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The map label for this gene is trxA [H]

Identifier: 159900920

GI number: 159900920

Start: 5629823

End: 5630164

Strand: Reverse

Name: trxA [H]

Synonym: Haur_4407

Alternate gene names: 159900920

Gene position: 5630164-5629823 (Counterclockwise)

Preceding gene: 159900921

Following gene: 159900919

Centisome position: 88.71

GC content: 47.95

Gene sequence:

>342_bases
ATGGCCAAGCCATTAGCAGTTAGCGATGCCGAATTCGAATCAGCAGTGATTAATTCCGATATTCCCGTTTTGGTTGATTT
TTGGGCACCATGGTGTGGGCCTTGCCGCTCAATCGCCCCTGTGCTCGAAGAGTTGGCTGACGAATACCAAGGCAAATTGT
TGATTGCCAAGGTTAACACCGATGAAGATAGTGGCAACGCTATGAAGTTTGGGGTCCAAGGTATCCCAACCTTGATCTTC
TTCCAAGGCGGTCAAGAAGTTGATCGGATTGTCGGCGCTGGCCCTAAGAAGATCTATCAAGAACGAATCGAAGCGATTCT
TAACCCAGTTACCGAAGCATAA

Upstream 100 bases:

>100_bases
GAGCAGCAAAAGATTAATATAACGCTTATTAGCTTTTGCCAAAAACGTGCTACACTACATGCAGGTGCAGCAATGCACAA
GCTATCAAGGAGGACTTTCA

Downstream 100 bases:

>100_bases
TCGACTTTAATCGTAAGTAACCACAGCACCGATCGTTATGATTGGTGCTGTTTTTTATTGCCCAACATTCCTTAGCATGC
TAAACTGCTTGAAGCAGGTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MAKPLAVSDAEFESAVINSDIPVLVDFWAPWCGPCRSIAPVLEELADEYQGKLLIAKVNTDEDSGNAMKFGVQGIPTLIF
FQGGQEVDRIVGAGPKKIYQERIEAILNPVTEA

Sequences:

>Translated_113_residues
MAKPLAVSDAEFESAVINSDIPVLVDFWAPWCGPCRSIAPVLEELADEYQGKLLIAKVNTDEDSGNAMKFGVQGIPTLIF
FQGGQEVDRIVGAGPKKIYQERIEAILNPVTEA
>Mature_112_residues
AKPLAVSDAEFESAVINSDIPVLVDFWAPWCGPCRSIAPVLEELADEYQGKLLIAKVNTDEDSGNAMKFGVQGIPTLIFF
QGGQEVDRIVGAGPKKIYQERIEAILNPVTEA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=82, Percent_Identity=40.2439024390244, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=38.0952380952381, Blast_Score=65, Evalue=9e-12,
Organism=Homo sapiens, GI4758304, Length=98, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=48.5714285714286, Blast_Score=113, Evalue=2e-27,
Organism=Escherichia coli, GI1788936, Length=81, Percent_Identity=48.1481481481481, Blast_Score=97, Evalue=4e-22,
Organism=Escherichia coli, GI87081747, Length=89, Percent_Identity=39.3258426966292, Blast_Score=70, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=38.1443298969072, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=47.887323943662, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=88, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=84, Percent_Identity=34.5238095238095, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=84, Percent_Identity=34.5238095238095, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=35, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=38.2716049382716, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=97, Percent_Identity=37.1134020618557, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=87, Percent_Identity=36.7816091954023, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=76, Percent_Identity=39.4736842105263, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=90, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=91, Percent_Identity=32.967032967033, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=91, Percent_Identity=32.967032967033, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=93, Percent_Identity=47.3118279569892, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323072, Length=92, Percent_Identity=44.5652173913043, Blast_Score=79, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=42.3529411764706, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24639826, Length=98, Percent_Identity=35.7142857142857, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=36.8421052631579, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=36.8421052631579, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=42.3529411764706, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=36.8421052631579, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658597, Length=86, Percent_Identity=37.2093023255814, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=34.1463414634146, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=34.4086021505376, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12263; Mature: 12132

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPLAVSDAEFESAVINSDIPVLVDFWAPWCGPCRSIAPVLEELADEYQGKLLIAKVNT
CCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DEDSGNAMKFGVQGIPTLIFFQGGQEVDRIVGAGPKKIYQERIEAILNPVTEA
CCCCCCEEEECCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKPLAVSDAEFESAVINSDIPVLVDFWAPWCGPCRSIAPVLEELADEYQGKLLIAKVNT
CCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DEDSGNAMKFGVQGIPTLIFFQGGQEVDRIVGAGPKKIYQERIEAILNPVTEA
CCCCCCEEEECCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA