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The map label for this gene is serC

Identifier: 159898243

GI number: 159898243

Start: 2001134

End: 2002216

Strand: Direct

Name: serC

Synonym: Haur_1719

Alternate gene names: 159898243

Gene position: 2001134-2002216 (Clockwise)

Preceding gene: 159898240

Following gene: 159898247

Centisome position: 31.53

GC content: 50.42

Gene sequence:

>1083_bases
ATGACGGTCTACAACTTCAATGCCGGTCCTGCGATTTTGCCACCCAGTGTTTTGAGCCAAGCCCAAGAAGAACTTCGCGA
TTTTGCGGGCACTGGCATTTCGGTGATGGAAACCAGCCATCGCGCTAAAGAATTCGAAGCGGTTAATAACGAAGTCGAAG
CTCGTTTTAAGGCTTTGCTGGGCATCGAAAGCGGCTATCGGGTTTTGTTGCTACAAGGCGGAGCCAGCACCCAATTTGCC
ATGATTCCCATGAATTTCTTGGGAGCGGATCAGGTTGCTGATTACATCATCACGGGCACATGGGCCGAAAAAGCCCGTGA
TGAAGCCCAAAAAATCGGCAAGGTGCATATTGCGGCTACTACTGAAGCCGAAAATCACAACCGTATCCCCAGCCAAACTG
AACTGCAATTCAGCGAAAATCCAGTGTATGTGCACTTAACCACCAATAACACGATTTATGGCACCCAATGGCAGAGCACC
CCGGAAACCAACGGCGTGCCAATTGTCGCCGATATGAGCAGCGATATTTTTTCGCGGCCTTTCGATGCTAGCAAGTTTGG
TTTAGTCTATGCTGGCGCACAGAAAAATCTTGGGCCTTCTGGCGTAACTGTGGTGCTGATTCGCGAAGATTGGCTGGATA
AAGGCGCGAAAAACGTGCCCACTATGTTGCGCTATAGCACGCACGCTAAAAACAACTCGCTCTATAACACCCCACCAACT
TTTGGGGTCTATATGCTGAACCTCGTTTTAGCTTGGATTCAAGAGCAAGGTGGTTTGGCGGGCATGGCTGAATACAACAC
CCGTAAAGCCAATGTTGTCTATAATGCGATCGATAATTCGGGTGGTTTCTATCGTGGTCATGCCGTGGCTGATAGCCGCT
CCCAAATGAATGTAACCTTTAATCTACCCACCCAAGAGCTTGAAAAGCAATTCTTGGCCGAAGCCAAAGCCCAAGGCATG
ATCGGCTTGCCAGGTCACCGTTCGGTTGGCGGGGTGCGGGCCTCGATCTACAATGCCATGAGCATCGAAGGGGTTGAAGC
CCTCGCCAGCTTTATGGCCCATTTTGCCGCCAAACAAGGCTAG

Upstream 100 bases:

>100_bases
AAACTGCTGGCAATGCTGCCTGAGCTAAACGACCACCTCGTGTTCAACGTTGAATACGTTTGGATAGGGGCTTTTTTTGT
TTGCGCCGAGGAGTGTACAA

Downstream 100 bases:

>100_bases
TTAACTGCAATCAAGCGCTCAGCGACAGGATGGTGAGCCTGTTGCTGAGCGCTTTGCTGAGCTTATTCTGCTTGAAATGC
CACAACTGGGCCTTGGACAC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTVYNFNAGPAILPPSVLSQAQEELRDFAGTGISVMETSHRAKEFEAVNNEVEARFKALLGIESGYRVLLLQGGASTQFA
MIPMNFLGADQVADYIITGTWAEKARDEAQKIGKVHIAATTEAENHNRIPSQTELQFSENPVYVHLTTNNTIYGTQWQST
PETNGVPIVADMSSDIFSRPFDASKFGLVYAGAQKNLGPSGVTVVLIREDWLDKGAKNVPTMLRYSTHAKNNSLYNTPPT
FGVYMLNLVLAWIQEQGGLAGMAEYNTRKANVVYNAIDNSGGFYRGHAVADSRSQMNVTFNLPTQELEKQFLAEAKAQGM
IGLPGHRSVGGVRASIYNAMSIEGVEALASFMAHFAAKQG

Sequences:

