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The map label for this gene is hipA [C]

Identifier: 160873800

GI number: 160873800

Start: 824247

End: 825548

Strand: Direct

Name: hipA [C]

Synonym: Sbal195_0678

Alternate gene names: 160873800

Gene position: 824247-825548 (Clockwise)

Preceding gene: 160873799

Following gene: 160873801

Centisome position: 15.41

GC content: 43.16

Gene sequence:

>1302_bases
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGCAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGTAAAATGTCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAAGATTTTGAACAACAGCTTGCTATGGCAATCGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGATTTACCACGGAATTTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCGGCCCTCGAT
GAGAATGAAACATCATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCGAAGTGTAG

Upstream 100 bases:

>100_bases
TGTTTATATCTCAACCGTATTCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAA
CTAACGGCTGGTATTAACCT

Downstream 100 bases:

>100_bases
TTCTAGCTACATCTTATCACCCAGCGGTAATTTCGTTGGAGGGAGAACTTCTTTAGCCACAGTGTTGGCTGTTAATCTTC
GGAGATTTGTGACTGTCCCA

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALD
ENETSFVAHYKAQLLARCDRYLSFAAEVRDVEV

Sequences:

>Translated_433_residues
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALD
ENETSFVAHYKAQLLARCDRYLSFAAEVRDVEV
>Mature_432_residues
STSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIESL
GVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYNG
EEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVDS
CQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSGM
EPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALDE
NETSFVAHYKAQLLARCDRYLSFAAEVRDVEV

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=440, Percent_Identity=28.6363636363636, Blast_Score=141, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 48703; Mature: 48572

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQI
CCCCCEEEEEEECCCEEEEEEECCCCCCEEEEEEECCHHHCCCCCCCCCCCCCCCCCCHH
SMFLVNLLPENKGLDYLIESLGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPI
HHHHEECCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCC
KAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYNGEEFAFAEGALSSTHIVKFE
CHHHHHHHHCCCCCCCHHHCCCCCCEEEECCCCCEEEEECCCEEEEECCCCCCCEEEEHH
KYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEEHHHHCCCCCHHHHHHHHHHH
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNL
HHHHHCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LTGNADAHGKNYSFFMTPSGMEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQL
HCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALDENETSFVAHYKAQLLARCDR
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YLSFAAEVRDVEV
HHHHHHHHHHCCC
>Mature Secondary Structure 
STSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQI
CCCCEEEEEEECCCEEEEEEECCCCCCEEEEEEECCHHHCCCCCCCCCCCCCCCCCCHH
SMFLVNLLPENKGLDYLIESLGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPI
HHHHEECCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCC
KAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYNGEEFAFAEGALSSTHIVKFE
CHHHHHHHHCCCCCCCHHHCCCCCCEEEECCCCCEEEEECCCEEEEECCCCCCCEEEEHH
KYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEEHHHHCCCCCHHHHHHHHHHH
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNL
HHHHHCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LTGNADAHGKNYSFFMTPSGMEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQL
HCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALDENETSFVAHYKAQLLARCDR
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YLSFAAEVRDVEV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]