Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 159901111

GI number: 159901111

Start: 5881084

End: 5881755

Strand: Reverse

Name: mdmC [H]

Synonym: Haur_4599

Alternate gene names: 159901111

Gene position: 5881755-5881084 (Counterclockwise)

Preceding gene: 159901112

Following gene: 159901110

Centisome position: 92.68

GC content: 51.19

Gene sequence:

>672_bases
ATGAATCAAACAACGTGGGATGCGGTTGATCAGTATATTTCCGATCGATTAGTCCAGGCTGATCCGGTGTTGGATGCAGC
GTTGCAGGCCAGTGCCGAAGCAGGTTTACCACCAATTAATGTTGCGCCCAATCAAGGCAAATTGCTGCATCTATTTGCGC
TGATGTGTGGGGCTAAGCGCATTTTGGAGATTGGCACGCTGGGAGGGTATAGCTCAATTTGGTTGGCTCGCGCCTTGCCT
GCCGATGGCAAATTAATTACTTTGGAATATGAGCCGCATCACGCCGAGGTTGCCACAGCCAATATCGCCAAGGCAGGCTT
GAGCCAAAAGGTTGAAGTTCGGGTTGGCGCAGCGCTCGATAGTCTAGCTCAGTTGGCTGAAGCAAAGATTGAGCCATTCG
ATCTGATTTTCATTGATGCCGACAAGCCCAATAACCCGCACTATTTGGCGTGGGCACTCAAATTTGCCCATGTTGGCACG
GTGATTATTGGCGATAATGTGGTGCGTAACGGCGCAGTCACCGATCCGAGCAATCCTGACCCAGCAATTCAAGGAACCCG
CCAGTTGTTTGATGATTTAGCTTCGAACCCCAAGCTGACCGCCACAGCCCTGCAAACTGTTGGCAGCAAAGGCTACGATG
GCTTTGCAATTGCGATTGTCCAGCAGCTCTAA

Upstream 100 bases:

>100_bases
ACGAAGAAGTTACCGTGGCGTTTCCAGGCAAAGGCGTGAAAAAGCTCTTGGCCGCCTTCGCCAAGCTCGAACGGGTTTAG
CTGTGGTTTAGGAGGATGCG

Downstream 100 bases:

>100_bases
ACATCAATGAATCCAGCCATAATTCAAGCCAGTTGATTAATCTCAACTGGCTTACTTGTTTAAGTGCATTTCGATGACAT
AATCAATCTCGATTCCATCG

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNQTTWDAVDQYISDRLVQADPVLDAALQASAEAGLPPINVAPNQGKLLHLFALMCGAKRILEIGTLGGYSSIWLARALP
ADGKLITLEYEPHHAEVATANIAKAGLSQKVEVRVGAALDSLAQLAEAKIEPFDLIFIDADKPNNPHYLAWALKFAHVGT
VIIGDNVVRNGAVTDPSNPDPAIQGTRQLFDDLASNPKLTATALQTVGSKGYDGFAIAIVQQL

Sequences:

>Translated_223_residues
MNQTTWDAVDQYISDRLVQADPVLDAALQASAEAGLPPINVAPNQGKLLHLFALMCGAKRILEIGTLGGYSSIWLARALP
ADGKLITLEYEPHHAEVATANIAKAGLSQKVEVRVGAALDSLAQLAEAKIEPFDLIFIDADKPNNPHYLAWALKFAHVGT
VIIGDNVVRNGAVTDPSNPDPAIQGTRQLFDDLASNPKLTATALQTVGSKGYDGFAIAIVQQL
>Mature_223_residues
MNQTTWDAVDQYISDRLVQADPVLDAALQASAEAGLPPINVAPNQGKLLHLFALMCGAKRILEIGTLGGYSSIWLARALP
ADGKLITLEYEPHHAEVATANIAKAGLSQKVEVRVGAALDSLAQLAEAKIEPFDLIFIDADKPNNPHYLAWALKFAHVGT
VIIGDNVVRNGAVTDPSNPDPAIQGTRQLFDDLASNPKLTATALQTVGSKGYDGFAIAIVQQL

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=195, Percent_Identity=28.7179487179487, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI72001127, Length=172, Percent_Identity=31.9767441860465, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565612, Length=174, Percent_Identity=31.0344827586207, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25148771, Length=208, Percent_Identity=29.3269230769231, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23713; Mature: 23713

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTTWDAVDQYISDRLVQADPVLDAALQASAEAGLPPINVAPNQGKLLHLFALMCGAKR
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILEIGTLGGYSSIWLARALPADGKLITLEYEPHHAEVATANIAKAGLSQKVEVRVGAALD
HHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEHHHHH
SLAQLAEAKIEPFDLIFIDADKPNNPHYLAWALKFAHVGTVIIGDNVVRNGAVTDPSNPD
HHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEHHHHCEEEECCCEECCCCCCCCCCCC
PAIQGTRQLFDDLASNPKLTATALQTVGSKGYDGFAIAIVQQL
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECC
>Mature Secondary Structure
MNQTTWDAVDQYISDRLVQADPVLDAALQASAEAGLPPINVAPNQGKLLHLFALMCGAKR
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILEIGTLGGYSSIWLARALPADGKLITLEYEPHHAEVATANIAKAGLSQKVEVRVGAALD
HHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEHHHHH
SLAQLAEAKIEPFDLIFIDADKPNNPHYLAWALKFAHVGTVIIGDNVVRNGAVTDPSNPD
HHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEHHHHCEEEECCCEECCCCCCCCCCCC
PAIQGTRQLFDDLASNPKLTATALQTVGSKGYDGFAIAIVQQL
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]