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The map label for this gene is hemD [H]

Identifier: 159900066

GI number: 159900066

Start: 4466067

End: 4466867

Strand: Direct

Name: hemD [H]

Synonym: Haur_3549

Alternate gene names: 159900066

Gene position: 4466067-4466867 (Clockwise)

Preceding gene: 159900065

Following gene: 159900067

Centisome position: 70.37

GC content: 51.44

Gene sequence:

>801_bases
ATGACGATGCACACACCCTTAACGGGCAAGCGAATTGTGTTGACCCGCGCCCGTGAGCAGATGACCGAGTTCGCTCAACT
CTTGGCAGACCATGGAGCCGAAACGCTCTATTGCTCGGCAATTCAAACCCTACCACCCGACGATTGGCAACCATTTGACC
GCGCTCTGAGCCAAATTGAAGGCTTCGATTGGATGATTGCTACCAGTACCAACGCCGTGCGAGCGTTCTTCGAGCGTTAT
GGGGTTTTAGGCTTGCCCTGCAACGCCTTAAATCAATTAAAAATTGCCGCGATTGGCAAGGCTACCGCCAAATTATTAAC
TGATTTTGGCCATGCGCCCGATTTTGTGCCGCATGCCTATGTTGCCGAGCAATTTCTCGTCGAATTTCAAGATATTGCTG
GCCAACGCATTTTTCTGCCCCAAGCTGATATTGCACGCCCACTGTTGCGCGAAGCATTAATCGAACGTGGCGCAGACGTA
ACGGCGGTGGTGGCTTATCGCACCGTGCCCGATCCACAGGTAGTCGCATTGGCTGAGTTGCTACGTCAGCAACGGGTTGA
TGTGGTGACATTCACCTCAAGTTCAACCGTGCGCTACACCATCGAAGCCTTGCATGCGGCAGGTATGCGCAATTCACAAG
AATTTTTAAATCAGACAATCATTGCAACAATTGGCCCTATCACCAGCCAAACCGCGCTTGATGTGGGCTTGCATGTTGAT
ATAGAGGCAGCGGAACATTCAACCCAAGGCTTAGTTGAAGCCCTGCTTGAATGGGCCAAAACCGAGAAGGAACTGGCATG
A

Upstream 100 bases:

>100_bases
AGGCCATAATCTTGTATACTACCAAGGCCGACGATTAATGAATTGCATATTGAATACTCGCCTATAGCTGCGTGCTAGCA
ACAGATTGTGGATTGCAACA

Downstream 100 bases:

>100_bases
GTATGCTCGAAAGCGTGCCAACGCCCAATCGTCGTTTGCGGCGCGGACGGCGCAACGCCACATTACGGCGCATGGTACGT
GAAACTCAATTAACTGTTGA

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTMHTPLTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWMIATSTNAVRAFFERY
GVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAYVAEQFLVEFQDIAGQRIFLPQADIARPLLREALIERGADV
TAVVAYRTVPDPQVVALAELLRQQRVDVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVD
IEAAEHSTQGLVEALLEWAKTEKELA

Sequences:

>Translated_266_residues
MTMHTPLTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWMIATSTNAVRAFFERY
GVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAYVAEQFLVEFQDIAGQRIFLPQADIARPLLREALIERGADV
TAVVAYRTVPDPQVVALAELLRQQRVDVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVD
IEAAEHSTQGLVEALLEWAKTEKELA
>Mature_265_residues
TMHTPLTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIEGFDWMIATSTNAVRAFFERYG
VLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAYVAEQFLVEFQDIAGQRIFLPQADIARPLLREALIERGADVT
AVVAYRTVPDPQVVALAELLRQQRVDVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVDI
EAAEHSTQGLVEALLEWAKTEKELA

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29328; Mature: 29197

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMHTPLTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIE
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCHHHHHHHHHC
GFDWMIATSTNAVRAFFERYGVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAY
CCCEEEEECHHHHHHHHHHCCCCCCCHHHHCCEEHHHHHHHHHHHHHHCCCCCCCCHHHH
VAEQFLVEFQDIAGQRIFLPQADIARPLLREALIERGADVTAVVAYRTVPDPQVVALAEL
HHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHH
LRQQRVDVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVD
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCEEEE
IEAAEHSTQGLVEALLEWAKTEKELA
EHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TMHTPLTGKRIVLTRAREQMTEFAQLLADHGAETLYCSAIQTLPPDDWQPFDRALSQIE
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCHHHHHHHHHC
GFDWMIATSTNAVRAFFERYGVLGLPCNALNQLKIAAIGKATAKLLTDFGHAPDFVPHAY
CCCEEEEECHHHHHHHHHHCCCCCCCHHHHCCEEHHHHHHHHHHHHHHCCCCCCCCHHHH
VAEQFLVEFQDIAGQRIFLPQADIARPLLREALIERGADVTAVVAYRTVPDPQVVALAEL
HHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHH
LRQQRVDVVTFTSSSTVRYTIEALHAAGMRNSQEFLNQTIIATIGPITSQTALDVGLHVD
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCEEEE
IEAAEHSTQGLVEALLEWAKTEKELA
EHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]