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The map label for this gene is nuoN2

Identifier: 159901502

GI number: 159901502

Start: 6328503

End: 6330122

Strand: Direct

Name: nuoN2

Synonym: Haur_4991

Alternate gene names: 159901502

Gene position: 6328503-6330122 (Clockwise)

Preceding gene: 159901501

Following gene: 159901503

Centisome position: 99.72

GC content: 52.1

Gene sequence:

>1620_bases
GTGAATTTTCAAATAGCTGATTTTACGCGGCTCATCCCTGAGTTTTTGCTACTGGCGATTGCGGCCATGGTGCTGCTTGG
CGATGTCCTGACGCGTTGGTCGAAGGGCAAGGAAGCATTAAACGATCGTACCGAAGAAGCCATCAGCATGACCTTGATGG
GCTTGGGTTTGGCATTTGTGATGGTGTTGATCCAAGGTGGTTTCTTCAGCTGGATGCAGTTTGGCGATTGGAAGTTCTAC
GACTTCAGTATTTTCCAAAATCTGCGCAGCAGCGGCCTTGATGGCAGTATTCTGGGCGGGGCATTTGTGGTTGATCCACT
GACCCACATTGGGCGCTTGGTGTTTATCGGCGCAGCCTTTGTGACGGTGATTTTGACTAGCAAAGCCAAGCCTTCGAATA
ATCCAGCCGAATTCTATGCCCTGATCTTATTTGCTACCCTTGGCATGATTTTCATGACCGCTGGCGGCGAATTGATTATG
ATTTACTTGGGCATTGAATTGACCAGTATTCCGCTGTATGTGTTGGCTGGCTACTTCCGCCGCAACCCGGTCAGCACCGA
AGCTGGGGCCAAATACTACATTTTCGGGGCACTTTCATCGGCAATCTTGCTGTTTGGTATGAGCTTGCTCTTGGGCTTGA
CTTTGATGAATGGTCAGACCATGACCACAACTCCAACCAGCTTGCGCTCAGTGGCAACGGCGGTTGAGTTGGCTTTTGCT
AACCCCGAAGGCCCAAGCCAAGGTGTTGCAATCTTAGCGCTGTTGTTCATCCTCGCGGGGATGGCCTACAAAGTTGCGAT
TGTGCCGTTCCACGCTTGGTCGCCAGACGTGTACCAAGGTGCGCCAACCTCGATGACGGCCTTTATCTCGACCGCCTCAA
AAACCGCTGGCTTCTTCTTGCTGTATCGGGTGTTGGTGACCGGCTTCGGCGCACCCAGCATTCTTGGTACGGCAGCAATT
GGCACCAGCACCAGTTTTGGTGGCTGGACAAGCCTGATCGCGATTTTGGCAGCCTTGACCATGCTGGTTGGCAACTTGGC
GGCTTTGCCCCAAACCAATGCCAAGCGCATGTTGGCCTATTCATCAATCGCCCAAGCAGGCTTCTTGATGTTAGGCTTGG
TTGGCACCCAACGCGATAGCGGCATCTCGCTCTTGATGTATTTGATTGCCTATACCGTCACCAACTTGAGCGCCTTCGGT
ATCTTGGCTTTGGTCGAAGATGCAGTGGGTGGGACCGACTTTAGCAACTTGAATGGCTTGGGCCGTCGTGCGCCTGGCTT
GGCGTTGCTCTTAACGGTTGCAATCTTGTCGTTGGCGGGGATTCCACCACTCTCAGGCTTCTTTGTGAAGTTCTATGTCT
TTATTGCTGCTTGGCAAGAAGGCGCAAAGTGGCTGGTGATCTTCGCAGTCAGCAATACCGTAATCAGCTTGTATTACTAC
CTGCGCTTCCTCAAGGCTGTCTATTTTGCGCCTGCGGAAACCGACGAACCAATCAAGGTTGGCTTTGGGCCTGGCATCGT
AATGACCGCCATCACCCTGTTGATCTTTGGTTTGGGGATTGTACCAACCTGGTTGTACGGGGTGCTTGAACAAGCTACCA
TTCGGATTGCGGCTCAATAA

Upstream 100 bases:

