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The map label for this gene is hap [H]

Identifier: 160873580

GI number: 160873580

Start: 522977

End: 525313

Strand: Reverse

Name: hap [H]

Synonym: Sbal195_0456

Alternate gene names: 160873580

Gene position: 525313-522977 (Counterclockwise)

Preceding gene: 160873581

Following gene: 160873575

Centisome position: 9.82

GC content: 48.14

Gene sequence:

>2337_bases
ATGATGCTAAACAAAAAACTGTCGCTACTCTTCATTGCTGTGTCGGCCACGTTAGGCACATCAGCATTTGCTGCTGATGT
TGTCGATGTCGGCACACTCAGAAGCGCGTCTTCAAGCAATAACTTAGTGTCTCAGTTCAACTTAGACGCAGGTAGCCAAC
TCAAAGTCGAGAAAAAACTCGACCTAGGTCAAGGCAAGCAAAAGCAACGTTTACAACAATATTTCCATGACGTGCCTGTT
TATGGTTTCTCTGTTGCAACGTCACAATCGAGCATGGGCTTCTACAGTGACATGTCTGGCCGCGTATTAAAAAATATTGA
AAAGTCGGCTGATTTTGTCAAACCCACTTTAACGGCTAACAAAGCGTTAGACATTGCCATTCGTGGCAAGTCAGAGAAAG
CTGTTGCCGGCCTAAAAGCTGAAAACAAACAAGCTAAATTATGGCTTTACCTGGATGATGCGGCTAAAACTCGCCTCGTT
TATGTGACGTCTTTTGTGGTATATGGCGATGAGCCAAGCCGTCCATTCACTATGATTGACGCACACTCAGGTGAAGTGCT
CAAGCGTTGGGAAGGGATTAACCACGCCGCTAGCGGTACAGGTCCTGGCGGTAACATCAAGACTGGCCAATACGAATACG
GTACGGATTTTTCTTACTTAGACGTTGAAGTGAGTGGTGACACCTGCACCATGAACTCACCTAACGTGAAAACCGTTAAC
TTAAACGGTGCCACATCAGGCGCAACAGCCTTCTCTTATACTTGCCCACGCAATACCGTTAAAGAGATCAACGGTGCTTA
CTCGCCATTAAACGATGCGCACTATTTTGGTAACGTGATCTACAACATGTATAGCGAGTGGTACAACACTGCGCCGTTAA
CTTTCCAGTTAACCATGCGGGTTCACTACAGCAGCAACTATGAAAACGCCTTCTGGGACGGCAGTGCTATGACCTTCGGT
GATGGCGCAACGACCTTCTATCCATTAGTGAGCTTAGATGTCTCGGCACACGAAGTGAGCCATGGTTTCACTGAGCAAAA
CTCAGGCCTGATTTACGATGCTCAATCTGGTGGCATGAACGAAGCCTTCTCTGATATGGCGGGTGAAGCTGCTGAATTTT
ACATGCACGGCACGAACGACTGGTTAGTCGGTGCAGATATCTTTAAAGGCAATGGCGCACTGCGTTACATGGCAGATCCA
ACCTTAGACGGTATCTCAATCGGCCATATCGACGATTACTATGATGGTATCGACGTACACCACAGTTCAGGTGTCTTCAA
CAAAGCCTTCTACACACTCGCAAACTTACCGGGCTGGGATACACGCACTGCATTCCAAACATTTGTGGTTGCTAACCAAT
TATATTGGACGGCTGACAGCTTGTTCTGGCAAGGCGCTTGTGGCGTTAAATCTGCAGCGACTGACTTAGGCTTAAGTGCT
GACGATGTGGTTACTGCGTTTGCAGCTGTGGGTATCACACCTTGTGAAACGCCACCACCACCGCCACCACCAGAAGCCAC
TGAGCTCGCGAACGGTGTCGCTGTGACGGATTTAGCGGGCGCATCTGGTAGCAAACAATACTACAAACTCGACGTAGCAA
GCGGTGCAACCAACCTGAGTTTTAATATGTCAGGCGGCACGGGTGATGCGGACATGTATGTTAAATTCGGCCAAGCTCCT
ACCTCTAGTAGCTATGATTGCCGTCCATACAAAGCCGGTAATGCCGAAAGCTGCCCTATCGATCCAGCCCAAACAGGAAC
TTATTGGATCATGGTCAGTGGCTATAGCAGCTACACAGGTGTGAGCCTAGTGGGTGCTTATGACGGTGGCGATGAGATAC
CAAACCAAGATCCAACAGCGGGCTTTACGGCAAGCTTTGCCAACGGTAACGGTAGCTTCACTAGCACCAGTACTGACAGC
GACGGTGATGTCGTTGCATGGAGCTGGAGTTTCGGTGATGGCACAACTGCTTCAGGCGCAAGTGTAAATCATCAGTATGC
ACAGTCAGGCAACTACACAGTGACACTGACAGTGACTGACAACGATGGCGCAACAGCAATCACTTCTGAAGAATTTGCGG
TTGAAGTACCAGAAGTGGCGTTAGAAATGACAGTGAAAAACGCTAACAAATCTCGTCGCGGTAGCATTCGTGTTGCACTC
GCATGGGAAGGCCATAACGCTGATGAGTACACTATCTTCCGTAACGGCGTTGCGGTTAGTACTTCAAGCAATTCATCGTT
TATTGACCGTTTCACTGACCTAGCTGGCACTAGCTTCAGCTATAAAGTGTGTGAAACTAACGGCCCTTGCTCAAACGAAG
AAACCGTTAACTTTTAA

Upstream 100 bases:

>100_bases
CGACGACCCTGTAGAAATTACAATAAAAAAACGCTCGCCCGAGCCAGTTAAGCAGTATGGCATTCCAACGTTAATGACAA
ACGGAAAAAGGATTTTAAGC

Downstream 100 bases:

>100_bases
TCGCATAAGATAATCGTATCGTGGCGCTAGCGTAAAATCCTAGCGCCGACTCATCGATAAACTTCTCGTTTCTTGTTAAT
GCCACTCAGCCTTTTTTGAG

Product: peptidase M4 thermolysin

Products: NA

Alternate protein names: HA/protease; Vibriolysin [H]

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKLDLGQGKQKQRLQQYFHDVPV
YGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTANKALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLV
YVTSFVVYGDEPSRPFTMIDAHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMRVHYSSNYENAFWDGSAMTFG
DGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMNEAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADP
TLDGISIGHIDDYYDGIDVHHSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLSFNMSGGTGDADMYVKFGQAP
TSSSYDCRPYKAGNAESCPIDPAQTGTYWIMVSGYSSYTGVSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDS
DGDVVAWSWSFGDGTTASGASVNHQYAQSGNYTVTLTVTDNDGATAITSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
AWEGHNADEYTIFRNGVAVSTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF

Sequences:

>Translated_778_residues
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKLDLGQGKQKQRLQQYFHDVPV
YGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTANKALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLV
YVTSFVVYGDEPSRPFTMIDAHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMRVHYSSNYENAFWDGSAMTFG
DGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMNEAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADP
TLDGISIGHIDDYYDGIDVHHSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLSFNMSGGTGDADMYVKFGQAP
TSSSYDCRPYKAGNAESCPIDPAQTGTYWIMVSGYSSYTGVSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDS
DGDVVAWSWSFGDGTTASGASVNHQYAQSGNYTVTLTVTDNDGATAITSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
AWEGHNADEYTIFRNGVAVSTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF
>Mature_778_residues
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKLDLGQGKQKQRLQQYFHDVPV
YGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTANKALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLV
YVTSFVVYGDEPSRPFTMIDAHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMRVHYSSNYENAFWDGSAMTFG
DGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMNEAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADP
TLDGISIGHIDDYYDGIDVHHSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLSFNMSGGTGDADMYVKFGQAP
TSSSYDCRPYKAGNAESCPIDPAQTGTYWIMVSGYSSYTGVSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDS
DGDVVAWSWSFGDGTTASGASVNHQYAQSGNYTVTLTVTDNDGATAITSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
AWEGHNADEYTIFRNGVAVSTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF

Specific function: May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR007280
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 83244; Mature: 83244

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50093 PKD ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKL
CCCCCCEEEEEEEEEHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEECC
DLGQGKQKQRLQQYFHDVPVYGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTAN
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCC
KALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLVYVTSFVVYGDEPSRPFTMID
CEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCCCCCCEEEEE
AHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCEEECCCCCEEEEE
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMR
ECCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VHYSSNYENAFWDGSAMTFGDGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMN
EEECCCCCCEEECCCEEEECCCCCEEEEEEEECCCHHHHHCCCCCCCCCEEEECCCCCCH
EAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADPTLDGISIGHIDDYYDGIDVH
HHHHHHCCCCEEEEEECCCCEEEEEEEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEE
HSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEEECCEEECCCCCCCHHHHHCCCCH
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLS
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCEEE
FNMSGGTGDADMYVKFGQAPTSSSYDCRPYKAGNAESCPIDPAQTGTYWIMVSGYSSYTG
EEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
VSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDSDGDVVAWSWSFGDGTTASGA
EEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCCCCCC
SVNHQYAQSGNYTVTLTVTDNDGATAITSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
CCCCHHHCCCCEEEEEEEECCCCCEEEECCCCEEECCCEEEEEEEECCCCCCCCEEEEEE
AWEGHNADEYTIFRNGVAVSTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF
EECCCCCCEEEEEECCEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMLNKKLSLLFIAVSATLGTSAFAADVVDVGTLRSASSSNNLVSQFNLDAGSQLKVEKKL
CCCCCCEEEEEEEEEHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEECC
DLGQGKQKQRLQQYFHDVPVYGFSVATSQSSMGFYSDMSGRVLKNIEKSADFVKPTLTAN
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCC
KALDIAIRGKSEKAVAGLKAENKQAKLWLYLDDAAKTRLVYVTSFVVYGDEPSRPFTMID
CEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCCCCCCEEEEE
AHSGEVLKRWEGINHAASGTGPGGNIKTGQYEYGTDFSYLDVEVSGDTCTMNSPNVKTVN
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCEEECCCCCEEEEE
LNGATSGATAFSYTCPRNTVKEINGAYSPLNDAHYFGNVIYNMYSEWYNTAPLTFQLTMR
ECCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VHYSSNYENAFWDGSAMTFGDGATTFYPLVSLDVSAHEVSHGFTEQNSGLIYDAQSGGMN
EEECCCCCCEEECCCEEEECCCCCEEEEEEEECCCHHHHHCCCCCCCCCEEEECCCCCCH
EAFSDMAGEAAEFYMHGTNDWLVGADIFKGNGALRYMADPTLDGISIGHIDDYYDGIDVH
HHHHHHCCCCEEEEEECCCCEEEEEEEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEE
HSSGVFNKAFYTLANLPGWDTRTAFQTFVVANQLYWTADSLFWQGACGVKSAATDLGLSA
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEEECCEEECCCCCCCHHHHHCCCCH
DDVVTAFAAVGITPCETPPPPPPPEATELANGVAVTDLAGASGSKQYYKLDVASGATNLS
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCEEE
FNMSGGTGDADMYVKFGQAPTSSSYDCRPYKAGNAESCPIDPAQTGTYWIMVSGYSSYTG
EEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
VSLVGAYDGGDEIPNQDPTAGFTASFANGNGSFTSTSTDSDGDVVAWSWSFGDGTTASGA
EEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCCCCCC
SVNHQYAQSGNYTVTLTVTDNDGATAITSEEFAVEVPEVALEMTVKNANKSRRGSIRVAL
CCCCHHHCCCCEEEEEEEECCCCCEEEECCCCEEECCCEEEEEEEECCCCCCCCEEEEEE
AWEGHNADEYTIFRNGVAVSTSSNSSFIDRFTDLAGTSFSYKVCETNGPCSNEETVNF
EECCCCCCEEEEEECCEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2045361; 10952301; 2123831 [H]