPDRKNWLEDKGDMALL

Sequences:

>Translated_628_residues
MTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHATKIEVVLHTDNSLEVTDDGRGMPVDIHP
EEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSRRVEVTVRRDGQVYDIAFENGFKVEELRPTGTCGRRN
TGTRVHFWPDASYFDSANFSNSKLIYLLRAKAVLCPGLRIKFTNKQTNEVHEWFYESGLTDYLKAAIGDNLRLPDEPFVG
CFKGQLEAADWAITWLPEGGESIGESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLIPRGIKLSPEDIWDRAAFIL
SVKMQEPQFAGQTKEKLSSRQCAAFVSGVVRDAFSLWLNSNTELAESLAEMCINNAQSRLKAAKKVARKKVTSGPALPGK
LTDCSGQDPMRGELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSSDISEL
RYGKICILADADSDGLHIATLLCALFLKHYRILVEQGHVYIAMPPLFRIDIGKEVYYALDEAERAGILDRIAAENKKGKV
QVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDIEETDALMDMLLAKKRSPDRKNWLEDKGDMALL
>Mature_627_residues
TNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHATKIEVVLHTDNSLEVTDDGRGMPVDIHPE
EGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSRRVEVTVRRDGQVYDIAFENGFKVEELRPTGTCGRRNT
GTRVHFWPDASYFDSANFSNSKLIYLLRAKAVLCPGLRIKFTNKQTNEVHEWFYESGLTDYLKAAIGDNLRLPDEPFVGC
FKGQLEAADWAITWLPEGGESIGESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLIPRGIKLSPEDIWDRAAFILS
VKMQEPQFAGQTKEKLSSRQCAAFVSGVVRDAFSLWLNSNTELAESLAEMCINNAQSRLKAAKKVARKKVTSGPALPGKL
TDCSGQDPMRGELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSSDISELR
YGKICILADADSDGLHIATLLCALFLKHYRILVEQGHVYIAMPPLFRIDIGKEVYYALDEAERAGILDRIAAENKKGKVQ
VTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDIEETDALMDMLLAKKRSPDRKNWLEDKGDMALL

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=618, Percent_Identity=24.7572815533981, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI19913406, Length=636, Percent_Identity=24.0566037735849, Blast_Score=123, Evalue=6e-28,
Organism=Escherichia coli, GI1789408, Length=628, Percent_Identity=74.3630573248408, Blast_Score=997, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=554, Percent_Identity=38.9891696750903, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17535065, Length=625, Percent_Identity=22.4, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=584, Percent_Identity=23.972602739726, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=627, Percent_Identity=24.0829346092504, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI17136538, Length=586, Percent_Identity=24.061433447099, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69646; Mature: 69515

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHATKIEVVLH
CCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
TDNSLEVTDDGRGMPVDIHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSRRVEVTVRRDGQVYDIAFENGFKVEELRPTGTCGRRNTGTRVHFWPDASYFDSANFS
HHHHHEEEEEECCCEEEEEEECCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
NSKLIYLLRAKAVLCPGLRIKFTNKQTNEVHEWFYESGLTDYLKAAIGDNLRLPDEPFVG
CCCEEEEEEEHHHHCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
CFKGQLEAADWAITWLPEGGESIGESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNL
HHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IPRGIKLSPEDIWDRAAFILSVKMQEPQFAGQTKEKLSSRQCAAFVSGVVRDAFSLWLNS
CCCCCCCCHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NTELAESLAEMCINNAQSRLKAAKKVARKKVTSGPALPGKLTDCSGQDPMRGELFLVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSSDISEL
CCCCCHHHHHCCHHHHCCCCCCCEEEEECCCHHHHHHHCCCEEEEEEEECCCCCCCHHHH
RYGKICILADADSDGLHIATLLCALFLKHYRILVEQGHVYIAMPPLFRIDIGKEVYYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCEEEEECCEEEEECCCHHHHHHH
EAERAGILDRIAAENKKGKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDIEETD
HHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEEHHHHHHH
ALMDMLLAKKRSPDRKNWLEDKGDMALL
HHHHHHHHHCCCCCHHHHHCCCCCEECC
>Mature Secondary Structure 
TNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHATKIEVVLH
CCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
TDNSLEVTDDGRGMPVDIHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSRRVEVTVRRDGQVYDIAFENGFKVEELRPTGTCGRRNTGTRVHFWPDASYFDSANFS
HHHHHEEEEEECCCEEEEEEECCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
NSKLIYLLRAKAVLCPGLRIKFTNKQTNEVHEWFYESGLTDYLKAAIGDNLRLPDEPFVG
CCCEEEEEEEHHHHCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
CFKGQLEAADWAITWLPEGGESIGESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNL
HHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IPRGIKLSPEDIWDRAAFILSVKMQEPQFAGQTKEKLSSRQCAAFVSGVVRDAFSLWLNS
CCCCCCCCHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NTELAESLAEMCINNAQSRLKAAKKVARKKVTSGPALPGKLTDCSGQDPMRGELFLVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSSDISEL
CCCCCHHHHHCCHHHHCCCCCCCEEEEECCCHHHHHHHCCCEEEEEEEECCCCCCCHHHH
RYGKICILADADSDGLHIATLLCALFLKHYRILVEQGHVYIAMPPLFRIDIGKEVYYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCEEEEECCEEEEECCCHHHHHHH
EAERAGILDRIAAENKKGKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDIEETD
HHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEEHHHHHHH
ALMDMLLAKKRSPDRKNWLEDKGDMALL
HHHHHHHHHCCCCCHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]