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The map label for this gene is adk [H]

Identifier: 159900921

GI number: 159900921

Start: 5630265

End: 5630936

Strand: Reverse

Name: adk [H]

Synonym: Haur_4408

Alternate gene names: 159900921

Gene position: 5630936-5630265 (Counterclockwise)

Preceding gene: 159900922

Following gene: 159900920

Centisome position: 88.72

GC content: 48.96

Gene sequence:

>672_bases
ATGAAACCGCTTAACCTCATTCTTTTTGGCCCCCCAGGTGCGGGGAAATCGACCCAAGCTGCCTATTTGGATAAATTGGC
AGCGATTGATTCAATCTCCACCGGCCAACGCCTACGCCAAACTGTCGAAACTGGCTCTGAATTGGGTCAAGAGGTCGCTC
AGGTCATGGCTGAAGGTCGTTTGGTTGACGATACATTAATGAACAAATTACTGAACGAATGGTTGCTAGGCATTCCTAGC
GAGGTTGGGGTGCTGCTCGATGGTTATCCACGCACGCTGAGCCAAGCCCAAAGCCTTGATCAATTGATGCAGACCATTAG
CCGTCCGCTTGATGTGGTGATTGCCCTAACCCTCTCTGATGAAGAGGCCATTCGGCGCTTAAGTGGCCGCCGCATCTGCC
GAATCAAAGGCCAGCCCGACCAAATTTTGCATATTAATGATCAAGCAGCTTTAGATGCTTGTCGAGCTAATGGCGGCATG
TTAATCGAGCGTGATGACGATAAGCCGGAGACGATCAAACGCCGTTTAGCTGAATACAATGCCAAAACTGAGCCACTGCT
ACAATTCTATGGCGAACGCGATTTGCTGATTTTGATCGATGCTGATGGTACACCTGATCAAGTTTCTAAGGCGATTGAAC
AAGCTTTGCAACAACGTTTTAATGGCGCTTAG

Upstream 100 bases:

>100_bases
TCGCGAATATTCGCGGTTGTTTTGTTTTAAACCTGCTACCTCAGCCATAAACGGCTGTGATAAGATTATGGCTAGTGTTG
TTTAATATCGAGGTATAAGG

Downstream 100 bases:

>100_bases
GAGCAGCAAAAGATTAATATAACGCTTATTAGCTTTTGCCAAAAACGTGCTACACTACATGCAGGTGCAGCAATGCACAA
GCTATCAAGGAGGACTTTCA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKPLNLILFGPPGAGKSTQAAYLDKLAAIDSISTGQRLRQTVETGSELGQEVAQVMAEGRLVDDTLMNKLLNEWLLGIPS
EVGVLLDGYPRTLSQAQSLDQLMQTISRPLDVVIALTLSDEEAIRRLSGRRICRIKGQPDQILHINDQAALDACRANGGM
LIERDDDKPETIKRRLAEYNAKTEPLLQFYGERDLLILIDADGTPDQVSKAIEQALQQRFNGA

Sequences:

>Translated_223_residues
MKPLNLILFGPPGAGKSTQAAYLDKLAAIDSISTGQRLRQTVETGSELGQEVAQVMAEGRLVDDTLMNKLLNEWLLGIPS
EVGVLLDGYPRTLSQAQSLDQLMQTISRPLDVVIALTLSDEEAIRRLSGRRICRIKGQPDQILHINDQAALDACRANGGM
LIERDDDKPETIKRRLAEYNAKTEPLLQFYGERDLLILIDADGTPDQVSKAIEQALQQRFNGA
>Mature_223_residues
MKPLNLILFGPPGAGKSTQAAYLDKLAAIDSISTGQRLRQTVETGSELGQEVAQVMAEGRLVDDTLMNKLLNEWLLGIPS
EVGVLLDGYPRTLSQAQSLDQLMQTISRPLDVVIALTLSDEEAIRRLSGRRICRIKGQPDQILHINDQAALDACRANGGM
LIERDDDKPETIKRRLAEYNAKTEPLLQFYGERDLLILIDADGTPDQVSKAIEQALQQRFNGA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=219, Percent_Identity=36.986301369863, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI4502013, Length=219, Percent_Identity=36.986301369863, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=32, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=29.7029702970297, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=29.7029702970297, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=29.7029702970297, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=29.7029702970297, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI28144897, Length=220, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI28144899, Length=220, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=23.3183856502242, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786680, Length=189, Percent_Identity=36.5079365079365, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17552384, Length=222, Percent_Identity=31.981981981982, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=205, Percent_Identity=26.3414634146341, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=25.3456221198157, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=207, Percent_Identity=35.2657004830918, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=193, Percent_Identity=32.6424870466321, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=223, Percent_Identity=35.8744394618834, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17737899, Length=224, Percent_Identity=30.3571428571429, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24645822, Length=224, Percent_Identity=30.3571428571429, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24663208, Length=220, Percent_Identity=29.0909090909091, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=28.110599078341, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24563; Mature: 24563

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLNLILFGPPGAGKSTQAAYLDKLAAIDSISTGQRLRQTVETGSELGQEVAQVMAEGR
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LVDDTLMNKLLNEWLLGIPSEVGVLLDGYPRTLSQAQSLDQLMQTISRPLDVVIALTLSD
CHHHHHHHHHHHHHHHCCCCHHCCEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
EEAIRRLSGRRICRIKGQPDQILHINDQAALDACRANGGMLIERDDDKPETIKRRLAEYN
HHHHHHHCCCEEEEECCCCCCEEEECCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCC
AKTEPLLQFYGERDLLILIDADGTPDQVSKAIEQALQQRFNGA
CCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPLNLILFGPPGAGKSTQAAYLDKLAAIDSISTGQRLRQTVETGSELGQEVAQVMAEGR
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LVDDTLMNKLLNEWLLGIPSEVGVLLDGYPRTLSQAQSLDQLMQTISRPLDVVIALTLSD
CHHHHHHHHHHHHHHHCCCCHHCCEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
EEAIRRLSGRRICRIKGQPDQILHINDQAALDACRANGGMLIERDDDKPETIKRRLAEYN
HHHHHHHCCCEEEEECCCCCCEEEECCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCC
AKTEPLLQFYGERDLLILIDADGTPDQVSKAIEQALQQRFNGA
CCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA