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The map label for this gene is tetA [H]

Identifier: 159897325

GI number: 159897325

Start: 899040

End: 900215

Strand: Direct

Name: tetA [H]

Synonym: Haur_0796

Alternate gene names: 159897325

Gene position: 899040-900215 (Clockwise)

Preceding gene: 159897324

Following gene: 159897328

Centisome position: 14.17

GC content: 53.32

Gene sequence:

>1176_bases
ATGAAACGCTCTCCACTTTTGACCATTTTTTTGATCGCGTTTGTTGGAACCATGAGCTATGGTGTGGTGATTCCGATCAC
GCCGTTTTATGCGCAGGAGTTTGGGGCTTCCGAGGTTCAGGTGGGCATGATTGTAGGCAGCTATGCCTTGATGCAATTTA
TCTTTGCCCCGATCCTTGGCCAATTATCCGACCGCTATGGTCGTCGCCCACTGCTGATTTTAAGTTTGATTGGCACGGTT
TGTAGTTTGTTGCTATTTGGTTTTGCCAATAGCCTGATTTGGCTGTTCGTCGGGCGCATGTTCGATGGCGCAACTGGCGG
TAACATCTCGATTGCCCAAGCCTATGTTAGCGATATCACCACCGACAAAGATCGTGCTCGCGGGATGGGCATGGTTGGGG
CGGCACTTGGCTTAGGCTTTATCGCTGGCCCAGCCATCGGCGCGTTGCTCAGCAAAGATGGCAATTATCAGTTGCCAATT
TTCGTAGCCGCAGGCATTGCAGTGCTCAGCCTGATTTTAACGATTGTGGTATTGCCTGAGCCAGAGCGCCATGCACCTCA
ACAAGGCCGTACTTTTAACCCAATGAAACTGCTGGCGGCAGTTCGCAAGCCCAATGTTGGCCGTTTGCTCAGTATTACCT
TGTTGATCAACTTGGCATTTGTGGCCTTTGAAACAACTTTTGCCTTGTTTGCGGCGCGACGGTTGGAGTTTGGCTCGCAT
CAAACAGGCTATACTTTGGCCGGGGTTGGGATTGTGGTCGCGATTGTGCAAGGCGGCTTAATTCGCCGTTTGGCGGCGCG
GTTTGGCGAAGCAACCCTGATTGTGTCTGGCTCGTTGCTGCTCGCGCTTTCGTTGGCGGGCTTGGGCTTTATTCAAAATG
TGTGGCATTTGGTGGCAATTTGTATTGTGCTGGCAGTTGGCGAGGGCTTGCTCACGCCATCGCTTTCGTCGTTGGTCAGC
CGCAATTCACCTGCTAGCGAGCGCGGCGAGAATATGGGCTTGTATCAGTCGATGAGCAGTTTGGCGCGGATTTTTGCCCC
GCTCTATGCCACCTGGATGCTCTCGAACGTTGGCGAAGCCTCGCCCTACCTGATGGGCAGCGTGTTGGTTGTGGCAGGCG
CATTAATTGCGGTTGGCTTGCCTAGCCCTGAACCGCAAGCCCAGCCAGCGCATTAG

Upstream 100 bases:

>100_bases
GTTGTTCGCTGGCGGTTGAAGATGTTCTCGCCGCTCGCCGTAACGGCAACGGCTAATCTAGTGATAAGGAGCCAGTAGCC
GCTTGGCTATAGACTCGCCT

Downstream 100 bases:

>100_bases
GCATAAATCGATGAATCAACATCGAAAATAAGTCCTTCGTTGGCCAGTTCTAGGGTTGGATCAAGTTGGTTCAACAAACG
GCGCTCATAGACAATCCAGC

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(B); Metal-tetracycline/H(+) antiporter [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKRSPLLTIFLIAFVGTMSYGVVIPITPFYAQEFGASEVQVGMIVGSYALMQFIFAPILGQLSDRYGRRPLLILSLIGTV
CSLLLFGFANSLIWLFVGRMFDGATGGNISIAQAYVSDITTDKDRARGMGMVGAALGLGFIAGPAIGALLSKDGNYQLPI
FVAAGIAVLSLILTIVVLPEPERHAPQQGRTFNPMKLLAAVRKPNVGRLLSITLLINLAFVAFETTFALFAARRLEFGSH
QTGYTLAGVGIVVAIVQGGLIRRLAARFGEATLIVSGSLLLALSLAGLGFIQNVWHLVAICIVLAVGEGLLTPSLSSLVS
RNSPASERGENMGLYQSMSSLARIFAPLYATWMLSNVGEASPYLMGSVLVVAGALIAVGLPSPEPQAQPAH

Sequences:

>Translated_391_residues
MKRSPLLTIFLIAFVGTMSYGVVIPITPFYAQEFGASEVQVGMIVGSYALMQFIFAPILGQLSDRYGRRPLLILSLIGTV
CSLLLFGFANSLIWLFVGRMFDGATGGNISIAQAYVSDITTDKDRARGMGMVGAALGLGFIAGPAIGALLSKDGNYQLPI
FVAAGIAVLSLILTIVVLPEPERHAPQQGRTFNPMKLLAAVRKPNVGRLLSITLLINLAFVAFETTFALFAARRLEFGSH
QTGYTLAGVGIVVAIVQGGLIRRLAARFGEATLIVSGSLLLALSLAGLGFIQNVWHLVAICIVLAVGEGLLTPSLSSLVS
RNSPASERGENMGLYQSMSSLARIFAPLYATWMLSNVGEASPYLMGSVLVVAGALIAVGLPSPEPQAQPAH
>Mature_391_residues
MKRSPLLTIFLIAFVGTMSYGVVIPITPFYAQEFGASEVQVGMIVGSYALMQFIFAPILGQLSDRYGRRPLLILSLIGTV
CSLLLFGFANSLIWLFVGRMFDGATGGNISIAQAYVSDITTDKDRARGMGMVGAALGLGFIAGPAIGALLSKDGNYQLPI
FVAAGIAVLSLILTIVVLPEPERHAPQQGRTFNPMKLLAAVRKPNVGRLLSITLLINLAFVAFETTFALFAARRLEFGSH
QTGYTLAGVGIVVAIVQGGLIRRLAARFGEATLIVSGSLLLALSLAGLGFIQNVWHLVAICIVLAVGEGLLTPSLSSLVS
RNSPASERGENMGLYQSMSSLARIFAPLYATWMLSNVGEASPYLMGSVLVVAGALIAVGLPSPEPQAQPAH

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=335, Percent_Identity=28.6567164179104, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI225703102, Length=335, Percent_Identity=28.6567164179104, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI39753965, Length=315, Percent_Identity=28.2539682539683, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI94721311, Length=315, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI217416366, Length=156, Percent_Identity=30.1282051282051, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI166064062, Length=336, Percent_Identity=22.0238095238095, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI166064060, Length=336, Percent_Identity=22.0238095238095, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87081738, Length=321, Percent_Identity=24.6105919003115, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787291, Length=385, Percent_Identity=21.8181818181818, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=361, Percent_Identity=28.5318559556787, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71985371, Length=393, Percent_Identity=24.1730279898219, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996331, Length=353, Percent_Identity=24.3626062322946, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17567337, Length=394, Percent_Identity=22.5888324873096, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997659, Length=159, Percent_Identity=30.8176100628931, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71997647, Length=159, Percent_Identity=30.8176100628931, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319871, Length=157, Percent_Identity=29.2993630573248, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17738085, Length=385, Percent_Identity=26.4935064935065, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21357569, Length=316, Percent_Identity=25.3164556962025, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656463, Length=316, Percent_Identity=25.6329113924051, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656468, Length=316, Percent_Identity=25.6329113924051, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221513297, Length=371, Percent_Identity=24.7978436657682, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161080926, Length=316, Percent_Identity=25.6329113924051, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161080924, Length=316, Percent_Identity=25.6329113924051, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24652013, Length=330, Percent_Identity=26.969696969697, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667557, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24667561, Length=172, Percent_Identity=26.7441860465116, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41297; Mature: 41297

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSPLLTIFLIAFVGTMSYGVVIPITPFYAQEFGASEVQVGMIVGSYALMQFIFAPILG
CCCCHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHH
QLSDRYGRRPLLILSLIGTVCSLLLFGFANSLIWLFVGRMFDGATGGNISIAQAYVSDIT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
TDKDRARGMGMVGAALGLGFIAGPAIGALLSKDGNYQLPIFVAAGIAVLSLILTIVVLPE
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
PERHAPQQGRTFNPMKLLAAVRKPNVGRLLSITLLINLAFVAFETTFALFAARRLEFGSH
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QTGYTLAGVGIVVAIVQGGLIRRLAARFGEATLIVSGSLLLALSLAGLGFIQNVWHLVAI
CCCCCHHHHHHHHHHHHCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
CIVLAVGEGLLTPSLSSLVSRNSPASERGENMGLYQSMSSLARIFAPLYATWMLSNVGEA
HHHHHHCCCCCCCCHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SPYLMGSVLVVAGALIAVGLPSPEPQAQPAH
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKRSPLLTIFLIAFVGTMSYGVVIPITPFYAQEFGASEVQVGMIVGSYALMQFIFAPILG
CCCCHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHH
QLSDRYGRRPLLILSLIGTVCSLLLFGFANSLIWLFVGRMFDGATGGNISIAQAYVSDIT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
TDKDRARGMGMVGAALGLGFIAGPAIGALLSKDGNYQLPIFVAAGIAVLSLILTIVVLPE
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
PERHAPQQGRTFNPMKLLAAVRKPNVGRLLSITLLINLAFVAFETTFALFAARRLEFGSH
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QTGYTLAGVGIVVAIVQGGLIRRLAARFGEATLIVSGSLLLALSLAGLGFIQNVWHLVAI
CCCCCHHHHHHHHHHHHCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
CIVLAVGEGLLTPSLSSLVSRNSPASERGENMGLYQSMSSLARIFAPLYATWMLSNVGEA
HHHHHHCCCCCCCCHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SPYLMGSVLVVAGALIAVGLPSPEPQAQPAH
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6319234; 6298728; 1848846; 2168416; 8995300 [H]