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The map label for this gene is paaJ [H]

Identifier: 159900901

GI number: 159900901

Start: 5604638

End: 5605792

Strand: Reverse

Name: paaJ [H]

Synonym: Haur_4388

Alternate gene names: 159900901

Gene position: 5605792-5604638 (Counterclockwise)

Preceding gene: 159900904

Following gene: 159900900

Centisome position: 88.33

GC content: 53.42

Gene sequence:

>1155_bases
ATGGCTGAAGCAGTGTTAATTGATGCCGTTCGCACGCCGATTGGTCGCCAACAAGGCAGCCTACGCGATGTGCGCCCCGA
TGTTTTATATGCCCATGTGCTCAACACTTTAATCGAACGCACTGGGATTGATCCAAACCTGATTGAAGATGTGGTTACTG
GTTGCGTAACCAATACTGGTGAGCAAGGCGCAAATATTGGTCGTTTGGGCGTGATGCTCTCCAATTTGCCAATTACGGTT
CCGGCGGTAACCCTCAACCGCATGTGTGGCTCGGCTCAGCAGGCGATTCATTTCGCGGCGCAGGCAATTGCCGCAGGCGA
CGTGAGCTATGCAATCGCTGGCGGGGTTGAATCGATGAGCCGCGTGCCGATGTTTAGCGATGTGACAGGCAATTTTGCCA
CCTTCAATCCTGCGATCAACGAAAAATATCAACTGGTGCACCAAGGCGAATCAGCCGAACTCATTGCCGAGAAATATCAA
TTATCGCGCACCGAGCTTGATGATTGGAGCTTTGAGAGCCATCAACGCGCCGCTGCCGCGACCAAGGCTGGTTGGTTTAG
CAGCCAACTCGCGCCAATCGTTGGCAGCGATAAAACTGGTAATCCCCACGAATTAATCTACGATGAAGGCATTCGCTTCG
AGGCTGATCGCGCCAAGATGGGCACGCTCAAAACGGTGTTCCGTGCCGATGGCGTGGTGACTGCCGCCAACGCCAGCCAA
ATTTCCGATGGTGCAGCGGTTGTATTAATTGGTGAGCGCGAGCAAGCTCTCGCCGATGGTTTCAAGCCCCGTGCTAAATT
CCGTGCTCGCGTGGTTGCCGCTGGTGATCCACGCATGCAGTTGCTCGAAGTAATTCCTGCGACGCATAAAGCCTTAGCCA
AGGCTGGCTTGAGCATCAACGATATTGATCTGGTCGAAATCAACGAGGCTTTTGCTTCAGTGGTGTTGGCATGGTTGCGT
GAATTCAAGCTTGATCCTAGCCGCGTAAATCCCAACGGCGGCGCGATTGCTCATGGTCACCCATTGGGCGCAACTGGCGC
AGTCTTGATGAGCAAAATGATCAACGAACTGGAACGCCGCGATGCTCAATTTGGCTTGCAAGTGATGTGCATCGGTCACG
GTCAAGCGACCGCCACCATTATTGAGCGGGTATAA

Upstream 100 bases:

>100_bases
TTCTCTGCTCCCTATGTTCTTTGCTCTATGCTCTATGTTCTCCAAATCTGCTATACTCGCGCATAACACAGGTGGTCAGT
AGCTCCAAGGAGGTAGCCTC

Downstream 100 bases:

>100_bases
CTTGGGGATTGGTTGTTAGGGATCGGGGGCTGGTAGAACATAGAACATAGAGCAATAGTGATTATGGGCTATATGTAATG
GTTTATCGCATTAACAACCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MAEAVLIDAVRTPIGRQQGSLRDVRPDVLYAHVLNTLIERTGIDPNLIEDVVTGCVTNTGEQGANIGRLGVMLSNLPITV
PAVTLNRMCGSAQQAIHFAAQAIAAGDVSYAIAGGVESMSRVPMFSDVTGNFATFNPAINEKYQLVHQGESAELIAEKYQ
LSRTELDDWSFESHQRAAAATKAGWFSSQLAPIVGSDKTGNPHELIYDEGIRFEADRAKMGTLKTVFRADGVVTAANASQ
ISDGAAVVLIGEREQALADGFKPRAKFRARVVAAGDPRMQLLEVIPATHKALAKAGLSINDIDLVEINEAFASVVLAWLR
EFKLDPSRVNPNGGAIAHGHPLGATGAVLMSKMINELERRDAQFGLQVMCIGHGQATATIIERV

Sequences:

>Translated_384_residues
MAEAVLIDAVRTPIGRQQGSLRDVRPDVLYAHVLNTLIERTGIDPNLIEDVVTGCVTNTGEQGANIGRLGVMLSNLPITV
PAVTLNRMCGSAQQAIHFAAQAIAAGDVSYAIAGGVESMSRVPMFSDVTGNFATFNPAINEKYQLVHQGESAELIAEKYQ
LSRTELDDWSFESHQRAAAATKAGWFSSQLAPIVGSDKTGNPHELIYDEGIRFEADRAKMGTLKTVFRADGVVTAANASQ
ISDGAAVVLIGEREQALADGFKPRAKFRARVVAAGDPRMQLLEVIPATHKALAKAGLSINDIDLVEINEAFASVVLAWLR
EFKLDPSRVNPNGGAIAHGHPLGATGAVLMSKMINELERRDAQFGLQVMCIGHGQATATIIERV
>Mature_383_residues
AEAVLIDAVRTPIGRQQGSLRDVRPDVLYAHVLNTLIERTGIDPNLIEDVVTGCVTNTGEQGANIGRLGVMLSNLPITVP
AVTLNRMCGSAQQAIHFAAQAIAAGDVSYAIAGGVESMSRVPMFSDVTGNFATFNPAINEKYQLVHQGESAELIAEKYQL
SRTELDDWSFESHQRAAAATKAGWFSSQLAPIVGSDKTGNPHELIYDEGIRFEADRAKMGTLKTVFRADGVVTAANASQI
SDGAAVVLIGEREQALADGFKPRAKFRARVVAAGDPRMQLLEVIPATHKALAKAGLSINDIDLVEINEAFASVVLAWLRE
FKLDPSRVNPNGGAIAHGHPLGATGAVLMSKMINELERRDAQFGLQVMCIGHGQATATIIERV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=34.5360824742268, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=35.8056265984655, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=34.8717948717949, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=33.0188679245283, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI194353979, Length=104, Percent_Identity=45.1923076923077, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=43.142144638404, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI48994986, Length=392, Percent_Identity=41.0714285714286, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=35.8778625954198, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=36.6834170854271, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=29.4840294840295, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=33.1619537275064, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=32.7455919395466, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=33.8461538461538, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.1627906976744, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=406, Percent_Identity=29.064039408867, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=33.8383838383838, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=32.25, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=32.3155216284987, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=32.3979591836735, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=31.8501170960187, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41060; Mature: 40929

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAVLIDAVRTPIGRQQGSLRDVRPDVLYAHVLNTLIERTGIDPNLIEDVVTGCVTNTG
CCCCEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
EQGANIGRLGVMLSNLPITVPAVTLNRMCGSAQQAIHFAAQAIAAGDVSYAIAGGVESMS
CCCCCCHHHHHHHHCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHEECCCHHHHH
RVPMFSDVTGNFATFNPAINEKYQLVHQGESAELIAEKYQLSRTELDDWSFESHQRAAAA
CCCCCCCCCCCCEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TKAGWFSSQLAPIVGSDKTGNPHELIYDEGIRFEADRAKMGTLKTVFRADGVVTAANASQ
HHCCCCHHCCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHCCCEEEECCCCC
ISDGAAVVLIGEREQALADGFKPRAKFRARVVAAGDPRMQLLEVIPATHKALAKAGLSIN
CCCCCEEEEECCCHHHHHCCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
DIDLVEINEAFASVVLAWLREFKLDPSRVNPNGGAIAHGHPLGATGAVLMSKMINELERR
CEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHH
DAQFGLQVMCIGHGQATATIIERV
HHHCCEEEEEEECCCHHHHHHHCC
>Mature Secondary Structure 
AEAVLIDAVRTPIGRQQGSLRDVRPDVLYAHVLNTLIERTGIDPNLIEDVVTGCVTNTG
CCCEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
EQGANIGRLGVMLSNLPITVPAVTLNRMCGSAQQAIHFAAQAIAAGDVSYAIAGGVESMS
CCCCCCHHHHHHHHCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHEECCCHHHHH
RVPMFSDVTGNFATFNPAINEKYQLVHQGESAELIAEKYQLSRTELDDWSFESHQRAAAA
CCCCCCCCCCCCEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TKAGWFSSQLAPIVGSDKTGNPHELIYDEGIRFEADRAKMGTLKTVFRADGVVTAANASQ
HHCCCCHHCCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHCCCEEEECCCCC
ISDGAAVVLIGEREQALADGFKPRAKFRARVVAAGDPRMQLLEVIPATHKALAKAGLSIN
CCCCCEEEEECCCHHHHHCCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
DIDLVEINEAFASVVLAWLREFKLDPSRVNPNGGAIAHGHPLGATGAVLMSKMINELERR
CEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHH
DAQFGLQVMCIGHGQATATIIERV
HHHCCEEEEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10766858 [H]