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The map label for this gene is uvrA [H]

Identifier: 159898240

GI number: 159898240

Start: 1996244

End: 1998481

Strand: Direct

Name: uvrA [H]

Synonym: Haur_1716

Alternate gene names: 159898240

Gene position: 1996244-1998481 (Clockwise)

Preceding gene: 159898237

Following gene: 159898243

Centisome position: 31.45

GC content: 49.11

Gene sequence:

>2238_bases
ATGATGCAGGATCGAGCGTTTATTGAGGTGTATGGCGCACGCGAAAACAACCTCAAAAATATTTCCTTGAATATTCCAAA
ACAGCGGGTGACAGTCTTTACCGGAGTCTCTGGTTCGGGCAAATCGTCGTTGGTGTTTGATACGATTGCCGCTGAGGCTC
AACGCCAACTCAATGAAACCTTTACCTTTTTTGTGCAAGGCTTTTTGCCGCACTATGGCCAGCCTGATGTCGAGCGGATC
GAGCATCTCAACTCGCCGATTATCATCGATCAAAAGCGGGTTGGCGGTGGTTCGCGCTCAACCGTCGGAACCTACACAGA
TATTGCGGTGTTGCTGCGCTTGTTGTTCTCGCGGATTGGTCAGCCCTACGTTGGGCCTGGCTATGCTTTTTCGTTCAACA
CGCCGCAGGGTATGTGCCCCGAATGTGAAGGCATTGGCAAAACGGTTCAGCTTGATATGGATAAATTGCTTGACCGCAGC
AAATCGCTGAATGAAGGTGCGATTTTGCACCCCGAATTCAAGGTTGGCAAATGGATGTGGAAGATGTATCCGCTGTCTGG
TTTGTTCGATAACGATAAGCCGATTCAGGATTATAACGAACAGGAATTGCAAGCATTTTTGTATGGCGCTGATCTTAAGG
TTTCGTGGGGCGAATTTAGCTCGAAATATGAAGGTTTGCTGGAACGTTTCGAGCGTATGTACCTCAAAAAAGATGCAGCA
GCCATGTCGGATCGCAATCGGGCCGTGTTTGAGCAATTTACCTCTTCACAAATCTGCCCAGTTTGCCATGGTGGGCGTTT
GACTCAAGCCGCGCTCAATTGTCGGATTGCTGGGCGTAACATTGCCGAATTAGCCGATTTTGAAGCGACTGATTTGATTA
GCTTTTTGGCTGATGTTACTGATCCGATTGGTGATCGGGTGGCGGCCAAGTTGTTGGAGCGCATGCAACAGTTGGTCGAT
ATTGGCTTGGGCTATTTGAGCTTGAGCCGCGAAACCTCGACGCTCTCTGGGGGCGAATCTCAGCGCGTCAAAATGATTCG
GCATCTTGGCAATAGCTTAACTGAAATGCTCTATATTCTCGATGAGCCAAGTGTGGGCTTGCATGCGCGTGATGTGGCGC
GGCTGAATAATTTATTGCAACAGTTGCGCGATAAGGGCAATACGGTGCTAGTGGTTGAGCATGATCCCGATGTGATTGCA
ATTGCCGACCATATTGTCGATATTGGGCCACGCGCGGGCGTGCACGGCGGCGAGGTTGTGTTTGAAGGCAGCTATGCCGA
TCTCAAACGTTCAAATACCTTAACTGGCAGCTATTTGCAACAAGTAGTGCCAACCAAACAGCATTCGCGTCAGCCAACTG
GCTACTTGCCGATTGTTAATGCCAACCTGCATAACCTTAAAAACGTCAATGTCAATATTCCAACGGGCGTGCTGACCGTG
GTGACAGGTGTGGCCGGATCAGGCAAAAGCACCTTAATTAATGAAGTCTTTTTGAGCCAACACCCCAATGCGATTGTGAT
CGATCAATCACGGGTAACGGCTAATAGCCGTTCGGCTCCGGCCACCTATACCGGAATTATGGATGATATTCGCCAGACCT
TTGCTAAGGCCAATGGCGTGAGCGCTTCGTTATTCAGCTTCAACTCAACTGGCAGTTGCGATAATTGTAATGGTTTGGGC
TTAGTCTACACCGATTTAGCCTTTATGGAAGGAATTTCCTCGACCTGTGAAATTTGCGAAGGCAAGCGTTTCAAAGCCGA
AGTGCTGGAATATCGGCTGCGCGGCAAATCGATCAGCGATGTGTTGGATATGACTGCCGAGGAAGCACTCGATTTCTTTA
ACGAAAAGAAGATCAAGCCTGTGCTCCAGGCTATGAATGATGTTGGCTTGAGCTATTTGAAACTTGGTCAACCACTCAGC
ACGATATCGGGTGGTGAGGGTCAACGGCTCAAATTGGCGACCGAACTCCACAAAAAGGCCAGCGTTTATGTGATGGACGA
GCCAACCACGGGTTTGCATCGCTCGGATATTGGGCTGCTGATGGGGATCATTGATCGTTTGGTTGATCTCAAGAATACCG
TGATTCTGATCGAACATCACTTGGATATTATTCGTCAGGCCGATTGGATTATCGACATTGGGCCTGAGGGCGGTAGCGCT
GGTGGCGAGATTATTTTTGAAGGGCCACCCATGGCCTTGAAAACTTGCCAACGCAGCATTACCGCCAAGTTTCTCTAA

Upstream 100 bases:

>100_bases
CCACCAAGTCAGAAGCCCCTCGCCCGCCGCAGTGGGCGAGGGGTTGGGGTGAGGGCATGAACTCAAAGCGACCAGAGATT
TGTAGTTATCAAGGAGTCTG

Downstream 100 bases:

>100_bases
TCAGCATGCCCTCACCCCCTCGCCTCGCGTGCGGGCGAGGGGGAACCGCTCTAGGAGTGATGCCCGCCGCCGTCGAGTGA
TGTCGGGGTGATGGGCGTTA

Product: ABC transporter-like protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MMQDRAFIEVYGARENNLKNISLNIPKQRVTVFTGVSGSGKSSLVFDTIAAEAQRQLNETFTFFVQGFLPHYGQPDVERI
EHLNSPIIIDQKRVGGGSRSTVGTYTDIAVLLRLLFSRIGQPYVGPGYAFSFNTPQGMCPECEGIGKTVQLDMDKLLDRS
KSLNEGAILHPEFKVGKWMWKMYPLSGLFDNDKPIQDYNEQELQAFLYGADLKVSWGEFSSKYEGLLERFERMYLKKDAA
AMSDRNRAVFEQFTSSQICPVCHGGRLTQAALNCRIAGRNIAELADFEATDLISFLADVTDPIGDRVAAKLLERMQQLVD
IGLGYLSLSRETSTLSGGESQRVKMIRHLGNSLTEMLYILDEPSVGLHARDVARLNNLLQQLRDKGNTVLVVEHDPDVIA
IADHIVDIGPRAGVHGGEVVFEGSYADLKRSNTLTGSYLQQVVPTKQHSRQPTGYLPIVNANLHNLKNVNVNIPTGVLTV
VTGVAGSGKSTLINEVFLSQHPNAIVIDQSRVTANSRSAPATYTGIMDDIRQTFAKANGVSASLFSFNSTGSCDNCNGLG
LVYTDLAFMEGISSTCEICEGKRFKAEVLEYRLRGKSISDVLDMTAEEALDFFNEKKIKPVLQAMNDVGLSYLKLGQPLS
TISGGEGQRLKLATELHKKASVYVMDEPTTGLHRSDIGLLMGIIDRLVDLKNTVILIEHHLDIIRQADWIIDIGPEGGSA
GGEIIFEGPPMALKTCQRSITAKFL

Sequences:

>Translated_745_residues
MMQDRAFIEVYGARENNLKNISLNIPKQRVTVFTGVSGSGKSSLVFDTIAAEAQRQLNETFTFFVQGFLPHYGQPDVERI
EHLNSPIIIDQKRVGGGSRSTVGTYTDIAVLLRLLFSRIGQPYVGPGYAFSFNTPQGMCPECEGIGKTVQLDMDKLLDRS
KSLNEGAILHPEFKVGKWMWKMYPLSGLFDNDKPIQDYNEQELQAFLYGADLKVSWGEFSSKYEGLLERFERMYLKKDAA
AMSDRNRAVFEQFTSSQICPVCHGGRLTQAALNCRIAGRNIAELADFEATDLISFLADVTDPIGDRVAAKLLERMQQLVD
IGLGYLSLSRETSTLSGGESQRVKMIRHLGNSLTEMLYILDEPSVGLHARDVARLNNLLQQLRDKGNTVLVVEHDPDVIA
IADHIVDIGPRAGVHGGEVVFEGSYADLKRSNTLTGSYLQQVVPTKQHSRQPTGYLPIVNANLHNLKNVNVNIPTGVLTV
VTGVAGSGKSTLINEVFLSQHPNAIVIDQSRVTANSRSAPATYTGIMDDIRQTFAKANGVSASLFSFNSTGSCDNCNGLG
LVYTDLAFMEGISSTCEICEGKRFKAEVLEYRLRGKSISDVLDMTAEEALDFFNEKKIKPVLQAMNDVGLSYLKLGQPLS
TISGGEGQRLKLATELHKKASVYVMDEPTTGLHRSDIGLLMGIIDRLVDLKNTVILIEHHLDIIRQADWIIDIGPEGGSA
GGEIIFEGPPMALKTCQRSITAKFL
>Mature_745_residues
MMQDRAFIEVYGARENNLKNISLNIPKQRVTVFTGVSGSGKSSLVFDTIAAEAQRQLNETFTFFVQGFLPHYGQPDVERI
EHLNSPIIIDQKRVGGGSRSTVGTYTDIAVLLRLLFSRIGQPYVGPGYAFSFNTPQGMCPECEGIGKTVQLDMDKLLDRS
KSLNEGAILHPEFKVGKWMWKMYPLSGLFDNDKPIQDYNEQELQAFLYGADLKVSWGEFSSKYEGLLERFERMYLKKDAA
AMSDRNRAVFEQFTSSQICPVCHGGRLTQAALNCRIAGRNIAELADFEATDLISFLADVTDPIGDRVAAKLLERMQQLVD
IGLGYLSLSRETSTLSGGESQRVKMIRHLGNSLTEMLYILDEPSVGLHARDVARLNNLLQQLRDKGNTVLVVEHDPDVIA
IADHIVDIGPRAGVHGGEVVFEGSYADLKRSNTLTGSYLQQVVPTKQHSRQPTGYLPIVNANLHNLKNVNVNIPTGVLTV
VTGVAGSGKSTLINEVFLSQHPNAIVIDQSRVTANSRSAPATYTGIMDDIRQTFAKANGVSASLFSFNSTGSCDNCNGLG
LVYTDLAFMEGISSTCEICEGKRFKAEVLEYRLRGKSISDVLDMTAEEALDFFNEKKIKPVLQAMNDVGLSYLKLGQPLS
TISGGEGQRLKLATELHKKASVYVMDEPTTGLHRSDIGLLMGIIDRLVDLKNTVILIEHHLDIIRQADWIIDIGPEGGSA
GGEIIFEGPPMALKTCQRSITAKFL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=673, Percent_Identity=39.0787518573551, Blast_Score=434, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 81940; Mature: 81940

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQDRAFIEVYGARENNLKNISLNIPKQRVTVFTGVSGSGKSSLVFDTIAAEAQRQLNET
CCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
FTFFVQGFLPHYGQPDVERIEHLNSPIIIDQKRVGGGSRSTVGTYTDIAVLLRLLFSRIG
HHHHHHHHCCCCCCCCHHHHHHCCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC
QPYVGPGYAFSFNTPQGMCPECEGIGKTVQLDMDKLLDRSKSLNEGAILHPEFKVGKWMW
CCCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCEECCCHHHHHHHH
KMYPLSGLFDNDKPIQDYNEQELQAFLYGADLKVSWGEFSSKYEGLLERFERMYLKKDAA
HHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AMSDRNRAVFEQFTSSQICPVCHGGRLTQAALNCRIAGRNIAELADFEATDLISFLADVT
HHCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHEEEECCCCHHHHHCCCHHHHHHHHHHHC
DPIGDRVAAKLLERMQQLVDIGLGYLSLSRETSTLSGGESQRVKMIRHLGNSLTEMLYIL
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DEPSVGLHARDVARLNNLLQQLRDKGNTVLVVEHDPDVIAIADHIVDIGPRAGVHGGEVV
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHCCCCCCCCCCCEE
FEGSYADLKRSNTLTGSYLQQVVPTKQHSRQPTGYLPIVNANLHNLKNVNVNIPTGVLTV
EECCHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHHHH
VTGVAGSGKSTLINEVFLSQHPNAIVIDQSRVTANSRSAPATYTGIMDDIRQTFAKANGV
HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SASLFSFNSTGSCDNCNGLGLVYTDLAFMEGISSTCEICEGKRFKAEVLEYRLRGKSISD
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCHHH
VLDMTAEEALDFFNEKKIKPVLQAMNDVGLSYLKLGQPLSTISGGEGQRLKLATELHKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCCCCCEEEHHHHHHCCC
SVYVMDEPTTGLHRSDIGLLMGIIDRLVDLKNTVILIEHHLDIIRQADWIIDIGPEGGSA
EEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCEEEEECCCCCCC
GGEIIFEGPPMALKTCQRSITAKFL
CCEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMQDRAFIEVYGARENNLKNISLNIPKQRVTVFTGVSGSGKSSLVFDTIAAEAQRQLNET
CCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
FTFFVQGFLPHYGQPDVERIEHLNSPIIIDQKRVGGGSRSTVGTYTDIAVLLRLLFSRIG
HHHHHHHHCCCCCCCCHHHHHHCCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC
QPYVGPGYAFSFNTPQGMCPECEGIGKTVQLDMDKLLDRSKSLNEGAILHPEFKVGKWMW
CCCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCEECCCHHHHHHHH
KMYPLSGLFDNDKPIQDYNEQELQAFLYGADLKVSWGEFSSKYEGLLERFERMYLKKDAA
HHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AMSDRNRAVFEQFTSSQICPVCHGGRLTQAALNCRIAGRNIAELADFEATDLISFLADVT
HHCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHEEEECCCCHHHHHCCCHHHHHHHHHHHC
DPIGDRVAAKLLERMQQLVDIGLGYLSLSRETSTLSGGESQRVKMIRHLGNSLTEMLYIL
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DEPSVGLHARDVARLNNLLQQLRDKGNTVLVVEHDPDVIAIADHIVDIGPRAGVHGGEVV
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHCCCCCCCCCCCEE
FEGSYADLKRSNTLTGSYLQQVVPTKQHSRQPTGYLPIVNANLHNLKNVNVNIPTGVLTV
EECCHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHHHH
VTGVAGSGKSTLINEVFLSQHPNAIVIDQSRVTANSRSAPATYTGIMDDIRQTFAKANGV
HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SASLFSFNSTGSCDNCNGLGLVYTDLAFMEGISSTCEICEGKRFKAEVLEYRLRGKSISD
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCHHH
VLDMTAEEALDFFNEKKIKPVLQAMNDVGLSYLKLGQPLSTISGGEGQRLKLATELHKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCCCCCEEEHHHHHHCCC
SVYVMDEPTTGLHRSDIGLLMGIIDRLVDLKNTVILIEHHLDIIRQADWIIDIGPEGGSA
EEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCEEEEECCCCCCC
GGEIIFEGPPMALKTCQRSITAKFL
CCEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]