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The map label for this gene is yahK [H]

Identifier: 159899470

GI number: 159899470

Start: 3724388

End: 3725437

Strand: Reverse

Name: yahK [H]

Synonym: Haur_2951

Alternate gene names: 159899470

Gene position: 3725437-3724388 (Counterclockwise)

Preceding gene: 159899471

Following gene: 159899469

Centisome position: 58.7

GC content: 50.57

Gene sequence:

>1050_bases
ATGCTAACGACCAAAGGGTTTGCTGCTTTTAGCGCCGATGCTCCGTTTGCCCCCTTCCAATTCGAGCGCCGCGATTTAAC
TGCCAACGATGTACAAATTGAAATTTTATATTGTGGCATTTGCCATTCCGATTTACATCAAGCCCGCAGCGAGTGGGATG
GCACGGTCTACCCGATTGTGCCTGGCCACGAAATTGTTGGGCGGGTTGTGGCAGTCGGTGCTGACGTGCACAAATTCAAC
CTCGGCGATGCCGTTGGGGTTGGCTGTATGGTCGATTCGTGTGGCGAATGTTTCGATTGCCGCGATGACCAAGAACAATT
CTGCCCGAAAACCACTTATACCTACAATAGCCCTGATTTGCACACTGGCGGCGTAACTTATGGCGGCTATTCCAGCCACA
TTGTGGTTGATCAGCATTTTGTGTTGCGGATTGCTGAGCATTTGGATTTAGCGCGGGTTGCGCCATTGCTCTGTGCTGGC
ATCACGACCTACTCGCCGTTGCACCATTGGAACGTCCAGCCAGGCCAAAAAGTTGGTGTGGTCGGCTTGGGCGGGCTGGG
GCATATTGGGGTGAAAATTGCCAAAGCCATGGGTGCGGAAGTGGTTTTGTTCACCACCTCGCCGCATAAAGCCGCTGATG
CCGAGCGTTTGGGCGCTTCAGTGGTAATCTCCAAAGATGCCGAAGCCATGCGCAGCCAACGCAACAGCTTCGATTTTATT
CTCAATACAGTTTCTGCCGCGCATAATCTCGATGATTATTTAAGCTTGTTGAAACGTGATGGTACGCTCTGCCTCGTTGG
CGTGCCGGAAAATCCTCATCCAACTCCGAGCTACCCCGATTTGATCTTTCGGCGACGGCAATTAACTGGCTCGTTGATTG
GCGGTATCGCCGAAACCCAAGCAATGTTAGATTTTTGTGCTGAACATAATGTTTTGGCGGATATCGAATTAATTGGGGTA
ACCCAAATCGACCAAGCCTACGAACGGATGCTCAAAAGTGATGTCAAATATCGTTTTGTGATTGATCTTGCCAGCCTGTC
AGCCAATTAA

Upstream 100 bases:

>100_bases
GTTAGCGAAACAAGCACCTGTGAAAATAAGCCTTAGGTCATATGCACGGTTAGCATTTTTTGGGTAAACTGCACATATGT
TTTGTTGTAGGAGGAAGCCC

Downstream 100 bases:

>100_bases
TCTGCTGTGGCAACTCAACATGTGGCCTCGTTGTGTCGGTTGAGTTTGAATTAAGGATGATGTATGACTCGGACTATCTC
GCTTGATCAAGCGCGGGCGA

Product: alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MLTTKGFAAFSADAPFAPFQFERRDLTANDVQIEILYCGICHSDLHQARSEWDGTVYPIVPGHEIVGRVVAVGADVHKFN
LGDAVGVGCMVDSCGECFDCRDDQEQFCPKTTYTYNSPDLHTGGVTYGGYSSHIVVDQHFVLRIAEHLDLARVAPLLCAG
ITTYSPLHHWNVQPGQKVGVVGLGGLGHIGVKIAKAMGAEVVLFTTSPHKAADAERLGASVVISKDAEAMRSQRNSFDFI
LNTVSAAHNLDDYLSLLKRDGTLCLVGVPENPHPTPSYPDLIFRRRQLTGSLIGGIAETQAMLDFCAEHNVLADIELIGV
TQIDQAYERMLKSDVKYRFVIDLASLSAN

Sequences:

>Translated_349_residues
MLTTKGFAAFSADAPFAPFQFERRDLTANDVQIEILYCGICHSDLHQARSEWDGTVYPIVPGHEIVGRVVAVGADVHKFN
LGDAVGVGCMVDSCGECFDCRDDQEQFCPKTTYTYNSPDLHTGGVTYGGYSSHIVVDQHFVLRIAEHLDLARVAPLLCAG
ITTYSPLHHWNVQPGQKVGVVGLGGLGHIGVKIAKAMGAEVVLFTTSPHKAADAERLGASVVISKDAEAMRSQRNSFDFI
LNTVSAAHNLDDYLSLLKRDGTLCLVGVPENPHPTPSYPDLIFRRRQLTGSLIGGIAETQAMLDFCAEHNVLADIELIGV
TQIDQAYERMLKSDVKYRFVIDLASLSAN
>Mature_349_residues
MLTTKGFAAFSADAPFAPFQFERRDLTANDVQIEILYCGICHSDLHQARSEWDGTVYPIVPGHEIVGRVVAVGADVHKFN
LGDAVGVGCMVDSCGECFDCRDDQEQFCPKTTYTYNSPDLHTGGVTYGGYSSHIVVDQHFVLRIAEHLDLARVAPLLCAG
ITTYSPLHHWNVQPGQKVGVVGLGGLGHIGVKIAKAMGAEVVLFTTSPHKAADAERLGASVVISKDAEAMRSQRNSFDFI
LNTVSAAHNLDDYLSLLKRDGTLCLVGVPENPHPTPSYPDLIFRRRQLTGSLIGGIAETQAMLDFCAEHNVLADIELIGV
TQIDQAYERMLKSDVKYRFVIDLASLSAN

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=25.4691689008043, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501929, Length=334, Percent_Identity=25.1497005988024, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI34577061, Length=334, Percent_Identity=25.748502994012, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4501939, Length=349, Percent_Identity=25.7879656160458, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=25.7879656160458, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71565152, Length=324, Percent_Identity=23.4567901234568, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262073058, Length=319, Percent_Identity=24.7648902821317, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI71743840, Length=319, Percent_Identity=24.7648902821317, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71565154, Length=243, Percent_Identity=27.5720164609054, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=60.9195402298851, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=32.8488372093023, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081918, Length=325, Percent_Identity=25.2307692307692, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788073, Length=256, Percent_Identity=28.515625, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790045, Length=284, Percent_Identity=26.056338028169, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=24.585635359116, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI226510992, Length=250, Percent_Identity=27.6, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786825, Length=192, Percent_Identity=28.6458333333333, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1788407, Length=252, Percent_Identity=26.5873015873016, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=348, Percent_Identity=26.4367816091954, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=324, Percent_Identity=29.0123456790123, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17562582, Length=325, Percent_Identity=27.6923076923077, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=331, Percent_Identity=25.0755287009063, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=333, Percent_Identity=24.9249249249249, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=256, Percent_Identity=26.171875, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=297, Percent_Identity=25.2525252525253, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=213, Percent_Identity=29.5774647887324, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=329, Percent_Identity=35.8662613981763, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319949, Length=328, Percent_Identity=34.7560975609756, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=29.7619047619048, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324486, Length=336, Percent_Identity=29.1666666666667, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=27.7286135693215, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323729, Length=323, Percent_Identity=28.7925696594427, Blast_Score=145, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=329, Percent_Identity=26.7477203647416, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=360, Percent_Identity=23.6111111111111, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=24.0641711229947, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37963; Mature: 37963

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTKGFAAFSADAPFAPFQFERRDLTANDVQIEILYCGICHSDLHQARSEWDGTVYPIV
CCCCCCCEEECCCCCCCCCEECCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCEEEEEC
PGHEIVGRVVAVGADVHKFNLGDAVGVGCMVDSCGECFDCRDDQEQFCPKTTYTYNSPDL
CCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEECCCCCC
HTGGVTYGGYSSHIVVDQHFVLRIAEHLDLARVAPLLCAGITTYSPLHHWNVQPGQKVGV
CCCCEEECCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCCEEEE
VGLGGLGHIGVKIAKAMGAEVVLFTTSPHKAADAERLGASVVISKDAEAMRSQRNSFDFI
EEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCEEEEECCHHHHHHHCCCHHHH
LNTVSAAHNLDDYLSLLKRDGTLCLVGVPENPHPTPSYPDLIFRRRQLTGSLIGGIAETQ
HHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AMLDFCAEHNVLADIELIGVTQIDQAYERMLKSDVKYRFVIDLASLSAN
HHHHHHHCCCEEEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MLTTKGFAAFSADAPFAPFQFERRDLTANDVQIEILYCGICHSDLHQARSEWDGTVYPIV
CCCCCCCEEECCCCCCCCCEECCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCEEEEEC
PGHEIVGRVVAVGADVHKFNLGDAVGVGCMVDSCGECFDCRDDQEQFCPKTTYTYNSPDL
CCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEECCCCCC
HTGGVTYGGYSSHIVVDQHFVLRIAEHLDLARVAPLLCAGITTYSPLHHWNVQPGQKVGV
CCCCEEECCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCCEEEE
VGLGGLGHIGVKIAKAMGAEVVLFTTSPHKAADAERLGASVVISKDAEAMRSQRNSFDFI
EEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCEEEEECCHHHHHHHCCCHHHH
LNTVSAAHNLDDYLSLLKRDGTLCLVGVPENPHPTPSYPDLIFRRRQLTGSLIGGIAETQ
HHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AMLDFCAEHNVLADIELIGVTQIDQAYERMLKSDVKYRFVIDLASLSAN
HHHHHHHCCCEEEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]