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The map label for this gene is uppS [H]

Identifier: 159896710

GI number: 159896710

Start: 207253

End: 207987

Strand: Reverse

Name: uppS [H]

Synonym: Haur_0177

Alternate gene names: 159896710

Gene position: 207987-207253 (Counterclockwise)

Preceding gene: 159896712

Following gene: 159896709

Centisome position: 3.28

GC content: 52.38

Gene sequence:

>735_bases
ATGACCGTACAACAACTTGAAACTACTGTCGCACCTCGACATGTCGCAATAATAATGGATGGCAATGGCCGTTGGGCACA
AGGCCGTGGACTCCCCCGTCTGGCAGGGCATCATGCTGGAACTGGTAATATCAAACGAATTGTGCGCGAGGCTATCTCCC
TAGGCATTCCCTATCTCACGATTTATGCCTTTTCAACCGAAAATTGGAAGCGCCCATCGTGGGAAGTGCGCGGATTAATG
CGCATTATGGCCGAATATCTTGATCGTGAGTTGCGCGAGTTGCATGCTGAAGGGGTACGCTTGCACTTGCTGGGCACGCT
CGAAGGGGTCGATTCGGCGCTCGCCAAGAAAATTCAAAATGCCATTACCATGACTGCCAATAATACCGCCTTGACGCTCT
CGGTAGCCTTCAACTATGGTGGTCGCGCCGATATCGTCAATGCAGTGCGCGAAATCGTGGCTAAGGGGATCAATCCTGAG
GATATTAGCGATGAGATGATCGCTGGGCACTTGTATACATCGGGCATTCCCGACCCCGATTTGATTGTGCGCACCAGTGG
CGAGCAACGCTTAAGCAACTTTTTGATTTGGCAGGCCGCCTATAGCGAATATTATATGACCCCGCTGCTGTGGCCCGATT
TTGGCCCCGACCAGTTTCGCGAGGCCGTCAGCAATTTTGGCAATCGCGAACGCCGTTACGGTGGTCGGATCGGTGAAGGC
GAAATGGCTAAATAA

Upstream 100 bases:

>100_bases
TCGCATAAATTGCACGCGAGTGCTTGCAACAATGGTAGTATATTCGTTACCCTACAACGAATGCTAGACAAACGCTTAAA
TTGATGAGGTCTTTAGATCT

Downstream 100 bases:

>100_bases
TCACATTTACGCCCTCACCCCCTAGCCCCCTCTCCCAACCAGCAGGCGAGGGGGAATCGTCCTATCATGCAACAGTGGGC
AAGAGGTTAGGGTGAGGGAA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTVQQLETTVAPRHVAIIMDGNGRWAQGRGLPRLAGHHAGTGNIKRIVREAISLGIPYLTIYAFSTENWKRPSWEVRGLM
RIMAEYLDRELRELHAEGVRLHLLGTLEGVDSALAKKIQNAITMTANNTALTLSVAFNYGGRADIVNAVREIVAKGINPE
DISDEMIAGHLYTSGIPDPDLIVRTSGEQRLSNFLIWQAAYSEYYMTPLLWPDFGPDQFREAVSNFGNRERRYGGRIGEG
EMAK

Sequences:

>Translated_244_residues
MTVQQLETTVAPRHVAIIMDGNGRWAQGRGLPRLAGHHAGTGNIKRIVREAISLGIPYLTIYAFSTENWKRPSWEVRGLM
RIMAEYLDRELRELHAEGVRLHLLGTLEGVDSALAKKIQNAITMTANNTALTLSVAFNYGGRADIVNAVREIVAKGINPE
DISDEMIAGHLYTSGIPDPDLIVRTSGEQRLSNFLIWQAAYSEYYMTPLLWPDFGPDQFREAVSNFGNRERRYGGRIGEG
EMAK
>Mature_243_residues
TVQQLETTVAPRHVAIIMDGNGRWAQGRGLPRLAGHHAGTGNIKRIVREAISLGIPYLTIYAFSTENWKRPSWEVRGLMR
IMAEYLDRELRELHAEGVRLHLLGTLEGVDSALAKKIQNAITMTANNTALTLSVAFNYGGRADIVNAVREIVAKGINPED
ISDEMIAGHLYTSGIPDPDLIVRTSGEQRLSNFLIWQAAYSEYYMTPLLWPDFGPDQFREAVSNFGNRERRYGGRIGEGE
MAK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=39.6396396396396, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=39.6396396396396, Blast_Score=164, Evalue=7e-41,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=48.0176211453744, Blast_Score=224, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=224, Percent_Identity=35.7142857142857, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=38.785046728972, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=30.2631578947368, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18857969, Length=245, Percent_Identity=35.5102040816327, Blast_Score=151, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27240; Mature: 27109

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQQLETTVAPRHVAIIMDGNGRWAQGRGLPRLAGHHAGTGNIKRIVREAISLGIPYLT
CCHHHHHHHCCCCEEEEEECCCCCEECCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCEEE
IYAFSTENWKRPSWEVRGLMRIMAEYLDRELRELHAEGVRLHLLGTLEGVDSALAKKIQN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHH
AITMTANNTALTLSVAFNYGGRADIVNAVREIVAKGINPEDISDEMIAGHLYTSGIPDPD
HEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
LIVRTSGEQRLSNFLIWQAAYSEYYMTPLLWPDFGPDQFREAVSNFGNRERRYGGRIGEG
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC
EMAK
CCCC
>Mature Secondary Structure 
TVQQLETTVAPRHVAIIMDGNGRWAQGRGLPRLAGHHAGTGNIKRIVREAISLGIPYLT
CHHHHHHHCCCCEEEEEECCCCCEECCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCEEE
IYAFSTENWKRPSWEVRGLMRIMAEYLDRELRELHAEGVRLHLLGTLEGVDSALAKKIQN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHH
AITMTANNTALTLSVAFNYGGRADIVNAVREIVAKGINPEDISDEMIAGHLYTSGIPDPD
HEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
LIVRTSGEQRLSNFLIWQAAYSEYYMTPLLWPDFGPDQFREAVSNFGNRERRYGGRIGEG
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC
EMAK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12446909 [H]