>100_bases
TTGGTTTATTCCCCAGCATCATCATGGACTACATTGCGACCGGTGTCCAGCCCATTGCCCAGCGCATGATTGATCTAGCA
GGACGTTAGGGAGGAATGAC

Downstream 100 bases:

>100_bases
CAGGAGCGATCCAATGGGTCAAATGCCTGCTCGCTGAGTGCGTAGCGGGCATTTGCTTTTTAACGGAAACACAACCGTGC
ATCCAAACGTCAATTATGAA

Product: proton-translocating NADH-quinone oxidoreductase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 2; NDH-1 subunit N 2

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MNFQIADFTRLIPEFLLLAIAAMVLLGDVLTRWSKGKEALNDRTEEAISMTLMGLGLAFVMVLIQGGFFSWMQFGDWKFY
DFSIFQNLRSSGLDGSILGGAFVVDPLTHIGRLVFIGAAFVTVILTSKAKPSNNPAEFYALILFATLGMIFMTAGGELIM
IYLGIELTSIPLYVLAGYFRRNPVSTEAGAKYYIFGALSSAILLFGMSLLLGLTLMNGQTMTTTPTSLRSVATAVELAFA
NPEGPSQGVAILALLFILAGMAYKVAIVPFHAWSPDVYQGAPTSMTAFISTASKTAGFFLLYRVLVTGFGAPSILGTAAI
GTSTSFGGWTSLIAILAALTMLVGNLAALPQTNAKRMLAYSSIAQAGFLMLGLVGTQRDSGISLLMYLIAYTVTNLSAFG
ILALVEDAVGGTDFSNLNGLGRRAPGLALLLTVAILSLAGIPPLSGFFVKFYVFIAAWQEGAKWLVIFAVSNTVISLYYY
LRFLKAVYFAPAETDEPIKVGFGPGIVMTAITLLIFGLGIVPTWLYGVLEQATIRIAAQ

Sequences:

>Translated_539_residues
MNFQIADFTRLIPEFLLLAIAAMVLLGDVLTRWSKGKEALNDRTEEAISMTLMGLGLAFVMVLIQGGFFSWMQFGDWKFY
DFSIFQNLRSSGLDGSILGGAFVVDPLTHIGRLVFIGAAFVTVILTSKAKPSNNPAEFYALILFATLGMIFMTAGGELIM
IYLGIELTSIPLYVLAGYFRRNPVSTEAGAKYYIFGALSSAILLFGMSLLLGLTLMNGQTMTTTPTSLRSVATAVELAFA
NPEGPSQGVAILALLFILAGMAYKVAIVPFHAWSPDVYQGAPTSMTAFISTASKTAGFFLLYRVLVTGFGAPSILGTAAI
GTSTSFGGWTSLIAILAALTMLVGNLAALPQTNAKRMLAYSSIAQAGFLMLGLVGTQRDSGISLLMYLIAYTVTNLSAFG
ILALVEDAVGGTDFSNLNGLGRRAPGLALLLTVAILSLAGIPPLSGFFVKFYVFIAAWQEGAKWLVIFAVSNTVISLYYY
LRFLKAVYFAPAETDEPIKVGFGPGIVMTAITLLIFGLGIVPTWLYGVLEQATIRIAAQ
>Mature_539_residues
MNFQIADFTRLIPEFLLLAIAAMVLLGDVLTRWSKGKEALNDRTEEAISMTLMGLGLAFVMVLIQGGFFSWMQFGDWKFY
DFSIFQNLRSSGLDGSILGGAFVVDPLTHIGRLVFIGAAFVTVILTSKAKPSNNPAEFYALILFATLGMIFMTAGGELIM
IYLGIELTSIPLYVLAGYFRRNPVSTEAGAKYYIFGALSSAILLFGMSLLLGLTLMNGQTMTTTPTSLRSVATAVELAFA
NPEGPSQGVAILALLFILAGMAYKVAIVPFHAWSPDVYQGAPTSMTAFISTASKTAGFFLLYRVLVTGFGAPSILGTAAI
GTSTSFGGWTSLIAILAALTMLVGNLAALPQTNAKRMLAYSSIAQAGFLMLGLVGTQRDSGISLLMYLIAYTVTNLSAFG
ILALVEDAVGGTDFSNLNGLGRRAPGLALLLTVAILSLAGIPPLSGFFVKFYVFIAAWQEGAKWLVIFAVSNTVISLYYY
LRFLKAVYFAPAETDEPIKVGFGPGIVMTAITLLIFGLGIVPTWLYGVLEQATIRIAAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=326, Percent_Identity=27.6073619631902, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI145693160, Length=410, Percent_Identity=36.0975609756098, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788614, Length=475, Percent_Identity=26.1052631578947, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788829, Length=245, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788831, Length=320, Percent_Identity=26.25, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788827, Length=295, Percent_Identity=24.0677966101695, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON2_HERA2 (A9B488)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547749.1
- GeneID:   5736827
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4991
- HOGENOM:   HBG747830
- OMA:   YYLRFLK
- ProtClustDB:   CLSK974507
- BioCyc:   HAUR316274:HAUR_4991-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 57587; Mature: 57587

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1aff3eac)-; HASH(0x1b161acc)-; HASH(0x159f2168)-; HASH(0x1b198704)-; HASH(0x1b2290c4)-; HASH(0x1b161b68)-; HASH(0x1a9e1564)-; HASH(0x1aad0708)-; HASH(0x18782214)-; HASH(0x1b161ad8)-; HASH(0x1b161a78)-; HASH(0x1ad98abc)-; HASH(0x1b161ae4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQIADFTRLIPEFLLLAIAAMVLLGDVLTRWSKGKEALNDRTEEAISMTLMGLGLAFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MVLIQGGFFSWMQFGDWKFYDFSIFQNLRSSGLDGSILGGAFVVDPLTHIGRLVFIGAAF
HHHHHCCHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VTVILTSKAKPSNNPAEFYALILFATLGMIFMTAGGELIMIYLGIELTSIPLYVLAGYFR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
RNPVSTEAGAKYYIFGALSSAILLFGMSLLLGLTLMNGQTMTTTPTSLRSVATAVELAFA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHEEC
NPEGPSQGVAILALLFILAGMAYKVAIVPFHAWSPDVYQGAPTSMTAFISTASKTAGFFL
CCCCCCHHHHHHHHHHHHHCHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LYRVLVTGFGAPSILGTAAIGTSTSFGGWTSLIAILAALTMLVGNLAALPQTNAKRMLAY
HHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
SSIAQAGFLMLGLVGTQRDSGISLLMYLIAYTVTNLSAFGILALVEDAVGGTDFSNLNGL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
GRRAPGLALLLTVAILSLAGIPPLSGFFVKFYVFIAAWQEGAKWLVIFAVSNTVISLYYY
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
LRFLKAVYFAPAETDEPIKVGFGPGIVMTAITLLIFGLGIVPTWLYGVLEQATIRIAAQ
HHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECH
>Mature Secondary Structure
MNFQIADFTRLIPEFLLLAIAAMVLLGDVLTRWSKGKEALNDRTEEAISMTLMGLGLAFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MVLIQGGFFSWMQFGDWKFYDFSIFQNLRSSGLDGSILGGAFVVDPLTHIGRLVFIGAAF
HHHHHCCHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VTVILTSKAKPSNNPAEFYALILFATLGMIFMTAGGELIMIYLGIELTSIPLYVLAGYFR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
RNPVSTEAGAKYYIFGALSSAILLFGMSLLLGLTLMNGQTMTTTPTSLRSVATAVELAFA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHEEC
NPEGPSQGVAILALLFILAGMAYKVAIVPFHAWSPDVYQGAPTSMTAFISTASKTAGFFL
CCCCCCHHHHHHHHHHHHHCHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LYRVLVTGFGAPSILGTAAIGTSTSFGGWTSLIAILAALTMLVGNLAALPQTNAKRMLAY
HHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
SSIAQAGFLMLGLVGTQRDSGISLLMYLIAYTVTNLSAFGILALVEDAVGGTDFSNLNGL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
GRRAPGLALLLTVAILSLAGIPPLSGFFVKFYVFIAAWQEGAKWLVIFAVSNTVISLYYY
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
LRFLKAVYFAPAETDEPIKVGFGPGIVMTAITLLIFGLGIVPTWLYGVLEQATIRIAAQ
HHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA