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The map label for this gene is guaA [H]

Identifier: 159899995

GI number: 159899995

Start: 4381663

End: 4383207

Strand: Reverse

Name: guaA [H]

Synonym: Haur_3478

Alternate gene names: 159899995

Gene position: 4383207-4381663 (Counterclockwise)

Preceding gene: 159899999

Following gene: 159899994

Centisome position: 69.06

GC content: 53.98

Gene sequence:

>1545_bases
ATGACACAGAATGAAGCAATTGTGGTGCTTGATTATGGCTCACAATATAGTCAATTGATTGTGCGGCGGGTTCGTGAAGC
GGGCGTTTATAGCGAGTTAGTGCGGTTCGATGCCGACGAGGCCACGGTTGCTGCGCTCAACCCCAAAGGCATCATTCTTT
CGGGTGGGCCGAATAGCGTCTATGCCGAGGGTGCGCCGCAACTGCCAGCATGGGTTTTGGCCAGCAACCTGCCTGTGTTG
GGCATTTGCTATGGTTTGCAATTGCAGGCCCATCATTTGGGTGGCAAAGTCGAGCCTTCCAACGACCGCGAATTTGGCCA
TGCCGTGATTACCATTACCGCTGAATCGCCACTCTTAGCCGATATTCCGACCGAACATTCGGTGTGGATGAGCCACGGCG
ATCGCTTGGAAACCCTGCCTGCTGGCTGGCATCCAATCGCGATCAGCCCCAACTCGCCCTATGCCGCTGCTGCCGATGAA
GATCGACGCTGGTATGGCTTGCAATTTCACCCTGAGGTCGTGCACTCACCCTATGGCAAGCAAGTGCTGCACAATTTTCT
CTACCGCATTTGCGCATGTGCTGGCAGTTGGCAGCCTAGCCACTTTATCCAAGAGGCGGTTGAGCGAATTCAGCAGCAAG
CGCCCAGCGGCCAAGTGATTTGTGCGCTCAGCGGTGGAGTTGATTCGGCGGTAGCAGCGTTGTTGGCCCACCAAGCCATT
GTCGAACGCTTGACCTGTATTTTTGTCGATAACGGTTTGTTGCGCCGCGGCGAGGCCGAGCAAGTTTCACGCACCTTCCG
CGATCACTTCCAAATCGAATTGATTACGGTTGATGCCGCTGAAGAATTTTTGGCAGCACTGGCAGGCGTGACCGATCCTG
AGCAAAAACGCAAGATCATCGGCGAAAAATTTATTCGCATTTTCGAGCGCGAAGCCCGTAACCTCGATGACGCGGCCTAT
TTGGTACAAGGCACGCTCTATCCCGATGTGATCGAATCGACAGCGCCAGATCGCAATGTGGCAGTCAAGATCAAAACCCA
TCATAATGTTGGCGGCTTGCCCGATGATATGAAACTCAAGGTGATCGAGCCATTACGCATGCTGTTTAAGGATGAAGTGC
GGGCAGCCGGTTTGGCCTTGGGTTTGCCCGAAGATTGGGTCTGGCGACATCCCTTCCCTGGGCCAGGTTTAGCGGTGCGG
TTGCTGGGCGCAATCAGCTTTGAGCGCTTAGAAACCTTGCGCCATGCCGATGCAATTTTCCTTGAAGAATTGCGGGCAGC
AGGCTTGTATCGCGCGACGCAGCAGGCCTTTGCGGTGTTGTTGCCAGTGCAAAGTGTCGGCGTGATGGGTGATTATCGCA
CCTATGCCGATACCATTGCGATTCGTGCGGTGAGCACCGAAGATTTTATGACCGCCGATTGGGCTCGCTTGCCCTATGAA
TTGTTGGCCAAAGTCTCCAGCCGCATTGTCAACGAGGTGACGGGAGTTAATCGGGTGGTGTATGATATTTCATCAAAACC
ACCAGCCACAATCGAATGGGAATAA

Upstream 100 bases:

>100_bases
CAACTCCTATGTTCTATGTTCTGCGTTCCTATGTTAAACTAGCCCCATCGTATGCTCAACCAAAATAACAACGCCGTTGT
TGTGCCAAACTGAGGAAACA

Downstream 100 bases:

>100_bases
TCTAAAAGCCCAGTCATCCTAGCAGCAACATCGGCCACCAAAATGGCCGATGTTGCAAAAAGAGCACTATGAGCGATTTG
CATCAATTAGTTTTATTAAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTQNEAIVVLDYGSQYSQLIVRRVREAGVYSELVRFDADEATVAALNPKGIILSGGPNSVYAEGAPQLPAWVLASNLPVL
GICYGLQLQAHHLGGKVEPSNDREFGHAVITITAESPLLADIPTEHSVWMSHGDRLETLPAGWHPIAISPNSPYAAAADE
DRRWYGLQFHPEVVHSPYGKQVLHNFLYRICACAGSWQPSHFIQEAVERIQQQAPSGQVICALSGGVDSAVAALLAHQAI
VERLTCIFVDNGLLRRGEAEQVSRTFRDHFQIELITVDAAEEFLAALAGVTDPEQKRKIIGEKFIRIFEREARNLDDAAY
LVQGTLYPDVIESTAPDRNVAVKIKTHHNVGGLPDDMKLKVIEPLRMLFKDEVRAAGLALGLPEDWVWRHPFPGPGLAVR
LLGAISFERLETLRHADAIFLEELRAAGLYRATQQAFAVLLPVQSVGVMGDYRTYADTIAIRAVSTEDFMTADWARLPYE
LLAKVSSRIVNEVTGVNRVVYDISSKPPATIEWE

Sequences:

>Translated_514_residues
MTQNEAIVVLDYGSQYSQLIVRRVREAGVYSELVRFDADEATVAALNPKGIILSGGPNSVYAEGAPQLPAWVLASNLPVL
GICYGLQLQAHHLGGKVEPSNDREFGHAVITITAESPLLADIPTEHSVWMSHGDRLETLPAGWHPIAISPNSPYAAAADE
DRRWYGLQFHPEVVHSPYGKQVLHNFLYRICACAGSWQPSHFIQEAVERIQQQAPSGQVICALSGGVDSAVAALLAHQAI
VERLTCIFVDNGLLRRGEAEQVSRTFRDHFQIELITVDAAEEFLAALAGVTDPEQKRKIIGEKFIRIFEREARNLDDAAY
LVQGTLYPDVIESTAPDRNVAVKIKTHHNVGGLPDDMKLKVIEPLRMLFKDEVRAAGLALGLPEDWVWRHPFPGPGLAVR
LLGAISFERLETLRHADAIFLEELRAAGLYRATQQAFAVLLPVQSVGVMGDYRTYADTIAIRAVSTEDFMTADWARLPYE
LLAKVSSRIVNEVTGVNRVVYDISSKPPATIEWE
>Mature_513_residues
TQNEAIVVLDYGSQYSQLIVRRVREAGVYSELVRFDADEATVAALNPKGIILSGGPNSVYAEGAPQLPAWVLASNLPVLG
ICYGLQLQAHHLGGKVEPSNDREFGHAVITITAESPLLADIPTEHSVWMSHGDRLETLPAGWHPIAISPNSPYAAAADED
RRWYGLQFHPEVVHSPYGKQVLHNFLYRICACAGSWQPSHFIQEAVERIQQQAPSGQVICALSGGVDSAVAALLAHQAIV
ERLTCIFVDNGLLRRGEAEQVSRTFRDHFQIELITVDAAEEFLAALAGVTDPEQKRKIIGEKFIRIFEREARNLDDAAYL
VQGTLYPDVIESTAPDRNVAVKIKTHHNVGGLPDDMKLKVIEPLRMLFKDEVRAAGLALGLPEDWVWRHPFPGPGLAVRL
LGAISFERLETLRHADAIFLEELRAAGLYRATQQAFAVLLPVQSVGVMGDYRTYADTIAIRAVSTEDFMTADWARLPYEL
LAKVSSRIVNEVTGVNRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=548, Percent_Identity=35.2189781021898, Blast_Score=288, Evalue=9e-78,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=54.0952380952381, Blast_Score=583, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=34.6153846153846, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=34.6153846153846, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=34.5008756567426, Blast_Score=289, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=52.7131782945737, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=35.7664233576642, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56717; Mature: 56586