>Translated_360_residues
MTVYNFNAGPAILPPSVLSQAQEELRDFAGTGISVMETSHRAKEFEAVNNEVEARFKALLGIESGYRVLLLQGGASTQFA
MIPMNFLGADQVADYIITGTWAEKARDEAQKIGKVHIAATTEAENHNRIPSQTELQFSENPVYVHLTTNNTIYGTQWQST
PETNGVPIVADMSSDIFSRPFDASKFGLVYAGAQKNLGPSGVTVVLIREDWLDKGAKNVPTMLRYSTHAKNNSLYNTPPT
FGVYMLNLVLAWIQEQGGLAGMAEYNTRKANVVYNAIDNSGGFYRGHAVADSRSQMNVTFNLPTQELEKQFLAEAKAQGM
IGLPGHRSVGGVRASIYNAMSIEGVEALASFMAHFAAKQG
>Mature_359_residues
TVYNFNAGPAILPPSVLSQAQEELRDFAGTGISVMETSHRAKEFEAVNNEVEARFKALLGIESGYRVLLLQGGASTQFAM
IPMNFLGADQVADYIITGTWAEKARDEAQKIGKVHIAATTEAENHNRIPSQTELQFSENPVYVHLTTNNTIYGTQWQSTP
ETNGVPIVADMSSDIFSRPFDASKFGLVYAGAQKNLGPSGVTVVLIREDWLDKGAKNVPTMLRYSTHAKNNSLYNTPPTF
GVYMLNLVLAWIQEQGGLAGMAEYNTRKANVVYNAIDNSGGFYRGHAVADSRSQMNVTFNLPTQELEKQFLAEAKAQGMI
GLPGHRSVGGVRASIYNAMSIEGVEALASFMAHFAAKQG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=359, Percent_Identity=43.4540389972145, Blast_Score=327, Evalue=7e-90,
Organism=Homo sapiens, GI10863955, Length=355, Percent_Identity=39.4366197183099, Blast_Score=283, Evalue=2e-76,
Organism=Escherichia coli, GI1787136, Length=360, Percent_Identity=46.6666666666667, Blast_Score=331, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI17506897, Length=356, Percent_Identity=44.1011235955056, Blast_Score=308, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324758, Length=390, Percent_Identity=36.1538461538462, Blast_Score=243, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21356589, Length=358, Percent_Identity=45.2513966480447, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_HERA2 (A9B6Q3)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544490.1
- ProteinModelPortal:   A9B6Q3
- SMR:   A9B6Q3
- GeneID:   5733606
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1719
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   HAUR316274:HAUR_1719-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39197; Mature: 39065

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 101-101 BINDING 151-151 BINDING 171-171 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYNFNAGPAILPPSVLSQAQEELRDFAGTGISVMETSHRAKEFEAVNNEVEARFKALL
CEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
GIESGYRVLLLQGGASTQFAMIPMNFLGADQVADYIITGTWAEKARDEAQKIGKVHIAAT
CCCCCCEEEEEECCCCCEEEEECHHHCCHHHHHHEEEECCHHHHHHHHHHHHCEEEEEEE
TEAENHNRIPSQTELQFSENPVYVHLTTNNTIYGTQWQSTPETNGVPIVADMSSDIFSRP
CCCCCCCCCCCCCEEEECCCCEEEEEECCCEEEECCCCCCCCCCCEEEEEECCCHHHCCC
FDASKFGLVYAGAQKNLGPSGVTVVLIREDWLDKGAKNVPTMLRYSTHAKNNSLYNTPPT
CCCCCCEEEEECCCCCCCCCCEEEEEEECCHHCCCCCCCCHHHEEECCCCCCCCCCCCCH
FGVYMLNLVLAWIQEQGGLAGMAEYNTRKANVVYNAIDNSGGFYRGHAVADSRSQMNVTF
HHHHHHHHHHHHHHHCCCEEEEHHCCCCCCEEEEEEECCCCCEEECCEECCCCCEEEEEE
NLPTQELEKQFLAEAKAQGMIGLPGHRSVGGVRASIYNAMSIEGVEALASFMAHFAAKQG
ECCHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVYNFNAGPAILPPSVLSQAQEELRDFAGTGISVMETSHRAKEFEAVNNEVEARFKALL
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
GIESGYRVLLLQGGASTQFAMIPMNFLGADQVADYIITGTWAEKARDEAQKIGKVHIAAT
CCCCCCEEEEEECCCCCEEEEECHHHCCHHHHHHEEEECCHHHHHHHHHHHHCEEEEEEE
TEAENHNRIPSQTELQFSENPVYVHLTTNNTIYGTQWQSTPETNGVPIVADMSSDIFSRP
CCCCCCCCCCCCCEEEECCCCEEEEEECCCEEEECCCCCCCCCCCEEEEEECCCHHHCCC
FDASKFGLVYAGAQKNLGPSGVTVVLIREDWLDKGAKNVPTMLRYSTHAKNNSLYNTPPT
CCCCCCEEEEECCCCCCCCCCEEEEEEECCHHCCCCCCCCHHHEEECCCCCCCCCCCCCH
FGVYMLNLVLAWIQEQGGLAGMAEYNTRKANVVYNAIDNSGGFYRGHAVADSRSQMNVTF
HHHHHHHHHHHHHHHCCCEEEEHHCCCCCCEEEEEEECCCCCEEECCEECCCCCEEEEEE
NLPTQELEKQFLAEAKAQGMIGLPGHRSVGGVRASIYNAMSIEGVEALASFMAHFAAKQG
ECCHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA