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The map label for this gene is proC [H]

Identifier: 159900081

GI number: 159900081

Start: 4480492

End: 4481307

Strand: Direct

Name: proC [H]

Synonym: Haur_3564

Alternate gene names: 159900081

Gene position: 4480492-4481307 (Clockwise)

Preceding gene: 159900080

Following gene: 159900082

Centisome position: 70.6

GC content: 56.62

Gene sequence:

>816_bases
ATGTTAACCAATCTCAATGTTGCAGTTATTGGCACAGGCACCATGGGCGAGGCCGTCATCGGTGGCCTGCTCCAAGCCGA
ATTAGTGCAGCCAACCCAGGTTTTGGCAGCCACTCCGCGCCCTGAGCGTCGCCGCGAGCTATCACAACGCTGGGGCATCG
CCACCACAGGCGATAATCGCGAGGCCGCAACCTGGGGCAATGTGGTCATTTTGGGCATCAAGCCTCAGATGACTGAGCAA
GTGCTGCCCCAACTCAACGGCGCATTTCAAACCGATGATCTGATCGTTTCAGTTTTAGCTGGGGTCAAGATGCGCCAAAT
TGCCGAAGCCACCGGACATAGCGCCATCGCCCGTTCGATGCCCAACACTCCGGCCCAAATTGCCGAAGGCATTACGGTTT
GGACAGCCAGCAAGGGGCTTGATCAAGCGCGGCGTGGTTGGGCCAAAATCGTGCTCAGTGCGATTGGCGAGGAAGTTGAG
GTTGAGGACGAGAAATTTATGGATATGGCCACAGCGCTCTCGGGCACAGGTCCAGCCTATGTTTTTATGGTAATGGAAGC
CTTGATCGATGCTGGCGTGCATATGGGTTTTCCCCGCCGGATCGCGGCCCAACTAGTCGAGCAAACCGTAATTGGGGCAG
TGCGCTACTCGGCCCAATCGGGCAAGCATGTCGCCGAATTACGCAATATGGTCACTTCGCCAGGAGGGACAACCGCCGCA
GCGCTTTATGAACTCGAAAAAGGTCGTTTGCGCACGGTTTTAGCCGATGGAGTTTGGGCTGCATATCGTCGCGCTCGTGA
ACTTGGCGGCGAGTAG

Upstream 100 bases:

>100_bases
CCCTTTGTGCCCTTCGTGGATCAAAATCAACGTTTCCGCAGCGTGGCGGCGAGGCAATGGTGCCTGTGAACCTTCAGCCA
ATCATGGAGAACACCAGACC

Downstream 100 bases:

>100_bases
TTGTTCAAATACAGCCGAAGTCTCAGCGAATTTTCGCATAATGCTTAGGCTGTGATTGAGTAGCAGCAAATCAATTGCAT
TTTTCAGCTGTCCATGTACC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MLTNLNVAVIGTGTMGEAVIGGLLQAELVQPTQVLAATPRPERRRELSQRWGIATTGDNREAATWGNVVILGIKPQMTEQ
VLPQLNGAFQTDDLIVSVLAGVKMRQIAEATGHSAIARSMPNTPAQIAEGITVWTASKGLDQARRGWAKIVLSAIGEEVE
VEDEKFMDMATALSGTGPAYVFMVMEALIDAGVHMGFPRRIAAQLVEQTVIGAVRYSAQSGKHVAELRNMVTSPGGTTAA
ALYELEKGRLRTVLADGVWAAYRRARELGGE

Sequences:

>Translated_271_residues
MLTNLNVAVIGTGTMGEAVIGGLLQAELVQPTQVLAATPRPERRRELSQRWGIATTGDNREAATWGNVVILGIKPQMTEQ
VLPQLNGAFQTDDLIVSVLAGVKMRQIAEATGHSAIARSMPNTPAQIAEGITVWTASKGLDQARRGWAKIVLSAIGEEVE
VEDEKFMDMATALSGTGPAYVFMVMEALIDAGVHMGFPRRIAAQLVEQTVIGAVRYSAQSGKHVAELRNMVTSPGGTTAA
ALYELEKGRLRTVLADGVWAAYRRARELGGE
>Mature_271_residues
MLTNLNVAVIGTGTMGEAVIGGLLQAELVQPTQVLAATPRPERRRELSQRWGIATTGDNREAATWGNVVILGIKPQMTEQ
VLPQLNGAFQTDDLIVSVLAGVKMRQIAEATGHSAIARSMPNTPAQIAEGITVWTASKGLDQARRGWAKIVLSAIGEEVE
VEDEKFMDMATALSGTGPAYVFMVMEALIDAGVHMGFPRRIAAQLVEQTVIGAVRYSAQSGKHVAELRNMVTSPGGTTAA
ALYELEKGRLRTVLADGVWAAYRRARELGGE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=33.7037037037037, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=33.7037037037037, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=32.7137546468402, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=33.8403041825095, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=28.3154121863799, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=30.6338028169014, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=35.3790613718412, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=34.9442379182156, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24647700, Length=156, Percent_Identity=41.6666666666667, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28977; Mature: 28977

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNLNVAVIGTGTMGEAVIGGLLQAELVQPTQVLAATPRPERRRELSQRWGIATTGDNR
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCEECCCCC
EAATWGNVVILGIKPQMTEQVLPQLNGAFQTDDLIVSVLAGVKMRQIAEATGHSAIARSM
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHCHHHHHHCC
PNTPAQIAEGITVWTASKGLDQARRGWAKIVLSAIGEEVEVEDEKFMDMATALSGTGPAY
CCCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHH
VFMVMEALIDAGVHMGFPRRIAAQLVEQTVIGAVRYSAQSGKHVAELRNMVTSPGGTTAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
ALYELEKGRLRTVLADGVWAAYRRARELGGE
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTNLNVAVIGTGTMGEAVIGGLLQAELVQPTQVLAATPRPERRRELSQRWGIATTGDNR
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCEECCCCC
EAATWGNVVILGIKPQMTEQVLPQLNGAFQTDDLIVSVLAGVKMRQIAEATGHSAIARSM
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHCHHHHHHCC
PNTPAQIAEGITVWTASKGLDQARRGWAKIVLSAIGEEVEVEDEKFMDMATALSGTGPAY
CCCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHH
VFMVMEALIDAGVHMGFPRRIAAQLVEQTVIGAVRYSAQSGKHVAELRNMVTSPGGTTAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
ALYELEKGRLRTVLADGVWAAYRRARELGGE
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]