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The map label for this gene is dctA [H]

Identifier: 160873432

GI number: 160873432

Start: 346811

End: 348007

Strand: Reverse

Name: dctA [H]

Synonym: Sbal195_0306

Alternate gene names: 160873432

Gene position: 348007-346811 (Counterclockwise)

Preceding gene: 160873436

Following gene: 160873429

Centisome position: 6.51

GC content: 48.54

Gene sequence:

>1197_bases
ATGTGGCAAAAGATAAAACCGTATAAAGATTCCATCGTGCTGCTCACCGCGTTATTACTGGGCGGCCTGCTCGGTGTAGG
TTTGCCAGAACTGGCGCTCAAGTTCAAACCTTTAGGGCAAATTTTTCTAAACCTGTTGTTTATGATTATCGTACCACTGG
TCGCCATTAGCGTGACCTCCTCCATTGCTCGCATGACGGATTTGAAGAAACTCGGCGCTCTGTTAGTGTCAATCATGGCG
GTGTCGATTGTGATGGCGATTATTCCCGCCGTTGGCATTATCGGACTGGCCTTGTTTTTCGACCCAGCCCAAGGTGTTAC
CTTAGATCTCAATCAAACTATCAGCGATACTGCGGGGACGATGGATTTTGTCGGCCTGCTGACCACCAATGACTTTTCAG
GTTTATTATCAAAATCCAATATCTTAGCCCTGATCATCATGTCGGTTATTGCGGGGATTGCGATAGGTCAATCGGGTGAG
GATGGCAGAAAAGTCTCGGTATTACTCGACAGTTTTAATACCGTCATCATGAAGATAGTGTCGATCATTATGGTGGCTGC
TCCCGTGGGACTGGGTGCCTATTTCGCCTCAACGATGGCAAGCCAAGATCCGCAGCTTGTTATCACCTTTGCCCGCGCCG
TTGGTCTGTTTATGGTCGCCTGTTTTATTTATCTAACAGTGGGTTCTACCTTTTACGCTTGGCTTGGCGGTGGCACTCAA
GGGGTTAAACAATTCTGGCGCTTCGCCCTCGAACCCGCAGTGATCGCACTGGGCACCACATCATCGCTTGCCACCTTACC
CGTCACCTTAAGAACCGCGCTAAAGATGGGCATCAAACCCGAAATTGCCGACATCAGCCTGCCATTATTGGTCAATTTAA
ATAAGGGCGGCGCCTCAATCATCACAGCCCTAAAAATCGTGTTTATCTACTCGTTACTCGGATTAGATTTCACCGTCGAT
GTGTTTATGGTGACCATACTGATTTCGGTTTTATCGGCCTTTATCATAGGCGGCGTACCGGGCGGCGCTTTCCTCGGAGA
GATTTTTATCGTCACGACATTAGGCTTGCCAATGGAAACCATCCCGATTTTAGTGGTGATAGGGGCAATAACCGATGCAC
CATCGACAGTCATTAACGTGGTACACGACTTGAACGCCTGCCAGATCATCGAGCGGCTAAATCGTAAACGACTCTAA

Upstream 100 bases:

>100_bases
TTGCGCTATAGCACACGACTCGCTAGCTTGAGAATGTCCATGCAGCACGATTAATCCTGATCACTTGGACGCTCTTATTC
ATAAAAATAGGCGCTTACCT

Downstream 100 bases:

>100_bases
AAAAATGCCCAAACACTCAGGTTTGGGCATAGCTATTTATCCACAGAGCTCTTATCAATTGGCTACCGATTGGCTTTTAT
CACGTCCAGTAACAGCTTGA

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MWQKIKPYKDSIVLLTALLLGGLLGVGLPELALKFKPLGQIFLNLLFMIIVPLVAISVTSSIARMTDLKKLGALLVSIMA
VSIVMAIIPAVGIIGLALFFDPAQGVTLDLNQTISDTAGTMDFVGLLTTNDFSGLLSKSNILALIIMSVIAGIAIGQSGE
DGRKVSVLLDSFNTVIMKIVSIIMVAAPVGLGAYFASTMASQDPQLVITFARAVGLFMVACFIYLTVGSTFYAWLGGGTQ
GVKQFWRFALEPAVIALGTTSSLATLPVTLRTALKMGIKPEIADISLPLLVNLNKGGASIITALKIVFIYSLLGLDFTVD
VFMVTILISVLSAFIIGGVPGGAFLGEIFIVTTLGLPMETIPILVVIGAITDAPSTVINVVHDLNACQIIERLNRKRL

Sequences:

>Translated_398_residues
MWQKIKPYKDSIVLLTALLLGGLLGVGLPELALKFKPLGQIFLNLLFMIIVPLVAISVTSSIARMTDLKKLGALLVSIMA
VSIVMAIIPAVGIIGLALFFDPAQGVTLDLNQTISDTAGTMDFVGLLTTNDFSGLLSKSNILALIIMSVIAGIAIGQSGE
DGRKVSVLLDSFNTVIMKIVSIIMVAAPVGLGAYFASTMASQDPQLVITFARAVGLFMVACFIYLTVGSTFYAWLGGGTQ
GVKQFWRFALEPAVIALGTTSSLATLPVTLRTALKMGIKPEIADISLPLLVNLNKGGASIITALKIVFIYSLLGLDFTVD
VFMVTILISVLSAFIIGGVPGGAFLGEIFIVTTLGLPMETIPILVVIGAITDAPSTVINVVHDLNACQIIERLNRKRL
>Mature_398_residues
MWQKIKPYKDSIVLLTALLLGGLLGVGLPELALKFKPLGQIFLNLLFMIIVPLVAISVTSSIARMTDLKKLGALLVSIMA
VSIVMAIIPAVGIIGLALFFDPAQGVTLDLNQTISDTAGTMDFVGLLTTNDFSGLLSKSNILALIIMSVIAGIAIGQSGE
DGRKVSVLLDSFNTVIMKIVSIIMVAAPVGLGAYFASTMASQDPQLVITFARAVGLFMVACFIYLTVGSTFYAWLGGGTQ
GVKQFWRFALEPAVIALGTTSSLATLPVTLRTALKMGIKPEIADISLPLLVNLNKGGASIITALKIVFIYSLLGLDFTVD
VFMVTILISVLSAFIIGGVPGGAFLGEIFIVTTLGLPMETIPILVVIGAITDAPSTVINVVHDLNACQIIERLNRKRL

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=268, Percent_Identity=30.9701492537313, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4827012, Length=273, Percent_Identity=27.8388278388278, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI169790839, Length=279, Percent_Identity=27.2401433691756, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI40254478, Length=278, Percent_Identity=27.3381294964029, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI223468564, Length=263, Percent_Identity=28.1368821292776, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI223468566, Length=263, Percent_Identity=28.1368821292776, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI21314632, Length=261, Percent_Identity=26.8199233716475, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5032093, Length=263, Percent_Identity=28.1368821292776, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194239697, Length=267, Percent_Identity=28.0898876404494, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=27.3399014778325, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790514, Length=381, Percent_Identity=25.4593175853018, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=398, Percent_Identity=22.8643216080402, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=434, Percent_Identity=25.3456221198157, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=274, Percent_Identity=24.8175182481752, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193206654, Length=409, Percent_Identity=23.2273838630807, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983099, Length=462, Percent_Identity=21.8614718614719, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71983106, Length=462, Percent_Identity=21.8614718614719, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17541374, Length=410, Percent_Identity=24.8780487804878, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583025, Length=410, Percent_Identity=22.6829268292683, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137668, Length=410, Percent_Identity=22.6829268292683, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583023, Length=410, Percent_Identity=22.6829268292683, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42040; Mature: 42040

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWQKIKPYKDSIVLLTALLLGGLLGVGLPELALKFKPLGQIFLNLLFMIIVPLVAISVTS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SIARMTDLKKLGALLVSIMAVSIVMAIIPAVGIIGLALFFDPAQGVTLDLNQTISDTAGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHCCCH
MDFVGLLTTNDFSGLLSKSNILALIIMSVIAGIAIGQSGEDGRKVSVLLDSFNTVIMKIV
HHHHHEEECCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHH
SIIMVAAPVGLGAYFASTMASQDPQLVITFARAVGLFMVACFIYLTVGSTFYAWLGGGTQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GVKQFWRFALEPAVIALGTTSSLATLPVTLRTALKMGIKPEIADISLPLLVNLNKGGASI
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHH
ITALKIVFIYSLLGLDFTVDVFMVTILISVLSAFIIGGVPGGAFLGEIFIVTTLGLPMET
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
IPILVVIGAITDAPSTVINVVHDLNACQIIERLNRKRL
HHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure
MWQKIKPYKDSIVLLTALLLGGLLGVGLPELALKFKPLGQIFLNLLFMIIVPLVAISVTS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SIARMTDLKKLGALLVSIMAVSIVMAIIPAVGIIGLALFFDPAQGVTLDLNQTISDTAGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHCCCH
MDFVGLLTTNDFSGLLSKSNILALIIMSVIAGIAIGQSGEDGRKVSVLLDSFNTVIMKIV
HHHHHEEECCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHH
SIIMVAAPVGLGAYFASTMASQDPQLVITFARAVGLFMVACFIYLTVGSTFYAWLGGGTQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GVKQFWRFALEPAVIALGTTSSLATLPVTLRTALKMGIKPEIADISLPLLVNLNKGGASI
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHH
ITALKIVFIYSLLGLDFTVDVFMVTILISVLSAFIIGGVPGGAFLGEIFIVTTLGLPMET
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
IPILVVIGAITDAPSTVINVVHDLNACQIIERLNRKRL
HHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA