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The map label for this gene is cyaA [H]

Identifier: 159898027

GI number: 159898027

Start: 1750568

End: 1752253

Strand: Direct

Name: cyaA [H]

Synonym: Haur_1502

Alternate gene names: 159898027

Gene position: 1750568-1752253 (Clockwise)

Preceding gene: 159898020

Following gene: 159898033

Centisome position: 27.58

GC content: 49.64

Gene sequence:

>1686_bases
ATGGCTCGCTCGTTTCAAGCTCTGATTCCCCGCTTGCGGCTGCATGCTGGTTTGACGCTGCTGCTCTATGTTACAACTCA
CCTGCTGAACCATGCGTGGGGCATCTTTGGCCTAGCTGCCTTGGAATCGTCGCGGCGGGTCTTTTTAAGTTTTTGGCGGC
ATCCAGCGGTCTTTTGGGTTGTGCCAGCTAGTTTATTGATCCATGTTCTGTTGGTCAGCTATAAATTATTGACAATTACC
AGTTGGCGACGCTTGCACTGGAACGAATGGCTGCAAATTGGCTTGGGCTTGATCATGCCGTTGCTGATTACCTCGCACAT
TTATGCCACTCGTTTTGCCACAATCTTGTATGGAATTCGCGATACCTATAGCTATGTATTGCTCAGCCAAGCGACGATTG
CCGTTGATCTCTATTTGATGTTGGTGGTGGTTTGGCTGCATGGCAACCTTGGCTTAATGGCGTATCTTTGGCATAAACCA
TGGTTTGCCCGCATCAAACAGCCCTTGCTGATTGCCCAAATTGTGATTCCATTGTTGGCCTTGGTGGGGATTGTGGTGGC
TCATCGCGAGGTGAATCAGCTTAAACAAGACCCACAATGGCTGGAGCAAGTGTGGCAATTTGCCAATCCACAGAATATTG
ATGTAGCAGCCGCGACTGCGGAATTTATGGGTTGGTTTGGCTCAGGCTATTTAGCTTTGCTGCTTGGCTTGGGTGGTGGG
CGGGCAATCATCTTGCGTTTGCGCCGTAAGCATTATTTAATTTCGGTGGAATATAAGGGCATTGCCACAGTGACAATTGC
CCCTGGAACGAGTTTGCTTGAAGCCAGCCTTGCCAATGGAATTCCCCATGCCCATAGTTGTGGTGGGCGCGGGCGTTGCT
CAACCTGCCGGATCGAAATTATCGAAGGTGTGAAAGCGCTGAATCCGCCGACTGAAACCGAGTTGCGTTTGCTCAAGCGT
TTTGGGGCAAGTGGCGATATTCGCTTAGCATGCCAAACCATCCCAACTGCTGCCTGCGTGGTGCGGCCATTGCTCCACCA
TCATGATCGTTCGCTACCAGGCGCACCAACCATGATTAGCCATGGTGCCGATAAGCAAATTGTGATTATGTTTGCCGATT
TGCGCGGCTTTACGACCCTTTCCGAGGGCAAGTTGCCCTACGATACGGTCTTTATTCTGAATCAATATTTTCAATCGATG
GGCCAAGTCATCGAGGCCAACGGTGGTTATCTCGATAAATTTATTGGCGATGGGATTATGGCGCTGTTTGGTTTGGATGG
TACGCTCGAACAAGCTTGTCATAATGCGTTAGCTGCCGCCCAAGCTATGGCCTATCAACTTGATGTGCTCAATCAGCGCC
TTGAACATGATGTCAACGAGCCATTGCGCATGGGCATTGGCATTCATTGTGGCCATGTAATTGTTGGTGATTTGGGCTAT
AAACGCGCTAAACATCTGACAGCGATCGGCGATGCAGTCAATATTGCCGCCCGTTTGGAAGAAGCCACCAAAACTTTGCA
AACCCAATTGGTCGTTTCGCGGGCGGTGATGCAACATAGTGCCTTAGATTTACACAATTTAGCTTTGAGCGAAATTCCGA
TTCGTGGCCGCACCCAGCCCTTGGAAATTTACTCAATCGAGAGTGCCAAGAGCTTGGTGCTTGTGCCACTAACCTTGAAT
ACCTAA

Upstream 100 bases:

>100_bases
CCAACTGATACCTTGCTTAGCTGTGTCTTTTATCCCCCAAGCCTGCAACCCAGATAGATGGTATACTCCCTCTATTGCTG
GCTTTACGGAGATTGGCTGC

Downstream 100 bases:

>100_bases
ACCTCAATCACCACGTTGCCTTTTTTGCGGCCAGTCTCAACATAGCGATGGGCCTCGACTAAATCGGCCAAGTGATAACG
TCGATCGATCACGGCTTTGA

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MARSFQALIPRLRLHAGLTLLLYVTTHLLNHAWGIFGLAALESSRRVFLSFWRHPAVFWVVPASLLIHVLLVSYKLLTIT
SWRRLHWNEWLQIGLGLIMPLLITSHIYATRFATILYGIRDTYSYVLLSQATIAVDLYLMLVVVWLHGNLGLMAYLWHKP
WFARIKQPLLIAQIVIPLLALVGIVVAHREVNQLKQDPQWLEQVWQFANPQNIDVAAATAEFMGWFGSGYLALLLGLGGG
RAIILRLRRKHYLISVEYKGIATVTIAPGTSLLEASLANGIPHAHSCGGRGRCSTCRIEIIEGVKALNPPTETELRLLKR
FGASGDIRLACQTIPTAACVVRPLLHHHDRSLPGAPTMISHGADKQIVIMFADLRGFTTLSEGKLPYDTVFILNQYFQSM
GQVIEANGGYLDKFIGDGIMALFGLDGTLEQACHNALAAAQAMAYQLDVLNQRLEHDVNEPLRMGIGIHCGHVIVGDLGY
KRAKHLTAIGDAVNIAARLEEATKTLQTQLVVSRAVMQHSALDLHNLALSEIPIRGRTQPLEIYSIESAKSLVLVPLTLN
T

Sequences:

>Translated_561_residues
MARSFQALIPRLRLHAGLTLLLYVTTHLLNHAWGIFGLAALESSRRVFLSFWRHPAVFWVVPASLLIHVLLVSYKLLTIT
SWRRLHWNEWLQIGLGLIMPLLITSHIYATRFATILYGIRDTYSYVLLSQATIAVDLYLMLVVVWLHGNLGLMAYLWHKP
WFARIKQPLLIAQIVIPLLALVGIVVAHREVNQLKQDPQWLEQVWQFANPQNIDVAAATAEFMGWFGSGYLALLLGLGGG
RAIILRLRRKHYLISVEYKGIATVTIAPGTSLLEASLANGIPHAHSCGGRGRCSTCRIEIIEGVKALNPPTETELRLLKR
FGASGDIRLACQTIPTAACVVRPLLHHHDRSLPGAPTMISHGADKQIVIMFADLRGFTTLSEGKLPYDTVFILNQYFQSM
GQVIEANGGYLDKFIGDGIMALFGLDGTLEQACHNALAAAQAMAYQLDVLNQRLEHDVNEPLRMGIGIHCGHVIVGDLGY
KRAKHLTAIGDAVNIAARLEEATKTLQTQLVVSRAVMQHSALDLHNLALSEIPIRGRTQPLEIYSIESAKSLVLVPLTLN
T
>Mature_560_residues
ARSFQALIPRLRLHAGLTLLLYVTTHLLNHAWGIFGLAALESSRRVFLSFWRHPAVFWVVPASLLIHVLLVSYKLLTITS
WRRLHWNEWLQIGLGLIMPLLITSHIYATRFATILYGIRDTYSYVLLSQATIAVDLYLMLVVVWLHGNLGLMAYLWHKPW
FARIKQPLLIAQIVIPLLALVGIVVAHREVNQLKQDPQWLEQVWQFANPQNIDVAAATAEFMGWFGSGYLALLLGLGGGR
AIILRLRRKHYLISVEYKGIATVTIAPGTSLLEASLANGIPHAHSCGGRGRCSTCRIEIIEGVKALNPPTETELRLLKRF
GASGDIRLACQTIPTAACVVRPLLHHHDRSLPGAPTMISHGADKQIVIMFADLRGFTTLSEGKLPYDTVFILNQYFQSMG
QVIEANGGYLDKFIGDGIMALFGLDGTLEQACHNALAAAQAMAYQLDVLNQRLEHDVNEPLRMGIGIHCGHVIVGDLGYK
RAKHLTAIGDAVNIAARLEEATKTLQTQLVVSRAVMQHSALDLHNLALSEIPIRGRTQPLEIYSIESAKSLVLVPLTLNT

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=157, Percent_Identity=33.7579617834395, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4580422, Length=173, Percent_Identity=30.635838150289, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI134152694, Length=258, Percent_Identity=26.3565891472868, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212645052, Length=140, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=145, Percent_Identity=30.3448275862069, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28574512, Length=153, Percent_Identity=28.1045751633987, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161076872, Length=153, Percent_Identity=28.1045751633987, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 62154; Mature: 62023

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50125 GUANYLATE_CYCLASES_2 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSFQALIPRLRLHAGLTLLLYVTTHLLNHAWGIFGLAALESSRRVFLSFWRHPAVFWV
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEE
VPASLLIHVLLVSYKLLTITSWRRLHWNEWLQIGLGLIMPLLITSHIYATRFATILYGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTYSYVLLSQATIAVDLYLMLVVVWLHGNLGLMAYLWHKPWFARIKQPLLIAQIVIPLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHH
LVGIVVAHREVNQLKQDPQWLEQVWQFANPQNIDVAAATAEFMGWFGSGYLALLLGLGGG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
RAIILRLRRKHYLISVEYKGIATVTIAPGTSLLEASLANGIPHAHSCGGRGRCSTCRIEI
HHHHHEECCCEEEEEEEECCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IEGVKALNPPTETELRLLKRFGASGDIRLACQTIPTAACVVRPLLHHHDRSLPGAPTMIS
HHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHC
HGADKQIVIMFADLRGFTTLSEGKLPYDTVFILNQYFQSMGQVIEANGGYLDKFIGDGIM
CCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCHH
ALFGLDGTLEQACHNALAAAQAMAYQLDVLNQRLEHDVNEPLRMGIGIHCGHVIVGDLGY
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEECCEEECCCCH
KRAKHLTAIGDAVNIAARLEEATKTLQTQLVVSRAVMQHSALDLHNLALSEIPIRGRTQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LEIYSIESAKSLVLVPLTLNT
EEEEEECCCCCEEEEEEEECC
>Mature Secondary Structure 
ARSFQALIPRLRLHAGLTLLLYVTTHLLNHAWGIFGLAALESSRRVFLSFWRHPAVFWV
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEE
VPASLLIHVLLVSYKLLTITSWRRLHWNEWLQIGLGLIMPLLITSHIYATRFATILYGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTYSYVLLSQATIAVDLYLMLVVVWLHGNLGLMAYLWHKPWFARIKQPLLIAQIVIPLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHH
LVGIVVAHREVNQLKQDPQWLEQVWQFANPQNIDVAAATAEFMGWFGSGYLALLLGLGGG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
RAIILRLRRKHYLISVEYKGIATVTIAPGTSLLEASLANGIPHAHSCGGRGRCSTCRIEI
HHHHHEECCCEEEEEEEECCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IEGVKALNPPTETELRLLKRFGASGDIRLACQTIPTAACVVRPLLHHHDRSLPGAPTMIS
HHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHC
HGADKQIVIMFADLRGFTTLSEGKLPYDTVFILNQYFQSMGQVIEANGGYLDKFIGDGIM
CCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCHH
ALFGLDGTLEQACHNALAAAQAMAYQLDVLNQRLEHDVNEPLRMGIGIHCGHVIVGDLGY
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEECCEEECCCCH
KRAKHLTAIGDAVNIAARLEEATKTLQTQLVVSRAVMQHSALDLHNLALSEIPIRGRTQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LEIYSIESAKSLVLVPLTLNT
EEEEEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]