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The map label for this gene is ung2 [H]

Identifier: 159901060

GI number: 159901060

Start: 5821111

End: 5821788

Strand: Reverse

Name: ung2 [H]

Synonym: Haur_4548

Alternate gene names: 159901060

Gene position: 5821788-5821111 (Counterclockwise)

Preceding gene: 159901062

Following gene: 159901058

Centisome position: 91.73

GC content: 49.12

Gene sequence:

>678_bases
ATGGCATTAACGATTCCTGCTTTGTGGCAACCAGTGCTCGCCGACGAAACCAGCAAGCCCTATTGGAACGATCTCGAAGC
ATTTGTCGCCGCCGAACGGGCTGAACAACAGGTGTTCCCGCCAGAAGATCAAGTTTTTTCAGCTTTAGAATTAACCTCGC
CTGAGCAAACCAAAGTGCTGTTGTTGGGGCAAGATCCTTACCATGGCCCAGGCCAAGCGCATGGCTTATGTTTCTCGGTG
CTGCCTGGGATCAAAGCGCCGCCATCGCTCAAAAATATGTTCAAGGAACTCAAAACTGATCTTGGTTGTGTTGTGCCTAA
TAATGGCTACCTGCTACCGTGGGCCAAACAAGGTATGTTAATGATCAATGCGGTGATGACGGTACGGGCGCATACCGCCA
ATTCACATAAAAATCGCGGCTGGGAGAAATTCACCGATGCCGTGATTCGCCAGGTCAATGCCAAACCAGAGCATGTAGTG
TTTGTATTGTGGGGAGCATATGCCCAAAAGAAGGCTAGCTTAATCGACAACAGCCGCCATACGATTATTCAATCGGCGCA
TCCCTCGCCACTTTCGGCCGATAATGGTTTTTTTGGCAGCCGCCCATTCTCTAAAATCAACGCAGCCCTTGAGGCTCATG
GTCAAAGCCAAATCGATTGGCAAATTCCAAATTTATAA

Upstream 100 bases:

>100_bases
ACAACCATTGACACAGGCTTGGGTGATTCTTAAGCTGTATGATATGGGCAACTTGTGCAGATGCAAGAGCCAACTTTGTG
TGAATATGAGGACAACAACG

Downstream 100 bases:

>100_bases
GGTAGGTTTTGAACAATGACTGGGGAGGATTTGTAGCCGATTTTCATGCCCTCACCCCTAGCCCCTCTCCCGCCCAGCAG
GCGAGGGAAACCATCTCATC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG 2 [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MALTIPALWQPVLADETSKPYWNDLEAFVAAERAEQQVFPPEDQVFSALELTSPEQTKVLLLGQDPYHGPGQAHGLCFSV
LPGIKAPPSLKNMFKELKTDLGCVVPNNGYLLPWAKQGMLMINAVMTVRAHTANSHKNRGWEKFTDAVIRQVNAKPEHVV
FVLWGAYAQKKASLIDNSRHTIIQSAHPSPLSADNGFFGSRPFSKINAALEAHGQSQIDWQIPNL

Sequences:

>Translated_225_residues
MALTIPALWQPVLADETSKPYWNDLEAFVAAERAEQQVFPPEDQVFSALELTSPEQTKVLLLGQDPYHGPGQAHGLCFSV
LPGIKAPPSLKNMFKELKTDLGCVVPNNGYLLPWAKQGMLMINAVMTVRAHTANSHKNRGWEKFTDAVIRQVNAKPEHVV
FVLWGAYAQKKASLIDNSRHTIIQSAHPSPLSADNGFFGSRPFSKINAALEAHGQSQIDWQIPNL
>Mature_224_residues
ALTIPALWQPVLADETSKPYWNDLEAFVAAERAEQQVFPPEDQVFSALELTSPEQTKVLLLGQDPYHGPGQAHGLCFSVL
PGIKAPPSLKNMFKELKTDLGCVVPNNGYLLPWAKQGMLMINAVMTVRAHTANSHKNRGWEKFTDAVIRQVNAKPEHVVF
VLWGAYAQKKASLIDNSRHTIIQSAHPSPLSADNGFFGSRPFSKINAALEAHGQSQIDWQIPNL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=55.1401869158878, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=55.1401869158878, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=52.3364485981308, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17556304, Length=215, Percent_Identity=47.906976744186, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=44.9152542372881, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24875; Mature: 24743

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTIPALWQPVLADETSKPYWNDLEAFVAAERAEQQVFPPEDQVFSALELTSPEQTKVL
CEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEE
LLGQDPYHGPGQAHGLCFSVLPGIKAPPSLKNMFKELKTDLGCVVPNNGYLLPWAKQGML
EEECCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCEEECCCCEECCCCCCCEE
MINAVMTVRAHTANSHKNRGWEKFTDAVIRQVNAKPEHVVFVLWGAYAQKKASLIDNSRH
EEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCC
TIIQSAHPSPLSADNGFFGSRPFSKINAALEAHGQSQIDWQIPNL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCC
>Mature Secondary Structure 
ALTIPALWQPVLADETSKPYWNDLEAFVAAERAEQQVFPPEDQVFSALELTSPEQTKVL
EEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEE
LLGQDPYHGPGQAHGLCFSVLPGIKAPPSLKNMFKELKTDLGCVVPNNGYLLPWAKQGML
EEECCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCEEECCCCEECCCCCCCEE
MINAVMTVRAHTANSHKNRGWEKFTDAVIRQVNAKPEHVVFVLWGAYAQKKASLIDNSRH
EEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCC
TIIQSAHPSPLSADNGFFGSRPFSKINAALEAHGQSQIDWQIPNL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]