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The map label for this gene is mvk [H]

Identifier: 159900828

GI number: 159900828

Start: 5508589

End: 5509530

Strand: Reverse

Name: mvk [H]

Synonym: Haur_4315

Alternate gene names: 159900828

Gene position: 5509530-5508589 (Counterclockwise)

Preceding gene: 159900829

Following gene: 159900827

Centisome position: 86.81

GC content: 52.97

Gene sequence:

>942_bases
ATGAATAGTGCGCCTGGAAAACTTATTTTAGCTGGCGAACATGCCGTGGTCTACGGCCAACCAGCCTTGGCGATGCCGAT
TGCCGCCTTACGTGCAAGCGTCGCCGTCGAACCAGCCCCACGCGGCGCGGGCATGACCGTGCATGCGCCAGATTTAGGCT
TGGTTTGGCGTTTGCGGGCCACTGCACCGTTGAGCGATTTGGCCCAGCGCACCTTAGATTATTTACAATTGCCAGAACCA
GATTTGCGCTTGACCATTAGTTCTAGTATTCCAATTGCTAGCGGGATGGGCAGCGGGGCAGCGGTTGGCGCAGCTTTAGT
CCGTGCCTTAGCTGAACAGGCAGGCCAACAACTTTCGGCCCAAGTTATTTCCGATCTGGTTTATCAGAGCGAAAAAGCTT
TTCATGGCACTCCCTCAGGCATTGATAACACCGTTGTAGCCTACGAACAACCAATTTTGTTTCAACGCCAAACCCAAGGT
GAACCACTGATTGCGCCGTTAGCAGTTGGTAATCAATGGCATTTTGTGGTGGCTGATAGCGGCATCGCCAGCGAAACCAA
AGCCGTCGTCGGCGATTTACGCCAGCGCTGGTTGGCCGATCCGGAGCTTTATAATCGCCAATTTGTGGCGGTTGGCAATT
TAGTACGCCAGATTCAAACGGCATTGGCTGGCAATGATGCCGAACTATTTGGCCAATTGCTGAGCCAAAATCATCAATTA
TTGCAAACCCTGGGCGTTTCAGCCGAAAAACTTGATTATTTGGTGCAAACAGCTTTAGCGGCTGGGGCGTGGGGAGCCAA
AATGTCGGGGGCTGGCTGGGGGGGAATTATGCTAGCACTCGTTCCGGCTGAACGCGCCAGTTATATTCAACAACAACTGC
GAGCGGCTGGCGCTGTGCAAACCTGGCAAACCAGCTTGCTACCAACGGATTCAAAGCGATGA

Upstream 100 bases:

>100_bases
GGTGATTGCTGGCAATCAATCGAATAGCGCAAATTGTATCATTCGTTTGCAAACCATAAGTCACACAGCATATTAAGATA
TTCGATCTATAATACGTGCA

Downstream 100 bases:

>100_bases
GGTTGCTTCTGTGACGATTGATGCTGCAATTATTGTTGTAACCTACAACCACGCCCGCTATATTGGCGATTGCCTCAGCT
CGTTGCTGGCGCTTGATCCT

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNSAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEPAPRGAGMTVHAPDLGLVWRLRATAPLSDLAQRTLDYLQLPEP
DLRLTISSSIPIASGMGSGAAVGAALVRALAEQAGQQLSAQVISDLVYQSEKAFHGTPSGIDNTVVAYEQPILFQRQTQG
EPLIAPLAVGNQWHFVVADSGIASETKAVVGDLRQRWLADPELYNRQFVAVGNLVRQIQTALAGNDAELFGQLLSQNHQL
LQTLGVSAEKLDYLVQTALAAGAWGAKMSGAGWGGIMLALVPAERASYIQQQLRAAGAVQTWQTSLLPTDSKR

Sequences:

>Translated_313_residues
MNSAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEPAPRGAGMTVHAPDLGLVWRLRATAPLSDLAQRTLDYLQLPEP
DLRLTISSSIPIASGMGSGAAVGAALVRALAEQAGQQLSAQVISDLVYQSEKAFHGTPSGIDNTVVAYEQPILFQRQTQG
EPLIAPLAVGNQWHFVVADSGIASETKAVVGDLRQRWLADPELYNRQFVAVGNLVRQIQTALAGNDAELFGQLLSQNHQL
LQTLGVSAEKLDYLVQTALAAGAWGAKMSGAGWGGIMLALVPAERASYIQQQLRAAGAVQTWQTSLLPTDSKR
>Mature_313_residues
MNSAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEPAPRGAGMTVHAPDLGLVWRLRATAPLSDLAQRTLDYLQLPEP
DLRLTISSSIPIASGMGSGAAVGAALVRALAEQAGQQLSAQVISDLVYQSEKAFHGTPSGIDNTVVAYEQPILFQRQTQG
EPLIAPLAVGNQWHFVVADSGIASETKAVVGDLRQRWLADPELYNRQFVAVGNLVRQIQTALAGNDAELFGQLLSQNHQL
LQTLGVSAEKLDYLVQTALAAGAWGAKMSGAGWGGIMLALVPAERASYIQQQLRAAGAVQTWQTSLLPTDSKR

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=325, Percent_Identity=25.5384615384615, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4557769, Length=325, Percent_Identity=25.5384615384615, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323864, Length=394, Percent_Identity=25.6345177664975, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI78707210, Length=370, Percent_Identity=27.5675675675676, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 33052; Mature: 33052

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEPAPRGAGMTVHAPDLGLVWRLRA
CCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCEEEEEEC
TAPLSDLAQRTLDYLQLPEPDLRLTISSSIPIASGMGSGAAVGAALVRALAEQAGQQLSA
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVISDLVYQSEKAFHGTPSGIDNTVVAYEQPILFQRQTQGEPLIAPLAVGNQWHFVVADS
HHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCEEEEEEECCEEEEEEECC
GIASETKAVVGDLRQRWLADPELYNRQFVAVGNLVRQIQTALAGNDAELFGQLLSQNHQL
CCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHH
LQTLGVSAEKLDYLVQTALAAGAWGAKMSGAGWGGIMLALVPAERASYIQQQLRAAGAVQ
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCHH
TWQTSLLPTDSKR
HHHHHCCCCCCCC
>Mature Secondary Structure
MNSAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEPAPRGAGMTVHAPDLGLVWRLRA
CCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCEEEEEEC
TAPLSDLAQRTLDYLQLPEPDLRLTISSSIPIASGMGSGAAVGAALVRALAEQAGQQLSA
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVISDLVYQSEKAFHGTPSGIDNTVVAYEQPILFQRQTQGEPLIAPLAVGNQWHFVVADS
HHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCEEEEEEECCEEEEEEECC
GIASETKAVVGDLRQRWLADPELYNRQFVAVGNLVRQIQTALAGNDAELFGQLLSQNHQL
CCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHH
LQTLGVSAEKLDYLVQTALAAGAWGAKMSGAGWGGIMLALVPAERASYIQQQLRAAGAVQ
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCHH
TWQTSLLPTDSKR
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]