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The map label for this gene is pepA [H]

Identifier: 159897157

GI number: 159897157

Start: 723177

End: 724667

Strand: Reverse

Name: pepA [H]

Synonym: Haur_0628

Alternate gene names: 159897157

Gene position: 724667-723177 (Counterclockwise)

Preceding gene: 159897160

Following gene: 159897156

Centisome position: 11.42

GC content: 53.52

Gene sequence:

>1491_bases
ATGCAGATTCGTGTAATACAAGGCGATGTTGCTCAACAAGCCGATGCCATTGTTGTTGTTGGTACATGGGCGAATGAGGA
ACTGCCTGCCAGCGTTGCTGGTTTAATTGAAGCGAGTGATTGGTCAGGTAAGTACAAAAAAACCACTGTGCTCTATCTTG
GCGCACAAGCGACAGGTATTCCCGCCTTCGCCAGCCGCCGGGTGCTGTTGGTTGGTTTGGGCAAGCGCGAATTATGGAAC
GCTGAGCGTGCTCGCGTCATCGGGGCAATTCTGGCCCAACGAGTACGCGATTTGGGCCTGACGAGCTATAGCCTGCCTTT
GCTTGGAAGCGAAGTTTTGGGTGTTAGCCGTAGCGCCGAGGCTTTGAGCGAAGGCGCATTGTTGGGTGCTTATCGCTTTG
ATGGCTTTAAAACTTTGCCCGACGATTTTGTGCCAGCCGTTGCTTTAGAACAGGTGACGTTGGTTGCCGAAGCTGAGCTT
GAAGCCGCCGAATTTGGCTCGAAATGGGGCATTGCGTTGGCTCATGGAGTCAATCTTGCCCGCGATTTGGGCAACAATCC
GCCAATCGTGGCAACGCCAACCTACTTGGCCGAAGCCGCTCAAACGATCGCCCGTGATTATGGCATGACCTGTTTGGTGC
TCGACCACGACCAACAAAAAGAGTTGGGTATGGGTGCGTTAATTGGGGTTGCCAAGGGTGCTGCCGAGCCAGCCAAGTTC
ATCGTTTTGGAGCATGGCCAAGCTGAGCCAGGCAAACCAACGATTTGTTTGGTCGGCAAAGGCATTACCTTCGATACAGG
CGGGATTTCGATCAAGCCAGCCGATAACATGGACAAAATGAAAATGGACATGCAAGGCGCTGGCGCAGTGATTGGCACGA
TGGAAGCGGTAGGTCGTTTGAAATTGCCAATTCACGTCGTAGCCTTGGTGGCCGCAACCGAAAATATGCCTGGCAGCAAT
GCCTACAAACCAGGCGATATTCTCAAAGCCATGAATGGCGTAACGATCGAAGTGCTCAACACCGATGCCGAAGGCCGTTT
GGTCTTGGCCGATGCCCTTTCCTATGCCCAAAAATACAATCCCGATGCAATTATCGACCTTGCAACCCTGACTGGCGCGT
GTGTCGTGGCGCTTGGCTCATATGCCGCAGGCGCAATGACCAACAATCCAGCTTTGTTGCAACGGGTGCAGCAAGCTGCC
GAAGGTTCAGGCGATCGGGTTTGGGAACTGCCATTGTGGGATGAATACCGCCGTCAAGTGCGTTCCGATGTTGCCGACAT
CAAAAATACTGGTGGCCGCAACGGTGGGGCGATTACCGCTGGGGCGTTCTTGAGCCATTTCGTTGGCGATTATCCATGGG
TCCATTTGGATATTGCCGGCGTGGCATGGACTGAAGATCAACCCAAGGAATACAACCCTAAAGGAGCAACCGGCTATGGG
GTGCGCCTCTTGACGGAATTGCTGCGCGAGTGGAGTGGCGTTTCGTTATAG

Upstream 100 bases:

>100_bases
CCCAATCAATATCAATCATTGACAGCGGCAAATTGAAACCGTTACAATACCAAGCAACTGTGCAAGCTCTTGTCAACCTC
TAGAAACCGGAAGGACTCCA

Downstream 100 bases:

