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The map label for this gene is ytpA [H]

Identifier: 159899475

GI number: 159899475

Start: 3729941

End: 3730774

Strand: Reverse

Name: ytpA [H]

Synonym: Haur_2956

Alternate gene names: 159899475

Gene position: 3730774-3729941 (Counterclockwise)

Preceding gene: 159899476

Following gene: 159899473

Centisome position: 58.78

GC content: 49.88

Gene sequence:

>834_bases
ATGGAACATACAACGGCAACATTTACAGGCGGCAACAACACGACGATTTTTTATCAAACATGGCGGCCAGCTGCGCCCAA
AGCCACCGTGGTGGTGGTGCATGGCTACGCCGAACATAGCGGGCGTTATCAACATGTAGCCGAGGCCTTGGTTGCGGCCA
ATTATAGTGTTTGGGCGCTTGATCATCGTGGCCATGGGCAATCGCAAGGCAATCGCGCAACGGTCAAACATTTCGATGAA
TTTGTCAACGATTTAGCCAGTTTTGTGCGCTTGGTGCGCGATAAAGAGCCAAATGGCCCGTTATTTATGCTTGGCCATAG
CATGGGTGGTTTGATCAGCACGCTCTACACGTTGGACTATGGACATAATTTGCATGGCTTGGTTTTGACTGGCCCAGCCT
TCAAAGTTGATGCCACAACTCCCAAAGTGGTGGTAAAAGTTGGGGCGTTTATTAGCAAATTTCTGCCAAACCTACCAGTT
GCCCCATTCGATCCCCAGTGGAACAGCCGCGATCCCAAGGTAGTCGAGGCCTTCAAGGCTGATCCCTTGAATTACAAAGG
TGGCATCAAAGCCCAAATGGGCACATCGATGATCAATGCAACCAAAGTGATCGACCAACGCGCCCACGAAATTAGCTTGC
CAGTGCTGCTCTTGCAAGGCTTAGCTGATCGCTTGGTTAGCCCTGCTGGCGCGATGCATGCCTTTGGATTGTTCAAATCG
CAAGATAAAACCCTGCATAGCTACCCTGGCTTGTATCATGAAGTGCTGAACGAGCCAGAACAAACCACATTAATCCCCTT
AGTTATTGAATGGCTTGATGCGCATATGGCCTAA

Upstream 100 bases:

>100_bases
ACCTTAGTGTTCTTCGCGGTTGCATCCTTCGTGACCTTTGTGGAGCAGAACCGATCCCCGATCCCCAACAACCGATCCCT
AAAAACAGAAAGGCTAGTGC

Downstream 100 bases:

>100_bases
ATTTGCCCATATTTCAAGCCATGCCAAAGCAATTTTGCGCTGTTACGCACCAAGCGCTCGGGATCGATTGTGCCTTGCGG
TGTGATTTGATCTTGGAGCG

Product: alpha/beta hydrolase fold-domain containing protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEHTTATFTGGNNTTIFYQTWRPAAPKATVVVVHGYAEHSGRYQHVAEALVAANYSVWALDHRGHGQSQGNRATVKHFDE
FVNDLASFVRLVRDKEPNGPLFMLGHSMGGLISTLYTLDYGHNLHGLVLTGPAFKVDATTPKVVVKVGAFISKFLPNLPV
APFDPQWNSRDPKVVEAFKADPLNYKGGIKAQMGTSMINATKVIDQRAHEISLPVLLLQGLADRLVSPAGAMHAFGLFKS
QDKTLHSYPGLYHEVLNEPEQTTLIPLVIEWLDAHMA

Sequences:

>Translated_277_residues
MEHTTATFTGGNNTTIFYQTWRPAAPKATVVVVHGYAEHSGRYQHVAEALVAANYSVWALDHRGHGQSQGNRATVKHFDE
FVNDLASFVRLVRDKEPNGPLFMLGHSMGGLISTLYTLDYGHNLHGLVLTGPAFKVDATTPKVVVKVGAFISKFLPNLPV
APFDPQWNSRDPKVVEAFKADPLNYKGGIKAQMGTSMINATKVIDQRAHEISLPVLLLQGLADRLVSPAGAMHAFGLFKS
QDKTLHSYPGLYHEVLNEPEQTTLIPLVIEWLDAHMA
>Mature_277_residues
MEHTTATFTGGNNTTIFYQTWRPAAPKATVVVVHGYAEHSGRYQHVAEALVAANYSVWALDHRGHGQSQGNRATVKHFDE
FVNDLASFVRLVRDKEPNGPLFMLGHSMGGLISTLYTLDYGHNLHGLVLTGPAFKVDATTPKVVVKVGAFISKFLPNLPV
APFDPQWNSRDPKVVEAFKADPLNYKGGIKAQMGTSMINATKVIDQRAHEISLPVLLLQGLADRLVSPAGAMHAFGLFKS
QDKTLHSYPGLYHEVLNEPEQTTLIPLVIEWLDAHMA

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=252, Percent_Identity=40.0793650793651, Blast_Score=171, Evalue=5e-43,
Organism=Homo sapiens, GI6005786, Length=255, Percent_Identity=39.6078431372549, Blast_Score=171, Evalue=5e-43,
Organism=Escherichia coli, GI1787678, Length=266, Percent_Identity=28.1954887218045, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI48994980, Length=313, Percent_Identity=23.961661341853, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 30431; Mature: 30431

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHTTATFTGGNNTTIFYQTWRPAAPKATVVVVHGYAEHSGRYQHVAEALVAANYSVWAL
CCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHCCCEEEEE
DHRGHGQSQGNRATVKHFDEFVNDLASFVRLVRDKEPNGPLFMLGHSMGGLISTLYTLDY
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCC
GHNLHGLVLTGPAFKVDATTPKVVVKVGAFISKFLPNLPVAPFDPQWNSRDPKVVEAFKA
CCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCC
DPLNYKGGIKAQMGTSMINATKVIDQRAHEISLPVLLLQGLADRLVSPAGAMHAFGLFKS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
QDKTLHSYPGLYHEVLNEPEQTTLIPLVIEWLDAHMA
CCCHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHTTATFTGGNNTTIFYQTWRPAAPKATVVVVHGYAEHSGRYQHVAEALVAANYSVWAL
CCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHCCCEEEEE
DHRGHGQSQGNRATVKHFDEFVNDLASFVRLVRDKEPNGPLFMLGHSMGGLISTLYTLDY
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCC
GHNLHGLVLTGPAFKVDATTPKVVVKVGAFISKFLPNLPVAPFDPQWNSRDPKVVEAFKA
CCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCC
DPLNYKGGIKAQMGTSMINATKVIDQRAHEISLPVLLLQGLADRLVSPAGAMHAFGLFKS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
QDKTLHSYPGLYHEVLNEPEQTTLIPLVIEWLDAHMA
CCCHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]