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The map label for this gene is hemB [H]

Identifier: 159900067

GI number: 159900067

Start: 4466864

End: 4467871

Strand: Direct

Name: hemB [H]

Synonym: Haur_3550

Alternate gene names: 159900067

Gene position: 4466864-4467871 (Clockwise)

Preceding gene: 159900066

Following gene: 159900068

Centisome position: 70.38

GC content: 51.79

Gene sequence:

>1008_bases
ATGAGTATGCTCGAAAGCGTGCCAACGCCCAATCGTCGTTTGCGGCGCGGACGGCGCAACGCCACATTACGGCGCATGGT
ACGTGAAACTCAATTAACTGTTGATAATCTAATTGCCCCATTATTTATTGTTGAAGGCCAGAATATTCGCAAGCCAATTA
GCTCGATGCCTGGTCAATTTCAACTTTCGCTCGATCAGCTCGGCACTGAGATTGATGAACTGGTTGCGGCGCAAATTCCA
GCAGTGCTGCTCTTTGGTATTCCCTTGCATAAAGATGCTCAAGGTAGCTCAGCTTGGGATGCGAATGGCCCTGTGCCTAG
CGCAATTCGGGCAATTAAACAGCAAGCACCACATTTGGTGGTAATTGCCGATGTTTGTATGTGCGAATATACCGACCACG
GCCATTGTGGCATTTTAACCAGCGGTGAGCCAGAAACAATCACCGTTGATAATGACCCAACCTTGGAATTATTAGCCCGT
GCTTCGGTGGCTTATGCCGAGGCTGGCGCTGATGTGGTTGCTCCCAGCGCCATGATGGATGGCCAAATTGCCGCAATTCG
CTATGGCCTTGATCAAGCAGGCTACCACGACACAATTATTTTGTCGTATGCAGCTAAATTTGCCTCGGCTTTTTATGGCC
CGTTCCGCGAAGCTGCTGAATCAACACCCCAATTTGGCGACCGCCGCTCGTACCAAATGGATGCGGCCAACGCCCGCGAG
GCGATTGCCGAAACCGCGCTCGATGTCGCCGAGGGAGCAGATTGGCTGATGGTCAAGCCAGCTGGGGCTTATTTGGATAT
TATTCGGGCAGTTTACGAAGAATTTGATCTACCACTAGCAGCCTATCAAGTGAGCGGCGAATATGCCATGATCAAGGCTG
CTGCTGCCAACGGCTGGATCGATGAGCAACGGGTGGCACTTGAAAGCTTGCTGGCAATTCGCCGAGCAGGCGCAAGTATG
ATCATAACCTATTATGCCAAGGCGGCGGCGCAGTGGTTGAAAGCCTAG

Upstream 100 bases:

>100_bases
TTGATGTGGGCTTGCATGTTGATATAGAGGCAGCGGAACATTCAACCCAAGGCTTAGTTGAAGCCCTGCTTGAATGGGCC
AAAACCGAGAAGGAACTGGC

Downstream 100 bases:

>100_bases
GGACGAAGAGCATAGAACATAGAGCATAGAACATAGGGCTGGGGATCGGCTGTTGGGGATTGGGGATTGGATTTAGCGCA
GAGGCGCAGAGTAAGAGCAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSMLESVPTPNRRLRRGRRNATLRRMVRETQLTVDNLIAPLFIVEGQNIRKPISSMPGQFQLSLDQLGTEIDELVAAQIP
AVLLFGIPLHKDAQGSSAWDANGPVPSAIRAIKQQAPHLVVIADVCMCEYTDHGHCGILTSGEPETITVDNDPTLELLAR
ASVAYAEAGADVVAPSAMMDGQIAAIRYGLDQAGYHDTIILSYAAKFASAFYGPFREAAESTPQFGDRRSYQMDAANARE
AIAETALDVAEGADWLMVKPAGAYLDIIRAVYEEFDLPLAAYQVSGEYAMIKAAAANGWIDEQRVALESLLAIRRAGASM
IITYYAKAAAQWLKA

Sequences:

>Translated_335_residues
MSMLESVPTPNRRLRRGRRNATLRRMVRETQLTVDNLIAPLFIVEGQNIRKPISSMPGQFQLSLDQLGTEIDELVAAQIP
AVLLFGIPLHKDAQGSSAWDANGPVPSAIRAIKQQAPHLVVIADVCMCEYTDHGHCGILTSGEPETITVDNDPTLELLAR
ASVAYAEAGADVVAPSAMMDGQIAAIRYGLDQAGYHDTIILSYAAKFASAFYGPFREAAESTPQFGDRRSYQMDAANARE
AIAETALDVAEGADWLMVKPAGAYLDIIRAVYEEFDLPLAAYQVSGEYAMIKAAAANGWIDEQRVALESLLAIRRAGASM
IITYYAKAAAQWLKA
>Mature_334_residues
SMLESVPTPNRRLRRGRRNATLRRMVRETQLTVDNLIAPLFIVEGQNIRKPISSMPGQFQLSLDQLGTEIDELVAAQIPA
VLLFGIPLHKDAQGSSAWDANGPVPSAIRAIKQQAPHLVVIADVCMCEYTDHGHCGILTSGEPETITVDNDPTLELLARA
SVAYAEAGADVVAPSAMMDGQIAAIRYGLDQAGYHDTIILSYAAKFASAFYGPFREAAESTPQFGDRRSYQMDAANAREA
IAETALDVAEGADWLMVKPAGAYLDIIRAVYEEFDLPLAAYQVSGEYAMIKAAAANGWIDEQRVALESLLAIRRAGASMI
ITYYAKAAAQWLKA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=309, Percent_Identity=44.6601941747573, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI87081728, Length=315, Percent_Identity=52.6984126984127, Blast_Score=318, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321398, Length=339, Percent_Identity=44.2477876106195, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI21358291, Length=318, Percent_Identity=44.6540880503145, Blast_Score=262, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36346; Mature: 36215

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLESVPTPNRRLRRGRRNATLRRMVRETQLTVDNLIAPLFIVEGQNIRKPISSMPGQF
CCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCCE
QLSLDQLGTEIDELVAAQIPAVLLFGIPLHKDAQGSSAWDANGPVPSAIRAIKQQAPHLV
EEEHHHHCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
VIADVCMCEYTDHGHCGILTSGEPETITVDNDPTLELLARASVAYAEAGADVVAPSAMMD
EEEHHHHHCCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHC
GQIAAIRYGLDQAGYHDTIILSYAAKFASAFYGPFREAAESTPQFGDRRSYQMDAANARE
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
AIAETALDVAEGADWLMVKPAGAYLDIIRAVYEEFDLPLAAYQVSGEYAMIKAAAANGWI
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCC
DEQRVALESLLAIRRAGASMIITYYAKAAAQWLKA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMLESVPTPNRRLRRGRRNATLRRMVRETQLTVDNLIAPLFIVEGQNIRKPISSMPGQF
CCHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCCE
QLSLDQLGTEIDELVAAQIPAVLLFGIPLHKDAQGSSAWDANGPVPSAIRAIKQQAPHLV
EEEHHHHCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE
VIADVCMCEYTDHGHCGILTSGEPETITVDNDPTLELLARASVAYAEAGADVVAPSAMMD
EEEHHHHHCCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHC
GQIAAIRYGLDQAGYHDTIILSYAAKFASAFYGPFREAAESTPQFGDRRSYQMDAANARE
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
AIAETALDVAEGADWLMVKPAGAYLDIIRAVYEEFDLPLAAYQVSGEYAMIKAAAANGWI
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCC
DEQRVALESLLAIRRAGASMIITYYAKAAAQWLKA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]