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The map label for this gene is galR [H]

Identifier: 159898986

GI number: 159898986

Start: 3154083

End: 3155093

Strand: Direct

Name: galR [H]

Synonym: Haur_2467

Alternate gene names: 159898986

Gene position: 3154083-3155093 (Clockwise)

Preceding gene: 159898984

Following gene: 159898988

Centisome position: 49.7

GC content: 48.96

Gene sequence:

>1011_bases
ATGACTGGAAGTAAACGGATCACCATCCATGATATTGCACGCAAAGCTGGCGTATCACCCAGTACTGTCTCGCGGGTCTT
GAACAGCACCACACCTGTAGCCGAAGCCAAACGCCAAGCTGTAACAACGGCGATTCAACAGTTGGATTATCGCCCAAATC
TGATTGCCCAAGGCTTGGCTCGTGGCACATCGACGATTATTGGCGTGCTGACCCAAGATATTGGTAGCCCGTTTTATGGC
GAGTTACTGCGCGGCATCGAATATGGATTTCGTGGCAGTCGCTATCACCCGATTTTTGCCGATGGCAACTGGCAACAAGC
TGAGGAATACAACGCATTAAACATTCTGCGCTCACGCCAACCTGAGGCATTAATTATTTTAGGTGGTTTAATGCCTGATG
CCGAAATGTTGGCCGCAGCCCAAGAATTTCCCTTGATCATTATTGGGCGAAGTGTGCCAAGTTTGGAAGAATATTGTGTT
TTGGTTGATAATTTCCAAGGAGCTTATCGCGCAACCCAATATTTAATTGAAATGGGCCATCAGCGGATTGCCCATATTAC
TGGAATTCGCAGCCATCAAGATACACTTGATCGCCAGGCAGGCTACGAACAAGCCCTGCGCGATGCCAACTTGCCAATTA
ATCCCGACCTGATTGTTGAGGGAACGTTTCAAGAACAATCGGGCTTACTAGCCGTCGAAACCTTATTAATGCGAGCAAAC
CCGTTTACCGCCCTCTTTGCAGCCAATGATCAAATGGCCTATGGTGCTCGCTTAGCGCTCTATCGGCGAGGAATTCGGGT
GCCCGAAGATGTTTCGCTGATTGGCTTTGATGATTTGCCAAGCTCAGCCTATACCACGCCCCCATTAACTACTGTTCGCC
AACCAACCTTCGAAATGGGCATGAGTGCAGCCAAAGCAACGCTTAATTTAATCGATCAACGGCCATGGCCATTGCCTCAG
CTAACTCCCGATTTAGTGATTCGTGAGTCAACTGGCTTCGCACGGCGTTAA

Upstream 100 bases:

>100_bases
CGGCAGAAGCCCATGCTTTGCATTCAAACGGGAATATGGTATTGTTGATGCTCATTATGAAACGATTGATAGCTTGGAAG
CGCTAGTTTGGTTAAGCACT

Downstream 100 bases:

>100_bases
ATAGCAATCGCAGCAAGCAAAAATCTATGGTGATTAATGGAGAGATTTGTGAGAAGGGGATTGATGGTGGGCCATGAGGG
ATTCGAACCCCCAACCAAGC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTGSKRITIHDIARKAGVSPSTVSRVLNSTTPVAEAKRQAVTTAIQQLDYRPNLIAQGLARGTSTIIGVLTQDIGSPFYG
ELLRGIEYGFRGSRYHPIFADGNWQQAEEYNALNILRSRQPEALIILGGLMPDAEMLAAAQEFPLIIIGRSVPSLEEYCV
LVDNFQGAYRATQYLIEMGHQRIAHITGIRSHQDTLDRQAGYEQALRDANLPINPDLIVEGTFQEQSGLLAVETLLMRAN
PFTALFAANDQMAYGARLALYRRGIRVPEDVSLIGFDDLPSSAYTTPPLTTVRQPTFEMGMSAAKATLNLIDQRPWPLPQ
LTPDLVIRESTGFARR

Sequences:

>Translated_336_residues
MTGSKRITIHDIARKAGVSPSTVSRVLNSTTPVAEAKRQAVTTAIQQLDYRPNLIAQGLARGTSTIIGVLTQDIGSPFYG
ELLRGIEYGFRGSRYHPIFADGNWQQAEEYNALNILRSRQPEALIILGGLMPDAEMLAAAQEFPLIIIGRSVPSLEEYCV
LVDNFQGAYRATQYLIEMGHQRIAHITGIRSHQDTLDRQAGYEQALRDANLPINPDLIVEGTFQEQSGLLAVETLLMRAN
PFTALFAANDQMAYGARLALYRRGIRVPEDVSLIGFDDLPSSAYTTPPLTTVRQPTFEMGMSAAKATLNLIDQRPWPLPQ
LTPDLVIRESTGFARR
>Mature_335_residues
TGSKRITIHDIARKAGVSPSTVSRVLNSTTPVAEAKRQAVTTAIQQLDYRPNLIAQGLARGTSTIIGVLTQDIGSPFYGE
LLRGIEYGFRGSRYHPIFADGNWQQAEEYNALNILRSRQPEALIILGGLMPDAEMLAAAQEFPLIIIGRSVPSLEEYCVL
VDNFQGAYRATQYLIEMGHQRIAHITGIRSHQDTLDRQAGYEQALRDANLPINPDLIVEGTFQEQSGLLAVETLLMRANP
FTALFAANDQMAYGARLALYRRGIRVPEDVSLIGFDDLPSSAYTTPPLTTVRQPTFEMGMSAAKATLNLIDQRPWPLPQL
TPDLVIRESTGFARR

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789202, Length=328, Percent_Identity=37.8048780487805, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1788474, Length=303, Percent_Identity=38.2838283828383, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1790369, Length=307, Percent_Identity=35.5048859934853, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787948, Length=331, Percent_Identity=32.3262839879154, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789068, Length=302, Percent_Identity=35.4304635761589, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790194, Length=327, Percent_Identity=33.6391437308869, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787906, Length=323, Percent_Identity=30.3405572755418, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787580, Length=319, Percent_Identity=29.153605015674, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=29.4498381877023, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=28.955223880597, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790715, Length=322, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789456, Length=330, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790689, Length=328, Percent_Identity=24.0853658536585, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786268, Length=321, Percent_Identity=21.8068535825545, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37098; Mature: 36967

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSKRITIHDIARKAGVSPSTVSRVLNSTTPVAEAKRQAVTTAIQQLDYRPNLIAQGLA
CCCCCEEEHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RGTSTIIGVLTQDIGSPFYGELLRGIEYGFRGSRYHPIFADGNWQQAEEYNALNILRSRQ
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCC
PEALIILGGLMPDAEMLAAAQEFPLIIIGRSVPSLEEYCVLVDNFQGAYRATQYLIEMGH
CCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHEEEEECCCHHHHHHHHHHHHHH
QRIAHITGIRSHQDTLDRQAGYEQALRDANLPINPDLIVEGTFQEQSGLLAVETLLMRAN
HHHHHHHCCCHHHHHHHHHHCHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PFTALFAANDQMAYGARLALYRRGIRVPEDVSLIGFDDLPSSAYTTPPLTTVRQPTFEMG
CCEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
MSAAKATLNLIDQRPWPLPQLTPDLVIRESTGFARR
HHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure 
TGSKRITIHDIARKAGVSPSTVSRVLNSTTPVAEAKRQAVTTAIQQLDYRPNLIAQGLA
CCCCEEEHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RGTSTIIGVLTQDIGSPFYGELLRGIEYGFRGSRYHPIFADGNWQQAEEYNALNILRSRQ
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCC
PEALIILGGLMPDAEMLAAAQEFPLIIIGRSVPSLEEYCVLVDNFQGAYRATQYLIEMGH
CCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHEEEEECCCHHHHHHHHHHHHHH
QRIAHITGIRSHQDTLDRQAGYEQALRDANLPINPDLIVEGTFQEQSGLLAVETLLMRAN
HHHHHHHCCCHHHHHHHHHHCHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PFTALFAANDQMAYGARLALYRRGIRVPEDVSLIGFDDLPSSAYTTPPLTTVRQPTFEMG
CCEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
MSAAKATLNLIDQRPWPLPQLTPDLVIRESTGFARR
HHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6283521; 9278503; 6350601; 8188660; 8982002 [H]