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The map label for this gene is 159898677

Identifier: 159898677

GI number: 159898677

Start: 2717011

End: 2718216

Strand: Direct

Name: 159898677

Synonym: Haur_2156

Alternate gene names: NA

Gene position: 2717011-2718216 (Clockwise)

Preceding gene: 159898675

Following gene: 159898682

Centisome position: 42.81

GC content: 51.16

Gene sequence:

>1206_bases
TTGAAGCGTCTATGGCTAAGTACGTTGGTTGTCGGCTGTTTGCTTGGTTTGGCTACTCCTACAAACACTGCTGGGCAGAC
TCGTTTGAAAGAAAAAACACCTGAACAATTGGCTGAGGCCGAAGCACCCGCAGTTGCCGGCCAATACCTGATTAAATTTA
AGCCTGCGCTGAATACAGCATCTCGCAGCACCACCCTTAAAAACCTCGGAGCCGATCATCTCCAACATCTCGCTAGCCTT
GATCTTGAGTTAATTGAATTTGCTCCACTCAAGCAGAACGCTACTCCAGAGCAAACTGAACGAGTGCTGGCCGAGCTAAA
AAACCATCCAGCAATTGAATATGTTGAGCCAAACTACCTCTATGCCCCACTGTATACGCCGAACGATCCTGGGTTGGGCC
AACAATGGGCTTGGGGAGTCATCAAAGCCTATGATGGTTGGAATATTACCCAAGGTAGCTCTAGCGTGATCATCGCGATT
GTTGACACTGGCATCCAAACCAACCACCCTGATCTTGATGCCAAAATTGTGGCTGGCTACGATTTTGTTGATAACGATAC
CAACGCGATGGATGGCAATGGTCATGGTACGCACTTAGCAGGCACAGCCGCCGCTGAAACCAACAATAGCACTGGTGGCG
CAGGGTTATGCCCCAATTGTCGCTTGATGCCAATCCGTGTTTTCAACAATAATGGCAGTGGTACCCTGGCTGCTGTGGCC
CAAGGCATTACTTTTGCTGCCAACAACGGAGCCAAAGTGATCAACTTAGGCTTGGGTGGCAGTGCCTCAACAACCCTGCA
AAATGCAGTTAATTACGCGTGGAACAAAGGTGCCTTCTTGACCTGTGCGGTTGGTGGCAGTAACTCGGGCACGCCAACCT
ATCCAGCAGCCTACCCCAACTGCTTCCCCGTGGCGGCTAGCGGCAAAACCGATATTAAAACACCTTCCTCAGGCTATGGC
ACATGGGTCAAAGTGGCGGCTCCCGGGGCAAGCATCTATTCAACCTGGCTCAACGGCGGCTATACCACAATTAGCGGTAC
CTCAACCGCTACCGCCCATGTTTCAGGTTTAGCAGGCTTGTTGGCCTCGCAAAACCGTACCAATGCCCAAATTCGCGATC
GCATTTGCGCCACCGCTGATCCAATTGCGGGCACTGGAACTTACTGGTCATGTGGCCGGATTAATGTTTATGCCGCTGTG
CAATAA

Upstream 100 bases:

>100_bases
TTGTGGTCAACATTGTTGCTCAGGTGCAGGTACGACCGCCAGTTGGAAGCGTACTGGATAACCGTTTGTTGCAACCATTT
CATTTGTTGAGGAGGCTCTC

Downstream 100 bases:

>100_bases
ACCCATTTTATATTGGATTAACGGCAGCTAGGTGGTCGATGTAATGGGTTAACACCTTGTCACCGTCCCTCACCCCAAGC
CTCTCGCCCACGACGACGCA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKRLWLSTLVVGCLLGLATPTNTAGQTRLKEKTPEQLAEAEAPAVAGQYLIKFKPALNTASRSTTLKNLGADHLQHLASL
DLELIEFAPLKQNATPEQTERVLAELKNHPAIEYVEPNYLYAPLYTPNDPGLGQQWAWGVIKAYDGWNITQGSSSVIIAI
VDTGIQTNHPDLDAKIVAGYDFVDNDTNAMDGNGHGTHLAGTAAAETNNSTGGAGLCPNCRLMPIRVFNNNGSGTLAAVA
QGITFAANNGAKVINLGLGGSASTTLQNAVNYAWNKGAFLTCAVGGSNSGTPTYPAAYPNCFPVAASGKTDIKTPSSGYG
TWVKVAAPGASIYSTWLNGGYTTISGTSTATAHVSGLAGLLASQNRTNAQIRDRICATADPIAGTGTYWSCGRINVYAAV
Q

Sequences:

>Translated_401_residues
MKRLWLSTLVVGCLLGLATPTNTAGQTRLKEKTPEQLAEAEAPAVAGQYLIKFKPALNTASRSTTLKNLGADHLQHLASL
DLELIEFAPLKQNATPEQTERVLAELKNHPAIEYVEPNYLYAPLYTPNDPGLGQQWAWGVIKAYDGWNITQGSSSVIIAI
VDTGIQTNHPDLDAKIVAGYDFVDNDTNAMDGNGHGTHLAGTAAAETNNSTGGAGLCPNCRLMPIRVFNNNGSGTLAAVA
QGITFAANNGAKVINLGLGGSASTTLQNAVNYAWNKGAFLTCAVGGSNSGTPTYPAAYPNCFPVAASGKTDIKTPSSGYG
TWVKVAAPGASIYSTWLNGGYTTISGTSTATAHVSGLAGLLASQNRTNAQIRDRICATADPIAGTGTYWSCGRINVYAAV
Q
>Mature_401_residues
MKRLWLSTLVVGCLLGLATPTNTAGQTRLKEKTPEQLAEAEAPAVAGQYLIKFKPALNTASRSTTLKNLGADHLQHLASL
DLELIEFAPLKQNATPEQTERVLAELKNHPAIEYVEPNYLYAPLYTPNDPGLGQQWAWGVIKAYDGWNITQGSSSVIIAI
VDTGIQTNHPDLDAKIVAGYDFVDNDTNAMDGNGHGTHLAGTAAAETNNSTGGAGLCPNCRLMPIRVFNNNGSGTLAAVA
QGITFAANNGAKVINLGLGGSASTTLQNAVNYAWNKGAFLTCAVGGSNSGTPTYPAAYPNCFPVAASGKTDIKTPSSGYG
TWVKVAAPGASIYSTWLNGGYTTISGTSTATAHVSGLAGLLASQNRTNAQIRDRICATADPIAGTGTYWSCGRINVYAAV
Q

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI31317307, Length=253, Percent_Identity=28.0632411067194, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI76443679, Length=177, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=283, Percent_Identity=30.0353356890459, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324576, Length=219, Percent_Identity=31.9634703196347, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319893, Length=218, Percent_Identity=32.1100917431193, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 41862; Mature: 41862

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLWLSTLVVGCLLGLATPTNTAGQTRLKEKTPEQLAEAEAPAVAGQYLIKFKPALNTA
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHCCCHHCCEEEEEEECCCCCC
SRSTTLKNLGADHLQHLASLDLELIEFAPLKQNATPEQTERVLAELKNHPAIEYVEPNYL
HHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEE
YAPLYTPNDPGLGQQWAWGVIKAYDGWNITQGSSSVIIAIVDTGIQTNHPDLDAKIVAGY
EEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCCEEEEEEECCCCCCCCCCCEEEEECC
DFVDNDTNAMDGNGHGTHLAGTAAAETNNSTGGAGLCPNCRLMPIRVFNNNGSGTLAAVA
EEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCEEHHHHH
QGITFAANNGAKVINLGLGGSASTTLQNAVNYAWNKGAFLTCAVGGSNSGTPTYPAAYPN
CCEEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
CFPVAASGKTDIKTPSSGYGTWVKVAAPGASIYSTWLNGGYTTISGTSTATAHVSGLAGL
CEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
LASQNRTNAQIRDRICATADPIAGTGTYWSCGRINVYAAVQ
HHCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCEEEEEEEC
>Mature Secondary Structure
MKRLWLSTLVVGCLLGLATPTNTAGQTRLKEKTPEQLAEAEAPAVAGQYLIKFKPALNTA
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHCCCHHCCEEEEEEECCCCCC
SRSTTLKNLGADHLQHLASLDLELIEFAPLKQNATPEQTERVLAELKNHPAIEYVEPNYL
HHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEE
YAPLYTPNDPGLGQQWAWGVIKAYDGWNITQGSSSVIIAIVDTGIQTNHPDLDAKIVAGY
EEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCCEEEEEEECCCCCCCCCCCEEEEECC
DFVDNDTNAMDGNGHGTHLAGTAAAETNNSTGGAGLCPNCRLMPIRVFNNNGSGTLAAVA
EEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCEEHHHHH
QGITFAANNGAKVINLGLGGSASTTLQNAVNYAWNKGAFLTCAVGGSNSGTPTYPAAYPN
CCEEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
CFPVAASGKTDIKTPSSGYGTWVKVAAPGASIYSTWLNGGYTTISGTSTATAHVSGLAGL
CEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
LASQNRTNAQIRDRICATADPIAGTGTYWSCGRINVYAAVQ
HHCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]