Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 160873659

GI number: 160873659

Start: 620981

End: 622384

Strand: Direct

Name: fumC [H]

Synonym: Sbal195_0537

Alternate gene names: 160873659

Gene position: 620981-622384 (Clockwise)

Preceding gene: 160873658

Following gene: 160873661

Centisome position: 11.61

GC content: 51.64

Gene sequence:

>1404_bases
ATGGCACAGCAATATCGAATCGAACACGACACTATGGGTGAGGTACAAGTCCCCGCAGACTGTTATTGGGGGGCGCAGAC
CGAGCGTTCACGGCAGCACTTTCGTATCGGTGTCGAAGCGTCAATGCCGATTGAAGTGATCCACGCATTTGGCTATCTCA
AAAAGGCCGCCGCCATTACCAATCAACAACTTGGCACTTTGACTCAAGCTAAAGCCCAACTGATTGCCCAAGTGTGCGAT
GAGCTGATTGCGGGCGAACTCGATACGCAATTTCCCTTGGTTATTTGGCAAACAGGCTCGGGCACGCAAACCAATATGAA
CATCAATGAAGTGATTGCCTATCGCGGCCATGCGCTCTCGGGCGGGCAACTCACGGATACGGTTAAATGTTTGCACCCCA
ATGACGATGTGAATCGCTCGCAATCTTCCAACGATACCTTTCCCACCGCCATGCACATTGCTGCCTATCGTCAAGCCGTT
GAGCTGGTTTTACCCTGCATGAAGTCACTGCAGCAGAGCTTGCAGCACAAGGCCGAGGAATTTGCGCACCTAGTTAAAAT
CGGCCGCACGCATTTTATGGATGCGACACCGTTAACCTTAGGCCAAGAGTTTTCGGGTTACGCCGCGCAATTAAGTCATG
GCATCGAAGGTATTGAGCACAGTCTCAAGCGGGTGGCCGAGTTAGCCTTAGGTGCGACCGCCGTGGGCACTGGGCTGAAT
ACACACAAGGATTACGCCGTTAAGGTGGCGGACAATATCGCTAAACTCACAGGCTTGCCCTTAGTGACGGCGCCGAATAA
GTTTGCCGCCCTTGCTGCCCACGATGAATTAGTCGCCCTGTCGGCGGCCTATAAAGTTGCGGCGGTCAGTTTAATGAAGA
TCGCAAATGATATTAGGATGTTAGGTTCTGGACCGCGCTGCGGCATCGCTGAGTTATTACTGCCTGAAAATGAACCCGGT
TCGTCCATCATGCCGGGCAAAGTCAACCCGACTCAGGTCGAGGCCATGACTATGGTGTGCGCGCAAATCATGGGCAATGA
TGTCGCCGTTAGCATTGGCGGCAGCAATGGTCAGTTTGAGCTCAATGTGTTTAAGCCGATGATTATCGCCAATGTGCTGC
AATCGGGGCGCTTATTGGGGGATGCTTGTCAGTCGTTTAATGACCATTGCGTGGTCGGCATAGTGGCAAATGAACCTCAG
ATTGCTAAGCATGTGGAAAACTCACTCATGCTAGTGACGGCGCTGAATCAACATATCGGTTATGAAAAGGCCGCTAAAAT
AGCTAAAAAAGCCCATAGCGAGCACAAGACACTGCGCCAAGCGGCATTAGAACTTGAGTTAGTTACGGCGGAAGAGTTCG
AGCTGTGGGTCGATGCCAACAAGATGTTAGGGCCAGATGCTTAA

Upstream 100 bases:

>100_bases
AATCAGCCTTATCATTGATACTCCTTGTTGGAGGTTAATTGTACTTTCGCCCTGAGCGAGTATGGTGAAGGCTTAGAGGG
TTTTAGCGAAGGAGATGCGC

Downstream 100 bases:

>100_bases
TATCTATTGCTTAATACATAATGTCTCAGCCTAGCTGCTGATAAATGAGCGAAAGAAATAGTGAGGCGAAACAGTGGAGT
AAGAATGCTGAAGCATTCGC

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAQQYRIEHDTMGEVQVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAITNQQLGTLTQAKAQLIAQVCD
ELIAGELDTQFPLVIWQTGSGTQTNMNINEVIAYRGHALSGGQLTDTVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAV
ELVLPCMKSLQQSLQHKAEEFAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVSLMKIANDIRMLGSGPRCGIAELLLPENEPG
SSIMPGKVNPTQVEAMTMVCAQIMGNDVAVSIGGSNGQFELNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQ
IAKHVENSLMLVTALNQHIGYEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA

Sequences:

>Translated_467_residues
MAQQYRIEHDTMGEVQVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAITNQQLGTLTQAKAQLIAQVCD
ELIAGELDTQFPLVIWQTGSGTQTNMNINEVIAYRGHALSGGQLTDTVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAV
ELVLPCMKSLQQSLQHKAEEFAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVSLMKIANDIRMLGSGPRCGIAELLLPENEPG
SSIMPGKVNPTQVEAMTMVCAQIMGNDVAVSIGGSNGQFELNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQ
IAKHVENSLMLVTALNQHIGYEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA
>Mature_466_residues
AQQYRIEHDTMGEVQVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAITNQQLGTLTQAKAQLIAQVCDE
LIAGELDTQFPLVIWQTGSGTQTNMNINEVIAYRGHALSGGQLTDTVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAVE
LVLPCMKSLQQSLQHKAEEFAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLNT
HKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVSLMKIANDIRMLGSGPRCGIAELLLPENEPGS
SIMPGKVNPTQVEAMTMVCAQIMGNDVAVSIGGSNGQFELNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQI
AKHVENSLMLVTALNQHIGYEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=468, Percent_Identity=61.965811965812, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=64.4067796610169, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=59.9128540305011, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI87082375, Length=467, Percent_Identity=38.3297644539615, Blast_Score=317, Evalue=9e-88,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=62.6349892008639, Blast_Score=583, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=65.3374233128834, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324993, Length=466, Percent_Identity=58.1545064377682, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640179, Length=466, Percent_Identity=59.4420600858369, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640177, Length=466, Percent_Identity=59.4420600858369, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=58.6206896551724, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=57.6344086021505, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=51.0775862068966, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50401; Mature: 50270

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQYRIEHDTMGEVQVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAIT
CCCCEECCCCCCCCEECCCHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
NQQLGTLTQAKAQLIAQVCDELIAGELDTQFPLVIWQTGSGTQTNMNINEVIAYRGHALS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCC
GGQLTDTVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAVELVLPCMKSLQQSLQHKAEE
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCC
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVSLMKIANDIRM
CCCCCEEEHHHHHHHHCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGSGPRCGIAELLLPENEPGSSIMPGKVNPTQVEAMTMVCAQIMGNDVAVSIGGSNGQFE
HCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEE
LNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQIAKHVENSLMLVTALNQHIG
EEEHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCEEEEEHHHHHCC
YEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
AQQYRIEHDTMGEVQVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAIT
CCCEECCCCCCCCEECCCHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
NQQLGTLTQAKAQLIAQVCDELIAGELDTQFPLVIWQTGSGTQTNMNINEVIAYRGHALS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCC
GGQLTDTVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAVELVLPCMKSLQQSLQHKAEE
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCC
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVSLMKIANDIRM
CCCCCEEEHHHHHHHHCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGSGPRCGIAELLLPENEPGSSIMPGKVNPTQVEAMTMVCAQIMGNDVAVSIGGSNGQFE
HCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEE
LNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQIAKHVENSLMLVTALNQHIG
EEEHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCEEEEEHHHHHCC
YEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]