>100_bases
CGGGAGTGTGGTCTATGGCTGGGACAATGCGGGTCACATTTTGGGGTGTTCGGGGTAGCTATCCGGTTCCCGGGTCGGAT
ACTGTGGGGTTTGGCGGCAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MQIRVIQGDVAQQADAIVVVGTWANEELPASVAGLIEASDWSGKYKKTTVLYLGAQATGIPAFASRRVLLVGLGKRELWN
AERARVIGAILAQRVRDLGLTSYSLPLLGSEVLGVSRSAEALSEGALLGAYRFDGFKTLPDDFVPAVALEQVTLVAEAEL
EAAEFGSKWGIALAHGVNLARDLGNNPPIVATPTYLAEAAQTIARDYGMTCLVLDHDQQKELGMGALIGVAKGAAEPAKF
IVLEHGQAEPGKPTICLVGKGITFDTGGISIKPADNMDKMKMDMQGAGAVIGTMEAVGRLKLPIHVVALVAATENMPGSN
AYKPGDILKAMNGVTIEVLNTDAEGRLVLADALSYAQKYNPDAIIDLATLTGACVVALGSYAAGAMTNNPALLQRVQQAA
EGSGDRVWELPLWDEYRRQVRSDVADIKNTGGRNGGAITAGAFLSHFVGDYPWVHLDIAGVAWTEDQPKEYNPKGATGYG
VRLLTELLREWSGVSL

Sequences:

>Translated_496_residues
MQIRVIQGDVAQQADAIVVVGTWANEELPASVAGLIEASDWSGKYKKTTVLYLGAQATGIPAFASRRVLLVGLGKRELWN
AERARVIGAILAQRVRDLGLTSYSLPLLGSEVLGVSRSAEALSEGALLGAYRFDGFKTLPDDFVPAVALEQVTLVAEAEL
EAAEFGSKWGIALAHGVNLARDLGNNPPIVATPTYLAEAAQTIARDYGMTCLVLDHDQQKELGMGALIGVAKGAAEPAKF
IVLEHGQAEPGKPTICLVGKGITFDTGGISIKPADNMDKMKMDMQGAGAVIGTMEAVGRLKLPIHVVALVAATENMPGSN
AYKPGDILKAMNGVTIEVLNTDAEGRLVLADALSYAQKYNPDAIIDLATLTGACVVALGSYAAGAMTNNPALLQRVQQAA
EGSGDRVWELPLWDEYRRQVRSDVADIKNTGGRNGGAITAGAFLSHFVGDYPWVHLDIAGVAWTEDQPKEYNPKGATGYG
VRLLTELLREWSGVSL
>Mature_496_residues
MQIRVIQGDVAQQADAIVVVGTWANEELPASVAGLIEASDWSGKYKKTTVLYLGAQATGIPAFASRRVLLVGLGKRELWN
AERARVIGAILAQRVRDLGLTSYSLPLLGSEVLGVSRSAEALSEGALLGAYRFDGFKTLPDDFVPAVALEQVTLVAEAEL
EAAEFGSKWGIALAHGVNLARDLGNNPPIVATPTYLAEAAQTIARDYGMTCLVLDHDQQKELGMGALIGVAKGAAEPAKF
IVLEHGQAEPGKPTICLVGKGITFDTGGISIKPADNMDKMKMDMQGAGAVIGTMEAVGRLKLPIHVVALVAATENMPGSN
AYKPGDILKAMNGVTIEVLNTDAEGRLVLADALSYAQKYNPDAIIDLATLTGACVVALGSYAAGAMTNNPALLQRVQQAA
EGSGDRVWELPLWDEYRRQVRSDVADIKNTGGRNGGAITAGAFLSHFVGDYPWVHLDIAGVAWTEDQPKEYNPKGATGYG
VRLLTELLREWSGVSL

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=443, Percent_Identity=40.4063205417607, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI47155554, Length=320, Percent_Identity=37.1875, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1790710, Length=514, Percent_Identity=40.8560311284047, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=37.6947040498442, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=332, Percent_Identity=33.433734939759, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=255, Percent_Identity=32.9411764705882, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355725, Length=504, Percent_Identity=32.7380952380952, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24661038, Length=495, Percent_Identity=31.9191919191919, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129969, Length=346, Percent_Identity=34.6820809248555, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24662227, Length=413, Percent_Identity=31.2348668280872, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161077148, Length=377, Percent_Identity=29.4429708222812, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20130057, Length=377, Percent_Identity=29.4429708222812, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21355645, Length=346, Percent_Identity=30.0578034682081, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24662223, Length=346, Percent_Identity=30.0578034682081, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI19922386, Length=407, Percent_Identity=30.2211302211302, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI221379063, Length=301, Percent_Identity=37.5415282392027, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI221379062, Length=301, Percent_Identity=37.5415282392027, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357381, Length=301, Percent_Identity=37.5415282392027, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20129963, Length=441, Percent_Identity=30.1587301587302, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24646701, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646703, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21358201, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52489; Mature: 52489

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRVIQGDVAQQADAIVVVGTWANEELPASVAGLIEASDWSGKYKKTTVLYLGAQATGI
CEEEEEECCHHCCCCEEEEEEECCCCCCCCHHHHEEECCCCCCCCEEEEEEEECCCCCCC
PAFASRRVLLVGLGKRELWNAERARVIGAILAQRVRDLGLTSYSLPLLGSEVLGVSRSAE
CHHHCCCEEEEECCCHHHHCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCHHH
ALSEGALLGAYRFDGFKTLPDDFVPAVALEQVTLVAEAELEAAEFGSKWGIALAHGVNLA
HHHCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEEHHHHHHHHHCCCCCCEEHHHCCHHH
RDLGNNPPIVATPTYLAEAAQTIARDYGMTCLVLDHDQQKELGMGALIGVAKGAAEPAKF
HHCCCCCCEEECHHHHHHHHHHHHHHHCCEEEEECCCCCHHCCCHHHHHHHCCCCCCEEE
IVLEHGQAEPGKPTICLVGKGITFDTGGISIKPADNMDKMKMDMQGAGAVIGTMEAVGRL
EEEECCCCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCCHHEEHHHHHCCC
KLPIHVVALVAATENMPGSNAYKPGDILKAMNGVTIEVLNTDAEGRLVLADALSYAQKYN
CCCHHEEEEEHHHCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHCC
PDAIIDLATLTGACVVALGSYAAGAMTNNPALLQRVQQAAEGSGDRVWELPLWDEYRRQV
CCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
RSDVADIKNTGGRNGGAITAGAFLSHFVGDYPWVHLDIAGVAWTEDQPKEYNPKGATGYG
HHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHH
VRLLTELLREWSGVSL
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQIRVIQGDVAQQADAIVVVGTWANEELPASVAGLIEASDWSGKYKKTTVLYLGAQATGI
CEEEEEECCHHCCCCEEEEEEECCCCCCCCHHHHEEECCCCCCCCEEEEEEEECCCCCCC
PAFASRRVLLVGLGKRELWNAERARVIGAILAQRVRDLGLTSYSLPLLGSEVLGVSRSAE
CHHHCCCEEEEECCCHHHHCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCHHH
ALSEGALLGAYRFDGFKTLPDDFVPAVALEQVTLVAEAELEAAEFGSKWGIALAHGVNLA
HHHCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEEHHHHHHHHHCCCCCCEEHHHCCHHH
RDLGNNPPIVATPTYLAEAAQTIARDYGMTCLVLDHDQQKELGMGALIGVAKGAAEPAKF
HHCCCCCCEEECHHHHHHHHHHHHHHHCCEEEEECCCCCHHCCCHHHHHHHCCCCCCEEE
IVLEHGQAEPGKPTICLVGKGITFDTGGISIKPADNMDKMKMDMQGAGAVIGTMEAVGRL
EEEECCCCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCCHHEEHHHHHCCC
KLPIHVVALVAATENMPGSNAYKPGDILKAMNGVTIEVLNTDAEGRLVLADALSYAQKYN
CCCHHEEEEEHHHCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHCC
PDAIIDLATLTGACVVALGSYAAGAMTNNPALLQRVQQAAEGSGDRVWELPLWDEYRRQV
CCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
RSDVADIKNTGGRNGGAITAGAFLSHFVGDYPWVHLDIAGVAWTEDQPKEYNPKGATGYG
HHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHH
VRLLTELLREWSGVSL
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA