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The map label for this gene is fruA [H]

Identifier: 159901226

GI number: 159901226

Start: 6022295

End: 6023746

Strand: Direct

Name: fruA [H]

Synonym: Haur_4714

Alternate gene names: 159901226

Gene position: 6022295-6023746 (Clockwise)

Preceding gene: 159901225

Following gene: 159901227

Centisome position: 94.89

GC content: 52.0

Gene sequence:

>1452_bases
ATGGCACGCATTGTTGCGATCACCTCATGTCCAACTGGTATTGCCCACACATTTATGGCCGCCGAAGGGGTTCAACGTGG
CGCAGAAGCCCTTGGTCATCAGATTAAAGTTGAAACCCAAGGTTCAGTTGGTGCGCAAAATGTGCTGACTGAGGCCGATA
TTCGTGAAGCCGATTTGGTGATTATCGCCGCTGATACCAAAGTTGATCTTGGTCGCTTTGTAGGCAAGCGGGTTTATGAA
ACCTCGACCAAAGCAGCGATTACCGATGGTCAGGGAATGGTCAAAACCGCCTTTGATCAAGCCAAAACCTATAACGCTAG
CGGTTCAGCCAACCTTGCTGATACCGTCGATGATCTCAAAGCTCAACGCTCGGCCAGCCGCTCCGGTCCCTACAAACACC
TAATGACTGGGGTTTCGTATATGCTGCCGTTTGTGGTTGCAGGCGGCTTGCTGATTGCCTTGGCTTTTGCGATTGGCGGC
ATTTATGTATATGAAGATCAATATGCCAACACGCTTGGTTGGTCGTTATTCCAAATTGGGGCTAAATCGGGCTTTGCGCT
GATGGTGCCAATTTTGGCGGGCTTTATTGCCTTCTCAATCGCTGATCGACCTGGCTTAGTGCCTGGAATGATTGGCGGGA
TGTTGGCCAGCAGCAATGGCTCCGGCTTCTTGGGTGGCATCATTGCTGGTTTTATTGCGGGCTACGCTACCGATTGGCTG
AACACCAACATTCGTTTGCCAAAAACCTTGGCTGGCCTCAAACCTGTGTTAATTCTACCGTTGCTCAGTACTGCAATCGT
CGGTTTGTTGATGATTTATGTGATTGGCAAGCCCGTTAGTGCGGTTAACACCAGTTTGAATGAGTGGCTGACCGGGTTGC
AAGGAACCAACGCGATTTTGCTGGGCTTGTTGCTTGGGGCAATGATGGCCTTCGATATGGGTGGGCCAGTCAACAAGGCC
GCCTATACCTTTGCGGTTGGATTATTGGCTAGCAATGTGTATGCTCCAATGGCTGCCGTAATGGCTGCTGGCATGACTCC
GCCGCTTGGTTTGGCCTTGGCCTCGTTACTCTTCAAAAATCGCTTTACCGCCGAAGAACAAGAAGCCGGCAAGGCAGCGG
CAGTGCTTGGCATTTCGTTTATCACCGAAGGCGCAATTCCCTTCGCAGCACGCGATCCATTCCGCGTGATTCCAGCGATT
ATGCTTGGCTCAGCCGTTACGGGAGCACTCTCGATGAGCTTTGGGGCAACCCTGCAAGTGCCACACGGCGGAGTGTTCGT
GTTGCCAATTCCCAATGCAGTTGGTAGTTTGGGCTTGTACATTGTGGCAATTTTGGTGGGCACAGTGGTGACGGCTGCCG
CCTTGTATGCGCTCAAACGCCCGTTGCTGCAAACTCCCGTTACTACTAGCGAAACCAATGCTAGTGCAACTTCAGCGGTC
AGCGTGCGCTAA

Upstream 100 bases:

>100_bases
GGCTAGCGGAACATACGTGGGTTTGGCAACAGGCGCTTGACATTGAAGGGATACCGATCCCCAGCCCCTGCCCCCGAACC
CTCGTTATAAGGAGCATCCC

Downstream 100 bases:

>100_bases
AACATCAACCGATCGAGCTAAAAACAAAAACCGTGATGAGCAATACTCATCACGGTTTTTTTGGCGACTCCGGCGCGACT
CGAACGCGCGACCTTTTGCT

Product: PTS system, fructose subfamily, IIC subunit

Products: NA

Alternate protein names: EIIBBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MARIVAITSCPTGIAHTFMAAEGVQRGAEALGHQIKVETQGSVGAQNVLTEADIREADLVIIAADTKVDLGRFVGKRVYE
TSTKAAITDGQGMVKTAFDQAKTYNASGSANLADTVDDLKAQRSASRSGPYKHLMTGVSYMLPFVVAGGLLIALAFAIGG
IYVYEDQYANTLGWSLFQIGAKSGFALMVPILAGFIAFSIADRPGLVPGMIGGMLASSNGSGFLGGIIAGFIAGYATDWL
NTNIRLPKTLAGLKPVLILPLLSTAIVGLLMIYVIGKPVSAVNTSLNEWLTGLQGTNAILLGLLLGAMMAFDMGGPVNKA
AYTFAVGLLASNVYAPMAAVMAAGMTPPLGLALASLLFKNRFTAEEQEAGKAAAVLGISFITEGAIPFAARDPFRVIPAI
MLGSAVTGALSMSFGATLQVPHGGVFVLPIPNAVGSLGLYIVAILVGTVVTAAALYALKRPLLQTPVTTSETNASATSAV
SVR

Sequences:

>Translated_483_residues
MARIVAITSCPTGIAHTFMAAEGVQRGAEALGHQIKVETQGSVGAQNVLTEADIREADLVIIAADTKVDLGRFVGKRVYE
TSTKAAITDGQGMVKTAFDQAKTYNASGSANLADTVDDLKAQRSASRSGPYKHLMTGVSYMLPFVVAGGLLIALAFAIGG
IYVYEDQYANTLGWSLFQIGAKSGFALMVPILAGFIAFSIADRPGLVPGMIGGMLASSNGSGFLGGIIAGFIAGYATDWL
NTNIRLPKTLAGLKPVLILPLLSTAIVGLLMIYVIGKPVSAVNTSLNEWLTGLQGTNAILLGLLLGAMMAFDMGGPVNKA
AYTFAVGLLASNVYAPMAAVMAAGMTPPLGLALASLLFKNRFTAEEQEAGKAAAVLGISFITEGAIPFAARDPFRVIPAI
MLGSAVTGALSMSFGATLQVPHGGVFVLPIPNAVGSLGLYIVAILVGTVVTAAALYALKRPLLQTPVTTSETNASATSAV
SVR
>Mature_482_residues
ARIVAITSCPTGIAHTFMAAEGVQRGAEALGHQIKVETQGSVGAQNVLTEADIREADLVIIAADTKVDLGRFVGKRVYET
STKAAITDGQGMVKTAFDQAKTYNASGSANLADTVDDLKAQRSASRSGPYKHLMTGVSYMLPFVVAGGLLIALAFAIGGI
YVYEDQYANTLGWSLFQIGAKSGFALMVPILAGFIAFSIADRPGLVPGMIGGMLASSNGSGFLGGIIAGFIAGYATDWLN
TNIRLPKTLAGLKPVLILPLLSTAIVGLLMIYVIGKPVSAVNTSLNEWLTGLQGTNAILLGLLLGAMMAFDMGGPVNKAA
YTFAVGLLASNVYAPMAAVMAAGMTPPLGLALASLLFKNRFTAEEQEAGKAAAVLGISFITEGAIPFAARDPFRVIPAIM
LGSAVTGALSMSFGATLQVPHGGVFVLPIPNAVGSLGLYIVAILVGTVVTAAALYALKRPLLQTPVTTSETNASATSAVS
VR

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=459, Percent_Identity=55.119825708061, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786951, Length=465, Percent_Identity=35.9139784946237, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI87082348, Length=470, Percent_Identity=35.3191489361702, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1790386, Length=321, Percent_Identity=44.2367601246106, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788729, Length=394, Percent_Identity=29.1878172588832, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790387, Length=79, Percent_Identity=48.1012658227848, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788730, Length=94, Percent_Identity=42.5531914893617, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790390, Length=92, Percent_Identity=35.8695652173913, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49721; Mature: 49590

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVAITSCPTGIAHTFMAAEGVQRGAEALGHQIKVETQGSVGAQNVLTEADIREADLV
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCEE
IIAADTKVDLGRFVGKRVYETSTKAAITDGQGMVKTAFDQAKTYNASGSANLADTVDDLK
EEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AQRSASRSGPYKHLMTGVSYMLPFVVAGGLLIALAFAIGGIYVYEDQYANTLGWSLFQIG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHH
AKSGFALMVPILAGFIAFSIADRPGLVPGMIGGMLASSNGSGFLGGIIAGFIAGYATDWL
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
NTNIRLPKTLAGLKPVLILPLLSTAIVGLLMIYVIGKPVSAVNTSLNEWLTGLQGTNAIL
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHH
LGLLLGAMMAFDMGGPVNKAAYTFAVGLLASNVYAPMAAVMAAGMTPPLGLALASLLFKN
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RFTAEEQEAGKAAAVLGISFITEGAIPFAARDPFRVIPAIMLGSAVTGALSMSFGATLQV
CCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
PHGGVFVLPIPNAVGSLGLYIVAILVGTVVTAAALYALKRPLLQTPVTTSETNASATSAV
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
SVR
ECC
>Mature Secondary Structure 
ARIVAITSCPTGIAHTFMAAEGVQRGAEALGHQIKVETQGSVGAQNVLTEADIREADLV
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCEE
IIAADTKVDLGRFVGKRVYETSTKAAITDGQGMVKTAFDQAKTYNASGSANLADTVDDLK
EEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AQRSASRSGPYKHLMTGVSYMLPFVVAGGLLIALAFAIGGIYVYEDQYANTLGWSLFQIG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHH
AKSGFALMVPILAGFIAFSIADRPGLVPGMIGGMLASSNGSGFLGGIIAGFIAGYATDWL
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
NTNIRLPKTLAGLKPVLILPLLSTAIVGLLMIYVIGKPVSAVNTSLNEWLTGLQGTNAIL
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHH
LGLLLGAMMAFDMGGPVNKAAYTFAVGLLASNVYAPMAAVMAAGMTPPLGLALASLLFKN
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RFTAEEQEAGKAAAVLGISFITEGAIPFAARDPFRVIPAIMLGSAVTGALSMSFGATLQV
CCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
PHGGVFVLPIPNAVGSLGLYIVAILVGTVVTAAALYALKRPLLQTPVTTSETNASATSAV
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
SVR
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2254279 [H]