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNEAIVVLDYGSQYSQLIVRRVREAGVYSELVRFDADEATVAALNPKGIILSGGPNSV
CCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCEEEEECCCCCE
YAEGAPQLPAWVLASNLPVLGICYGLQLQAHHLGGKVEPSNDREFGHAVITITAESPLLA
ECCCCCCCCHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEE
DIPTEHSVWMSHGDRLETLPAGWHPIAISPNSPYAAAADEDRRWYGLQFHPEVVHSPYGK
CCCCCCCHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEEECHHHHCCCCHH
QVLHNFLYRICACAGSWQPSHFIQEAVERIQQQAPSGQVICALSGGVDSAVAALLAHQAI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
VERLTCIFVDNGLLRRGEAEQVSRTFRDHFQIELITVDAAEEFLAALAGVTDPEQKRKII
HHHHHEEEECCCCCCCCCHHHHHHHHHHCEEEEEEEECCHHHHHHHHHCCCCHHHHHHHH
GEKFIRIFEREARNLDDAAYLVQGTLYPDVIESTAPDRNVAVKIKTHHNVGGLPDDMKLK
HHHHHHHHHHHHCCCCCHHHHEECCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHH
VIEPLRMLFKDEVRAAGLALGLPEDWVWRHPFPGPGLAVRLLGAISFERLETLRHADAIF
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEELRAAGLYRATQQAFAVLLPVQSVGVMGDYRTYADTIAIRAVSTEDFMTADWARLPYE
HHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCHHHHHHEEEEEEECCCCCCCCHHHHCCHH
LLAKVSSRIVNEVTGVNRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECC
>Mature Secondary Structure 
TQNEAIVVLDYGSQYSQLIVRRVREAGVYSELVRFDADEATVAALNPKGIILSGGPNSV
CCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCEEEEECCCCCE
YAEGAPQLPAWVLASNLPVLGICYGLQLQAHHLGGKVEPSNDREFGHAVITITAESPLLA
ECCCCCCCCHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEE
DIPTEHSVWMSHGDRLETLPAGWHPIAISPNSPYAAAADEDRRWYGLQFHPEVVHSPYGK
CCCCCCCHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEEECHHHHCCCCHH
QVLHNFLYRICACAGSWQPSHFIQEAVERIQQQAPSGQVICALSGGVDSAVAALLAHQAI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
VERLTCIFVDNGLLRRGEAEQVSRTFRDHFQIELITVDAAEEFLAALAGVTDPEQKRKII
HHHHHEEEECCCCCCCCCHHHHHHHHHHCEEEEEEEECCHHHHHHHHHCCCCHHHHHHHH
GEKFIRIFEREARNLDDAAYLVQGTLYPDVIESTAPDRNVAVKIKTHHNVGGLPDDMKLK
HHHHHHHHHHHHCCCCCHHHHEECCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHH
VIEPLRMLFKDEVRAAGLALGLPEDWVWRHPFPGPGLAVRLLGAISFERLETLRHADAIF
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEELRAAGLYRATQQAFAVLLPVQSVGVMGDYRTYADTIAIRAVSTEDFMTADWARLPYE
HHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCHHHHHHEEEEEEECCCCCCCCHHHHCCHH
LLAKVSSRIVNEVTGVNRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA