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The map label for this gene is strD [H]

Identifier: 159897750

GI number: 159897750

Start: 1412296

End: 1413285

Strand: Direct

Name: strD [H]

Synonym: Haur_1221

Alternate gene names: 159897750

Gene position: 1412296-1413285 (Clockwise)

Preceding gene: 159897748

Following gene: 159897751

Centisome position: 22.25

GC content: 46.77

Gene sequence:

>990_bases
ATGAATGTAATTATTCCTACCGCCGGTCTTGGAACCCGCCTACGTCCACATACCCATACCCGTCCAAAGCCGTTGGTTCC
GGTTGCAGGCAAAGCCGTAATTGGCCACCTGCTTGATAAGCTCAAGGTGCTACCACTCGACGACGTGGTGTTTATTACCG
GGTATTTGGGTACACAAATTGAGGAATATGTTCGTAAGAACTATAACTTCAAGAGCCATTTTGTTGAACAAACTGAGCTA
AAAGGCCAAGCCCATGCAATTGCTTTGGCCCGCGAGATGGTCTCTGGCCCAACCTTGATTTTATTCGTCGATACGATTTT
TGAAGCAAACCTGAATGTTTTGAACCAAACTGATGCCGACGGCGTGATCTATGTAAGCGAAGTTGAAGATCCCTCGCGCT
TCGGGGTGGCATTGCTCGAAGATGGGATTATTACAAAACTGGTGGAAAAACCAAGTACGCCAGTTTCCAATTTGGCCTTG
ATCGGCGCATACTATGTGCGTGAAGTCAAAGAATTGTTCGCAGCGATCGATGTGCTGATCGAGCAGAATATTCAAACCAA
AGGCGAGTTTTATTTGGCCGATGCACTCCAACTCATGATTAGCAATGGCACGCGATTTAGTGCCGAAACTGCAACCATGT
GGGAAGATTGTGGCACAGCCCCCGCCTTGTTACGCACCAATCGCTATTTATTGCAACACGAAACTGGCAACGTCGAACAA
CGTGATGGCGCGATCATCGTTCCACCAGTCTTTATTGGCGAGAATGTTGAGATTCGCAACTCAATTATTGGGCCATACGT
CTCAGTTGCTGACCATAGCGTGATTGTCGATTCGATTGTGCGCGATTCGATTATCAATCAAGGAGCCAGCATTCAATCAT
CAACCTTGGAAGGCTCACTTATCGGTGAAGGAGCGCATATCAAAGGCGAATTCCAACACCTTAACGTCGGTGATTCATCA
GTTATTACATTTGGTAGCACGATTCAGTAA

Upstream 100 bases:

>100_bases
GTGCATGCATTCCAAAACAAGAGCTAAATTCTGCAAATCAATGAAAGGGAGTACGGTTTGGTGGCGCGTTTAACGTGATC
ACACCGCCGTAAAATGCAGT

Downstream 100 bases:

>100_bases
TGCATGATCAAGCAGGGAACCGGATGTCCCCACCAACCAGTTTGCAGCGTGGCACTGGCTTTCATCATCTGATCGCCGAT
GAATATCGGTTGATTGCTCA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNVIIPTAGLGTRLRPHTHTRPKPLVPVAGKAVIGHLLDKLKVLPLDDVVFITGYLGTQIEEYVRKNYNFKSHFVEQTEL
KGQAHAIALAREMVSGPTLILFVDTIFEANLNVLNQTDADGVIYVSEVEDPSRFGVALLEDGIITKLVEKPSTPVSNLAL
IGAYYVREVKELFAAIDVLIEQNIQTKGEFYLADALQLMISNGTRFSAETATMWEDCGTAPALLRTNRYLLQHETGNVEQ
RDGAIIVPPVFIGENVEIRNSIIGPYVSVADHSVIVDSIVRDSIINQGASIQSSTLEGSLIGEGAHIKGEFQHLNVGDSS
VITFGSTIQ

Sequences:

>Translated_329_residues
MNVIIPTAGLGTRLRPHTHTRPKPLVPVAGKAVIGHLLDKLKVLPLDDVVFITGYLGTQIEEYVRKNYNFKSHFVEQTEL
KGQAHAIALAREMVSGPTLILFVDTIFEANLNVLNQTDADGVIYVSEVEDPSRFGVALLEDGIITKLVEKPSTPVSNLAL
IGAYYVREVKELFAAIDVLIEQNIQTKGEFYLADALQLMISNGTRFSAETATMWEDCGTAPALLRTNRYLLQHETGNVEQ
RDGAIIVPPVFIGENVEIRNSIIGPYVSVADHSVIVDSIVRDSIINQGASIQSSTLEGSLIGEGAHIKGEFQHLNVGDSS
VITFGSTIQ
>Mature_329_residues
MNVIIPTAGLGTRLRPHTHTRPKPLVPVAGKAVIGHLLDKLKVLPLDDVVFITGYLGTQIEEYVRKNYNFKSHFVEQTEL
KGQAHAIALAREMVSGPTLILFVDTIFEANLNVLNQTDADGVIYVSEVEDPSRFGVALLEDGIITKLVEKPSTPVSNLAL
IGAYYVREVKELFAAIDVLIEQNIQTKGEFYLADALQLMISNGTRFSAETATMWEDCGTAPALLRTNRYLLQHETGNVEQ
RDGAIIVPPVFIGENVEIRNSIIGPYVSVADHSVIVDSIVRDSIINQGASIQSSTLEGSLIGEGAHIKGEFQHLNVGDSS
VITFGSTIQ

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=334, Percent_Identity=27.8443113772455, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI11761621, Length=333, Percent_Identity=27.6276276276276, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1790224, Length=258, Percent_Identity=24.8062015503876, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788351, Length=276, Percent_Identity=24.6376811594203, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=335, Percent_Identity=28.955223880597, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17509979, Length=327, Percent_Identity=25.3822629969419, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=334, Percent_Identity=24.8502994011976, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=334, Percent_Identity=25.748502994012, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355443, Length=320, Percent_Identity=28.125, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24644084, Length=320, Percent_Identity=28.125, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 35874; Mature: 35874

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIIPTAGLGTRLRPHTHTRPKPLVPVAGKAVIGHLLDKLKVLPLDDVVFITGYLGTQI
CEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECHHHHHH
EEYVRKNYNFKSHFVEQTELKGQAHAIALAREMVSGPTLILFVDTIFEANLNVLNQTDAD
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCEEECCCCC
GVIYVSEVEDPSRFGVALLEDGIITKLVEKPSTPVSNLALIGAYYVREVKELFAAIDVLI
CEEEEEECCCCHHHCHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQNIQTKGEFYLADALQLMISNGTRFSAETATMWEDCGTAPALLRTNRYLLQHETGNVEQ
HCCCCCCCCEEHHHHHHHHHCCCCEECCHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCC
RDGAIIVPPVFIGENVEIRNSIIGPYVSVADHSVIVDSIVRDSIINQGASIQSSTLEGSL
CCCEEEECCEEECCCEEEHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
IGEGAHIKGEFQHLNVGDSSVITFGSTIQ
ECCCCEEECEEEEECCCCCCEEECCCCCC
>Mature Secondary Structure
MNVIIPTAGLGTRLRPHTHTRPKPLVPVAGKAVIGHLLDKLKVLPLDDVVFITGYLGTQI
CEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECHHHHHH
EEYVRKNYNFKSHFVEQTELKGQAHAIALAREMVSGPTLILFVDTIFEANLNVLNQTDAD
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCEEECCCCC
GVIYVSEVEDPSRFGVALLEDGIITKLVEKPSTPVSNLALIGAYYVREVKELFAAIDVLI
CEEEEEECCCCHHHCHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQNIQTKGEFYLADALQLMISNGTRFSAETATMWEDCGTAPALLRTNRYLLQHETGNVEQ
HCCCCCCCCEEHHHHHHHHHCCCCEECCHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCC
RDGAIIVPPVFIGENVEIRNSIIGPYVSVADHSVIVDSIVRDSIINQGASIQSSTLEGSL
CCCEEEECCEEECCCEEEHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
IGEGAHIKGEFQHLNVGDSSVITFGSTIQ
ECCCCEEECEEEEECCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]