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The map label for this gene is mdh [H]

Identifier: 159900861

GI number: 159900861

Start: 5556427

End: 5557584

Strand: Reverse

Name: mdh [H]

Synonym: Haur_4348

Alternate gene names: 159900861

Gene position: 5557584-5556427 (Counterclockwise)

Preceding gene: 159900862

Following gene: 159900860

Centisome position: 87.57

GC content: 52.94

Gene sequence:

>1158_bases
ATGCAAGAATTTTTTGAGTTTCGTTTACTGCCACGGGTGTTGTATAAATCAGGGTTGGTTGCCGAAATGGGAGCTGAATT
AAGCTCGCTGGGCGCAACCAAGGCCTTCATTGTGACCGATGCTGGTTTGGTCAAGTCAGGCTTGGTCGAGCAAGTTCAAC
AAGCGTTGGCCGAGACGGTCGAAGTCGTCGGCGTTTATAGCGATGTTCCGCCAAATTCCTCGGTGACCGTGGTTGAAGCA
GCTGCGGCTCAAGCCCGCGAATCGGGCGCTGATCTGTTGGTGGCGCTTGGCGGTGGTTCACCAATTGATACCGCCAAAGC
CATGCGTATTTTGATCACCGAGGGCGGCAATTTACTCGATTATGAAGGGATTAATGTGCTGGAACGGCGCTTAATTCCGA
TGGTGGCAATTCCTACGACCGCTGGCACTGGCTCGGAAGCTAGCAACTTTGCCGTAATCAAGGATGAAGCCAATAACGTT
AAGCTTTCATTTACCAGCCCTTACCTTGCGCCTGAGTTGGCGATTCTTGACCCGCAAGTAACCCAAAGTTTGCCAGCACA
TTTGGCTGCCGCAACGGGCATGGATACGCTGACGCATGCCTTTGAAACCTATGTCTCAACCGAATCTGAGCCAATGAGTG
ATGCCTTGGCCTTGGGCGCGGTCGAGATTGTTTCAAATTATCTGCGTGACGCAACCCACCATGGCTCGACCAATGAAGAA
GCTCGCGGCCAGATGTTGATTGCCTCGTGTATGGCGGGGATTGCCTTTACCAACTCATATTTGGGTGCGGTGCATGCCTT
GGCTCACGCTACTGGCGGCCATTTCCCCTTGCACCATGGCTTGCTCAATTCGATTTTCTTGCCGCATGTAGTTGCCTTTA
ATGCCAGCACCGTGCCCGATCGCTATGCGCGGTTGGCACGAGCCTTTGGGATCAACACTGGTGGTCGGCCACGCGAGGAA
GTGATCGACGATTTGATTGCAGGTTTGCGTCAGTTGGCCAGCGACTGCGGCCTGATCACCCAACTGCGCGATTTGGGCAT
TCCTGAAGATTCCTTGCCAATGTTGGCTGAACAAGCCTTTGGCGATGGAGCGGTTTACCATAACCCTGTTGCGCCAACTG
TTGATGATTTACTGGGGATTTTGCAAGCAGCATGGTAG

Upstream 100 bases:

>100_bases
CTTGGAAGGAGGGGATAAAAGTCGTCATTTGGGTACTTTGTGGTTTCAACTTCTGATCCCTAGCCCCTGACGACTGATCC
CTCGAAAAAAGGAGCCAATT

Downstream 100 bases:

>100_bases
TTGATACGATGACGATCTTCAGCCAGCGTCGCCAGTGGTTGACGCTGGTTACGTTATTAATTGGGCTTTTAATTGGTTTG
GGCTTTGTATCCAATCGCCA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MQEFFEFRLLPRVLYKSGLVAEMGAELSSLGATKAFIVTDAGLVKSGLVEQVQQALAETVEVVGVYSDVPPNSSVTVVEA
AAAQARESGADLLVALGGGSPIDTAKAMRILITEGGNLLDYEGINVLERRLIPMVAIPTTAGTGSEASNFAVIKDEANNV
KLSFTSPYLAPELAILDPQVTQSLPAHLAAATGMDTLTHAFETYVSTESEPMSDALALGAVEIVSNYLRDATHHGSTNEE
ARGQMLIASCMAGIAFTNSYLGAVHALAHATGGHFPLHHGLLNSIFLPHVVAFNASTVPDRYARLARAFGINTGGRPREE
VIDDLIAGLRQLASDCGLITQLRDLGIPEDSLPMLAEQAFGDGAVYHNPVAPTVDDLLGILQAAW

Sequences:

>Translated_385_residues
MQEFFEFRLLPRVLYKSGLVAEMGAELSSLGATKAFIVTDAGLVKSGLVEQVQQALAETVEVVGVYSDVPPNSSVTVVEA
AAAQARESGADLLVALGGGSPIDTAKAMRILITEGGNLLDYEGINVLERRLIPMVAIPTTAGTGSEASNFAVIKDEANNV
KLSFTSPYLAPELAILDPQVTQSLPAHLAAATGMDTLTHAFETYVSTESEPMSDALALGAVEIVSNYLRDATHHGSTNEE
ARGQMLIASCMAGIAFTNSYLGAVHALAHATGGHFPLHHGLLNSIFLPHVVAFNASTVPDRYARLARAFGINTGGRPREE
VIDDLIAGLRQLASDCGLITQLRDLGIPEDSLPMLAEQAFGDGAVYHNPVAPTVDDLLGILQAAW
>Mature_385_residues
MQEFFEFRLLPRVLYKSGLVAEMGAELSSLGATKAFIVTDAGLVKSGLVEQVQQALAETVEVVGVYSDVPPNSSVTVVEA
AAAQARESGADLLVALGGGSPIDTAKAMRILITEGGNLLDYEGINVLERRLIPMVAIPTTAGTGSEASNFAVIKDEANNV
KLSFTSPYLAPELAILDPQVTQSLPAHLAAATGMDTLTHAFETYVSTESEPMSDALALGAVEIVSNYLRDATHHGSTNEE
ARGQMLIASCMAGIAFTNSYLGAVHALAHATGGHFPLHHGLLNSIFLPHVVAFNASTVPDRYARLARAFGINTGGRPREE
VIDDLIAGLRQLASDCGLITQLRDLGIPEDSLPMLAEQAFGDGAVYHNPVAPTVDDLLGILQAAW

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=415, Percent_Identity=27.9518072289157, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI48994951, Length=359, Percent_Identity=38.4401114206128, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=34.4919786096257, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87082107, Length=389, Percent_Identity=34.7043701799486, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787493, Length=406, Percent_Identity=31.2807881773399, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789386, Length=369, Percent_Identity=26.0162601626016, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=397, Percent_Identity=28.2115869017632, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=381, Percent_Identity=35.4330708661417, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24657991, Length=386, Percent_Identity=30.0518134715026, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40557; Mature: 40557

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEFFEFRLLPRVLYKSGLVAEMGAELSSLGATKAFIVTDAGLVKSGLVEQVQQALAETV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
EVVGVYSDVPPNSSVTVVEAAAAQARESGADLLVALGGGSPIDTAKAMRILITEGGNLLD
HHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCCHHHHEEEEEECCCCEEC
YEGINVLERRLIPMVAIPTTAGTGSEASNFAVIKDEANNVKLSFTSPYLAPELAILDPQV
CCCHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEECHHH
TQSLPAHLAAATGMDTLTHAFETYVSTESEPMSDALALGAVEIVSNYLRDATHHGSTNEE
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
ARGQMLIASCMAGIAFTNSYLGAVHALAHATGGHFPLHHGLLNSIFLPHVVAFNASTVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
RYARLARAFGINTGGRPREEVIDDLIAGLRQLASDCGLITQLRDLGIPEDSLPMLAEQAF
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
GDGAVYHNPVAPTVDDLLGILQAAW
CCCCEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQEFFEFRLLPRVLYKSGLVAEMGAELSSLGATKAFIVTDAGLVKSGLVEQVQQALAETV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
EVVGVYSDVPPNSSVTVVEAAAAQARESGADLLVALGGGSPIDTAKAMRILITEGGNLLD
HHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCCHHHHEEEEEECCCCEEC
YEGINVLERRLIPMVAIPTTAGTGSEASNFAVIKDEANNVKLSFTSPYLAPELAILDPQV
CCCHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEECHHH
TQSLPAHLAAATGMDTLTHAFETYVSTESEPMSDALALGAVEIVSNYLRDATHHGSTNEE
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
ARGQMLIASCMAGIAFTNSYLGAVHALAHATGGHFPLHHGLLNSIFLPHVVAFNASTVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
RYARLARAFGINTGGRPREEVIDDLIAGLRQLASDCGLITQLRDLGIPEDSLPMLAEQAF
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
GDGAVYHNPVAPTVDDLLGILQAAW
CCCCEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]