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The map label for this gene is lon1

Identifier: 159898145

GI number: 159898145

Start: 1880143

End: 1882590

Strand: Direct

Name: lon1

Synonym: Haur_1621

Alternate gene names: 159898145

Gene position: 1880143-1882590 (Clockwise)

Preceding gene: 159898144

Following gene: 159898151

Centisome position: 29.62

GC content: 51.55

Gene sequence:

>2448_bases
ATGTCAGAAGTTGAACGAACAACCACGATTCCAGATGAAATCGCGATTTTGCCGTTATTGGGAACCGTCGCCTATCCCCA
AACGATTATGCCATTGGCAATTGGTCAGCCTGAGTCGATCCGTTTGATCGATGATCTGATGGCTGGCCAGCGAATTGTGG
GCTTGATGGCGCTGAAAAATGAAGATGAACGACCTAACCCTGTCCTGCCTGAGGATTTTTATCAGCTTGGCAGCGCTGCG
GTTGTGCATAAATTAATGAAATTGCCCGATGGTACGCTGCGAGCGGCGATGCAGGTGCTTGAGCGGATAGAGATTGTTGA
AATTATTCAGACCGAACCCTATTATCGCGCCAAAATTCGGGTTATGCCCGATGCGCTGGCTGAGAGTGAGCAGCTTGAAG
TAACCGCCTTGATGCGCTCGATTGGCACGATTGCCAGCCAAATTGCTCCCTTGATTCCGCAATTTCCAACTGAATTATTG
AATTCGGTGTTGAGCGAAGAAGATCCACGGCGTTTGGCCTATTTGGTGGCTTCGTATGCCCGTATGAGCGTGACCGACCG
CCAAGCGGTGCTAGCTGAACCAAGCATCAAGCAAAAATTGCTCAAATTGAACGAAGTGCTGACCCGCGAATTAAATGTGT
TGCAAATTGGCCAGCAAATTCAATCGCAGGTGCAAGATGAAATGAGTAAAACGCAGCGCGAATATGTGTTGCGCGAACAG
CTCAAAGCAATTCGCAAAGAGTTGGGCGAAAATAATGAACAAGAGGTTGAGGTTGATCGTTTAGCCGAGCAAATTGAGGC
GGCTGGCATGAGCGCCGAAGCTCATCAGCAAGCCATGCGCGAGCTTGATCGGTTGCGCCAAATGCCAACGGCGGCGGCTG
AATATAGCGTGATTCGCGGCTACTTGGAAACCCTGATTGCCTTGCCATGGCAAAAACGCAGCGACGACACGATTGATGTG
GCTCAGGCTACCGAAGTTCTCGATGCTGATCATTATGGCTTGGACGAAATCAAAGAGCGGATTTTGGATTATTTAGCGGT
GCGTGAGCTACGCCGCAAACGATCGCCAGAGCGTGATCCTGGGCGTGGGGCGATTCTGTGTTTCGTTGGCCCTCCAGGTG
TGGGCAAAACTAGCCTTGGTCGCTCGATTGCCAAAGCCATGAATCGCGAGTTTGTGCGTTTGTCGTTGGGCGGTGTGCAC
GACGAGGCTGAAATTCGCGGCCATCGCCGCACCTATATCGGCGCAATGCCAGGCAGTTTGATCCAAGCGATTCGGCGCAG
TGGCGTGAACAATCCGGTTGTTTTGCTCGACGAAATCGATAAATTGAGTTCAGATCACCGTGGCGATCCAACCTCGGCCA
TGCTTGAGGTGCTTGATCCAGCCCAAAACACCAATTTCCGCGACCATTATTTAGATGTGGCGTGGGATTTGTCGCCTGTG
ATGTTTATTGCAACCGCCAATACCCTGCAAACTATCCCAGCGCCATTACGCGATCGTTTGGAGATTATTCAGCTTGGCAG
CTATACCATGCGGGAAAAGTATGAAATTGCCAGCCGTTATTTGGTGCCAGAACAACGTGAGCAACATAGCCTAGCGCCAA
ATGAAGTAGAAATTGATCATGAAGCCTTATTGGTAGCGATTGAAGAATATACTCGTGAGGCTGGGGTGCGAAATTTGGAG
CAACAAATTGGCACATTAATGCGCAAGGCAGCTCGCCAAGTTGCGCTTGGTTCTGCCACGCCAATTGTGCTCGACCCAGC
CAAAACCCGCGAATATTTGGGCAAACGTCGTTACTTCTCGGAAATTCACGAGCGCACCGATCGACCTGGCATTGTCACGG
GCTTGGTTTGGACTCCGGTTGGCGGCGATATCATCTTCATCGAAGCGACCAAAATGACAGGGCGCGGCAACTTCGCCTTG
AGTGGCCAGCTTGGCGATGTGATGAAAGAATCGGCACGGGCAGCGCTGAGTTGGGTGCGGGCTGAGGGCGAAGCCTATGG
CATTGATCCAAATTTTGCCCAGCACTACGATTTACATGTGCATGTTCCGGCTGGTGCTCAGCCCAAAGATGGCCCATCGG
CGGGGATTGCCATGGCCACAGCCTTGGTTTCGTTGCTGACAGGGCGAGTTTTACGCGACGATGTAGCAATGACTGGCGAA
ATTACTTTGCGTGGTAAAGTCTTGCCAATTGGTGGGGTACGCGAAAAAGTCTTGGCAGCCCATCGCGCAGGCATTCGCAC
AATCATTTTGCCACAGCGCAATCTGGCCGATTTGGATGAAATTCCGGCGGATGTATTGGCTGAGGTTCAATTCCATGGGG
TGGAGCATGTAGGGCAAGTGATTGAATTGGCGTTGCGAGCTGAGGCAAGCGAAGCGCCAGTGAGCGTGCCTGAATCAGCG
GTCATGCCAAACTTATTCCAATCAGACGTTGAAGTGCTGGTGCATTAA

Upstream 100 bases:

>100_bases
TCGCGCTGCCCAAGCGTCATCCAGCCCAAACCGAACCACGGCGGATCTCGATTGAACAAACCAACGTCTAAATTACATTG
GTGCTAACAAGGGGTTTTGT

Downstream 100 bases:

>100_bases
ACACAAACAGCGCCGTTGGAATTGCTCCAACGGCGCTGTAACTTGAGAATCTGAATTATTGTGCCGATTCGACGGCAGCT
TGTTGATGGCGTTGCATGGC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MSEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKNEDERPNPVLPEDFYQLGSAA
VVHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIRVMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELL
NSVLSEEDPRRLAYLVASYARMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQ
LKAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRGYLETLIALPWQKRSDDTIDV
AQATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDPGRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVH
DEAEIRGHRRTYIGAMPGSLIQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPV
MFIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDHEALLVAIEEYTREAGVRNLE
QQIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFSEIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFAL
SGQLGDVMKESARAALSWVRAEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGE
ITLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQVIELALRAEASEAPVSVPESA
VMPNLFQSDVEVLVH

Sequences:

>Translated_815_residues
MSEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKNEDERPNPVLPEDFYQLGSAA
VVHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIRVMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELL
NSVLSEEDPRRLAYLVASYARMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQ
LKAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRGYLETLIALPWQKRSDDTIDV
AQATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDPGRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVH
DEAEIRGHRRTYIGAMPGSLIQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPV
MFIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDHEALLVAIEEYTREAGVRNLE
QQIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFSEIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFAL
SGQLGDVMKESARAALSWVRAEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGE
ITLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQVIELALRAEASEAPVSVPESA
VMPNLFQSDVEVLVH
>Mature_814_residues
SEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKNEDERPNPVLPEDFYQLGSAAV
VHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIRVMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELLN
SVLSEEDPRRLAYLVASYARMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQL
KAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRGYLETLIALPWQKRSDDTIDVA
QATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDPGRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVHD
EAEIRGHRRTYIGAMPGSLIQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPVM
FIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDHEALLVAIEEYTREAGVRNLEQ
QIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFSEIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFALS
GQLGDVMKESARAALSWVRAEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGEI
TLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQVIELALRAEASEAPVSVPESAV
MPNLFQSDVEVLVH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=774, Percent_Identity=40.1808785529716, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI21396489, Length=674, Percent_Identity=40.2077151335312, Blast_Score=532, Evalue=1e-151,
Organism=Escherichia coli, GI1786643, Length=787, Percent_Identity=47.141041931385, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=661, Percent_Identity=39.3343419062027, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17556486, Length=542, Percent_Identity=42.2509225092251, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319449, Length=444, Percent_Identity=40.5405405405405, Blast_Score=354, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24666867, Length=674, Percent_Identity=41.0979228486647, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=674, Percent_Identity=41.0979228486647, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON1_HERA2 (A9B5N1)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544392.1
- ProteinModelPortal:   A9B5N1
- GeneID:   5733493
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1621
- HOGENOM:   HBG566281
- OMA:   FRYLIPR
- BioCyc:   HAUR316274:HAUR_1621-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 90407; Mature: 90276

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 693-693 ACT_SITE 736-736

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKN
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHCC
EDERPNPVLPEDFYQLGSAAVVHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIR
CCCCCCCCCCHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELLNSVLSEEDPRRLAYLVASYA
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
RMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQ
HHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YLETLIALPWQKRSDDTIDVAQATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDP
HHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVHDEAEIRGHRRTYIGAMPGSL
CCEEEEEEECCCCCCHHHHHHHHHHHHCHHEEEEECCCCCCHHHHCCCCCEEEECCCHHH
IQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPV
HHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHEEHEECCCCE
MFIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDH
EEEEECHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEECH
EALLVAIEEYTREAGVRNLEQQIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
EIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFALSGQLGDVMKESARAALSWVR
HHHHHCCCCCEEEEEEEECCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHH
AEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGE
HCCCEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHEECE
ITLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQV
EEEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCHHHCCHHHHHHHHHHCHHHHHHH
IELALRAEASEAPVSVPESAVMPNLFQSDVEVLVH
HHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKN
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHCC
EDERPNPVLPEDFYQLGSAAVVHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIR
CCCCCCCCCCHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELLNSVLSEEDPRRLAYLVASYA
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
RMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQ
HHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YLETLIALPWQKRSDDTIDVAQATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDP
HHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVHDEAEIRGHRRTYIGAMPGSL
CCEEEEEEECCCCCCHHHHHHHHHHHHCHHEEEEECCCCCCHHHHCCCCCEEEECCCHHH
IQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPV
HHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHEEHEECCCCE
MFIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDH
EEEEECHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEECH
EALLVAIEEYTREAGVRNLEQQIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
EIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFALSGQLGDVMKESARAALSWVR
HHHHHCCCCCEEEEEEEECCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHH
AEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGE
HCCCEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHEECE
ITLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQV
EEEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCHHHCCHHHHHHHHHHCHHHHHHH
IELALRAEASEAPVSVPESAVMPNLFQSDVEVLVH
HHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA