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The map label for this gene is napA [H]

Identifier: 159899956

GI number: 159899956

Start: 4326574

End: 4327911

Strand: Reverse

Name: napA [H]

Synonym: Haur_3439

Alternate gene names: 159899956

Gene position: 4327911-4326574 (Counterclockwise)

Preceding gene: 159899967

Following gene: 159899955

Centisome position: 68.19

GC content: 50.9

Gene sequence:

>1338_bases
ATGTCGCTGGTCTTGGTTCAATCCAACGTCGCCCCTTCGCCTGCCGCCGCTGCTGGAGGCGATGGAATGTCGCCGCTGTT
GCAGTTGGTGTTGGCTTTGGCCGTTTTGATCGCCGCTGCCAAAATTGGTGGGCTTGTGAGCACCAAGCTCAAACAACCTG
CCGTTTTAGGCGAGCTTTTAGTGGGGATTTTGCTTGGCCCCAGTGTTTTGGATTTTCTCAACCTAAGCTTTTTCACGAGC
ACCCACTTACAAGATACGGTTTTTGAAATCGCCGAAATTGGGGTGATTTTCTTGATGTTTGTGGCTGGGCTTGAGGTCAA
ATTGCCCGATCTGCTGGCGGCGGGCAAGGTCTCGACAATTGCTGGAGTGTTGGGGGTCATCATCCCATTGCTTGGTGGTT
TTGCTCTCGCGTGGTTCTGGCCTAATAACTATTCATTCACCAAAAGCCTGTTTATTGGCATTTTGCTGACTGCTACCAGC
GTTTCGATTTCGGCCCAAACCTTGCTCGAATTGGGCAAACTGCGCTCGCGGGTTGGGCTATCGTTGTTAGGTGCGGCGAT
TGTCGATGATGTGTTGGTAATTGTCTTGCTTTCGACCTTTGTGGCCTTGACGGCGAGCAGCGGCGGCGGGGTTATGACTG
TGCTGAGCATTGTCGGTGTGATGCTGCTGTATTTCGTGGTGATGAGCATTTTTGGGCTACGCGCTTTGCCATGGATTATT
CGTAAAGCTGCTAAATTGCCAATTAGCCAACCGCTGGTGAGTACGGCACTGGTGTTGGTGCTATTTGCCTCGTGGAGCGC
CGAAGCCTTGGGTGGAGTGGCGGCAATTACGGGGGCATTTTTGATGGGCGTATTTTTGGGCCGCACGCCCTATCACAACC
GGATTGAAGATGGCGTGCAAACCTTGACCTATGCCTTCTTTGTGCCAATTTTCTTTGCCAGCATCGGCTTGCATGCCAAT
ATTTTCTCGTTGCCAAGTGATTTGGTGGCCTTCGCCGCTGTGCTGTGTGTGATTGCTGTGGTTACCAAGATTGTAGGTTG
TGGAATTGGGGCAAAAATTGGCGGCATGAACAATAAAGAATCGTTGCAAGTTGGTTTGGGCATGATTTCGCGGGGCGAAG
TTGGCTTGATTGTGGCCAGCGTGGGTATTCGCCAAGGCATTATTGGCGAAGATGTGTTTGCCATGACCGTGCTGATGGTA
CTTGTAACCACCTTGGTTACTCCCTTATTATTACGCTGGTCGTTTGGCAACGAACAAACACCCAAAGATCAAGAAAAGCC
CAAATCTGAAAAACCCGTACTCAAACCTGCCCATGCTGGCGAAGAAGCAGGTCATTAA

Upstream 100 bases:

>100_bases
GGAGTCAGTCGCAGTAATGCGGCTTTTTTAGTTTAGTTTTGGTTGATTTGACGGATATAGCAGGGTATAGCCGCAAGCAC
GACCAAATTAGGAGGAGCGT

Downstream 100 bases:

>100_bases
TTGGCTTTACAAAGGAGTAAATAATGAATCAACCACAAGTCGAATCGTTAATGTTTATTTTGAATGATGTTGATCTGTTA
AATGAAGTGCTGCGTGTGTG

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSLVLVQSNVAPSPAAAAGGDGMSPLLQLVLALAVLIAAAKIGGLVSTKLKQPAVLGELLVGILLGPSVLDFLNLSFFTS
THLQDTVFEIAEIGVIFLMFVAGLEVKLPDLLAAGKVSTIAGVLGVIIPLLGGFALAWFWPNNYSFTKSLFIGILLTATS
VSISAQTLLELGKLRSRVGLSLLGAAIVDDVLVIVLLSTFVALTASSGGGVMTVLSIVGVMLLYFVVMSIFGLRALPWII
RKAAKLPISQPLVSTALVLVLFASWSAEALGGVAAITGAFLMGVFLGRTPYHNRIEDGVQTLTYAFFVPIFFASIGLHAN
IFSLPSDLVAFAAVLCVIAVVTKIVGCGIGAKIGGMNNKESLQVGLGMISRGEVGLIVASVGIRQGIIGEDVFAMTVLMV
LVTTLVTPLLLRWSFGNEQTPKDQEKPKSEKPVLKPAHAGEEAGH

Sequences:

>Translated_445_residues
MSLVLVQSNVAPSPAAAAGGDGMSPLLQLVLALAVLIAAAKIGGLVSTKLKQPAVLGELLVGILLGPSVLDFLNLSFFTS
THLQDTVFEIAEIGVIFLMFVAGLEVKLPDLLAAGKVSTIAGVLGVIIPLLGGFALAWFWPNNYSFTKSLFIGILLTATS
VSISAQTLLELGKLRSRVGLSLLGAAIVDDVLVIVLLSTFVALTASSGGGVMTVLSIVGVMLLYFVVMSIFGLRALPWII
RKAAKLPISQPLVSTALVLVLFASWSAEALGGVAAITGAFLMGVFLGRTPYHNRIEDGVQTLTYAFFVPIFFASIGLHAN
IFSLPSDLVAFAAVLCVIAVVTKIVGCGIGAKIGGMNNKESLQVGLGMISRGEVGLIVASVGIRQGIIGEDVFAMTVLMV
LVTTLVTPLLLRWSFGNEQTPKDQEKPKSEKPVLKPAHAGEEAGH
>Mature_444_residues
SLVLVQSNVAPSPAAAAGGDGMSPLLQLVLALAVLIAAAKIGGLVSTKLKQPAVLGELLVGILLGPSVLDFLNLSFFTST
HLQDTVFEIAEIGVIFLMFVAGLEVKLPDLLAAGKVSTIAGVLGVIIPLLGGFALAWFWPNNYSFTKSLFIGILLTATSV
SISAQTLLELGKLRSRVGLSLLGAAIVDDVLVIVLLSTFVALTASSGGGVMTVLSIVGVMLLYFVVMSIFGLRALPWIIR
KAAKLPISQPLVSTALVLVLFASWSAEALGGVAAITGAFLMGVFLGRTPYHNRIEDGVQTLTYAFFVPIFFASIGLHANI
FSLPSDLVAFAAVLCVIAVVTKIVGCGIGAKIGGMNNKESLQVGLGMISRGEVGLIVASVGIRQGIIGEDVFAMTVLMVL
VTTLVTPLLLRWSFGNEQTPKDQEKPKSEKPVLKPAHAGEEAGH

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1789749, Length=395, Percent_Identity=27.3417721518987, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786685, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322367, Length=412, Percent_Identity=26.4563106796117, Blast_Score=126, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46398; Mature: 46267

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLVLVQSNVAPSPAAAAGGDGMSPLLQLVLALAVLIAAAKIGGLVSTKLKQPAVLGELL
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VGILLGPSVLDFLNLSFFTSTHLQDTVFEIAEIGVIFLMFVAGLEVKLPDLLAAGKVSTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
AGVLGVIIPLLGGFALAWFWPNNYSFTKSLFIGILLTATSVSISAQTLLELGKLRSRVGL
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLGAAIVDDVLVIVLLSTFVALTASSGGGVMTVLSIVGVMLLYFVVMSIFGLRALPWII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKAAKLPISQPLVSTALVLVLFASWSAEALGGVAAITGAFLMGVFLGRTPYHNRIEDGVQ
HHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TLTYAFFVPIFFASIGLHANIFSLPSDLVAFAAVLCVIAVVTKIVGCGIGAKIGGMNNKE
HHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
SLQVGLGMISRGEVGLIVASVGIRQGIIGEDVFAMTVLMVLVTTLVTPLLLRWSFGNEQT
HHHHHHHHCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PKDQEKPKSEKPVLKPAHAGEEAGH
CCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]