Click here to switch to the map view.

The map label for this gene is yciC [H]

Identifier: 159898584

GI number: 159898584

Start: 2573262

End: 2574455

Strand: Direct

Name: yciC [H]

Synonym: Haur_2062

Alternate gene names: 159898584

Gene position: 2573262-2574455 (Clockwise)

Preceding gene: 159898583

Following gene: 159898585

Centisome position: 40.55

GC content: 51.59

Gene sequence:

>1194_bases
ATGGCGAAACTTCCCGTTACTGTGCTTTCTGGGTTTCTTGGTGCCGGTAAGACAACCGTCTTGAATCATGTCCTAACCAA
TCGTGCAGGCCTCCGCGTCGCCGTGATTGTAAACGATATGAGTGAGATCAATATTGATGCCCAATTGATCACCGAAGGGA
CGGCCCAGCTCAGTCGCACGAAGGAAGCCTTGGTCGAACTGTCAAACGGCTGTATTTGTTGTACCCTACGCGATGATCTG
CTACGCGAAGTCGCTCGTTTGGCACGCGATGGGCGCTTCGATTATCTGTTGATTGAATCAACTGGCATTTCAGAGCCATT
ACCGGTCGCGATGACCTTTAGCTTTGAGACCCCTGATGGGATTGACCGCCTCGTCGATATCGCTCAGTTGGATACCATGG
TAACGGTTGTTGATGCCCATACATGGCTTGCTGACTATCGTGCTGGTCAGGCGTTGCATACGTTGGATATGGGAATCAGT
CCTGCTGATCACCGCACCATTGCCGATCTGCTTATTGACCAAGTTGAGTTTGCCAATGTTATTGTGCTGAACAAGATCGA
TTTAGTTGATACGCGGCAACTTCATGAACTCGAAGGGGTCTTGCATACCTTGAACCCGGATGCGCGAGTTCTGCATGCAA
CCAATGGTGTCATTGAACCAACAGCGATTCTCCATACCGGATTATTTGACATGGAGCGTGCGCAACAATCCGCTGGCTGG
ATCAAAGAGCTGAATGGTGAGCATACCCCCGAAACCGAAGCGTATGGAATTGGCAGTGTTGTGTTTCGCGCACGGCGACC
GTTTCATCCGCAACGGCTATTGAGCGTGCTCACCGGACCAGAACTCCAACCCGTCCTGCGTTCGAAAGGGGTCTTGTGGC
TTGCGTCACGCCATGATCACGGGTTGCGGTGGTCGTTAGCGGGGAAGATTGCCCGGGTTTCAGACAGTGGTGCGTGGCTT
GCCGCGACTCCTGACGATACGTGGCCACAAAACGATCAAGTAGGCATATACATCGAACGGTATTGGCAAGAACCGTTTGG
TGATCGCCGCCAAGAGTTAGTGTTTATTGGCATTGATATGCCACATGAGCAATTGGTCGCAAAACTCGAACACGCGTTAT
TAACCGACCAAGAACTTGCGGCTGGCCCGCCGCTGTGGAAGCGATTTGAAGATCTGTTTCCGCATTTTAACTGA

Upstream 100 bases:

>100_bases
TAAACACGGAGGTCACGCGCTTGGTGAAGTTGCCTGTTTTTTGTTTTATTGATATATTGTATCAATAAGAATTCGCATTG
GAACCATAAGGAGCATCCCG

Downstream 100 bases:

>100_bases
TCCAGAGGCATGGTAAGGATGCACGATAAACGGTCCACTGCCAAAATCACGACGCTCTTGACTCTAGGCTGGACGAAATT
CGCTGCCGCGACCCGTTTGG

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MAKLPVTVLSGFLGAGKTTVLNHVLTNRAGLRVAVIVNDMSEINIDAQLITEGTAQLSRTKEALVELSNGCICCTLRDDL
LREVARLARDGRFDYLLIESTGISEPLPVAMTFSFETPDGIDRLVDIAQLDTMVTVVDAHTWLADYRAGQALHTLDMGIS
PADHRTIADLLIDQVEFANVIVLNKIDLVDTRQLHELEGVLHTLNPDARVLHATNGVIEPTAILHTGLFDMERAQQSAGW
IKELNGEHTPETEAYGIGSVVFRARRPFHPQRLLSVLTGPELQPVLRSKGVLWLASRHDHGLRWSLAGKIARVSDSGAWL
AATPDDTWPQNDQVGIYIERYWQEPFGDRRQELVFIGIDMPHEQLVAKLEHALLTDQELAAGPPLWKRFEDLFPHFN

Sequences:

>Translated_397_residues
MAKLPVTVLSGFLGAGKTTVLNHVLTNRAGLRVAVIVNDMSEINIDAQLITEGTAQLSRTKEALVELSNGCICCTLRDDL
LREVARLARDGRFDYLLIESTGISEPLPVAMTFSFETPDGIDRLVDIAQLDTMVTVVDAHTWLADYRAGQALHTLDMGIS
PADHRTIADLLIDQVEFANVIVLNKIDLVDTRQLHELEGVLHTLNPDARVLHATNGVIEPTAILHTGLFDMERAQQSAGW
IKELNGEHTPETEAYGIGSVVFRARRPFHPQRLLSVLTGPELQPVLRSKGVLWLASRHDHGLRWSLAGKIARVSDSGAWL
AATPDDTWPQNDQVGIYIERYWQEPFGDRRQELVFIGIDMPHEQLVAKLEHALLTDQELAAGPPLWKRFEDLFPHFN
>Mature_396_residues
AKLPVTVLSGFLGAGKTTVLNHVLTNRAGLRVAVIVNDMSEINIDAQLITEGTAQLSRTKEALVELSNGCICCTLRDDLL
REVARLARDGRFDYLLIESTGISEPLPVAMTFSFETPDGIDRLVDIAQLDTMVTVVDAHTWLADYRAGQALHTLDMGISP
ADHRTIADLLIDQVEFANVIVLNKIDLVDTRQLHELEGVLHTLNPDARVLHATNGVIEPTAILHTGLFDMERAQQSAGWI
KELNGEHTPETEAYGIGSVVFRARRPFHPQRLLSVLTGPELQPVLRSKGVLWLASRHDHGLRWSLAGKIARVSDSGAWLA
ATPDDTWPQNDQVGIYIERYWQEPFGDRRQELVFIGIDMPHEQLVAKLEHALLTDQELAAGPPLWKRFEDLFPHFN

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=230, Percent_Identity=33.0434782608696, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI126722884, Length=230, Percent_Identity=32.6086956521739, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI146231952, Length=230, Percent_Identity=32.6086956521739, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI223941779, Length=213, Percent_Identity=33.8028169014084, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI148727351, Length=230, Percent_Identity=32.1739130434783, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI119120938, Length=139, Percent_Identity=38.8489208633094, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223941776, Length=218, Percent_Identity=31.1926605504587, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI87082430, Length=382, Percent_Identity=29.0575916230367, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788499, Length=309, Percent_Identity=24.9190938511327, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324356, Length=217, Percent_Identity=29.4930875576037, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 44179; Mature: 44048

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLPVTVLSGFLGAGKTTVLNHVLTNRAGLRVAVIVNDMSEINIDAQLITEGTAQLSRT
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCCEEEHHHHHHHHHH
KEALVELSNGCICCTLRDDLLREVARLARDGRFDYLLIESTGISEPLPVAMTFSFETPDG
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCH
IDRLVDIAQLDTMVTVVDAHTWLADYRAGQALHTLDMGISPADHRTIADLLIDQVEFANV
HHHHHHHHHHHHHEEEHHHHHHHHHHHCCCEEEHHHCCCCCCCHHHHHHHHHHHHHHCCE
IVLNKIDLVDTRQLHELEGVLHTLNPDARVLHATNGVIEPTAILHTGLFDMERAQQSAGW
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCHHHHHHHHHHCCH
IKELNGEHTPETEAYGIGSVVFRARRPFHPQRLLSVLTGPELQPVLRSKGVLWLASRHDH
HHHCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCCEEEEEECCCC
GLRWSLAGKIARVSDSGAWLAATPDDTWPQNDQVGIYIERYWQEPFGDRRQELVFIGIDM
CCEEEECCCEEEECCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCC
PHEQLVAKLEHALLTDQELAAGPPLWKRFEDLFPHFN
CHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKLPVTVLSGFLGAGKTTVLNHVLTNRAGLRVAVIVNDMSEINIDAQLITEGTAQLSRT
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCCEEEHHHHHHHHHH
KEALVELSNGCICCTLRDDLLREVARLARDGRFDYLLIESTGISEPLPVAMTFSFETPDG
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCH
IDRLVDIAQLDTMVTVVDAHTWLADYRAGQALHTLDMGISPADHRTIADLLIDQVEFANV
HHHHHHHHHHHHHEEEHHHHHHHHHHHCCCEEEHHHCCCCCCCHHHHHHHHHHHHHHCCE
IVLNKIDLVDTRQLHELEGVLHTLNPDARVLHATNGVIEPTAILHTGLFDMERAQQSAGW
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCHHHHHHHHHHCCH
IKELNGEHTPETEAYGIGSVVFRARRPFHPQRLLSVLTGPELQPVLRSKGVLWLASRHDH
HHHCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCCEEEEEECCCC
GLRWSLAGKIARVSDSGAWLAATPDDTWPQNDQVGIYIERYWQEPFGDRRQELVFIGIDM
CCEEEECCCEEEECCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCC
PHEQLVAKLEHALLTDQELAAGPPLWKRFEDLFPHFN
CHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]