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The map label for this gene is fabG2 [H]

Identifier: 159900900

GI number: 159900900

Start: 5603479

End: 5604246

Strand: Reverse

Name: fabG2 [H]

Synonym: Haur_4387

Alternate gene names: 159900900

Gene position: 5604246-5603479 (Counterclockwise)

Preceding gene: 159900901

Following gene: 159900899

Centisome position: 88.3

GC content: 54.04

Gene sequence:

>768_bases
ATGGAAATACAAAGTTTGAGTGTAGTGGTAACTGGTGGAGCTTCTGGTTTGGGCGGGGCAACCGTGCGACGCTTGTATAG
CGCTGGAGCCAAGGTCGTAATTGCCGATCGTAACATTGAGGTTGGTGAGGCGCTTGCCAAGGAATTAGGCTCAAATGCCC
AATTTGTGGCTTGTGATGTAACCGATGAAACATCGCTGGCCGCCGCATTTGATCAAGCGATTGCCACCAATGGGCGTTTG
CAAGCGGTGATTAGCTGTGCCGGTGTTGGCAGCGCCGAGAAAATTCTGGGCCGCAATGGCGTGCATAGCCTTGAACTTTT
CAATCGGGTAATCCAGGTTAACTTAAATGGGGTGTTTAATGCCTTGCGCTTGGGTGCTGAACGCATGAGCCAAAATGAGC
CAAATGCGGCTGGCGAACGCGGGGTCATTATTAACACTGCCTCGATTGCCGCCTTCGATGGCCAAATTGGTCAAGTCGCC
TATAGCGCCTCGAAAGGTGCAATTGTTGGGCTAACCCTGCCTGCTGCCCGCGAATTGGCGCGGCATGGCATTCGGGTGAT
GACGATTGCGCCAGGTACATTTGATACGCCGTTGTTGGCAGGTTTGCCCGAACCAGCCCGCCAAACCTTGGCCGCGCAAG
TGCCCTTCCCGCCACGCTTGGGCGATCCGGCGGAGTTTGCCATGCTGGCCCAGCATATTCTCGAAAACCCGATGTTAAAT
GGTGAGACCATTCGCTTGGATGGCGCATTACGCATGGGCTATAAGTAA

Upstream 100 bases:

>100_bases
CCAATAGCCAAAAGTCTATAGCCTGTCTTCGTGTTCTTCGTGGTTAAAAAACTGATCCCCAATAACCAACAACCGATCCC
CATTTAGATAAGGACCAACA

Downstream 100 bases:

>100_bases
GTATTAGGCTGGGGCAGTGGTACAATCAGCCACTGCCTTAGTTTTTTAGGAGCATGGCGATGAGCGGGATGCAATTATTT
TTAACTGCCTTGATTTTGGC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MEIQSLSVVVTGGASGLGGATVRRLYSAGAKVVIADRNIEVGEALAKELGSNAQFVACDVTDETSLAAAFDQAIATNGRL
QAVISCAGVGSAEKILGRNGVHSLELFNRVIQVNLNGVFNALRLGAERMSQNEPNAAGERGVIINTASIAAFDGQIGQVA
YSASKGAIVGLTLPAARELARHGIRVMTIAPGTFDTPLLAGLPEPARQTLAAQVPFPPRLGDPAEFAMLAQHILENPMLN
GETIRLDGALRMGYK

Sequences:

>Translated_255_residues
MEIQSLSVVVTGGASGLGGATVRRLYSAGAKVVIADRNIEVGEALAKELGSNAQFVACDVTDETSLAAAFDQAIATNGRL
QAVISCAGVGSAEKILGRNGVHSLELFNRVIQVNLNGVFNALRLGAERMSQNEPNAAGERGVIINTASIAAFDGQIGQVA
YSASKGAIVGLTLPAARELARHGIRVMTIAPGTFDTPLLAGLPEPARQTLAAQVPFPPRLGDPAEFAMLAQHILENPMLN
GETIRLDGALRMGYK
>Mature_255_residues
MEIQSLSVVVTGGASGLGGATVRRLYSAGAKVVIADRNIEVGEALAKELGSNAQFVACDVTDETSLAAAFDQAIATNGRL
QAVISCAGVGSAEKILGRNGVHSLELFNRVIQVNLNGVFNALRLGAERMSQNEPNAAGERGVIINTASIAAFDGQIGQVA
YSASKGAIVGLTLPAARELARHGIRVMTIAPGTFDTPLLAGLPEPARQTLAAQVPFPPRLGDPAEFAMLAQHILENPMLN
GETIRLDGALRMGYK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=252, Percent_Identity=57.9365079365079, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=54.3650793650794, Blast_Score=250, Evalue=8e-67,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=31.8181818181818, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=30.0411522633745, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI31542939, Length=259, Percent_Identity=28.957528957529, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI59889578, Length=241, Percent_Identity=31.1203319502075, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI224922801, Length=181, Percent_Identity=32.0441988950276, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5031737, Length=193, Percent_Identity=31.6062176165803, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=31.9371727748691, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI10190704, Length=225, Percent_Identity=30.2222222222222, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=29.8449612403101, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=31.25, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=30.8, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786812, Length=201, Percent_Identity=31.8407960199005, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=28.2868525896414, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=29.4573643410853, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787905, Length=223, Percent_Identity=30.0448430493274, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=30.1587301587302, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788459, Length=194, Percent_Identity=27.8350515463918, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=51.792828685259, Blast_Score=232, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=32.4, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=30.2788844621514, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=29.6992481203008, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=26.3358778625954, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=221, Percent_Identity=28.9592760180996, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=198, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=212, Percent_Identity=27.8301886792453, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=28.515625, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=198, Percent_Identity=29.7979797979798, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=206, Percent_Identity=27.6699029126214, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=27.5590551181102, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=213, Percent_Identity=26.7605633802817, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=25.5555555555556, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=211, Percent_Identity=27.4881516587678, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=189, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=55.952380952381, Blast_Score=274, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=32.5396825396825, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=29.0983606557377, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357041, Length=235, Percent_Identity=28.936170212766, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI23397609, Length=195, Percent_Identity=31.7948717948718, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007236, Length=209, Percent_Identity=31.1004784688995, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=235, Percent_Identity=26.3829787234043, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571526, Length=235, Percent_Identity=26.3829787234043, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24665243, Length=209, Percent_Identity=25.3588516746411, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331218, Length=209, Percent_Identity=25.3588516746411, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24665247, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221331216, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26499; Mature: 26499

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIQSLSVVVTGGASGLGGATVRRLYSAGAKVVIADRNIEVGEALAKELGSNAQFVACDV
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEC
TDETSLAAAFDQAIATNGRLQAVISCAGVGSAEKILGRNGVHSLELFNRVIQVNLNGVFN
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHEEECHHHHH
ALRLGAERMSQNEPNAAGERGVIINTASIAAFDGQIGQVAYSASKGAIVGLTLPAARELA
HHHHHHHHHCCCCCCCCCCCCEEEEECEEEEECCCCCCEEEECCCCEEEEEECHHHHHHH
RHGIRVMTIAPGTFDTPLLAGLPEPARQTLAAQVPFPPRLGDPAEFAMLAQHILENPMLN
HCCEEEEEECCCCCCCCHHCCCCCHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHCCCCC
GETIRLDGALRMGYK
CCEEEECCEEECCCC
>Mature Secondary Structure
MEIQSLSVVVTGGASGLGGATVRRLYSAGAKVVIADRNIEVGEALAKELGSNAQFVACDV
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEC
TDETSLAAAFDQAIATNGRLQAVISCAGVGSAEKILGRNGVHSLELFNRVIQVNLNGVFN
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHEEECHHHHH
ALRLGAERMSQNEPNAAGERGVIINTASIAAFDGQIGQVAYSASKGAIVGLTLPAARELA
HHHHHHHHHCCCCCCCCCCCCEEEEECEEEEECCCCCCEEEECCCCEEEEEECHHHHHHH
RHGIRVMTIAPGTFDTPLLAGLPEPARQTLAAQVPFPPRLGDPAEFAMLAQHILENPMLN
HCCEEEEEECCCCCCCCHHCCCCCHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHCCCCC
GETIRLDGALRMGYK
CCEEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]