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The map label for this gene is lldD [H]

Identifier: 159896762

GI number: 159896762

Start: 264904

End: 265998

Strand: Direct

Name: lldD [H]

Synonym: Haur_0229

Alternate gene names: 159896762

Gene position: 264904-265998 (Clockwise)

Preceding gene: 159896761

Following gene: 159896763

Centisome position: 4.17

GC content: 56.35

Gene sequence:

>1095_bases
ATGAGCAAGCCGATTAATCTCCACGAGTATGAGCAACAGGCAATGACGCTGTTGGATGGCCCAACCTGCGATTATTATGC
AGGTGGCTGCGAGGATGAAGTGACTTTGCGAGCGAATCTGCTTTCGTTTGAGCAGGTACGTTTGCGCCCACGCTTTTTGG
TCGATGTGCGTGAAGTCTCAACCGCTACAACTCTGCTAGGCAAGCCGCTTGATTCGCCAATTTTGGTTGCACCATCGGCC
TACCATGGCTTGGCCCATGCTGAGGGCGAATGTGAAACTGCACGCGGTGTGGCTCAAGCTGGCTCAATTTTCACCGTAAG
CACGCTCGCCACCCGCTCGTTGGAAGAAGTTGCGGCTGCCGCCGAATGCCCGCTCTGGTTTCAATTGTATGTCTATCGTG
ATCGCAGCGTGTCGGAGCGTTTGATTGCTCGCGCCGAAGCTGCTGGCTATCAAGCTTTGATGTTGACGATTGATCGCCCG
TGGCTTGGGCGGCGCGAGCGTGAGTTACGCAGTGGTTTTGGCGTGCCTGCTCATCTGAGTATGGCCAATTTTCGCGATGT
GCCTGCCGCTCAGAACTATCGGCGTGCTGGCCCGAATGCCTTGCCCGACCCCAAAGCCGATATGTTCGATGCTGGGTTAA
CTTGGGAATCGATCGCTTGGTTGCGCTCAGTGACCAGTTTGCCCATCATCGTCAAAGGGATTTTGACCGCTGAGGATGCG
CTGTTGGCGGCAGAGGCAGGCGCGGCGGCGATCGTGGTGTCAAATCATGGTGGCCGCCAAATTGATGGTACAGTTACCAC
GCTTGAAGCCTTGCCCGAAGTTGTCGCAGCATTGGCGCAAAGCCCGTGCGAAATTTATATCGATGGCGGGATTCGCCGCG
GCAGCGATGCGCTTAAAGCCTTGGCCTTAGGAGCGCAGGCAATTATGCTTGGGCGGCCAGTCTTATGGGGCTTGGCAGTG
GCGGGTAGTGCTGGGGTTGCCGATGTGCTGACGACCATGCAGCGTGAATTGCAACGCTCGATGGCGCTATGTGGCCGCCC
CAATTTAGCCAGCATCGATCGCAGCTTAGTGCGACCAAGCGGCATGGTTTTCTAA

Upstream 100 bases:

>100_bases
GCAGCGCTAACGATTGGCTCAATTGTGCTACTGAAATTGGCTTGAGCATCTGCTACACTAGAGCCACCGGATTATTTCAG
GCTGCGAAAGGATCGCTGCA

Downstream 100 bases:

>100_bases
AATAGAGGGGTCAGGGGCTAGTGTTCAGTCCATACGACAGGAGTCCTTCGTGGCCTTCGTGGATCAAAACCTGGCCATGA
CCCCTGACCCTTCGATCGCA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSKPINLHEYEQQAMTLLDGPTCDYYAGGCEDEVTLRANLLSFEQVRLRPRFLVDVREVSTATTLLGKPLDSPILVAPSA
YHGLAHAEGECETARGVAQAGSIFTVSTLATRSLEEVAAAAECPLWFQLYVYRDRSVSERLIARAEAAGYQALMLTIDRP
WLGRRERELRSGFGVPAHLSMANFRDVPAAQNYRRAGPNALPDPKADMFDAGLTWESIAWLRSVTSLPIIVKGILTAEDA
LLAAEAGAAAIVVSNHGGRQIDGTVTTLEALPEVVAALAQSPCEIYIDGGIRRGSDALKALALGAQAIMLGRPVLWGLAV
AGSAGVADVLTTMQRELQRSMALCGRPNLASIDRSLVRPSGMVF

Sequences:

>Translated_364_residues
MSKPINLHEYEQQAMTLLDGPTCDYYAGGCEDEVTLRANLLSFEQVRLRPRFLVDVREVSTATTLLGKPLDSPILVAPSA
YHGLAHAEGECETARGVAQAGSIFTVSTLATRSLEEVAAAAECPLWFQLYVYRDRSVSERLIARAEAAGYQALMLTIDRP
WLGRRERELRSGFGVPAHLSMANFRDVPAAQNYRRAGPNALPDPKADMFDAGLTWESIAWLRSVTSLPIIVKGILTAEDA
LLAAEAGAAAIVVSNHGGRQIDGTVTTLEALPEVVAALAQSPCEIYIDGGIRRGSDALKALALGAQAIMLGRPVLWGLAV
AGSAGVADVLTTMQRELQRSMALCGRPNLASIDRSLVRPSGMVF
>Mature_363_residues
SKPINLHEYEQQAMTLLDGPTCDYYAGGCEDEVTLRANLLSFEQVRLRPRFLVDVREVSTATTLLGKPLDSPILVAPSAY
HGLAHAEGECETARGVAQAGSIFTVSTLATRSLEEVAAAAECPLWFQLYVYRDRSVSERLIARAEAAGYQALMLTIDRPW
LGRRERELRSGFGVPAHLSMANFRDVPAAQNYRRAGPNALPDPKADMFDAGLTWESIAWLRSVTSLPIIVKGILTAEDAL
LAAEAGAAAIVVSNHGGRQIDGTVTTLEALPEVVAALAQSPCEIYIDGGIRRGSDALKALALGAQAIMLGRPVLWGLAVA
GSAGVADVLTTMQRELQRSMALCGRPNLASIDRSLVRPSGMVF

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=42.1052631578947, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI54234014, Length=357, Percent_Identity=42.296918767507, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI7705393, Length=357, Percent_Identity=42.296918767507, Blast_Score=287, Evalue=1e-77,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=35.5614973262032, Blast_Score=217, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI193208036, Length=346, Percent_Identity=43.0635838150289, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI32566217, Length=269, Percent_Identity=40.8921933085502, Blast_Score=211, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323587, Length=367, Percent_Identity=36.5122615803815, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI78707188, Length=353, Percent_Identity=44.1926345609065, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI281363140, Length=355, Percent_Identity=43.943661971831, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI78707190, Length=355, Percent_Identity=43.943661971831, Blast_Score=305, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 39071; Mature: 38940

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPINLHEYEQQAMTLLDGPTCDYYAGGCEDEVTLRANLLSFEQVRLRPRFLVDVREVS
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHEEEHHHHH
TATTLLGKPLDSPILVAPSAYHGLAHAEGECETARGVAQAGSIFTVSTLATRSLEEVAAA
HHHHHHCCCCCCCEEECCCHHCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHH
AECPLWFQLYVYRDRSVSERLIARAEAAGYQALMLTIDRPWLGRRERELRSGFGVPAHLS
HCCCEEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEE
MANFRDVPAAQNYRRAGPNALPDPKADMFDAGLTWESIAWLRSVTSLPIIVKGILTAEDA
HHCCCCCCCCHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LLAAEAGAAAIVVSNHGGRQIDGTVTTLEALPEVVAALAQSPCEIYIDGGIRRGSDALKA
HHEECCCCEEEEEECCCCCEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LALGAQAIMLGRPVLWGLAVAGSAGVADVLTTMQRELQRSMALCGRPNLASIDRSLVRPS
HHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
GMVF
CCCC
>Mature Secondary Structure 
SKPINLHEYEQQAMTLLDGPTCDYYAGGCEDEVTLRANLLSFEQVRLRPRFLVDVREVS
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHEEEHHHHH
TATTLLGKPLDSPILVAPSAYHGLAHAEGECETARGVAQAGSIFTVSTLATRSLEEVAAA
HHHHHHCCCCCCCEEECCCHHCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHH
AECPLWFQLYVYRDRSVSERLIARAEAAGYQALMLTIDRPWLGRRERELRSGFGVPAHLS
HCCCEEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEE
MANFRDVPAAQNYRRAGPNALPDPKADMFDAGLTWESIAWLRSVTSLPIIVKGILTAEDA
HHCCCCCCCCHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LLAAEAGAAAIVVSNHGGRQIDGTVTTLEALPEVVAALAQSPCEIYIDGGIRRGSDALKA
HHEECCCCEEEEEECCCCCEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LALGAQAIMLGRPVLWGLAVAGSAGVADVLTTMQRELQRSMALCGRPNLASIDRSLVRPS
HHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
GMVF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA