Click here to switch to the map view.

The map label for this gene is pth

Identifier: 159896843

GI number: 159896843

Start: 369614

End: 370234

Strand: Reverse

Name: pth

Synonym: Haur_0310

Alternate gene names: 159896843

Gene position: 370234-369614 (Counterclockwise)

Preceding gene: 159896847

Following gene: 159896842

Centisome position: 5.83

GC content: 50.08

Gene sequence:

>621_bases
ATGTTTTTAATTGTTGGGCTGGGCAATCCAGGTGAGAAATATCTGAATAATCGGCATAATGTGGGCTTTCAATGTGTAGC
CGAGTTTGCCCGTCGCCATCATTTAAGTTTCGATGGCAAGCGCTCCGATGCCCGCATTGCTGAGGGCTTGGTCAATGGCC
AACGCGTGGCCTTGGCTCGCCCGCAAACCTTTATGAACGATAGTGGCAAATCAGTCGTCGGCCTCGTAAATTGGTACAAA
ATCGACCCAGCCAGCGAATTATTGGTGGTTTACGACGATTTAGATCTGCCTTTTGGCACGATCAAGCTGCGCAATCAAGG
TAGTTCTGGTGGTCAGCGTGGCATGAATTCGATTATTCAATTGCTGGGAACTCAAAAATTTGCCCGCTTGCGCTTTGGCA
TTGGCCGCCCACCTGAAGGTTGGGAAGTGATTAATTTTGTGCTCGGCAATTGGAATGCTGCCGAACGCGAAACCTTGCCA
AAACTCTACGATCGGGCGGTTGAGGCCTGCGAATTGTGCTTGAGTGATGGCGTGACCAAAGCCATGAACGCCGTCAATGG
CGAAGCCCCCAAGAAAAGTAAAGATCAAGCAAAGGAGCCAGCCAATGAGCAACCACGTTGA

Upstream 100 bases:

>100_bases
TGCGCATACTTCCCTATGGTACAATGCTTCAGCCTGCGCCATTGGCGGCGCATTGCCTGTAGTATATCGCGATTTTAACC
AAACCTGTCGTGGGGATGTC

Downstream 100 bases:

>100_bases
TTATGCCCAAGCTCGCAGCTATTGCCTGAGCCTTGACGACGTAATTGAAGATTATCCATTTGGGATTGAACCCTTGGTGT
TTAAAATTGGCGATGAGCGC

Product: aminoacyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MFLIVGLGNPGEKYLNNRHNVGFQCVAEFARRHHLSFDGKRSDARIAEGLVNGQRVALARPQTFMNDSGKSVVGLVNWYK
IDPASELLVVYDDLDLPFGTIKLRNQGSSGGQRGMNSIIQLLGTQKFARLRFGIGRPPEGWEVINFVLGNWNAAERETLP
KLYDRAVEACELCLSDGVTKAMNAVNGEAPKKSKDQAKEPANEQPR

Sequences:

>Translated_206_residues
MFLIVGLGNPGEKYLNNRHNVGFQCVAEFARRHHLSFDGKRSDARIAEGLVNGQRVALARPQTFMNDSGKSVVGLVNWYK
IDPASELLVVYDDLDLPFGTIKLRNQGSSGGQRGMNSIIQLLGTQKFARLRFGIGRPPEGWEVINFVLGNWNAAERETLP
KLYDRAVEACELCLSDGVTKAMNAVNGEAPKKSKDQAKEPANEQPR
>Mature_206_residues
MFLIVGLGNPGEKYLNNRHNVGFQCVAEFARRHHLSFDGKRSDARIAEGLVNGQRVALARPQTFMNDSGKSVVGLVNWYK
IDPASELLVVYDDLDLPFGTIKLRNQGSSGGQRGMNSIIQLLGTQKFARLRFGIGRPPEGWEVINFVLGNWNAAERETLP
KLYDRAVEACELCLSDGVTKAMNAVNGEAPKKSKDQAKEPANEQPR

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=35.8823529411765, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=40.1041666666667, Blast_Score=111, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_HERA2 (A9B7I9)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543090.1
- ProteinModelPortal:   A9B7I9
- SMR:   A9B7I9
- GeneID:   5732205
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0310
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- BioCyc:   HAUR316274:HAUR_0310-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22784; Mature: 22784

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLIVGLGNPGEKYLNNRHNVGFQCVAEFARRHHLSFDGKRSDARIAEGLVNGQRVALAR
CEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEC
PQTFMNDSGKSVVGLVNWYKIDPASELLVVYDDLDLPFGTIKLRNQGSSGGQRGMNSIIQ
CHHHHCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHH
LLGTQKFARLRFGIGRPPEGWEVINFVLGNWNAAERETLPKLYDRAVEACELCLSDGVTK
HHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
AMNAVNGEAPKKSKDQAKEPANEQPR
HHHHHCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MFLIVGLGNPGEKYLNNRHNVGFQCVAEFARRHHLSFDGKRSDARIAEGLVNGQRVALAR
CEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEC
PQTFMNDSGKSVVGLVNWYKIDPASELLVVYDDLDLPFGTIKLRNQGSSGGQRGMNSIIQ
CHHHHCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHH
LLGTQKFARLRFGIGRPPEGWEVINFVLGNWNAAERETLPKLYDRAVEACELCLSDGVTK
HHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
AMNAVNGEAPKKSKDQAKEPANEQPR
HHHHHCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA