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The map label for this gene is lpxC

Identifier: 160873543

GI number: 160873543

Start: 476646

End: 477566

Strand: Direct

Name: lpxC

Synonym: Sbal195_0418

Alternate gene names: 160873543

Gene position: 476646-477566 (Clockwise)

Preceding gene: 160873542

Following gene: 160873545

Centisome position: 8.91

GC content: 47.34

Gene sequence:

>921_bases
ATGATATTTCAAAGAACTGTTCAGAAAATGGTGAAAACTACTGGTGTCGGATTGCATTCTGGCAACAAGGTCACTTTGAG
CATAATGCCCGCGCCCGTTAATTCAGGGATCGTACTCGTGCGCACTGATTTGAGTCCTGCCGTCGCCATTCCAGCGAAGG
CGGAGCAAGTTCGTGAAACCACTATGTGTACGGCACTTGTCAATGACGAAGGTATTCGTATCTCGACCATTGAGCATTTA
TTTGCAGCACTTGCGGGTTTAGGCATAGATAACGCCGTAATCGAAGTGGACGCGCCTGAAATTCCTATTATGGATGGCAG
TGCGAGCCCATTTGTCTTCTTATTGCAGTCTGCGGGTATTAAAGAGCAGGCCGCACCTAAGAAGTACTTAAAGATTAAGC
GCCCTGTGCGTGTTGAAGATGGCGACAAATGGGCCGAGCTGAAACCCTTTAAAGGTTTTAGAGTCAATTTTAAAATTGAC
TTCGCGCACCCAGAAATCGCTCGTAGCCAACAGCATGTGGTGATGGACTTTTCAACGTCTGCTTTCGTGAAAGATATCAG
CCGCGCCCGTACTTTTGGGTTTATGCGTGATATCGAATATCTGCGAGCCAACAACCTAGCGTTGGGCGGCAGCATGGAAA
ACGCAGTTGTACTTGATGAATATCGCGTCCTTAATCCCGACGGCCTGCGTTATGAGGACGAATTTGTTAAGCACAAAATT
CTAGATGCGTTTGGTGATTTATATGTGGCAGGACACGCTATTTTAGGTGAGTTCACTGCGTATAAAACCGGTCATGCACT
GAACAACCAATTGGTGCGTGCTTTACTGGCGCAACAGGATGCGTGGGAGTTGGTCAGCTTTGAAAAAGAAGCCGATGTTC
CCGTTAGCTTTACCGTGCCAGGTGGCGCTGTATTTGCTTAA

Upstream 100 bases:

>100_bases
TAATAAAGTTATGTTATTATGTTGAACCAGTGCGGCCAATTTGCCGACGCTGAGTGTACAAATATTAGGCTTTATAATTG
GCATATAAACGGGTAACTGA

Downstream 100 bases:

>100_bases
AAAGCGGTGAGATTATTTATTACGGCTGGCCAATGAGGCCAGCCGTTTTAGTTTTTCGCCCAGTGAACCGCCAATATTTT
CCGCTAATGCCGCAATATGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIFQRTVQKMVKTTGVGLHSGNKVTLSIMPAPVNSGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKID
FAHPEIARSQQHVVMDFSTSAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFTVPGGAVFA

Sequences:

>Translated_306_residues
MIFQRTVQKMVKTTGVGLHSGNKVTLSIMPAPVNSGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKID
FAHPEIARSQQHVVMDFSTSAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFTVPGGAVFA
>Mature_306_residues
MIFQRTVQKMVKTTGVGLHSGNKVTLSIMPAPVNSGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHL
FAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKID
FAHPEIARSQQHVVMDFSTSAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFTVPGGAVFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=61.8421052631579, Blast_Score=416, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_SHEB2 (B8E6A3)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002356389.1
- ProteinModelPortal:   B8E6A3
- SMR:   B8E6A3
- GeneID:   7089570
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_0432
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33605; Mature: 33605

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQRTVQKMVKTTGVGLHSGNKVTLSIMPAPVNSGIVLVRTDLSPAVAIPAKAEQVRET
CCHHHHHHHHHHHHCCCEECCCEEEEEEEECCCCCCEEEEEECCCCCEECCCCHHHHHHH
TMCTALVNDEGIRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCCC
KEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKIDFAHPEIARSQQHVVMDFSTS
CHHCCCHHHHEECCCEEECCCCCCCCCCCCCCEEEEEEEEECCCHHHCCCCEEEEEECHH
AFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFTVP
HHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEECC
GGAVFA
CCCCCC
>Mature Secondary Structure
MIFQRTVQKMVKTTGVGLHSGNKVTLSIMPAPVNSGIVLVRTDLSPAVAIPAKAEQVRET
CCHHHHHHHHHHHHCCCEECCCEEEEEEEECCCCCCEEEEEECCCCCEECCCCHHHHHHH
TMCTALVNDEGIRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGI
HHEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCCC
KEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKIDFAHPEIARSQQHVVMDFSTS
CHHCCCHHHHEECCCEEECCCCCCCCCCCCCCEEEEEEEEECCCHHHCCCCEEEEEECHH
AFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKI
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCHHHHHHHHH
LDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFTVP
HHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEECC
GGAVFA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA