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The map label for this gene is nuoD2

Identifier: 159901494

GI number: 159901494

Start: 6318561

End: 6319673

Strand: Direct

Name: nuoD2

Synonym: Haur_4983

Alternate gene names: 159901494

Gene position: 6318561-6319673 (Clockwise)

Preceding gene: 159901493

Following gene: 159901495

Centisome position: 99.56

GC content: 50.04

Gene sequence:

>1113_bases
ATGCTAAAGACTGAAGAACTGCAAATTAATATTGGTCCTCAGCACCCTTCGACTCACGGTGTGTTTCGGATGTTGGTGAC
TGTCGATGGCGAAACCTTGGTTGACCTTAAACCAGTGTTTGGCTATTTGCATCGTAATCACGAGCAGCTTGGTGAAGTCA
ATACCTATTTGCAAAATATGCCCTTCACCGACCGTCTCGATTACTTTAATTCGATGGTCAACAATCATGCCTATGCCCGG
GCTGTCGAGACGCTTGCCGGCGTTGAAGTGCCTGAACGTGCCCAATACATTCGCGTCATTATGGATGAGCTTTCGCGAAT
TTTGAACCACGCTACCGCAATGGGCTTTATGCTCGGCGACATGGGTGCGTGGCAAACGGCATTGCTCTGGGGTATGCGCG
AACGGGAAAAAATTCTCGACATGTTTGAGTATGTGTCGGGCGCTCGCATGATGTGTAACTACTGCCGCTTTGGCGGGGTG
GTGCGCGATATCGACGATTGGTTCATCACCGAATTGAAGAAGTTGATGCAGGGTTTACCGCACTACTTCGACGATTTTGA
AGGCTTGTTGCTCAACAGTGAAATTCTTTTGGCGCGTGCCCGTAATATTGGCGTGTTGCCCAAAGAGTTGGCGCTGGCCT
ATAGCGTGACTGGTCCAGTCTTGCGTGGTTCAGGCGTTGCCTATGATATTCGCAAAGCCGAACCCTATGCCGTTTACGAT
CGCTTCAAATTTAAAGTACCAGTTGGCACAGTTGGCGATGTGTACGACCGCTTCTTGGTACGGATCGCCGAAATGCGCGA
ATCGTACAAAATTTTGGAGCAAGCGATCGAACAATTGCCCGATGCAACTGGTGGCTTTATCAACCCCAAAGTCAAGCAAC
AAAGCCTCAAAGCTCCTGCTGGCGAAGCCTATGCGCGGGTTGAATCGCCCAAAGGCGAACTTGGTTTCTACCTTGTGAGC
GATGGCTCAGGTAGCGCGTATCGCTATAAAGTGCGTGCTCCATCGTTCATCAACCTTTCATCGCTGGCTGATATGTGCAA
AGGCTACTCGATTGCCGACGTTGTGGTTATCTTGGGTAGTATCGATATCGTGATGGGCGAGGTAGACCGATGA

Upstream 100 bases:

>100_bases
GGCACGGATCTATATGTGGGATGAGTTTAAGGGCTTTCCAATGCGGAAAGACTTCCCCAAGACGGGCGATAAATATACCC
ACGTCACGGGAGAATAGTCA

Downstream 100 bases:

>100_bases
CGTTGAGCCACTTAGCAACTGAAGACGTGTTCGTTGTTGAACGCAATGACGCGGATTTTCGGGCTGGTCAGGGGATGACC
AAGGGCTTGGGAATTGTGTT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 2; NDH-1 subunit D 2

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MLKTEELQINIGPQHPSTHGVFRMLVTVDGETLVDLKPVFGYLHRNHEQLGEVNTYLQNMPFTDRLDYFNSMVNNHAYAR
AVETLAGVEVPERAQYIRVIMDELSRILNHATAMGFMLGDMGAWQTALLWGMREREKILDMFEYVSGARMMCNYCRFGGV
VRDIDDWFITELKKLMQGLPHYFDDFEGLLLNSEILLARARNIGVLPKELALAYSVTGPVLRGSGVAYDIRKAEPYAVYD
RFKFKVPVGTVGDVYDRFLVRIAEMRESYKILEQAIEQLPDATGGFINPKVKQQSLKAPAGEAYARVESPKGELGFYLVS
DGSGSAYRYKVRAPSFINLSSLADMCKGYSIADVVVILGSIDIVMGEVDR

Sequences:

>Translated_370_residues
MLKTEELQINIGPQHPSTHGVFRMLVTVDGETLVDLKPVFGYLHRNHEQLGEVNTYLQNMPFTDRLDYFNSMVNNHAYAR
AVETLAGVEVPERAQYIRVIMDELSRILNHATAMGFMLGDMGAWQTALLWGMREREKILDMFEYVSGARMMCNYCRFGGV
VRDIDDWFITELKKLMQGLPHYFDDFEGLLLNSEILLARARNIGVLPKELALAYSVTGPVLRGSGVAYDIRKAEPYAVYD
RFKFKVPVGTVGDVYDRFLVRIAEMRESYKILEQAIEQLPDATGGFINPKVKQQSLKAPAGEAYARVESPKGELGFYLVS
DGSGSAYRYKVRAPSFINLSSLADMCKGYSIADVVVILGSIDIVMGEVDR
>Mature_370_residues
MLKTEELQINIGPQHPSTHGVFRMLVTVDGETLVDLKPVFGYLHRNHEQLGEVNTYLQNMPFTDRLDYFNSMVNNHAYAR
AVETLAGVEVPERAQYIRVIMDELSRILNHATAMGFMLGDMGAWQTALLWGMREREKILDMFEYVSGARMMCNYCRFGGV
VRDIDDWFITELKKLMQGLPHYFDDFEGLLLNSEILLARARNIGVLPKELALAYSVTGPVLRGSGVAYDIRKAEPYAVYD
RFKFKVPVGTVGDVYDRFLVRIAEMRESYKILEQAIEQLPDATGGFINPKVKQQSLKAPAGEAYARVESPKGELGFYLVS
DGSGSAYRYKVRAPSFINLSSLADMCKGYSIADVVVILGSIDIVMGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=42.6356589147287, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI260898743, Length=381, Percent_Identity=41.7322834645669, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI145693162, Length=384, Percent_Identity=36.4583333333333, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1789076, Length=365, Percent_Identity=29.041095890411, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788832, Length=365, Percent_Identity=29.041095890411, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17568379, Length=387, Percent_Identity=40.3100775193798, Blast_Score=306, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17555284, Length=387, Percent_Identity=39.7932816537468, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24638644, Length=385, Percent_Identity=41.038961038961, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=43.6031331592689, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD2_HERA2 (A9B480)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547741.1
- ProteinModelPortal:   A9B480
- SMR:   A9B480
- GeneID:   5736819
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4983
- HOGENOM:   HBG459705
- OMA:   FGPFLAD
- ProtClustDB:   CLSK935598
- BioCyc:   HAUR316274:HAUR_4983-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 41672; Mature: 41672

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTEELQINIGPQHPSTHGVFRMLVTVDGETLVDLKPVFGYLHRNHEQLGEVNTYLQNM
CCCCCEEEEEECCCCCCCHHHEEEEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHHHHCC
PFTDRLDYFNSMVNNHAYARAVETLAGVEVPERAQYIRVIMDELSRILNHATAMGFMLGD
CCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MGAWQTALLWGMREREKILDMFEYVSGARMMCNYCRFGGVVRDIDDWFITELKKLMQGLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
HYFDDFEGLLLNSEILLARARNIGVLPKELALAYSVTGPVLRGSGVAYDIRKAEPYAVYD
HHHHCCCCEEECCHHHHHHHCCCCCCHHHHHHHHCCCCCCEECCCCEEEECCCCCEEEEE
RFKFKVPVGTVGDVYDRFLVRIAEMRESYKILEQAIEQLPDATGGFINPKVKQQSLKAPA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCC
GEAYARVESPKGELGFYLVSDGSGSAYRYKVRAPSFINLSSLADMCKGYSIADVVVILGS
CHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCEECHHHHHHHHCCCCHHHHHHHHHH
IDIVMGEVDR
HHHEECCCCC
>Mature Secondary Structure
MLKTEELQINIGPQHPSTHGVFRMLVTVDGETLVDLKPVFGYLHRNHEQLGEVNTYLQNM
CCCCCEEEEEECCCCCCCHHHEEEEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHHHHCC
PFTDRLDYFNSMVNNHAYARAVETLAGVEVPERAQYIRVIMDELSRILNHATAMGFMLGD
CCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MGAWQTALLWGMREREKILDMFEYVSGARMMCNYCRFGGVVRDIDDWFITELKKLMQGLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
HYFDDFEGLLLNSEILLARARNIGVLPKELALAYSVTGPVLRGSGVAYDIRKAEPYAVYD
HHHHCCCCEEECCHHHHHHHCCCCCCHHHHHHHHCCCCCCEECCCCEEEECCCCCEEEEE
RFKFKVPVGTVGDVYDRFLVRIAEMRESYKILEQAIEQLPDATGGFINPKVKQQSLKAPA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCC
GEAYARVESPKGELGFYLVSDGSGSAYRYKVRAPSFINLSSLADMCKGYSIADVVVILGS
CHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCEECHHHHHHHHCCCCHHHHHHHHHH
IDIVMGEVDR
HHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA