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The map label for this gene is rnhA [H]

Identifier: 159901221

GI number: 159901221

Start: 6015703

End: 6016413

Strand: Reverse

Name: rnhA [H]

Synonym: Haur_4709

Alternate gene names: 159901221

Gene position: 6016413-6015703 (Counterclockwise)

Preceding gene: 159901222

Following gene: 159901218

Centisome position: 94.8

GC content: 54.43

Gene sequence:

>711_bases
ATGGCAAAACGAAAATTTTATGCGGTGGTCAAGGGTCGCCAACCTGGAATCTACAACGAATGGTTTGGCAACGATGGTGC
TGAAGCCCAAGTCAAGGGCATCGATCAGGCGGTTTTTAAGGGGTTTGCTAGCTTTGCTGATGCCGAGGCATGGTATCGCG
AACGGGCGGGCCGTGCGCCTCAACGCATTCCCCAAAACGTTGATCTCACTCCAGTCAGCTTAGCAATTGATCCGCAAAAA
GCTTTGGACGAAGGCAAAGTGGTGTTGTTCAGCGATGGCGGCAGCGATGGCAATCCTGGACCAGGCGGTTATGGCGTGGT
ATTGCGTTCTGGCTCGGAGATGCGCGAATTAACGGGCGGCTTTGCTCGCACCACCAACAACCGCATGGAGTTGATGGGCG
TGATTACCGGCCTGCAAGCCTTGAGCCAGCCGAGCAAGGTAGTGGTTTATAGCGATTCGGCCTATGTGATCAATGGCATG
CACAAAGGTTGGGCCGAGCGTTGGAGCAAGAATGGCTGGCGCACAACAACTGGCCCAGTCAAAAATCCGGATCTTTGGCA
ACAATTGTTGGAGCTAGCTCAAGGCCACACAATTGAATGGGTGCAAGTGCCTGGCCACGCTGGAGTCAAGGATAACGAGC
GTTGCGATCGCTTGGCGGTGCAGGCAGCCCATCAGCCCAATTTGCCGATCGATCAAGGCTATCGCGATTAG

Upstream 100 bases:

>100_bases
ATAGTGTCAGCGGCGCGTTGAAGTTGCTGATTAAGTAAGTATTTGTACCCCAACTCAGGCTTGTTTGAGTTGGGGTGTTT
TAGGTTAAATAGAAAGTTGT

Downstream 100 bases:

>100_bases
TTAAAGTGGTTGGTAGGGAATTTCGATTTCGAGGATGAGACCGCCGCCAGCCCGATTGTGCACGCGGAAACGCCCGCCAA
CCAGCGCCACCCGTTCGCTC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MAKRKFYAVVKGRQPGIYNEWFGNDGAEAQVKGIDQAVFKGFASFADAEAWYRERAGRAPQRIPQNVDLTPVSLAIDPQK
ALDEGKVVLFSDGGSDGNPGPGGYGVVLRSGSEMRELTGGFARTTNNRMELMGVITGLQALSQPSKVVVYSDSAYVINGM
HKGWAERWSKNGWRTTTGPVKNPDLWQQLLELAQGHTIEWVQVPGHAGVKDNERCDRLAVQAAHQPNLPIDQGYRD

Sequences:

>Translated_236_residues
MAKRKFYAVVKGRQPGIYNEWFGNDGAEAQVKGIDQAVFKGFASFADAEAWYRERAGRAPQRIPQNVDLTPVSLAIDPQK
ALDEGKVVLFSDGGSDGNPGPGGYGVVLRSGSEMRELTGGFARTTNNRMELMGVITGLQALSQPSKVVVYSDSAYVINGM
HKGWAERWSKNGWRTTTGPVKNPDLWQQLLELAQGHTIEWVQVPGHAGVKDNERCDRLAVQAAHQPNLPIDQGYRD
>Mature_235_residues
AKRKFYAVVKGRQPGIYNEWFGNDGAEAQVKGIDQAVFKGFASFADAEAWYRERAGRAPQRIPQNVDLTPVSLAIDPQKA
LDEGKVVLFSDGGSDGNPGPGGYGVVLRSGSEMRELTGGFARTTNNRMELMGVITGLQALSQPSKVVVYSDSAYVINGMH
KGWAERWSKNGWRTTTGPVKNPDLWQQLLELAQGHTIEWVQVPGHAGVKDNERCDRLAVQAAHQPNLPIDQGYRD

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=260, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1786408, Length=151, Percent_Identity=48.3443708609272, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI115532542, Length=249, Percent_Identity=28.9156626506024, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552509, Length=148, Percent_Identity=30.4054054054054, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17137476, Length=148, Percent_Identity=30.4054054054054, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 25897; Mature: 25766

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRKFYAVVKGRQPGIYNEWFGNDGAEAQVKGIDQAVFKGFASFADAEAWYRERAGRAP
CCCCEEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QRIPQNVDLTPVSLAIDPQKALDEGKVVLFSDGGSDGNPGPGGYGVVLRSGSEMRELTGG
HHCCCCCCCCEEEEEECHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHCC
FARTTNNRMELMGVITGLQALSQPSKVVVYSDSAYVINGMHKGWAERWSKNGWRTTTGPV
HHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCC
KNPDLWQQLLELAQGHTIEWVQVPGHAGVKDNERCDRLAVQAAHQPNLPIDQGYRD
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKRKFYAVVKGRQPGIYNEWFGNDGAEAQVKGIDQAVFKGFASFADAEAWYRERAGRAP
CCCEEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QRIPQNVDLTPVSLAIDPQKALDEGKVVLFSDGGSDGNPGPGGYGVVLRSGSEMRELTGG
HHCCCCCCCCEEEEEECHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHCC
FARTTNNRMELMGVITGLQALSQPSKVVVYSDSAYVINGMHKGWAERWSKNGWRTTTGPV
HHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCC
KNPDLWQQLLELAQGHTIEWVQVPGHAGVKDNERCDRLAVQAAHQPNLPIDQGYRD
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA